DE68929208D1 - Anwendungen von Acemannan - Google Patents
Anwendungen von AcemannanInfo
- Publication number
- DE68929208D1 DE68929208D1 DE68929208T DE68929208T DE68929208D1 DE 68929208 D1 DE68929208 D1 DE 68929208D1 DE 68929208 T DE68929208 T DE 68929208T DE 68929208 T DE68929208 T DE 68929208T DE 68929208 D1 DE68929208 D1 DE 68929208D1
- Authority
- DE
- Germany
- Prior art keywords
- acemannan
- applications
- defective virus
- master seed
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/10011—Birnaviridae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/229,164 US5106616A (en) | 1988-01-14 | 1988-08-05 | Administration of acemannan |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68929208D1 true DE68929208D1 (de) | 2000-06-15 |
DE68929208T2 DE68929208T2 (de) | 2000-09-07 |
Family
ID=22860075
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68920019T Expired - Fee Related DE68920019T2 (de) | 1988-08-05 | 1989-08-03 | Aloe-zusammensetzungen und deren verwendungen. |
DE68929208T Expired - Fee Related DE68929208T2 (de) | 1988-08-05 | 1989-08-03 | Anwendungen von Acemannan |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68920019T Expired - Fee Related DE68920019T2 (de) | 1988-08-05 | 1989-08-03 | Aloe-zusammensetzungen und deren verwendungen. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5106616A (de) |
EP (4) | EP0965345A3 (de) |
JP (1) | JP2888249B2 (de) |
AT (2) | ATE115405T1 (de) |
AU (1) | AU637985B2 (de) |
CA (1) | CA1336581C (de) |
DE (2) | DE68920019T2 (de) |
WO (1) | WO1990001253A1 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5106616A (en) * | 1988-01-14 | 1992-04-21 | Carrington Laboratories, Inc. | Administration of acemannan |
US5468737A (en) * | 1982-05-07 | 1995-11-21 | Carrington Laboratories, Inc. | Wound healing accelerated by systemic administration of polysaccharide from aloe |
US5308838A (en) * | 1982-05-07 | 1994-05-03 | Carrington Laboratories, Inc. | Uses of aloe products |
US5814611A (en) * | 1988-12-14 | 1998-09-29 | Cytoven J.V. | Pharmaceutical for the therapy of immune deficiency conditions |
US6136788A (en) * | 1987-12-30 | 2000-10-24 | Cytran, Inc. | Pharmaceutical preparation for the therapy of immune deficiency conditions |
US5658957A (en) * | 1991-03-01 | 1997-08-19 | Warner Lambert Company | Immunostimulating wound healing compositions and method for preparing and using same |
WO1993008810A1 (en) * | 1991-11-05 | 1993-05-13 | Carrington Laboratories, Inc. | Uses of aloe products, e.g. acemannan, in the treatment of diseases requiring intervention of the immune system for cure |
IL104382A0 (en) * | 1992-01-17 | 1993-05-13 | Solvay Animal Health Inc | Vaccine containing acemannan as an adjuvant |
US5409703A (en) * | 1993-06-24 | 1995-04-25 | Carrington Laboratories, Inc. | Dried hydrogel from hydrophilic-hygroscopic polymer |
US5902796A (en) * | 1995-09-22 | 1999-05-11 | Carrington Laboratories, Inc. | Bioactive factors of aloe vera plants |
US5858378A (en) * | 1996-05-02 | 1999-01-12 | Galagen, Inc. | Pharmaceutical composition comprising cryptosporidium parvum oocysts antigen and whole cell candida species antigen |
ATE218065T1 (de) * | 1996-08-09 | 2002-06-15 | Mannatech Inc | Zusammensetzungen auf pflanzliicher kohlenhydratbasis als nahrungsergänzungsstoffe |
US6929807B1 (en) * | 1996-08-09 | 2005-08-16 | Mannatech, Inc. | Compositions of plant carbohydrates as dietary supplements |
US6303584B1 (en) | 1996-11-20 | 2001-10-16 | The University Of Montana | Water soluble lipidated arabinogalactan |
CU22629A1 (es) * | 1997-03-06 | 2000-12-22 | Ct Ingenieria Genetica Biotech | Formulaciones inmunopotenciadoras para uso vacunal |
