AU2006254543A1 - PEGylated G-CSF polypeptides and methods of producing same - Google Patents
PEGylated G-CSF polypeptides and methods of producing same Download PDFInfo
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- AU2006254543A1 AU2006254543A1 AU2006254543A AU2006254543A AU2006254543A1 AU 2006254543 A1 AU2006254543 A1 AU 2006254543A1 AU 2006254543 A AU2006254543 A AU 2006254543A AU 2006254543 A AU2006254543 A AU 2006254543A AU 2006254543 A1 AU2006254543 A1 AU 2006254543A1
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- Prior art keywords
- peg
- polypeptide
- isomers
- csf
- pegylated
- Prior art date
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
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- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
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| US68672605P | 2005-06-01 | 2005-06-01 | |
| US60/686,726 | 2005-06-01 | ||
| PCT/DK2006/000292 WO2006128460A2 (en) | 2005-06-01 | 2006-05-26 | Pegylated g-csf polypeptides and methods of producing same |
Publications (1)
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| EP (1) | EP1888119B1 (enExample) |
| JP (2) | JP5137821B2 (enExample) |
| KR (1) | KR20080027291A (enExample) |
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| AT (1) | ATE500847T1 (enExample) |
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| BR (1) | BRPI0611221A2 (enExample) |
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| DE (1) | DE602006020562D1 (enExample) |
| IL (1) | IL187009A0 (enExample) |
| MX (1) | MX2007015156A (enExample) |
| NO (1) | NO20075708L (enExample) |
| RU (1) | RU2007149238A (enExample) |
| WO (1) | WO2006128460A2 (enExample) |
| ZA (1) | ZA200709704B (enExample) |
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| RU2007149238A (ru) | 2005-06-01 | 2009-07-20 | Максиджен Холдингз Лтд. (Ky) | Пегилированные полипептиды гксф и способы их получения |
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| EP2344203A2 (en) * | 2008-09-19 | 2011-07-20 | Maxygen, Inc. | Method for the treatment of radiation-induced neutropenia by administration of a multi-pegylated granulocyte colony stimulating factor (g-csf) variant |
| US7914828B2 (en) * | 2008-10-17 | 2011-03-29 | Levine Brian M | Combination herbal product to benefit respiratory tract |
| WO2011041376A1 (en) * | 2009-09-30 | 2011-04-07 | Prolong Pharmaceuticals | Modified granulocyte colony stimulating factor (g-csf) |
| EP2494050A4 (en) * | 2009-10-30 | 2013-10-30 | Merck Sharp & Dohme | GRANULOCYTIC COLONY STIMULATING FACTOR MADE IN GLYCOENGINEERED PICHIA PASTORIS |
| AR083006A1 (es) * | 2010-09-23 | 2013-01-23 | Lilly Co Eli | Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas |
| WO2012064845A2 (en) * | 2010-11-09 | 2012-05-18 | Nektar Therapeutics | G-csf polymer conjugates having a releasable linkage |
| US20140187488A1 (en) * | 2011-05-17 | 2014-07-03 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
| CN104109199B (zh) * | 2013-04-16 | 2019-04-30 | 深圳未名新鹏生物医药有限公司 | 一种聚乙二醇单修饰的人粒细胞集落刺激因子的制备方法及其产品 |
| AU2016277147A1 (en) * | 2015-06-11 | 2018-01-18 | Ambio Pharmaceuticals, Llc | Pegylated granulocyte colony stimulating factor (GCSF) |
| KR102020995B1 (ko) * | 2017-10-30 | 2019-09-16 | 한국코러스 주식회사 | 콜로니자극인자와 폴리올이 접합된 접합물을 고수율로 제조하는 방법 |
| US20210386680A1 (en) * | 2018-12-06 | 2021-12-16 | Board Of Regents, The University Of Texas System | Selectively cleavable therapeutic nanoparticles |
| CN114853872B (zh) * | 2022-04-27 | 2023-11-17 | 山东新时代药业有限公司 | 一种聚乙二醇修饰rhG-CSF的制备方法 |
