|
CA1202840A
(en)
|
1985-06-10 |
1986-04-08 |
Jonathan R. Kleinsasser |
Combination wet and dry feeder for animals
|
|
JPS63152393A
(ja)
|
1986-07-03 |
1988-06-24 |
Takeda Chem Ind Ltd |
グリコシル誘導体
|
|
US5714585A
(en)
|
1987-10-26 |
1998-02-03 |
Sterling Winthrop, Inc. |
Antibodies that are immunoreactive with interleukin-7
|
|
US4965195A
(en)
|
1987-10-26 |
1990-10-23 |
Immunex Corp. |
Interleukin-7
|
|
US5032396A
(en)
|
1989-02-17 |
1991-07-16 |
Immunex Corporation |
IL-7 to stimulate platelet production
|
|
US5231012A
(en)
|
1989-06-28 |
1993-07-27 |
Schering Corporation |
Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10)
|
|
US6217857B1
(en)
|
1989-06-28 |
2001-04-17 |
Schering Corporation |
Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof
|
|
US5229115A
(en)
|
1990-07-26 |
1993-07-20 |
Immunex Corporation |
Adoptive immunotherapy with interleukin-7
|
|
US5252714A
(en)
|
1990-11-28 |
1993-10-12 |
The University Of Alabama In Huntsville |
Preparation and use of polyethylene glycol propionaldehyde
|
|
ES2074879T3
(es)
|
1991-01-16 |
1995-09-16 |
Schering Corp |
Uso de interleuquina-10 en inmunoterapia adoptiva de cancer.
|
|
ATE116550T1
(de)
|
1991-01-16 |
1995-01-15 |
Schering Corp |
Behandlung von neoplastischen krankenheiten mit interleukin-10.
|
|
US5624823A
(en)
|
1991-11-22 |
1997-04-29 |
The General Hospital Corporation |
DNA encoding procine interleukin-10
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
WO1994017773A2
(en)
|
1993-02-01 |
1994-08-18 |
Université Libre de Bruxelles |
Use of a pharmaceutical composition comprising an effective amount of interleukin-10, an analog and/or an agonist of interleukin-10
|
|
US5328989A
(en)
|
1993-03-05 |
1994-07-12 |
Schering-Plough |
Purification of human interleukin-10 from a cell culture medium
|
|
US5552303A
(en)
|
1993-03-08 |
1996-09-03 |
Immunex Corporation |
DNA encoding epithelium-derived T-cell factor
|
|
WO1994022473A1
(en)
|
1993-04-01 |
1994-10-13 |
University Of Washington |
Use of interleukin 7 to improve vaccine potency
|
|
US5665345A
(en)
|
1993-05-24 |
1997-09-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Methods of inhibiting viral replication using IL-10
|
|
JPH08507930A
(ja)
|
1993-07-26 |
1996-08-27 |
シェリング・コーポレーション |
ヒトインターロイキン−１０のアゴニストおよびアンタゴニスト
|
|
GB9317618D0
(en)
|
1993-08-24 |
1993-10-06 |
Royal Free Hosp School Med |
Polymer modifications
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
NZ259584A
(en)
|
1994-01-20 |
1998-01-26 |
Schering Corp |
Cancer treatment using interleukin 10 activated peripheral blood mononuclear cells optionally combined with il-10 alone or in combination with il-2 or alpha interferon (alpha-ifn), to stimulate peripheral blood mononuclear cells
|
|
US5696234A
(en)
|
1994-08-01 |
1997-12-09 |
Schering Corporation |
Muteins of mammalian cytokine interleukin-13
|
|
US5650234A
(en)
|
1994-09-09 |
1997-07-22 |
Surface Engineering Technologies, Division Of Innerdyne, Inc. |
Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US6410008B1
(en)
|
1994-12-12 |
2002-06-25 |
Beth Israel Hospital Association |
Chimeric IL-10 proteins and uses thereof
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US5866134A
(en)
|
1995-03-24 |
1999-02-02 |
Schering Corporation |
Method for enhancing the antibody response to specific antigens with Interleukin-10
|
|
US5770190A
(en)
|
1995-07-14 |
1998-06-23 |
Schering Corporation |
Method of treatment of acute leukemia with inteleukin-10
|
|
GB2304047A
(en)
|
1995-08-09 |
1997-03-12 |
Univ Manchester |
Pharmaceutical compositions containing cytokines
|
|
US5744451A
(en)
|
1995-09-12 |
1998-04-28 |
Warner-Lambert Company |
N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
|
|
US5908621A
(en)
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
|
US5759859A
(en)
|
1996-07-15 |
1998-06-02 |
United States Of America As Represented By The Secretary Of The Army |
Sensor and method for detecting trace underground energetic materials
|
|
US5945097A
(en)
|
1996-09-06 |
1999-08-31 |
Schering Corporation |
Method for lowering cholesterol levels with interleukin-10
|
|
US5989867A
(en)
|
1996-09-23 |
1999-11-23 |
Knappe; Andrea |
DNA encoding IL-10-like homologue; related reagents
|
|
US6660258B1
(en)
|
1997-05-09 |
2003-12-09 |
Pharma Pacific Pty Ltd |
Oromucosal cytokine compositions and uses thereof
|
|
ES2297889T3
(es)
|
1997-07-14 |
2008-05-01 |
Bolder Biotechnology, Inc. |
Derivados de hormona de crecimiento y proteinas relacionadas.
