JP2008524233A - 炎症性疾患、増殖性疾患および免疫介在性疾患の治療のためのｔｅｃファミリータンパク質キナーゼのインヒビターとして有用なピリド−２−オン - Google Patents

炎症性疾患、増殖性疾患および免疫介在性疾患の治療のためのｔｅｃファミリータンパク質キナーゼのインヒビターとして有用なピリド−２−オン Download PDF

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JP2008524233A
JP2008524233A JP2007546878A JP2007546878A JP2008524233A JP 2008524233 A JP2008524233 A JP 2008524233A JP 2007546878 A JP2007546878 A JP 2007546878A JP 2007546878 A JP2007546878 A JP 2007546878A JP 2008524233 A JP2008524233 A JP 2008524233A
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JP2008524233A5 (https=
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ジャン−ダミアン シャリエ，
スティーブン デュラン，
シャーン ラマヤ，
ファン−ミゲル ヒメネス，
アリステア ラザーフォード，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012501343A (ja) * 2008-08-29 2012-01-19 トレヴェンティス コーポレイション 神経系疾患用の診断ツール及び治療としてのブチリルコリンエステラーゼリガンド
JP2012532931A (ja) * 2009-07-13 2012-12-20 ギリアード サイエンシーズ， インコーポレイテッド アポトーシスシグナル調節キナーゼ阻害剤
JP2014524743A (ja) * 2011-07-13 2014-09-25 マルティーン フリガー 多成分栄養系
WO2014175370A1 (ja) * 2013-04-25 2014-10-30 塩野義製薬株式会社 ピロリジン誘導体およびそれらを含有する医薬組成物
JP2017507147A (ja) * 2014-02-19 2017-03-16 アルデア ファーマシューティカルズ インコーポレイテッド ミトコンドリアアルデヒドデヒドロゲナーゼ２（ａｌｄｈ２）に結合する多環式アミド
JP2017530167A (ja) * 2014-10-06 2017-10-12 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーター
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US12350262B2 (en) 2017-07-17 2025-07-08 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
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US12415798B2 (en) 2017-12-08 2025-09-16 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2591413A1 (en) 2004-12-16 2006-06-22 Vertex Pharmaceuticals Incorporated Pyrid-2-ones useful as inhibitors of tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases
WO2007027594A1 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
JP2009506123A (ja) * 2005-08-29 2009-02-12 バーテックス ファーマシューティカルズ インコーポレイテッド 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン
EP1919905B1 (en) * 2005-08-29 2011-02-23 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-recptor tyrosine kinases
WO2007035428A1 (en) * 2005-09-15 2007-03-29 Bristol-Myers Squibb Company Met kinase inhibitors
WO2007062459A1 (en) * 2005-11-29 2007-06-07 Cytopia Research Pty Ltd Selective kinase inhibitors based on pyridine scaffold
CN102532133A (zh) 2006-01-17 2012-07-04 沃泰克斯药物股份有限公司 适用作詹纳斯激酶抑制剂的吖吲哚类
WO2007087443A2 (en) 2006-01-25 2007-08-02 Synta Pharmaceuticals Corp. Vinyl-phenyl derivatives for inflammation and immune-related uses
AR063707A1 (es) 2006-09-11 2009-02-11 Cgi Pharmaceuticals Inc Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmacéuticas que las comprenden.
AR063706A1 (es) 2006-09-11 2009-02-11 Cgi Pharmaceuticals Inc Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
AU2007338754A1 (en) 2006-12-21 2008-07-03 Vertex Pharmaceuticals Incorporated 5-cyan0-4- (pyrrolo [2, 3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
AU2008205252B2 (en) * 2007-01-09 2013-02-21 Amgen Inc. Bis-aryl amide derivatives useful for the treatment of cancer
CN101778825A (zh) * 2007-03-22 2010-07-14 沃泰克斯药物股份有限公司 适用作詹纳斯激酶抑制剂的n-杂环类化合物
CA2710462C (en) * 2008-02-05 2015-11-24 F. Hoffmann-La Roche Ag Pyridinones and pyridazinones
WO2009145814A2 (en) * 2008-03-10 2009-12-03 Vertex Pharmaceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
EP2340244A4 (en) * 2008-10-14 2012-07-25 Ning Xi COMPOUNDS AND APPLICATION PROCEDURES
ES2578990T3 (es) * 2009-03-21 2016-08-03 Sunshine Lake Pharma Co., Ltd. Derivados de amino éster, sales de los mismos y métodos de uso
HRP20140371T1 (hr) 2009-05-15 2014-05-23 Novartis Ag Arilpiridini kao inhibitori sinteze aldosterona
RS57869B1 (sr) 2009-06-17 2018-12-31 Vertex Pharma Inhibitori replikacije virusa gripa
CN102140093A (zh) * 2010-02-03 2011-08-03 上海源力生物技术有限公司 吡啶酮酰胺类衍生物、其制备方法及其在医药上的应用
MX2012014273A (es) 2010-06-07 2013-03-22 Novomedix Llc Compuestos furanilo y su uso.