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| WO1985000817A1 (en) | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of interleukin ii |
| JPS61227526A (ja) | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | 新規なコロニー刺激因子 |
| ATE65798T1 (de) | 1985-02-08 | 1991-08-15 | Chugai Pharmaceutical Co Ltd | Menschlicher granuloxcyt-koloniestimulierungsfaktor. |
| US6004548A (en) | 1985-08-23 | 1999-12-21 | Amgen, Inc. | Analogs of pluripotent granulocyte colony-stimulating factor |
| JPS63500636A (ja) | 1985-08-23 | 1988-03-10 | 麒麟麦酒株式会社 | 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ |
| US4810643A (en) | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| JPS6263335A (ja) | 1985-09-13 | 1987-03-20 | Fuji Photo Film Co Ltd | 化学反応情報の処理方法 |
| DE3681551D1 (de) | 1985-09-30 | 1991-10-24 | Chugai Pharmaceutical Co Ltd | Menschlicher granulozyten-colony stimulierender faktor. |
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| DK203187A (da) | 1986-04-22 | 1987-10-23 | Immunex Corp | Human g-csf proteinekspression |
| EP0256843A1 (en) | 1986-08-11 | 1988-02-24 | Cetus Corporation | Expression of g-csf and muteins thereof and their use |
| US4704692A (en) | 1986-09-02 | 1987-11-03 | Ladner Robert C | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
| NO176799C (no) | 1986-12-23 | 1995-05-31 | Kyowa Hakko Kogyo Kk | DNA som koder for et polypeptid, rekombinant plasmid som koder for og kan uttrykke et polypeptid og fremgangsmåte for fremstilling av dette polypeptid |
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| US5714581A (en) | 1986-12-23 | 1998-02-03 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US4853871A (en) | 1987-04-06 | 1989-08-01 | Genex Corporation | Computer-based method for designing stablized proteins |
| US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| GB2213821B (en) | 1987-12-23 | 1992-01-02 | British Bio Technology | Synthetic human granulocyte colony stimulating factor gene |
| CA1340810C (en) | 1988-03-31 | 1999-11-02 | Motoo Yamasaki | Polypeptide derivatives of human granulocyte colony stimulating factor |
| WO1989010932A1 (en) | 1988-05-13 | 1989-11-16 | Amgen Inc. | Compositions and method for treating or preventing infections in animals |
| EP0344796B1 (en) | 1988-06-03 | 1994-09-21 | Chugai Seiyaku Kabushiki Kaisha | Crystalline human granulocyte colony stimulating factor and process for preparing the same |
| US5025388A (en) | 1988-08-26 | 1991-06-18 | Cramer Richard D Iii | Comparative molecular field analysis (CoMFA) |
| US5218092A (en) | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
| US5349052A (en) | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
| US5104651A (en) | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
| US20020177688A1 (en) * | 1988-12-22 | 2002-11-28 | Kirin-Amgen, Inc., | Chemically-modified G-CSF |
| US6166183A (en) | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
| JP2989002B2 (ja) * | 1988-12-22 | 1999-12-13 | キリン―アムジエン・インコーポレーテツド | 化学修飾顆粒球コロニー刺激因子 |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| US5109119A (en) | 1989-06-06 | 1992-04-28 | Schering Corporation | Crystalline r-h-gm-csf and method |
| IE66494B1 (en) | 1989-09-26 | 1996-01-10 | Immunex Corp | Granulocyte-colony stimulating factor receptors |
| EP0648501A1 (en) | 1989-10-10 | 1995-04-19 | Amgen Inc. | Compositions comprising G-CSF for treating or preventing infections in canine and feline animals |
| US5265030A (en) | 1990-04-24 | 1993-11-23 | Scripps Clinic And Research Foundation | System and method for determining three-dimensional structures of proteins |
| GB9107846D0 (en) | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