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
PT1053019E
(pt)
|
1998-01-07 |
2004-04-30 |
Debio Rech Pharma Sa |
Acrilatos de poli(etileno-glicol) heterobifuncional degradaveis e geles e conjugados derivados dos mesmos
|
|
US6428985B1
(en)
|
1998-12-02 |
2002-08-06 |
The Regents Of The University Of Michigan |
Immunosuppressive structural definition of IL-10
|
|
WO2000037096A2
(en)
|
1998-12-22 |
2000-06-29 |
Schering Corporation |
Treatment of hepatitis c virus infections with interleukin-10
|
|
US7666400B2
(en)
|
2005-04-06 |
2010-02-23 |
Ibc Pharmaceuticals, Inc. |
PEGylation by the dock and lock (DNL) technique
|
|
WO2001005821A2
(en)
|
1999-07-16 |
2001-01-25 |
Maria Teresa Bejarano |
Viral il-10 for the inhibition of angiogenesis, tumorigenesis and metastasis
|
|
US6989377B2
(en)
|
1999-12-21 |
2006-01-24 |
Wisconsin Alumni Research Foundation |
Treating vitamin D responsive diseases
|
|
WO2001058950A1
(en)
|
2000-02-11 |
2001-08-16 |
Maxygen Aps |
Improved interleukin 10
|
|
US20030186386A1
(en)
|
2000-02-11 |
2003-10-02 |
Hansen Christian Karsten |
Interleukin 10
|
|
EP2295450B1
(en)
*
|
2000-09-29 |
2015-01-28 |
Merck Sharp & Dohme Corp. |
Pegylated interleukin-10
|
|
JP2002142770A
(ja)
|
2000-11-08 |
2002-05-21 |
Dnavec Research Inc |
循環系への遺伝子送達用パラミクソウイルスベクター
|
|
US6838452B2
(en)
|
2000-11-24 |
2005-01-04 |
Vascular Biogenics Ltd. |
Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
|
|
EP1234583A1
(en)
|
2001-02-23 |
2002-08-28 |
F. Hoffmann-La Roche Ag |
PEG-conjugates of HGF-NK4
|
|
WO2002085300A2
(en)
|
2001-04-23 |
2002-10-31 |
The Regents Of The University Of California |
Methods of using interleukin-7 to modulate physiological processes in mammalian pulmonary fibroblasts
|
|
GB0212648D0
(en)
|
2002-05-31 |
2002-07-10 |
Immunoclin Lab Ltd |
Treatment with cytokines
|
|
EP1391513A1
(en)
|
2002-08-08 |
2004-02-25 |
Cytheris |
IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof
|
|
DE60332358D1
(de)
|
2002-09-09 |
2010-06-10 |
Hanall Pharmaceutical Co Ltd |
Protease-resistente modifizierte interferon alpha polypeptide
|
|
AU2003280315A1
(en)
|
2002-11-14 |
2004-06-03 |
Maxygen, Inc. |
Conjugates of interleukin-10 and polymers
|
|
WO2004050090A1
(en)
|
2002-11-29 |
2004-06-17 |
Maria Grazia Roncarolo |
Rapamycin and il-10 for the treatment of immune diseases
|
|
AU2003303222A1
(en)
|
2002-12-19 |
2004-07-14 |
Universiteit Gent |
Mutant proteins showing increased secretion
|
|
CN101899114A
(zh)
|
2002-12-23 |
2010-12-01 |
惠氏公司 |
抗pd-1抗体及其用途
|
|
GEP20084487B
(en)
|
2002-12-26 |
2008-09-25 |
