JP2017524675A5 - - Google Patents
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- Publication number
- JP2017524675A5 JP2017524675A5 JP2016573808A JP2016573808A JP2017524675A5 JP 2017524675 A5 JP2017524675 A5 JP 2017524675A5 JP 2016573808 A JP2016573808 A JP 2016573808A JP 2016573808 A JP2016573808 A JP 2016573808A JP 2017524675 A5 JP2017524675 A5 JP 2017524675A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- pharmaceutical composition
- composition according
- fxii
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 102000000429 Factor XII Human genes 0.000 claims 10
- 108010080865 Factor XII Proteins 0.000 claims 10
- 239000003112 inhibitor Substances 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 208000014674 injury Diseases 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 230000008736 traumatic injury Effects 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 3
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000001802 infusion Methods 0.000 claims 3
- 208000020431 spinal cord injury Diseases 0.000 claims 3
- 230000009529 traumatic brain injury Effects 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 229940009550 c1 esterase inhibitor Drugs 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 230000014759 maintenance of location Effects 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 210000000278 spinal cord Anatomy 0.000 claims 2
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 claims 1
- 102100036774 Afamin Human genes 0.000 claims 1
- 101710149366 Afamin Proteins 0.000 claims 1
- 102100023635 Alpha-fetoprotein Human genes 0.000 claims 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 claims 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 claims 1
- 102100029880 Glycodelin Human genes 0.000 claims 1
- 101000585553 Homo sapiens Glycodelin Proteins 0.000 claims 1
- 101000956004 Homo sapiens Vitamin D-binding protein Proteins 0.000 claims 1
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 229960004544 cortisone Drugs 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 102000051433 human GC Human genes 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14172910.3 | 2014-06-18 | ||
| EP14172910 | 2014-06-18 | ||
| PCT/EP2015/063760 WO2015193457A1 (en) | 2014-06-18 | 2015-06-18 | Therapy using a factor xii inhibitor in a neurotraumatic disorder |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017524675A JP2017524675A (ja) | 2017-08-31 |
| JP2017524675A5 true JP2017524675A5 (https=) | 2018-07-19 |
| JP7109160B2 JP7109160B2 (ja) | 2022-07-29 |
Family
ID=50972542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016573808A Active JP7109160B2 (ja) | 2014-06-18 | 2015-06-18 | 神経外傷性障害において第ｘｉｉ因子インヒビターを使用する療法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20170114119A1 (https=) |
| EP (1) | EP3157548B1 (https=) |
| JP (1) | JP7109160B2 (https=) |
| KR (1) | KR102513050B1 (https=) |
| CN (1) | CN106456778A (https=) |
| AU (1) | AU2015276089B2 (https=) |
| BR (1) | BR112016029624A2 (https=) |
| CA (1) | CA2950988C (https=) |
| DK (1) | DK3157548T3 (https=) |
| ES (1) | ES2886859T3 (https=) |
| PL (1) | PL3157548T3 (https=) |
| WO (1) | WO2015193457A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7109160B2 (ja) | 2014-06-18 | 2022-07-29 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 神経外傷性障害において第ｘｉｉ因子インヒビターを使用する療法 |
| EP3436009B1 (en) * | 2016-03-30 | 2024-03-06 | Sinntaxis AB | Negative allosteric modulators of mglur5 for use in the treatment of mature brain damages. |
| US11174321B2 (en) | 2016-04-06 | 2021-11-16 | Csl Limited | Method of treating atherosclerosis |
| AU2018382222B2 (en) | 2017-12-15 | 2025-09-04 | Csl Limited | Use of a FXIIa-inhibitor in the treatment of renal fibrosis and/or chronic kidney disease |
| US12134657B2 (en) * | 2018-11-28 | 2024-11-05 | Oregon Health & Science University | Therapeutic factor XII antibody |
| US20240228585A1 (en) * | 2021-05-03 | 2024-07-11 | President And Fellows Of Harvard College | Fc-fusion protein therapeutic for the treatment of pancreatitis |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
| US4963657A (en) | 1988-06-09 | 1990-10-16 | Temple University Of The Commonwealth System Of Higher Education | Monoclonal antibodies to the light chain region of human factor XII and methods of preparing and using the same |
| WO1990006952A1 (fr) | 1988-12-22 | 1990-06-28 | Kirin-Amgen, Inc. | Facteur de stimulation de colonies de granulocytes modifies chimiquement |