| DE4014750A1 (de) | 1990-05-08 | 1991-11-14 | Boehringer Mannheim Gmbh | Muteine des granulozyten-stimulierenden faktors (g-csf) |
| US5399345A (en) | 1990-05-08 | 1995-03-21 | Boehringer Mannheim, Gmbh | Muteins of the granulocyte colony stimulating factor |
| JP3249147B2 (ja) | 1990-06-01 | 2002-01-21 | キリン−アムジエン・インコーポレーテツド | 生理活性蛋白含有経口製剤 |
| IE912365A1 (en) | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
| ATE167896T1 (de) | 1990-08-29 | 1998-07-15 | Genetics Inst | Aus mehreren domänen bestehende hämatopoese- stimulatoren |
| US5124297A (en) | 1990-12-07 | 1992-06-23 | Amoco Corporation | Olefin polymerization and copolymerization catalyst |
| DE4105480A1 (de) | 1991-02-21 | 1992-08-27 | Boehringer Mannheim Gmbh | Verbesserte aktivierung von rekombinanten proteinen |
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-
2006
- 2006-05-26 RU RU2007149238/13A patent/RU2007149238A/ru not_active Application Discontinuation
- 2006-05-26 CN CN2006800195588A patent/CN101193658B/zh not_active Expired - Fee Related
- 2006-05-26 US US11/420,546 patent/US7381805B2/en not_active Expired - Fee Related
- 2006-05-26 KR KR1020077030982A patent/KR20080027291A/ko not_active Abandoned
- 2006-05-26 DE DE602006020562T patent/DE602006020562D1/de active Active
- 2006-05-26 WO PCT/DK2006/000292 patent/WO2006128460A2/en not_active Ceased
- 2006-05-26 AT AT06722962T patent/ATE500847T1/de not_active IP Right Cessation
- 2006-05-26 BR BRPI0611221-8A patent/BRPI0611221A2/pt not_active IP Right Cessation
- 2006-05-26 CA CA2607844A patent/CA2607844C/en not_active Expired - Fee Related
- 2006-05-26 MX MX2007015156A patent/MX2007015156A/es unknown
- 2006-05-26 AU AU2006254543A patent/AU2006254543A1/en not_active Abandoned
- 2006-05-26 EP EP06722962A patent/EP1888119B1/en not_active Not-in-force
- 2006-05-26 JP JP2008513928A patent/JP5137821B2/ja not_active Expired - Fee Related
- 2006-09-18 US US11/532,818 patent/US20070014763A1/en not_active Abandoned
- 2006-09-18 US US11/532,808 patent/US20070014762A1/en not_active Abandoned
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2007
- 2007-04-30 US US11/742,445 patent/US7655766B2/en not_active Expired - Fee Related
- 2007-04-30 US US11/742,551 patent/US20080167218A1/en not_active Abandoned
- 2007-10-30 IL IL187009A patent/IL187009A0/en unknown
- 2007-11-08 NO NO20075708A patent/NO20075708L/no not_active Application Discontinuation
- 2007-11-12 ZA ZA200709704A patent/ZA200709704B/xx unknown
-
2012
- 2012-08-06 JP JP2012173959A patent/JP2013010765A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200709704B (en) | 2008-11-26 |
| KR20080027291A (ko) | 2008-03-26 |
| CA2607844C (en) | 2012-07-10 |
| EP1888119A2 (en) | 2008-02-20 |
| CN101193658B (zh) | 2011-08-31 |
| US7655766B2 (en) | 2010-02-02 |
| US20070014762A1 (en) | 2007-01-18 |
| NO20075708L (no) | 2008-02-27 |
| CA2607844A1 (en) | 2006-12-07 |
| WO2006128460A3 (en) | 2007-03-01 |
| JP2008542311A (ja) | 2008-11-27 |
| US20070014763A1 (en) | 2007-01-18 |
| IL187009A0 (en) | 2008-02-09 |
| DE602006020562D1 (de) | 2011-04-21 |
| ATE500847T1 (de) | 2011-03-15 |
| RU2007149238A (ru) | 2009-07-20 |
| BRPI0611221A2 (pt) | 2010-08-24 |
| EP1888119B1 (en) | 2011-03-09 |
| US20080090764A1 (en) | 2008-04-17 |
| CN101193658A (zh) | 2008-06-04 |
| US20070009478A1 (en) | 2007-01-11 |
| US7381805B2 (en) | 2008-06-03 |
| MX2007015156A (es) | 2008-02-15 |
| US20080167218A1 (en) | 2008-07-10 |
| JP2013010765A (ja) | 2013-01-17 |
| WO2006128460A2 (en) | 2006-12-07 |
| JP5137821B2 (ja) | 2013-02-06 |
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