ES2074879T3 - Uso de interleuquina-10 en inmunoterapia adoptiva de cancer. - Google Patents
Uso de interleuquina-10 en inmunoterapia adoptiva de cancer.Info
- Publication number
- ES2074879T3 ES2074879T3 ES92905179T ES92905179T ES2074879T3 ES 2074879 T3 ES2074879 T3 ES 2074879T3 ES 92905179 T ES92905179 T ES 92905179T ES 92905179 T ES92905179 T ES 92905179T ES 2074879 T3 ES2074879 T3 ES 2074879T3
- Authority
- ES
- Spain
- Prior art keywords
- interleukin
- tils
- cancer immunotherapy
- adoptive cancer
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000003814 Interleukin-10 Human genes 0.000 title abstract 5
- 108090000174 Interleukin-10 Proteins 0.000 title abstract 5
- 229940076144 interleukin-10 Drugs 0.000 title abstract 5
- 238000002619 cancer immunotherapy Methods 0.000 title abstract 2
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000001370 static light scattering Methods 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
SE PREVE UN METODO PARA EMPLEAR INTERLEUKIN-10 EN LA INMUNOTERAPIA ADOPTIVA DEL CANCER. SE EXPANDE UNA POBLACION DE LINFOCITOS INFILTRADOS DE TUMOR (TILS) EN UN CULTIVO, EN PRESENCIA DE INTERLEUKIN-10 (IL-10). DESPUES DE LA ADMINISTRACION DE LOS TILS AL PACIENTE, SE ADMINISTRA UNA CANTIDAD EFECTIVA DE AMBOS IL-2 Y IL-10 PARA INCREMENTAR LA CITOTOXICIDAD DE LAS CELULAS TUMORALES DE LOS TILS Y PARA REDUCIR LOS EFECTOS COLATERALES CAUSADOS POR LA PRODUCCION DE CITOKINA INDUCIDA POR IL-2 EN LOS TILS Y OTRAS CELULAS DEL PACIENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64134291A | 1991-01-16 | 1991-01-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2074879T3 true ES2074879T3 (es) | 1995-09-16 |
Family
ID=24571960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92905179T Expired - Lifetime ES2074879T3 (es) | 1991-01-16 | 1992-01-15 | Uso de interleuquina-10 en inmunoterapia adoptiva de cancer. |
Country Status (17)
Country | Link |
---|---|
US (1) | US5776451A (es) |
EP (2) | EP0567586B1 (es) |
JP (1) | JPH06505250A (es) |
CN (1) | CN1063308A (es) |
AT (1) | ATE124866T1 (es) |
AU (1) | AU1273992A (es) |
DE (1) | DE69203443T2 (es) |
DK (1) | DK0567586T3 (es) |
ES (1) | ES2074879T3 (es) |
GR (1) | GR3017597T3 (es) |
IE (1) | IE68836B1 (es) |
IL (1) | IL100667A0 (es) |
MX (1) | MX9200161A (es) |
MY (1) | MY108267A (es) |
NZ (1) | NZ241321A (es) |
WO (1) | WO1992012726A1 (es) |
ZA (1) | ZA92304B (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW381026B (en) * | 1993-01-13 | 2000-02-01 | Schering Corp | Method of extracorporally activating cytolytic activity of peripheral blood mononuclear cells and pharmaceutical composition comprising the activated peripheral blood mononuclear cells |
JPH09508116A (ja) * | 1994-01-20 | 1997-08-19 | シェーリング コーポレイション | 末梢血単核細胞溶解活性を刺激するためのil−10の使用 |
US5770190A (en) * | 1995-07-14 | 1998-06-23 | Schering Corporation | Method of treatment of acute leukemia with inteleukin-10 |
AU2062497A (en) * | 1996-02-28 | 1997-09-16 | University Of Medicine And Dentistry Of New Jersey | Antisense interleukin 10 and methods of use |
ES2322877T3 (es) | 1996-08-30 | 2009-06-30 | Human Genome Sciences, Inc. | Interleucina 19. |
AU6517900A (en) * | 1999-08-03 | 2001-02-19 | Smith & Nephew, Inc. | Controlled release implantable devices |
IL154925A0 (en) | 2000-09-14 | 2003-10-31 | Beth Israel Hospital | Modulation of il-2 and il-15-mediated t cell responses |
US7052686B2 (en) | 2000-09-29 | 2006-05-30 | Schering Corporation | Pegylated interleukin-10 |