CN103237798A (zh) 2010-10-01 2013-08-07 百时美施贵宝公司 可用作cyp17调节剂的取代的苯并咪唑和咪唑并吡啶化合物
AU2011343642A1 (en) 2010-12-16 2013-05-02 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
WO2013153539A1 (en) 2012-04-13 2013-10-17 Glenmark Pharmaceuticals S.A. Tricyclic compounds as tec kinase inhibitors
CN104704129A (zh) 2012-07-24 2015-06-10 药品循环公司 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变
HRP20170217T1 (hr) 2013-04-25 2017-04-21 Beigene, Ltd. Fuzinirani heterociklički spojevi kao inhibitori protein kinaze
RU2016101548A (ru) * 2013-07-03 2017-08-08 Ф. Хоффманн-Ля Рош Аг Соединения амидов гетероарилпиридона и азапиридона
EA034666B1 (ru) 2013-09-13 2020-03-04 Бейджин Свитзерланд Гмбх Антитело против pd-1 и его применение для лечения рака или вирусной инфекции и фрагмент антитела
RU2570907C2 (ru) * 2013-10-21 2015-12-20 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Производные 3-ациламинопиридин-2(1h)-она, применимые как ингибиторы серин-треониновой протеинкиназы gsk3b в качестве лекарственных препаратов для лечения диабета ii типа.
US9795604B2 (en) 2013-10-25 2017-10-24 Pharmacyclics Llc Methods of treating and preventing graft versus host disease
RS59144B1 (sr) 2013-11-13 2019-09-30 Vertex Pharma Inhibitori replikacije virusa influence
HRP20181272T1 (hr) 2013-11-13 2018-10-05 Vertex Pharmaceuticals Incorporated Postupci priprave inhibitora replikacije virusa influence
WO2015082583A1 (en) 2013-12-05 2015-06-11 F. Hoffmann-La Roche Ag Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality
WO2015108881A1 (en) 2014-01-14 2015-07-23 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
AU2015206652A1 (en) 2014-01-14 2016-08-04 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
WO2015200650A1 (en) * 2014-06-25 2015-12-30 Epizyme, Inc. Substituted benzene and 6,5-fused bicyclic heteroaryl compounds
TWI726608B (zh) 2014-07-03 2021-05-01 英屬開曼群島商百濟神州有限公司 抗pd-l1抗體及其作為治療及診斷之用途
TWI685491B (zh) 2014-12-23 2020-02-21 美商基利科學股份有限公司 製備５-（４-環丙基-１ｈ-咪唑-１-基）-ｎ-（６-（４-異丙基-４ｈ-１,２,４-三唑-３-基）吡啶-２-基）-２-氟-４-甲基苯甲醯胺之方法
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
AU2016317049A1 (en) 2015-08-31 2018-03-15 Pharmacyclics Llc BTK inhibitor combinations for treating multiple myeloma
MX383856B (es) 2016-06-14 2025-03-14 Novartis Ag Compuestos y composiciones para inhibir la actividad de shp2.