KR100729887B1 (ko) | 1997-10-10 | 2007-06-18 | 유니젠 파아마슈티컬스,인크. | 알로에로부터 유래된 다당류를 포함하는 조성물 |
US6136794A (en) * | 1998-02-02 | 2000-10-24 | Merck & Co., Inc. | Platelet aggregation inhibition using low molecular weight heparin in combination with a GP IIb/IIIa antagonist |
US7022683B1 (en) * | 1998-05-13 | 2006-04-04 | Carrington Laboratories, Inc. | Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation |
CU22740A1 (es) * | 1998-09-07 | 2002-02-28 | Ct Ingenieria Genetica Biotech | Formulación de ácidos nucleicos y acemanano |
US7494669B2 (en) | 2001-02-28 | 2009-02-24 | Carrington Laboratories, Inc. | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
US20030175370A1 (en) * | 2002-03-07 | 2003-09-18 | Carrington Laboratories, Inc. | Dispersed solid-containing complex carbohydrate |
US6884783B2 (en) * | 2002-05-03 | 2005-04-26 | Unigen Pharmaceuticals, Inc. | 7-Hydroxy chromones as potent antioxidants |
US7060304B2 (en) * | 2003-04-16 | 2006-06-13 | Access Business Group International Llc | Skin whitening compositions containing black cohosh extract |
WO2005030232A2 (en) * | 2003-07-14 | 2005-04-07 | Shambabu Ayare | Herbal compositions for effective treatment of aids, preparation thereof and method for treatment of aids patients |
CA2558266C (en) | 2004-03-05 | 2017-10-17 | Gen-Probe Incorporated | Reagents, methods and kits for use in deactivating nucleic acids |
US8128966B2 (en) | 2004-03-26 | 2012-03-06 | La Jolla Pharmaceutical Company | Modified pectins, compositions and methods related thereto |
WO2005108979A1 (ja) * | 2004-04-16 | 2005-11-17 | Ajinomoto Co., Inc. | 末梢血単核球の多糖結合能測定キット |
KR100720973B1 (ko) * | 2005-03-18 | 2007-05-22 | 주식회사 유니젠 | 천연물 유래 아이소오리엔틴을 포함하는 히스타민 억제용약학 조성물 |
WO2007024589A2 (en) * | 2005-08-24 | 2007-03-01 | The Trustees Of Columbia University In The City Of New York | Phagocyte enhancement therapy for atherosclerosis |
WO2007044936A2 (en) * | 2005-10-13 | 2007-04-19 | The University Of Mississippi | Animal model of anxiety and depression |
US8999293B2 (en) | 2005-10-13 | 2015-04-07 | University Of Mississippi | Animal model of anxiety and depression |
US20070275150A1 (en) * | 2006-05-26 | 2007-11-29 | Ciell Michael P | Nutritional composition and method of making the same |
AU2007268684B2 (en) * | 2006-05-31 | 2012-02-23 | Toyama Chemical Co., Ltd. | Anti-foot-and-mouth disease virus agent for animal belonging to family Suidae or sheep, and method for prevention or treatment of foot-and-mouth disease in animal belonging to family Suidae or sheep |
TWI454261B (zh) | 2007-01-09 | 2014-10-01 | Unigen Inc | 作為治療劑之色酮類 |
US10543247B2 (en) * | 2007-05-11 | 2020-01-28 | Woodcliff Skincare Solutions, Inc. | Aloe preparation for skin enhancement |
US7833829B2 (en) * | 2008-10-28 | 2010-11-16 | Honeywell International Inc. | MEMS devices and methods of assembling micro electromechanical systems (MEMS) |
WO2011050135A1 (en) * | 2009-10-21 | 2011-04-28 | Curemark Llc | Methods and compositions for the prevention and treatment of influenza |
WO2011079260A2 (en) * | 2009-12-23 | 2011-06-30 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Stabilized virus like particles having enhanced mucosal immunogenicity |
US8604187B2 (en) | 2010-01-14 | 2013-12-10 | North Texas Medical Associates | Compositions and methods of aloe polysaccharides |
WO2011146635A1 (en) * | 2010-05-21 | 2011-11-24 | North Texas Medical Associates | Malignant neoplasm treatment protocol |
AP2013006738A0 (en) * | 2010-07-23 | 2013-02-28 | North Texas Medical Ass | Anti-viral properties of aloe vera and acquired immune deficiency syndrome (AIDS) treatment |
AU2011353765B2 (en) * | 2011-01-06 | 2017-04-06 | Bespoke Bioscience, Llc | Compositions and methods of aloe polysaccharides |