CA2515779A1 (en) | 2003-02-14 | 2004-09-02 | The Curators Of The University Of Missouri | Contraceptive method and compositions related to proteasomal interference |
US7294262B2 (en) * | 2003-08-27 | 2007-11-13 | Sta-Rite Industries, Llc | Modular fluid treatment apparatus |
EP2468293B1 (en) | 2006-09-28 | 2014-10-22 | Merck Sharp & Dohme Corp. | Use of pegylated il-10 to prevent metastasis of a cancer or tumor to the lung |
US20080089875A1 (en) * | 2006-10-13 | 2008-04-17 | Zheng Cui | Methods and compositions for the treatment of cancer |
JP2012510284A (ja) | 2008-12-03 | 2012-05-10 | プロイェクト、デ、ビオメディシナ、シーマ、ソシエダッド、リミターダ | ワクチンの開発のためのフェノール可溶性モジュリンの使用 |
PT2379115T (pt) | 2008-12-17 | 2018-01-03 | Merck Sharp & Dohme | Produção de mono- e di-peg-il-10; e utilizações |
US20100310591A1 (en) * | 2009-01-28 | 2010-12-09 | Robert Humphreys | Ii-KEY HYBRID PEPTIDES THAT MODULATE THE IMMUNE RESPONSE TO INFLUENZA |
BR112012012917A2 (pt) * | 2009-11-30 | 2016-10-25 | Biotest Ag | anticorpo, ácido nucleico, vetor, célula hospedeira, método para a produção de um anticorpo ou um fragmento do mesmo, composição farmacêutica, método para tratar ou prevenir uma condição médica em um indivíduo, uso de um anticorpo ou fragmento do mesmo, e, métodos in vitro para neutralizar il-10 em uma amostra, in vitro para detectar a presença de il-10 em uma amostra e para diagnosticar lúpus eritematoso sistêmico (sle) em um indivíduo |
WO2012123269A1 (en) | 2011-03-11 | 2012-09-20 | Proyecto De Biomedicina Cima, S.L. | Immunogenic compositions and methods for their use |
EP2505640A1 (en) | 2011-03-29 | 2012-10-03 | Neo Virnatech, S.L. | Vaccine compositions for birnavirus-borne diseases |
MX2015014438A (es) | 2013-04-18 | 2016-05-18 | Armo Biosciences Inc | Metodos de uso de interleucina-10 para tratar enfermedades y trastornos. |
EP3434277A1 (en) | 2013-06-17 | 2019-01-30 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
CA2920679A1 (en) | 2013-08-30 | 2015-03-05 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
CA2928526A1 (en) | 2013-11-01 | 2015-05-07 | Spherium Biomed S.L. | Inclusion bodies for transdermal delivery of therapeutic and cosmetic agents |
AU2014346537A1 (en) | 2013-11-11 | 2016-05-19 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
JP2017507950A (ja) | 2014-02-27 | 2017-03-23 | リセラ・コーポレイションLycera Corporation | レチノイン酸受容体関連オーファン受容体ガンマのアゴニストを使用する養子細胞療法及び関連治療方法 |
WO2015171558A2 (en) | 2014-05-05 | 2015-11-12 | Lycera Corporation | BENZENESULFONAMIDO AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORγ AND THE TREATEMENT OF DISEASE |
JP6728061B2 (ja) | 2014-05-05 | 2020-07-22 | リセラ・コーポレイションLycera Corporation | RORγアゴニストとして用いるテトラヒドロキノリンスルホンアミド及び関連化合物ならびに疾患の治療 |
CN106573072A (zh) | 2014-06-02 | 2017-04-19 | 阿尔莫生物科技股份有限公司 | 降低血清胆固醇的方法 |
CA2963989A1 (en) | 2014-10-14 | 2016-04-21 | Armo Biosciences, Inc. | Interleukin-15 compositions and uses thereof |
MX2017004983A (es) | 2014-10-22 | 2017-11-13 | Armo Biosciences Inc | Metodos para usar interleucina 10 para tratar enfermedades y trastornos. |
US10618970B2 (en) | 2015-02-03 | 2020-04-14 | Armo Biosciences, Inc. | Method of treating cancer with IL-10 and antibodies that induce ADCC |
EP3292119A4 (en) | 2015-05-05 | 2018-10-03 | Lycera Corporation | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE |
CN107847583A (zh) | 2015-05-28 | 2018-03-27 | 阿尔莫生物科技股份有限公司 | 用于治疗癌症的聚乙二醇化白细胞介素‑10 |
JP6838004B2 (ja) | 2015-06-11 | 2021-03-03 | リセラ・コーポレイションLycera Corporation | RORγのアゴニストとしての使用及び疾患の治療のためのアリールジヒドロ−2H−ベンゾ[b][1,4]オキサジンスルホンアミド及び関連化合物 |
