JP2008519813A5 - - Google Patents
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- JP2008519813A5 JP2008519813A5 JP2007540709A JP2007540709A JP2008519813A5 JP 2008519813 A5 JP2008519813 A5 JP 2008519813A5 JP 2007540709 A JP2007540709 A JP 2007540709A JP 2007540709 A JP2007540709 A JP 2007540709A JP 2008519813 A5 JP2008519813 A5 JP 2008519813A5
- Authority
- JP
- Japan
- Prior art keywords
- endogenous target
- ligand
- target compound
- use according
- moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/985,847 US20060002935A1 (en) | 2002-06-28 | 2004-11-10 | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| PCT/GB2005/004319 WO2006051288A2 (en) | 2004-11-10 | 2005-11-10 | Ligands that enhance endogenous compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008519813A JP2008519813A (ja) | 2008-06-12 |
| JP2008519813A5 true JP2008519813A5 (https=) | 2008-12-04 |
Family
ID=36282598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540709A Pending JP2008519813A (ja) | 2004-11-10 | 2005-11-10 | 内因性化合物を増強するリガンド |
Country Status (11)
| Country | Link |
|---|---|
| EP (3) | EP2371390A3 (https=) |
| JP (1) | JP2008519813A (https=) |
| KR (2) | KR20070084069A (https=) |
| CN (2) | CN101724071A (https=) |
| AU (1) | AU2005303584A1 (https=) |
| BR (1) | BRPI0517569A (https=) |
| CA (1) | CA2587206A1 (https=) |
| MA (2) | MA29427B1 (https=) |
| NO (2) | NO20071788L (https=) |
| RU (2) | RU2401842C2 (https=) |
| WO (1) | WO2006051288A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| TW200607523A (en) | 2004-06-01 | 2006-03-01 | Domantis Ltd | Drug compositions, fusions and conjugates |
| EP1802333A2 (en) * | 2004-09-13 | 2007-07-04 | Arrowsmith Technologies LLP | Antibody buffering of a ligand in vivo |
| RU2411957C2 (ru) * | 2004-12-02 | 2011-02-20 | Домантис Лимитед | Способы лечения респираторного заболевания с применением антагонистов рецептора интерлейкина-1 типа 1 |
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| US12203113B2 (en) | 2009-07-09 | 2025-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| CN102010473A (zh) * | 2010-11-10 | 2011-04-13 | 曹鹏 | 重组胃泌酸调节素融合蛋白及其制备和应用 |
| CN105601748B (zh) | 2011-07-01 | 2021-08-27 | 恩格姆生物制药公司 | 用于代谢病症和疾病治疗的组合物、应用和方法 |
| EP3539374A1 (en) * | 2012-03-16 | 2019-09-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing ph-sensitive immunoglobulin sequences |
| HK1207564A1 (en) | 2012-04-19 | 2016-02-05 | Opko Biologics Ltd | Long-acting oxyntomodulin variants and methods of producing same |
| HUE055348T2 (hu) | 2012-11-20 | 2021-11-29 | Opko Biologics Ltd | Eljárás polipeptidek hidrodinamikus térfogatának növelésére gonadotropin karboxil-terminális peptidekhez való kapcsolással |
| HK1214832A1 (zh) | 2012-11-28 | 2016-08-05 | 恩格姆生物制药公司 | 用於代謝病症和疾病治療的組合物和方法 |
| ES2915851T3 (es) | 2012-12-27 | 2022-06-27 | Ngm Biopharmaceuticals Inc | Péptidos quiméricos de FGF19 para usar en el tratamiento de trastornos de ácidos biliares |
| RU2560699C2 (ru) * | 2013-08-02 | 2015-08-20 | федеральное государственное автономное образовательное учреждение высшего профессионального образования "Национальный исследовательский ядерный университет МИФИ" (НИЯУ МИФИ) | Способ создания наноразмерной диагностической метки на основе конъюгатов наночастиц и однодоменных антител |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| AU2015296640B2 (en) | 2014-07-30 | 2020-05-21 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| RU2729161C2 (ru) | 2014-10-23 | 2020-08-04 | ЭнДжиЭм БАЙОФАРМАСЬЮТИКАЛЗ, ИНК. | Фармацевтические композиции, содержащие варианты пептидов, и способы их применения |