Mountain View Pharmaceuticals |
Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof
|
|
ES2396368T3
(es)
|
2003-03-03 |
2013-02-21 |
Dyax Corporation |
Péptidos que se unen específicamente al receptor del HGF (CMET) y usos de los mismos
|
|
EP2261244A3
(en)
|
2003-04-15 |
2011-02-23 |
Glaxosmithkline LLC |
Human il-18 substitution mutants and their conjugates
|
|
US7261882B2
(en)
|
2003-06-23 |
2007-08-28 |
Reagents Of The University Of Colorado |
Methods for treating neuropathic pain by administering IL-10 polypeptides
|
|
JPWO2005033307A1
(ja)
|
2003-09-30 |
2006-12-14 |
技術研究組合 生物分子工学研究所 |
新規のリフォールディング方法およびその方法によって得られたタンパク質
|
|
US8133700B2
(en)
|
2003-11-28 |
2012-03-13 |
The University Of Sydney |
Latent phase viral interleukin-10-(VII-10) and uses thereof
|
|
ES2305886T3
(es)
|
2003-12-30 |
2008-11-01 |
Merck Patent Gmbh |
Proteinas de fusion de il-7 con porciones de anticuerpo, su preparacion y su empleo.
|
|
US20060078942A1
(en)
|
2004-03-10 |
2006-04-13 |
Pepgen Corporation |
Method of treatment using interferon-tau
|
|
JP5191729B2
(ja)
|
2004-03-11 |
2013-05-08 |
フレゼニウス・カビ・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
還元的アミノ化によって製造される、ヒドロキシアルキルデンプンとタンパク質とのコンジュゲート
|
|
ES2401114T3
(es)
|
2004-08-10 |
2013-04-17 |
Genzyme Corporation |
Modulación antisentido de la expresión de apolipoproteína B
|
|
US20060046961A1
(en)
|
2004-09-02 |
2006-03-02 |
Mckay William F |
Controlled and directed local delivery of anti-inflammatory compositions
|
|
CN100334112C
(zh)
|
2004-10-15 |
2007-08-29 |
上海海欣生物技术有限公司 |
人白细胞介素15与Fc融合蛋白
|
|
RU2437893C2
(ru)
|
2004-12-09 |
2011-12-27 |
Мерк Патент Гмбх |
Варианты il-7 со сниженной иммуногенностью
|
|
GB0500643D0
(en)
|
2005-01-13 |
2005-02-23 |
Renovo Ltd |
Medicaments
|
|
WO2006094530A1
(en)
|
2005-03-11 |
2006-09-14 |
Siegfried Ltd. |
Di-polymer protein conjugates and processes for their preparation
|
|
UY29460A1
(es)
|
2005-04-08 |
2006-11-30 |
Noxxon Pharma Ag |
Acidos nucleicos de union a ghrelin
|
|
WO2006119170A2
(en)
|
2005-05-02 |
2006-11-09 |
Avigen, Inc. |
Use of cytokine-derived peptides in treatment of pain and neurodegenerative disease
|
|
DK2439273T3
(da)
*
|
2005-05-09 |
2019-06-03 |
Ono Pharmaceutical Co |
Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
|
|
WO2006130580A2
(en)
|
2005-05-31 |
2006-12-07 |
Avigen, Inc. |
Mutant il-10
|
|
EP1910513B1
(en)
|
2005-07-01 |
2016-08-10 |
John Schrader |
Methods of isolating antibody secreting cells from blood samples of immunized animals and generating monoclonal antibodies from said antibody secreting cells.