US10864203B2 (en) 2016-07-05 2020-12-15 Beigene, Ltd. Combination of a PD-1 antagonist and a RAF inhibitor for treating cancer
CA3033827A1 (en) 2016-08-16 2018-02-22 Beigene, Ltd. Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl )-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide,preparation, and uses thereof
PT3500299T (pt) 2016-08-19 2024-02-21 Beigene Switzerland Gmbh Combinação de zanubrutinib com um anticorpo anti-cd20 ou anti-pd-1 para utilização no tratamento do cancro
CN109982687A (zh) 2016-09-19 2019-07-05 梅制药公司 联合疗法
AU2017355544A1 (en) 2016-11-03 2019-05-16 Juno Therapeutics, Inc. Combination therapy of a T cell therapy and a BTK inhibitor
MA46995A (fr) 2016-12-03 2019-10-09 Acerta Pharma Bv Méthodes et compositions pour l'utilisation de lymphocytes t thérapeutiques en association avec des inhibiteurs de kinase
US20190343836A1 (en) 2017-01-10 2019-11-14 Novartis Ag Pharmaceutical combination comprising an alk inhibitor and a shp2 inhibitor
EP3573989A4 (en) 2017-01-25 2020-11-18 Beigene, Ltd. CRYSTALLINE FORMS OF (S) -7- (1- (BUT-2-YNOYL) PIPERIDIN-4-YL) -2- (4-PHENOXYPHENYL) -4, 5, 6, 7-TETRAHY DROPYRAZOLO [1, 5-A ] PYRIMIDINE-3-CARBOXAMIDE, PREPARATION AND ASSOCIATED USES
TW202515616A (zh) 2017-06-26 2025-04-16 英屬開曼群島商百濟神州有限公司 抗pd-1抗體或其抗原結合片段在製備治療用於患有肝細胞癌(hcc)之藥物的用途
WO2019034009A1 (en) 2017-08-12 2019-02-21 Beigene, Ltd. BTK INHIBITOR WITH ENHANCED DOUBLE SELECTIVITY
CN111801334B (zh) 2017-11-29 2023-06-09 百济神州瑞士有限责任公司 使用包含btk抑制剂的组合治疗惰性或侵袭性b-细胞淋巴瘤
US20210121466A1 (en) 2018-05-03 2021-04-29 Juno Therapeutics, Inc. Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor
WO2020249001A1 (zh) 2019-06-10 2020-12-17 百济神州瑞士有限责任公司 一种含有布鲁顿氏酪氨酸激酶抑制剂的口服固体片剂及其制备方法
TW202334117A (zh) 2020-08-24 2023-09-01 美商達薩瑪治療公司 Ｓａｒｍ１之抑制劑
KR20240133695A (ko) * 2021-12-10 2024-09-04 프로테나 바이오사이언시즈 리미티드 Dyrk1a 억제제로서의 헤테로시클릭 화합물
WO2023220655A1 (en) 2022-05-11 2023-11-16 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
US11786531B1 (en) 2022-06-08 2023-10-17 Beigene Switzerland Gmbh Methods of treating B-cell proliferative disorder
CN117886801B (zh) * 2024-03-14 2024-05-17 中国药科大学 吡啶酮嘧啶类cdk抑制剂及其制备方法和应用

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017438A1 (en) * 1979-03-28 1980-10-15 American Cyanamid Company Substituted 3-alkyl-6-phenyl-1,2,4-triazolo(4,3-a)pyridines, processes for their preparation and pharmaceutical compositions containing them
JPS56135473A (en) * 1980-03-03 1981-10-22 Sandoz Ag ''(1h)-pyridinone derivative, manufacture and pharmaceutical composition containing same
JPS57192363A (en) * 1981-03-30 1982-11-26 Sterling Drug Inc 3-amino-5-(substituted)-2-(1h)-pyridinone, manufacture and cardiac stimulant therefrom
GB2065642B (en) * 1979-11-26 1984-04-04 Sterling Drug Inc 5-(pyridinyl)-2-(1h)-pyridinones useful as cardiotonic agents and their preparation
EP0127756A1 (en) * 1983-04-20 1984-12-12 Fabrica De Productos Quimicos Y Farmaceuticos Abello, S.A. Process for the preparation of 5-pyridyl-pyridine-2(1H)-ones
JPS6097960A (ja) * 1983-11-02 1985-05-31 Banyu Pharmaceut Co Ltd ５．６−置換−２−ピリドン誘導体
US4539321A (en) * 1981-10-26 1985-09-03 William H. Rorer, Inc. 5-Diaza-aryl-3-substituted pyridone compounds
JPS6110557A (ja) * 1984-02-22 1986-01-18 メルク・パテント・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 新規なピリドン化合物