| GB8901859D0 (en) | 1989-01-27 | 1989-03-15 | Shield Diagnostics Limited | Diagnostic test |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| CA2082643A1 (en) | 1990-05-10 | 1991-11-11 | Jan H. Nuijens | Inhibitors of factor xii activation and applications thereof |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| ATE240740T1 (de) | 1991-03-15 | 2003-06-15 | Amgen Inc | Pegylation von polypeptiden |
| DE69534265T2 (de) | 1994-12-12 | 2006-05-04 | Beth Israel Deaconess Medical Center, Inc., Boston | Chimäre zytokine und ihre verwendung |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| EP2213743A1 (en) | 2000-04-12 | 2010-08-04 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| AU2003210806A1 (en) | 2002-03-05 | 2003-09-22 | Eli Lilly And Company | Heterologous g-csf fusion proteins |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| PL2298347T3 (pl) | 2003-05-06 | 2016-03-31 | Bioverativ Therapeutics Inc | Białka chimeryczne czynnika krzepnięcia do leczenia zaburzenia hemostazy |
| DK1641823T3 (da) | 2003-06-12 | 2011-12-12 | Lilly Co Eli | GLP-1-analog fusionsproteiner |
| CA2537273A1 (en) | 2003-09-05 | 2005-03-17 | Gtc Biotherapeutics, Inc. | Method for the production of fusion proteins in transgenic mammal milk |
| RU2370276C2 (ru) | 2003-12-31 | 2009-10-20 | Мерк Патент Гмбх | Fc-ЭРИТРОПОЭТИН СЛИТЫЙ БЕЛОК С УЛУЧШЕННОЙ ФАРМАКОКИНЕТИКОЙ |
| CA2591786C (en) * | 2004-12-23 | 2013-07-16 | Bernhard Nieswandt | Prevention of thrombus formation and/or stabilization |
| CA2678001C (en) | 2007-02-12 | 2017-07-11 | Stefan Schulte | Therapeutic application of kazal-type serine protease inhibitors |
| WO2011069090A1 (en) * | 2009-12-04 | 2011-06-09 | Alavita Pharmaceuticals, Inc. | Inhibition of the activation of coagulation factor xii by ligands of phosphatidylserine |
| AU2011343739A1 (en) | 2010-12-17 | 2013-05-02 | Anthrogenesis Corporation | Treatment of spinal cord injury and traumatic brain injury using placental stem cells |
| EP2497489A1 (en) | 2011-03-09 | 2012-09-12 | CSL Behring GmbH | Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs |
| US9352016B2 (en) | 2011-03-09 | 2016-05-31 | Csl Behring Gmbh | Factor XII inhibitors for the administration with medical procedures comprising contact with artificial surfaces |
| EP2548892A1 (en) | 2011-07-22 | 2013-01-23 | CSL Behring GmbH | Inhibitory anti-Factor XII/XIIa monoclonal Antibodies and their uses |
| IL230564B2 (en) | 2011-07-22 | 2023-09-01 | Csl Ltd | Anticoagulant monoclonal antibodies anti–factor xii/fxiia, a method for their preparation, a pharmaceutical compound containing them and medical uses. |
| KR101956585B1 (ko) | 2011-09-24 | 2019-03-11 | 체에스엘 베링 게엠베하 | 면역글로불린과 ｃ1-억제제를 사용하는 병용 치료요법 |
| EP2623110A1 (en) | 2012-01-31 | 2013-08-07 | CSL Behring GmbH | Factor XII inhibitors for the treatment of neurological inflammatory disorders |
| CN105188750A (zh) | 2013-03-08 | 2015-12-23 | 德国杰特贝林生物制品有限公司 | 治疗和预防远端缺血-再灌注损伤 |
| CA2916399C (en) | 2013-06-28 | 2022-08-02 | Marc Nolte | Combination therapy using a factor xii inhibitor and a c1-inhibitor |
| US9587903B2 (en) | 2014-02-24 | 2017-03-07 | Brian E. Sullivan | Pneumatic launcher system and method |
| JP7109160B2 (ja) | 2014-06-18 | 2022-07-29 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 神経外傷性障害において第ｘｉｉ因子インヒビターを使用する療法 |
| US11174321B2 (en) | 2016-04-06 | 2021-11-16 | Csl Limited | Method of treating atherosclerosis |
-
2015
- 2015-06-18 JP JP2016573808A patent/JP7109160B2/ja active Active
- 2015-06-18 WO PCT/EP2015/063760 patent/WO2015193457A1/en not_active Ceased
- 2015-06-18 US US15/318,550 patent/US20170114119A1/en not_active Abandoned
- 2015-06-18 BR BR112016029624A patent/BR112016029624A2/pt not_active Application Discontinuation
- 2015-06-18 CN CN201580032338.8A patent/CN106456778A/zh active Pending
- 2015-06-18 KR KR1020177001620A patent/KR102513050B1/ko active Active
- 2015-06-18 DK DK15741128.1T patent/DK3157548T3/da active
- 2015-06-18 CA CA2950988A patent/CA2950988C/en active Active
- 2015-06-18 EP EP15741128.1A patent/EP3157548B1/en active Active
- 2015-06-18 AU AU2015276089A patent/AU2015276089B2/en active Active
- 2015-06-18 PL PL15741128T patent/PL3157548T3/pl unknown
- 2015-06-18 ES ES15741128T patent/ES2886859T3/es active Active
-
2019
- 2019-10-29 US US16/666,886 patent/US12065481B2/en active Active
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