TW200633980A - Pyridones useful as inhibitors of kinases - Google Patents
Pyridones useful as inhibitors of kinasesInfo
- Publication number
- TW200633980A TW200633980A TW094144949A TW94144949A TW200633980A TW 200633980 A TW200633980 A TW 200633980A TW 094144949 A TW094144949 A TW 094144949A TW 94144949 A TW94144949 A TW 94144949A TW 200633980 A TW200633980 A TW 200633980A
- Authority
- TW
- Taiwan
- Prior art keywords
- inhibitors
- kinases
- compounds
- useful
- pyridones useful
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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| DE19826671A1 (de) | 1998-06-16 | 1999-12-23 | Hoechst Schering Agrevo Gmbh | 1,3-Oxazolin- und 1,3-Thiazolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| US6118002A (en) * | 1999-03-02 | 2000-09-12 | Wyckoff Chemical Company, Inc. | Purification of 1,2-dihydro-6-alkyl-2-oxo-5-(pyridinyl)-nicotinonitriles |
| US6306897B1 (en) * | 1999-03-19 | 2001-10-23 | Parker Hughes Institute | Calanolides for inhibiting BTK |
| US6403596B1 (en) * | 1999-06-28 | 2002-06-11 | Merck & Co., Inc. | Substituted pyridones having cytokine inhibitory activity |
| ES2320973T3 (es) * | 2000-06-12 | 2009-06-01 | EISAI R&D MANAGEMENT CO., LTD. | Compuestos de 1,2-dihidropiridina, procedimiento para su preparacion y uso de los mismos. |
| WO2002050071A1 (en) * | 2000-12-21 | 2002-06-27 | Bristol-Myers Squibb Company | Thiazolyl inhibitors of tec family tyrosine kinases |
| KR100828982B1 (ko) | 2000-12-28 | 2008-05-14 | 시오노기세이야쿠가부시키가이샤 | 칸나비노이드 2형 수용체 친화 작용을 갖는 피리돈 유도체 |
| GEP20053660B (en) * | 2001-03-28 | 2005-11-10 | Bristol Myers Squibb Co | Novel Tyrosine Kinase Inhibitors |
| MXPA03000145A (es) * | 2002-01-07 | 2003-07-15 | Pfizer | Compuestos de oxo u oxi-piridina como moduladores de receptores 5-ht4. |
| SE0202463D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
| US20040147561A1 (en) * | 2002-12-27 | 2004-07-29 | Wenge Zhong | Pyrid-2-one derivatives and methods of use |
| US8101770B2 (en) | 2004-12-16 | 2012-01-24 | Vertex Pharmaceuticals Incorporated | Pyridones useful as inhibitors of kinases |
| CA2599925A1 (en) | 2005-03-14 | 2006-09-21 | Merck & Co., Inc. | Cgrp receptor antagonists |
-
2005
- 2005-12-15 US US11/304,057 patent/US8101770B2/en not_active Expired - Fee Related
- 2005-12-15 KR KR1020077016337A patent/KR20070095952A/ko not_active Ceased
- 2005-12-15 JP JP2007546878A patent/JP2008524233A/ja not_active Withdrawn
- 2005-12-15 EP EP05854119.4A patent/EP1831168B1/en not_active Expired - Lifetime
- 2005-12-15 RU RU2007126832/04A patent/RU2423351C2/ru not_active IP Right Cessation
- 2005-12-15 MX MX2007007330A patent/MX2007007330A/es not_active Application Discontinuation
- 2005-12-15 WO PCT/US2005/045336 patent/WO2006065946A1/en not_active Ceased
- 2005-12-15 AU AU2005316540A patent/AU2005316540A1/en not_active Abandoned
- 2005-12-15 CA CA002591413A patent/CA2591413A1/en not_active Abandoned
- 2005-12-16 TW TW094144949A patent/TW200633980A/zh unknown
-
2007
- 2007-06-14 IL IL183922A patent/IL183922A0/en unknown
- 2007-07-16 NO NO20073628A patent/NO20073628L/no not_active Application Discontinuation
-
2008
- 2008-11-07 JP JP2008287171A patent/JP2009062391A/ja active Pending
-
2011
- 2011-12-14 US US13/325,089 patent/US8338597B2/en not_active Expired - Fee Related
-
2012
- 2012-11-16 US US13/679,012 patent/US20130184259A1/en not_active Abandoned
-
2013
- 2013-07-12 JP JP2013146296A patent/JP2013213046A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20060183911A1 (en) | 2006-08-17 |
| JP2008524233A (ja) | 2008-07-10 |
| JP2013213046A (ja) | 2013-10-17 |
| AU2005316540A1 (en) | 2006-06-22 |
| KR20070095952A (ko) | 2007-10-01 |
| CA2591413A1 (en) | 2006-06-22 |
| US20130184259A1 (en) | 2013-07-18 |
| EP1831168B1 (en) | 2014-07-02 |
| JP2009062391A (ja) | 2009-03-26 |
| NO20073628L (no) | 2007-07-16 |
| US20120190699A1 (en) | 2012-07-26 |
| US8338597B2 (en) | 2012-12-25 |
| US8101770B2 (en) | 2012-01-24 |
| EP1831168A1 (en) | 2007-09-12 |
| MX2007007330A (es) | 2007-10-04 |
| IL183922A0 (en) | 2007-10-31 |
| RU2007126832A (ru) | 2009-03-27 |
| RU2423351C2 (ru) | 2011-07-10 |
| WO2006065946A1 (en) | 2006-06-22 |
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