| EP3701969A1 (en) | 2014-10-31 | 2020-09-02 | NGM Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| EP3230309B1 (en) | 2014-12-10 | 2023-03-29 | OPKO Biologics Ltd. | Methods of producing long acting ctp-modified growth hormone polypeptides |
| PL3310347T3 (pl) | 2015-06-19 | 2021-12-27 | Opko Biologics Ltd. | Długo działające czynniki krzepnięcia i sposoby wytwarzania |
| JP6728352B2 (ja) | 2015-11-09 | 2020-07-22 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | 胆汁酸に関係した障害の治療方法 |
| MY206271A (en) | 2016-07-11 | 2024-12-06 | Opko Biologics Ltd | Long-acting coagulation factor vii and methods of producing same |
| US11214820B2 (en) * | 2016-09-02 | 2022-01-04 | Ikaria Inc. | Functionally modified polypeptides and radiobiosynthesis |
| CN110128536A (zh) * | 2018-02-02 | 2019-08-16 | 暨南大学 | 抗肿瘤干细胞标志蛋白cd133的单域抗体及其应用 |
| JP7646542B2 (ja) | 2018-11-01 | 2025-03-17 | バイオインベント インターナショナル アクティエボラーグ | 新規アンタゴニスト抗ｔｎｆｒ２抗体分子 |
| CN109468294A (zh) * | 2018-11-06 | 2019-03-15 | 青岛古高生物科技有限公司 | 一种血红素-GroEL复合体及其制备方法和应用 |
| WO2021214501A1 (en) | 2020-04-22 | 2021-10-28 | Genima Innovations Marketing Gmbh | Antiviral decontamination in the runner suction hose or the antechamber of a breathing mask |
| CN115944714B (zh) * | 2022-10-20 | 2023-12-15 | 苏州大学 | 能够同时抗白细胞介素1和肿瘤坏死因子炎症的纳米材料及其制备方法与应用 |
| CN120882743A (zh) * | 2023-03-02 | 2025-10-31 | 瑞韦博治疗公司 | 包含单特异性和双特异性非阻断性抗细胞因子抗体的基于细胞因子的疗法和方法 |
Family Cites Families (66)
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|---|---|---|---|---|
| US109159A (en) | 1870-11-08 | Improvement in journal-boxes for cars | ||
| US8922A (en) | 1852-05-04 | Adjustable wrench | ||
| EP0467416A1 (en) * | 1983-09-01 | 1992-01-22 | Hybritech Incorporated | Antibody compositions of therapeutic agents having an extended serum half-life |
| SU1441787A1 (ru) | 1987-04-29 | 1990-09-23 | Институт Белка Ан Ссср | Способ получени пептидов и белков в бесклеточной системе трансл ции |
| DE3889783T2 (de) * | 1987-07-07 | 1994-09-08 | Hybrisens Ltd | Verwendung von Antikörper-Antigen-Wechselwirkung zum Schutz oder Modulation der biologischen Aktivität. |
| GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
| US5225540A (en) * | 1988-04-26 | 1993-07-06 | Du Pont Merck Pharmaceutical Company | Monoclonal antibodies to tissue plasminogen activator (t-pa) which prolong its functional half-life |
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| AU649217B2 (en) | 1988-11-18 | 1994-05-19 | Regents Of The University Of California, The | Method for site-specifically incorporating unnatural amino acids into proteins |
| SU1705302A1 (ru) | 1988-12-22 | 1992-01-15 | Институт Белка Ан Ссср | Способ препаративной экспрессии генов в бесклеточной системе сопр женной транскрипции/трансл ции |
| ATE92107T1 (de) | 1989-04-29 | 1993-08-15 | Delta Biotechnology Ltd | N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen. |
| ATE147787T1 (de) | 1989-07-31 | 1997-02-15 | Inst Of Protein Research Russi | Verfahren zur herstellung von polypeptiden in einem zellfreien system |
| US5977307A (en) | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
| AU638762B2 (en) | 1989-10-05 | 1993-07-08 | Optein Inc | Cell-free synthesis and isolation of novel genes and polypeptides |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| AU8498091A (en) | 1990-08-02 | 1992-03-02 | Regents Of The University Of Colorado, The | Systematic polypeptide evolution by reverse translation |
| WO1992005258A1 (en) | 1990-09-20 | 1992-04-02 | La Trobe University | Gene encoding barley enzyme |
| JPH06508022A (ja) | 1991-02-21 | 1994-09-14 | ギリアド サイエンシズ，インコーポレイテッド | 生体分子に特異的なアプタマーおよび生産方法 |
| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| DK1621554T4 (da) | 1992-08-21 | 2012-12-17 | Univ Bruxelles | Immunoglobuliner blottet for lette kæder |
| ES2156149T3 (es) | 1992-12-04 | 2001-06-16 | Medical Res Council | Proteinas de union multivalente y multiespecificas, su fabricacion y su uso. |
| WO1995011922A1 (en) | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| GB9416721D0 (en) | 1994-08-18 | 1994-10-12 | Short Brothers Plc | A bias yarn assembly forming device |
| DE69626829T2 (de) * | 1995-08-04 | 2004-03-18 | Lek Farmacevtska Druzba D.D. | Monoklonale antikörper gegen lösliche tnf-alpha rezeptoren p55 und p75 als auch gegen tnf-alpha und dessen analogen |
| ES2176484T3 (es) | 1995-08-18 | 2002-12-01 | Morphosys Ag | Bancos de proteinas/(poli)peptidos. |
| US5837251A (en) | 1995-09-13 | 1998-11-17 | Fordham University | Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases |
| ES2294799T3 (es) | 1996-06-27 | 2008-04-01 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Moleculas de anticuerpos que interactuan especificamente con el sitio activo o hendidura de una molecula diana. |
| CA2292415A1 (en) | 1997-06-20 | 1998-12-30 | Innogenetics N.V. | B7-binding molecules for treating immune diseases |
| ES2230701T3 (es) | 1997-07-07 | 2005-05-01 | Medical Research Council | Procedimiento de seleccion in vitro. |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| DK1027439T3 (da) | 1997-10-27 | 2010-05-10 | Bac Ip Bv | Multivalente antigenbindende proteiner |
| AU3596599A (en) | 1998-01-26 | 1999-08-09 | Unilever Plc | Method for producing antibody fragments |
| EP1002861A1 (en) | 1998-10-26 | 2000-05-24 | Unilever Plc | Antigen-binding proteins comprising a linker which confers restricted conformational flexibility |
| IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| GB9900298D0 (en) | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
| DK1144616T4 (da) | 1999-01-19 | 2009-03-30 | Unilever Nv | Fremgangsmåde til fremstilling af antistoffragmenter |
| WO2000065067A2 (en) | 1999-04-23 | 2000-11-02 | University Of Washington | Prostate-specific polynucleotides, polypeptides and their methods of use |
| EP1179013A1 (en) | 1999-05-14 | 2002-02-13 | Medical Research Council | Protein scaffold and its use to multimerise monomeric polypeptides |
| WO2001040310A2 (en) | 1999-11-29 | 2001-06-07 | Unilever Plc | Immobilisation of proteins using a polypeptide segment |
| US7148061B2 (en) | 2000-02-11 | 2006-12-12 | The United States Of America As Represented By The Department Of Health And Human Services | Identification of a novel domain in the tumor necrosis factor receptor family that mediates pre-ligand receptor assembly and function |
| ES2324280T3 (es) | 2000-03-14 | 2009-08-04 | Unilever N.V. | Dominios variables de la cadena pesada de anticuerpos frente a lipasas dieteticas humanas y sus usos. |
| KR100919593B1 (ko) | 2000-06-29 | 2009-09-29 | 아보트 러보러터리즈 | 이중 특이성 항체 및 이의 제조 방법 및 이를 포함하는 조성물 |
| US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
| US20050089932A1 (en) | 2001-04-26 | 2005-04-28 | Avidia Research Institute | Novel proteins with targeted binding |
| DK1399484T3 (da) | 2001-06-28 | 2010-11-08 | Domantis Ltd | Dobbelt-specifik ligand og anvendelse af denne |
| US6608742B2 (en) | 2001-07-06 | 2003-08-19 | Schweitzer Engineering Laboratories, Inc. | Voltage and current source selection system for use in the protection, automation and control of an electric power system |
| JP2005289809A (ja) * | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| DE10160133A1 (de) | 2001-12-07 | 2003-06-26 | Transmit Technologietransfer | Verwendung von koagulationsaktivem Antithrombin III zur Therapie von Angiogenese-abhängigen Erkrankungen |