JPS61140583A (ja) * 1984-12-14 1986-06-27 Banyu Pharmaceut Co Ltd ５−（チアゾ−ル−４−イル）−２−ピリドン誘導体
JPS6377879A (ja) * 1986-09-22 1988-04-08 Eisai Co Ltd １−（イミダゾ〔１，２−ａ〕ピリジン−６−イル）−２−プロパノン誘導体
JPH05221992A (ja) * 1991-10-18 1993-08-31 Dr Karl Thomae Gmbh ヘテロビアリール誘導体、これらの化合物を含む医薬組成物及びそれらの調製法
JP2003212868A (ja) * 2002-01-07 2003-07-30 Pfizer Pharmaceuticals Inc ５−ｈｔ４レセプターモジュレーターとしてのオキソ又はオキシピリジン
JP2003528801A (ja) * 1999-03-19 2003-09-30 パーカー ヒューズ インスティテュート Ｂｔｋ阻害用カラノライド
WO2004016609A1 (en) * 2002-08-14 2004-02-26 Astrazeneca Ab Substituted pyrrolopyridines
US6706717B2 (en) * 2000-12-21 2004-03-16 Bristol-Myers Squibb Company Thiazolyl inhibitors of Tec family tyrosine kinases
JP2004534010A (ja) * 2001-03-28 2004-11-11 ブリストル−マイヤーズ　スクイブ　カンパニー 新規なチロシンキナーゼ阻害剤

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4941396A (https=) * 1972-08-21 1974-04-18
US4072746A (en) 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones
US4004012A (en) 1975-10-14 1977-01-18 Sterling Drug Inc. 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones
US4313951A (en) 1979-11-26 1982-02-02 Sterling Drug Inc. 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor
IL61537A0 (en) 1979-12-03 1980-12-31 Sterling Drug Inc Bipyridyl derivatives,their preparation and pharmaceutical compositions containing them
US4271168A (en) 1979-12-26 1981-06-02 Sterling Drug Inc. Selected 3-acylamino-5-[4(or 3)-pyridinyl]-2(1H)-pyridinones
US4514400A (en) 1981-10-26 1985-04-30 William H. Rorer, Inc. Cardiotonic 5-heteroaryl-pyridone
US4563528A (en) 1984-04-19 1986-01-07 Fabrica De Productos Quimicos Y Farmaceuticos Abello, S.A. Process for preparing 5 pyridyl pyridine-2 (1H)-ones
US4583528A (en) * 1984-11-08 1986-04-22 Jack Bauman Examining device with improved optical coupling between the light source and light conductor
IL98526A0 (en) 1990-06-18 1992-07-15 Merck & Co Inc Pyridones,processes for their preparation and pharmaceutical compositions containing them
IL99731A0 (en) 1990-10-18 1992-08-18 Merck & Co Inc Hydroxylated pyridine derivatives,their preparation and pharmaceutical compositions containing them
US5521179A (en) 1991-04-18 1996-05-28 Zeneca Limited Heterocyclic amides
DE4221583A1 (de) * 1991-11-12 1993-05-13 Bayer Ag Substituierte biphenylpyridone
IL130181A0 (en) * 1996-12-05 2000-06-01 Amgen Inc Substituted pyrimidone and pyridone compounds and methods of use
US6452008B2 (en) 1998-02-25 2002-09-17 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for preparing the same
DE19826671A1 (de) 1998-06-16 1999-12-23 Hoechst Schering Agrevo Gmbh 1,3-Oxazolin- und 1,3-Thiazolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel
US6118002A (en) 1999-03-02 2000-09-12 Wyckoff Chemical Company, Inc. Purification of 1,2-dihydro-6-alkyl-2-oxo-5-(pyridinyl)-nicotinonitriles
US6403596B1 (en) * 1999-06-28 2002-06-11 Merck & Co., Inc. Substituted pyridones having cytokine inhibitory activity
IL152848A0 (en) 2000-06-12 2003-06-24 Eisai Co Ltd 1,2-dihydropyridine derivatives, pharmaceutical compositions containing the same and methods for the production thereof
ES2330719T3 (es) 2000-12-28 2009-12-15 SHIONOGI & CO., LTD. Derivados de 2-piridona con afinidad para el receptor cannabinoide de tipo 2.