MX2018002298A (es) | 2015-08-25 | 2018-07-06 | Armo Biosciences Inc | Metodos de uso de interleucina 10 para el tratamiento de enfermedades y trastornos. |
WO2018162450A1 (en) | 2017-03-06 | 2018-09-13 | Fundación Para La Investigación Médica Aplicada | New inmunostimulatory compositions comprising an entity of cold inducible rna-binding protein with an antigen for the activation of dendritic cells |
WO2019143883A2 (en) * | 2018-01-18 | 2019-07-25 | Vedanta Biosciences, Inc. | Compositions and methods for the treatment of cancer |
CA3150859A1 (en) | 2019-08-16 | 2021-02-25 | Applied Molecular Transport Inc. | Compositions, formulations, and interleukin production and purification |
CN110669139A (zh) * | 2019-09-18 | 2020-01-10 | 沣潮医药科技(上海)有限公司 | 二聚体免疫粘附素、药物组合物和用途 |
CN112625137B (zh) * | 2019-10-08 | 2021-10-08 | 北京东方百泰生物科技股份有限公司 | 一种人白细胞介素10-Fc融合蛋白及其医药用途 |
CN114805538B (zh) * | 2022-05-20 | 2023-06-09 | 广州智瓴生物医药有限公司 | 一种增强til功效的培养方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4690915A (en) * | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
JPH0751496B2 (ja) * | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
WO1990004633A1 (en) * | 1988-10-21 | 1990-05-03 | Brigham And Women's Hospital | ACTIVATION AND GROWTH OF HUMAN TUMOR-INFILTRATING LYMPHOCYTES USING ANTIBODIES TO CD3 OR TcR |
ATE110770T1 (de) * | 1989-02-21 | 1994-09-15 | Terumo Corp | Proliferation von cd4-lymfocyten. |
IL94878A (en) * | 1989-06-28 | 2003-01-12 | Schering Corp | Cytokine synthesis inhibitory factor, antagonists thereof and methods of using same |
-
1992
- 1992-01-15 MY MYPI92000065A patent/MY108267A/en unknown
- 1992-01-15 MX MX9200161A patent/MX9200161A/es unknown
- 1992-01-15 JP JP4505288A patent/JPH06505250A/ja active Pending
- 1992-01-15 ES ES92905179T patent/ES2074879T3/es not_active Expired - Lifetime
- 1992-01-15 DK DK92905179.5T patent/DK0567586T3/da active
- 1992-01-15 EP EP92905179A patent/EP0567586B1/en not_active Expired - Lifetime
- 1992-01-15 AU AU12739/92A patent/AU1273992A/en not_active Abandoned
- 1992-01-15 ZA ZA92304A patent/ZA92304B/xx unknown
- 1992-01-15 DE DE69203443T patent/DE69203443T2/de not_active Expired - Fee Related
- 1992-01-15 AT AT92905179T patent/ATE124866T1/de not_active IP Right Cessation
- 1992-01-15 EP EP92300331A patent/EP0495639A1/en active Pending
- 1992-01-15 IE IE920113A patent/IE68836B1/en not_active IP Right Cessation
- 1992-01-15 IL IL100667A patent/IL100667A0/xx unknown
- 1992-01-15 WO PCT/US1992/000067 patent/WO1992012726A1/en active IP Right Grant
- 1992-01-16 CN CN92100319A patent/CN1063308A/zh active Pending
- 1992-01-16 NZ NZ241321A patent/NZ241321A/en unknown
-
1994
- 1994-07-05 US US08/270,805 patent/US5776451A/en not_active Expired - Fee Related
-
1995
- 1995-10-02 GR GR950402710T patent/GR3017597T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO1992012726A1 (en) | 1992-08-06 |
MX9200161A (es) | 1992-07-01 |
MY108267A (en) | 1996-09-30 |
AU1273992A (en) | 1992-08-27 |
IE68836B1 (en) | 1996-07-10 |
GR3017597T3 (en) | 1996-01-31 |
EP0567586B1 (en) | 1995-07-12 |
ZA92304B (en) | 1992-09-30 |
EP0567586A1 (en) | 1993-11-03 |
JPH06505250A (ja) | 1994-06-16 |
IL100667A0 (en) | 1992-09-06 |
US5776451A (en) | 1998-07-07 |
IE920113A1 (en) | 1992-07-29 |
ATE124866T1 (de) | 1995-07-15 |
EP0495639A1 (en) | 1992-07-22 |
DE69203443D1 (de) | 1995-08-17 |
NZ241321A (en) | 1997-06-24 |
DE69203443T2 (de) | 1995-12-07 |
CN1063308A (zh) | 1992-08-05 |
DK0567586T3 (da) | 1995-12-04 |
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