| AU2002358959A1 (en) | 2001-12-11 | 2003-07-09 | Majorem Ltd. | Massive multiplayer real-time persistant network game engine |
| AU2003210806A1 (en) | 2002-03-05 | 2003-09-22 | Eli Lilly And Company | Heterologous g-csf fusion proteins |
| EP1576172A2 (en) * | 2002-06-21 | 2005-09-21 | Dyax Corporation | Serum protein-associated target-specific ligands and identification method therefor |
| US20060002935A1 (en) * | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| AU2003244817B2 (en) * | 2002-06-28 | 2010-08-26 | Domantis Limited | Antigen-binding immunoglobulin single variable domains and dual-specific constructs |
| AU2003251238A1 (en) | 2002-08-07 | 2004-02-25 | Umc Utrecht Holding B.V. | Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha |
| WO2004041863A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Single domain antibodies directed against interferon- gamma and uses therefor |
| US6683132B1 (en) | 2002-12-19 | 2004-01-27 | Eastman Chemical Company | Self-crosslinking aqueous acetoacetate-functionalized sulfonated alkyd systems |
| EP1578801A2 (en) * | 2002-12-27 | 2005-09-28 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| JP2006517789A (ja) | 2003-01-10 | 2006-08-03 | アブリンクス エン．ヴェー． | 治療用ポリペプチド、その相同物、その断片、および血小板媒介凝集の調節での使用 |
| US20090005257A1 (en) * | 2003-05-14 | 2009-01-01 | Jespers Laurent S | Process for Recovering Polypeptides that Unfold Reversibly from a Polypeptide Repertoire |
| DE602004017726D1 (de) * | 2003-06-30 | 2008-12-24 | Domantis Ltd | Pegylierte Single-domain-antikörper (dAb) |
| US20050164301A1 (en) | 2003-10-24 | 2005-07-28 | Avidia Research Institute | LDL receptor class A and EGF domain monomers and multimers |
| ATE485307T1 (de) | 2003-11-07 | 2010-11-15 | Ablynx Nv | Camelidae schwere ketten antikörper vhhs gegen epidermalen wachstumfaktor rezeptor (egfr) und ihre verwendung |
| HUE027902T2 (en) | 2004-02-09 | 2016-11-28 | Human Genome Sciences Inc Corp Service Company | Albumin fusion proteins |
| US20070202099A1 (en) * | 2004-03-30 | 2007-08-30 | Hiroshi Inooka | Antibody Drug |
-
2005
- 2005-10-07 EP EP10182954A patent/EP2371390A3/en not_active Withdrawn
- 2005-10-07 CN CN200910246166A patent/CN101724071A/zh active Pending
- 2005-10-07 KR KR1020077010453A patent/KR20070084069A/ko not_active Ceased
- 2005-10-07 RU RU2007112509/10A patent/RU2401842C2/ru not_active IP Right Cessation
- 2005-11-10 CA CA002587206A patent/CA2587206A1/en not_active Abandoned
- 2005-11-10 EP EP11161978A patent/EP2420251A3/en not_active Withdrawn
- 2005-11-10 EP EP05801585A patent/EP1814584A2/en not_active Ceased
- 2005-11-10 BR BRPI0517569-0A patent/BRPI0517569A/pt not_active IP Right Cessation
- 2005-11-10 AU AU2005303584A patent/AU2005303584A1/en not_active Abandoned
- 2005-11-10 JP JP2007540709A patent/JP2008519813A/ja active Pending
- 2005-11-10 CN CNA2005800461844A patent/CN101098712A/zh active Pending
- 2005-11-10 KR KR1020077012946A patent/KR20070089930A/ko not_active Withdrawn
- 2005-11-10 WO PCT/GB2005/004319 patent/WO2006051288A2/en not_active Ceased
- 2005-11-10 RU RU2007117196/13A patent/RU2007117196A/ru not_active Application Discontinuation
-
2007
- 2007-04-03 NO NO20071788A patent/NO20071788L/no not_active Application Discontinuation
- 2007-05-07 MA MA29876A patent/MA29427B1/fr unknown
- 2007-05-16 NO NO20072475A patent/NO20072475L/no not_active Application Discontinuation
- 2007-06-06 MA MA29969A patent/MA29221B1/fr unknown
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