US20040147561A1 (en) * 2002-12-27 2004-07-29 Wenge Zhong Pyrid-2-one derivatives and methods of use
CA2591413A1 (en) 2004-12-16 2006-06-22 Vertex Pharmaceuticals Incorporated Pyrid-2-ones useful as inhibitors of tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases
CN101208303A (zh) 2005-03-14 2008-06-25 默克公司 Cgrp受体拮抗剂

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017438A1 (en) * 1979-03-28 1980-10-15 American Cyanamid Company Substituted 3-alkyl-6-phenyl-1,2,4-triazolo(4,3-a)pyridines, processes for their preparation and pharmaceutical compositions containing them
GB2065642B (en) * 1979-11-26 1984-04-04 Sterling Drug Inc 5-(pyridinyl)-2-(1h)-pyridinones useful as cardiotonic agents and their preparation
JPS56135473A (en) * 1980-03-03 1981-10-22 Sandoz Ag ''(1h)-pyridinone derivative, manufacture and pharmaceutical composition containing same
JPS57192363A (en) * 1981-03-30 1982-11-26 Sterling Drug Inc 3-amino-5-(substituted)-2-(1h)-pyridinone, manufacture and cardiac stimulant therefrom
US4539321A (en) * 1981-10-26 1985-09-03 William H. Rorer, Inc. 5-Diaza-aryl-3-substituted pyridone compounds
EP0127756A1 (en) * 1983-04-20 1984-12-12 Fabrica De Productos Quimicos Y Farmaceuticos Abello, S.A. Process for the preparation of 5-pyridyl-pyridine-2(1H)-ones
JPS6097960A (ja) * 1983-11-02 1985-05-31 Banyu Pharmaceut Co Ltd ５．６−置換−２−ピリドン誘導体
JPS6110557A (ja) * 1984-02-22 1986-01-18 メルク・パテント・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 新規なピリドン化合物
JPS61140583A (ja) * 1984-12-14 1986-06-27 Banyu Pharmaceut Co Ltd ５−（チアゾ−ル−４−イル）−２−ピリドン誘導体
JPS6377879A (ja) * 1986-09-22 1988-04-08 Eisai Co Ltd １−（イミダゾ〔１，２−ａ〕ピリジン−６−イル）−２−プロパノン誘導体
JPH05221992A (ja) * 1991-10-18 1993-08-31 Dr Karl Thomae Gmbh ヘテロビアリール誘導体、これらの化合物を含む医薬組成物及びそれらの調製法
JP2003528801A (ja) * 1999-03-19 2003-09-30 パーカー ヒューズ インスティテュート Ｂｔｋ阻害用カラノライド
US6706717B2 (en) * 2000-12-21 2004-03-16 Bristol-Myers Squibb Company Thiazolyl inhibitors of Tec family tyrosine kinases
JP2004534010A (ja) * 2001-03-28 2004-11-11 ブリストル−マイヤーズ　スクイブ　カンパニー 新規なチロシンキナーゼ阻害剤
JP2003212868A (ja) * 2002-01-07 2003-07-30 Pfizer Pharmaceuticals Inc ５−ｈｔ４レセプターモジュレーターとしてのオキソ又はオキシピリジン
WO2004016609A1 (en) * 2002-08-14 2004-02-26 Astrazeneca Ab Substituted pyrrolopyridines

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6011047884; ＧＯＭＥＺ-ＰＡＲＲＡ，Ｖ． ｅｔ ａｌ: 'Ｎｅｗ ｃａｒｄｉｏｔｏｎｉｃ ａｇｅｎｔｓ ｒｅｌａｔｅｄ ｔｏ ａｍｒｉｎｏｎｅ： ｓｙｎｔｈｅｓｉｓ ｏｆ １，２-ｄｉｈｙｄｒｏ-５-ａｒｙｌｐｙｒｉｄｉｎ-２-ｏｎｅｓ' Ａｒｃｈｉｖ ｄｅｒ Ｐｈａｒｍａｚｉｅ（Ｗｅｉｎｈｅｉｍ， Ｇｅｒｍａｎｙ） , 1992, ｐ．４８３-４９０ *
JPN6011047886; ＫＲＡＵＺＥ，Ａ．　ｅｔ　ａｌ: 'Ｓｙｎｔｈｅｓｉｓ　ｏｆ　３-（Ｎ-Ｒ）-ｃａｒｂａｍｏｙｌ-５-（ｐｙｒｉｄ-４'-ｙｌ）ｐｙｒｉｄｉｎｅ-２（１Ｈ）-ｔｈｉｏｎｅｓ　ａｎｄ　ｔｈｅｉｒ　ｄｅｒｉｖａｔｉｖｅｓ' Ｋｈｉｍｉｙａ　Ｇｅｔｅｒｏｔｓｉｋｌｉｃｈｅｓｋｉｋｈ　Ｓｏｅｄｉｎｅｎｉｉ Ｎｏ．１, 1992, ｐ．７５-７９ *
JPN6011047889; ＨＡＩＤＥＲ，Ｎ． ｅｔ ａｌ: 'Ｐｙｒｉｄａｚｉｎｅｓ． Ｐａｒｔ ４３． Ｐｙｒｉｄａｚｉｎｅ ａｎａｌｏｇｓ ｏｆ ｂｉｏｌｏｇｉｃａｌｌｙ ａｃｔｉｖｅ ｃｏｍｐｏｕｎｄｓ． Ｐａｒｔ ５： Ｎｏｖｅｌ ｐｏｔｅｎｔｉ' Ｐｈａｒｍａｚｉｅ Ｖｏｌ．４４， Ｎｏ．９, 1989, ｐ．５９８-６０１ *

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