US9327029B2 (en) | 2011-05-05 | 2016-05-03 | Celacare Technologies, Llc | Antimicrobial silver hydrogel composition for the treatment of burns and wounds |
JP6129947B2 (ja) * | 2015-12-28 | 2017-05-17 | ビスポーク バイオサイエンス,エルエルシー | アロエ多糖体の組成物及び方法 |
MX2020010036A (es) | 2018-03-28 | 2021-03-02 | Herbalife Int Of America Inc | Acetilacion de polisacaridos. |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3892853A (en) * | 1967-05-22 | 1975-07-01 | Aloe 99 & 0 Inc | Stabilized aloe vera gel and preparation of same |
US3470109A (en) * | 1968-01-31 | 1969-09-30 | Aloe Creme Lab Inc | Method of making reconstitutable aloe gel in crystalline form |
US4178372A (en) * | 1978-03-06 | 1979-12-11 | Coats Billy C | Hypoallergenic stabilized aloe vera gel |
US5106616A (en) * | 1988-01-14 | 1992-04-21 | Carrington Laboratories, Inc. | Administration of acemannan |
US4851224A (en) * | 1986-06-05 | 1989-07-25 | Carrington Laboratories, Inc. | Process for preparation of aloe products |
US4555987A (en) * | 1983-07-22 | 1985-12-03 | Tumlinson Larry N | Method and apparatus for extraction of aloe vera gel |
DE3447572A1 (de) * | 1984-12-22 | 1986-07-03 | Wolfgang Wirth | Mittel zur regenerierung und staerkung tierischer und menschlicher organismen koerpereigener abwehrkraefte und der haut sowie zu deren schutz aus aloe-wirkstoffen |
JPS61233627A (ja) * | 1985-04-10 | 1986-10-17 | Agency Of Ind Science & Technol | 肥満細胞脱顆粒抑制剤 |
JPS63501221A (ja) * | 1985-06-28 | 1988-05-12 | カ−リントン ラボラトリ−ズ インコ−ポレ−テツド | アロエ製品の製造方法、該方法によって得られた製品およびその組成物 |
DE3665262D1 (en) * | 1985-06-28 | 1989-10-05 | Carrington Lab Inc | Processes for preparation of aloe products, products produced thereby and compositions thereof |
IL104382A0 (en) * | 1992-01-17 | 1993-05-13 | Solvay Animal Health Inc | Vaccine containing acemannan as an adjuvant |
-
1988
- 1988-08-05 US US07/229,164 patent/US5106616A/en not_active Expired - Lifetime
-
1989
- 1989-08-03 EP EP99115500A patent/EP0965345A3/de not_active Withdrawn
- 1989-08-03 EP EP94105182A patent/EP0619117B1/de not_active Expired - Lifetime
- 1989-08-03 AT AT89910539T patent/ATE115405T1/de not_active IP Right Cessation
- 1989-08-03 EP EP97119661A patent/EP0857485A3/de not_active Withdrawn
- 1989-08-03 AT AT94105182T patent/ATE192653T1/de not_active IP Right Cessation
- 1989-08-03 JP JP1509805A patent/JP2888249B2/ja not_active Expired - Fee Related
- 1989-08-03 EP EP89910539A patent/EP0382840B1/de not_active Expired - Lifetime
- 1989-08-03 CA CA000607449A patent/CA1336581C/en not_active Expired - Lifetime
- 1989-08-03 AU AU43194/89A patent/AU637985B2/en not_active Ceased
- 1989-08-03 DE DE68920019T patent/DE68920019T2/de not_active Expired - Fee Related
- 1989-08-03 DE DE68929208T patent/DE68929208T2/de not_active Expired - Fee Related
- 1989-08-03 WO PCT/US1989/003381 patent/WO1990001253A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP0965345A2 (de) | 1999-12-22 |
EP0382840A4 (en) | 1991-04-17 |
DE68920019T2 (de) | 1995-04-20 |
AU637985B2 (en) | 1993-06-17 |
US5106616A (en) | 1992-04-21 |
ATE192653T1 (de) | 2000-05-15 |
JPH03501624A (ja) | 1991-04-11 |
EP0619117B1 (de) | 2000-05-10 |
EP0965345A3 (de) | 2000-09-06 |
DE68929208T2 (de) | 2000-09-07 |
EP0857485A2 (de) | 1998-08-12 |
JP2888249B2 (ja) | 1999-05-10 |
EP0619117A3 (de) | 1994-12-21 |
WO1990001253A1 (en) | 1990-02-22 |
AU4319489A (en) | 1990-03-05 |
CA1336581C (en) | 1995-08-08 |
DE68920019D1 (de) | 1995-01-26 |
EP0857485A3 (de) | 1999-03-24 |
EP0382840A1 (de) | 1990-08-22 |
EP0382840B1 (de) | 1994-12-14 |
EP0619117A2 (de) | 1994-10-12 |
ATE115405T1 (de) | 1994-12-15 |
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