|
|
EP1746161A1
(en)
|
2005-07-20 |
2007-01-24 |
Cytheris |
Glycosylated IL-7, preparation and uses
|
|
CA2625208A1
(en)
|
2005-10-04 |
2007-04-12 |
Zymogenetics, Inc. |
Production and purification of il-29
|
|
WO2007061657A2
(en)
|
2005-11-14 |
2007-05-31 |
The Brigham & Women's Hospital, Inc. |
Interleukin-10 compositions for the treatment of adenocarcinomas
|
|
US7868139B2
(en)
|
2006-01-24 |
2011-01-11 |
Uab Research Foundation |
Compositions and methods for the identification and treatment of immune-mediated inflammatory diseases
|
|
US7662965B2
(en)
*
|
2006-01-26 |
2010-02-16 |
Cornerstone Therapeutics, Inc. |
Anabaseine derivatives, pharmaceutical compositions and method of use thereof
|
|
EP2066336B1
(en)
*
|
2006-09-28 |
2012-09-19 |
Merck Sharp & Dohme Corp. |
Use of pegylated il-10 to treat cancer
|
|
US20100068147A1
(en)
|
2006-10-05 |
2010-03-18 |
Agency for Science , Technology and Research |
Dengue diagnosis and treatment
|
|
ES2409756T3
(es)
|
2006-12-04 |
2013-06-27 |
Promedior, Inc. |
Combinación de SAP y de enalapril para su uso en tratamiento de trastornos fibróticos o fibroproliferativos
|
|
CA2989778C
(en)
|
2007-01-19 |
2020-06-30 |
Kai Pharmaceuticals, Inc. |
Method of modifying peptide compositions
|
|
WO2009014708A2
(en)
|
2007-07-23 |
2009-01-29 |
Cell Genesys, Inc. |
Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
|
|
EP2190863B1
(en)
|
2007-07-31 |
2015-09-02 |
Affibody AB |
New albumin binding compositions, methods and uses
|
|
WO2009036568A1
(en)
|
2007-09-19 |
2009-03-26 |
University Health Network |
Methods and compositions for treating tumors and viral infections
|
|
EP2200649A4
(en)
|
2007-10-19 |
2012-09-26 |
Univ California |
COMPOSITIONS AND METHODS FOR TREATING CNS INFUSION, PSYCHOSIS, DELIRE, PTSD OR PTSS
|
|
CA2706700A1
(en)
|
2007-11-08 |
2009-05-14 |
Cytimmune Sciences, Inc. |
Compositions and methods for generating antibodies
|
|
GB0724231D0
(en)
|
2007-12-12 |
2008-01-30 |
Renono Ltd |
Methods for inhibiting scarring
|
|
US20090311187A1
(en)
|
2008-05-29 |
2009-12-17 |
Bristol-Myers Squibb Company |
Methods for predicting patient response to modulation of the Co-stimulatory pathway
|
|
WO2010022227A1
(en)
|
2008-08-20 |
2010-02-25 |
Schering Corporation |
Methods for monitoring il-10 therapy
|
|
WO2010059315A1
(en)
|
2008-11-18 |
2010-05-27 |
Merrimack Pharmaceuticals, Inc. |
Human serum albumin linkers and conjugates thereof
|
|
ES2655364T3
(es)
|
2008-12-17 |
2018-02-19 |
Merck Sharp & Dohme Corp. |
Producción de IL-10 mono- y dipegilada y sus usos
|
|
CA2769822C
(en)
*
|
2009-08-13 |
2019-02-19 |
The Johns Hopkins University |
Methods of modulating immune function
|
|
EP2486049A1
(en)
|
2009-10-06 |
2012-08-15 |
The Board Of Trustees Of The UniversityOf Illinois |
Human single-chain t cell receptors
|
|
WO2011045704A1
(en)
*
|
2009-10-12 |
2011-04-21 |
Pfizer Inc. |
Cancer treatment
|
|
EP2493921B1
(en)
|
2009-10-30 |
2018-09-26 |
Albumedix Ltd |
Albumin variants
|
|
JP2013511994A
(ja)
|
2009-11-30 |
2013-04-11 |
バイオテスト・アクチエンゲゼルシヤフト |
全身性エリテマトーデス（ｓｌｅ）を治療するためのヒト化抗ｉｌ−１０抗体
|
|
CA3253628A1
(en)
*
|
2010-03-05 |
2025-11-29 |
The Johns Hopkins University |
Compositions and methods for targeted immunomodulatory antibodies and fusion proteins
|
|
WO2011159878A1
(en)
|
2010-06-16 |
2011-12-22 |
Abbott Laboratories |
Comparison of protein samples
|
|
WO2011159877A2
(en)
|
2010-06-18 |
2011-12-22 |
The Brigham And Women's Hospital, Inc. |
Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
|
|
CN103003296A
(zh)
|
2010-07-09 |
2013-03-27 |
阿菲博迪公司 |
多肽
|
|
US8759617B2
(en)
|
2010-09-21 |
2014-06-24 |
National Institute Of Agrobiological Sciences |
Method for extraction and purification of recombinant proteins from transgenic plants
|
|
PT2621515T
(pt)
|
2010-09-28 |
2017-07-12 |
Aegerion Pharmaceuticals Inc |
Polipéptido quimérico de leptina de foca-ser humano com solubilidade aumentada
|
|
CA2812951A1
(en)
|
2010-09-28 |
2012-04-19 |
Amylin Pharmaceuticals, Llc |
Engineered polypeptides having enhanced duration of action
|
|
US8895537B2
(en)
|
2010-10-29 |
2014-11-25 |
Infirst Healthcare Ltd. |
Compositions and methods for treating cardiovascular diseases
|
|
US9987308B2
(en)
|
2011-03-23 |
2018-06-05 |
Fred Hutchinson Cancer Research Center |
Method and compositions for cellular immunotherapy
|
|
CN102145178B
(zh)
|
2011-04-15 |
2012-09-26 |
北京凯因科技股份有限公司 |
Peg化白介素15
|
|
EP2537933A1
(en)
|
2011-06-24 |
2012-12-26 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
An IL-15 and IL-15Ralpha sushi domain based immunocytokines
|
|
US20140242081A1
(en)
*
|
2011-07-18 |
2014-08-28 |
Micromet Ag |
Dosing regimens for treatment of cea-expressing cancers
|
|
US20140256626A1
(en)
|
2011-10-18 |
2014-09-11 |
Prolynx Llc |
Peg conjugates of exenatide
|
|
US10391126B2
(en)
|
2011-11-18 |
2019-08-27 |
Board Of Regents, The University Of Texas System |
CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA
|
|
EP3683228A3
(en)
|
2012-01-26 |
2020-07-29 |
Amgen Inc. |
Growth differentiation factor 15 (gdf-15) polypeptides
|
|
EP2820033A1
(en)
|
2012-02-29 |
2015-01-07 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates and their uses
|
|
WO2013169971A1
(en)
*
|
2012-05-10 |
2013-11-14 |
Bristol-Myers Squibb Company |
Anti-tumor antibodies as predictive or prognostic biomarkers of efficacy and survival in ipilimumab-treated patients
|
|
EP2947111B1
(en)
|
2013-01-17 |
2018-03-07 |
Xiamen Sinopeg Biotech Co., Ltd. |
Monofunctional branched polyethyleneglycol and bio-related substance modified by same
|
|
MX2015014438A
(es)
|
2013-04-18 |
2016-05-18 |
Armo Biosciences Inc |
Metodos de uso de interleucina-10 para tratar enfermedades y trastornos.
|
|
EP2989240A4
(en)
|
2013-04-24 |
2016-10-19 |
Armo Biosciences Inc |
INTERLEUKIN-10 COMPOSITIONS AND USES THEREOF
|
|
EP3010527B1
(en)
|
2013-06-17 |
2018-08-08 |
Armo Biosciences, Inc. |
Method for assessing protein identity and stability
|
|
CN105658232A
(zh)
|
2013-08-30 |
2016-06-08 |
阿尔莫生物科技股份有限公司 |
使用白细胞介素-10治疗疾病和病症的方法
|
|
CN120242030A
(zh)
|
2013-11-11 |
2025-07-04 |
阿尔莫生物科技股份有限公司 |
将白细胞介素-10用于治疗疾病和病症的方法
|
|
US20160375101A1
(en)
|
2014-01-15 |
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|
|
WO2015112626A1
(en)
|
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2015-07-30 |
June Carl H |
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|
|
MA39711A
(fr)
|
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2015-10-08 |
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|
|
WO2015187295A2
(en)
|
2014-06-02 |
2015-12-10 |
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|
|
AU2016228555B2
(en)
|
2015-03-11 |
2021-12-23 |
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Conjugates of an IL-7 moiety and a polymer
|
|
US20160361415A1
(en)
|
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Armo Biosciences, Inc. |
Methods of Using Interleukin-10 for Treating Diseases and Disorders
|