JP2020505350A5 - - Google Patents

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Publication number
JP2020505350A5
JP2020505350A5 JP2019538484A JP2019538484A JP2020505350A5 JP 2020505350 A5 JP2020505350 A5 JP 2020505350A5 JP 2019538484 A JP2019538484 A JP 2019538484A JP 2019538484 A JP2019538484 A JP 2019538484A JP 2020505350 A5 JP2020505350 A5 JP 2020505350A5
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JP
Japan
Prior art keywords
seq
amino acid
combination according
acid sequence
constant region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2019538484A
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English (en)
Japanese (ja)
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JP2020505350A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/IB2018/050348 external-priority patent/WO2018134782A1/en
Publication of JP2020505350A publication Critical patent/JP2020505350A/ja
Publication of JP2020505350A5 publication Critical patent/JP2020505350A5/ja
Ceased legal-status Critical Current

Links

JP2019538484A 2017-01-20 2018-01-19 癌の治療のための組合せ療法 Ceased JP2020505350A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762448460P 2017-01-20 2017-01-20
US62/448,460 2017-01-20
PCT/IB2018/050348 WO2018134782A1 (en) 2017-01-20 2018-01-19 Combination therapy for the treatment of cancer

Publications (2)

Publication Number Publication Date
JP2020505350A JP2020505350A (ja) 2020-02-20
JP2020505350A5 true JP2020505350A5 (https=) 2021-02-25

Family

ID=61168137

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019538484A Ceased JP2020505350A (ja) 2017-01-20 2018-01-19 癌の治療のための組合せ療法

Country Status (10)

Country Link
US (1) US20220356222A9 (https=)
EP (1) EP3570869A1 (https=)
JP (1) JP2020505350A (https=)
KR (1) KR20190105584A (https=)
CN (1) CN110177568A (https=)
AU (2) AU2018208883B2 (https=)
CA (1) CA3046120A1 (https=)
IL (1) IL266993A (https=)
RU (1) RU2019122408A (https=)
WO (1) WO2018134782A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
EP3896089A4 (en) * 2018-12-13 2022-09-07 Jiangsu Hengrui Medicine Co., Ltd. USE OF IL-15 PROTEIN COMPLEXES IN CONJUNCTION WITH PD-L1 ANTIBODIES FOR THE TREATMENT OF TUMOR DISEASES
CN116574183A (zh) * 2019-08-22 2023-08-11 盛禾(中国)生物制药有限公司 多功能抗体、其制备及其用途
US20210244821A1 (en) * 2020-02-05 2021-08-12 Novartis Ag Cho cell expressed het il-15

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL71691A (en) 1984-04-27 1991-04-15 Yeda Res & Dev Production of interferon-ypsilon
US6174666B1 (en) 1992-03-27 2001-01-16 The United States Of America As Represented By The Department Of Health And Human Services Method of eliminating inhibitory/instability regions from mRNA
TW402639B (en) 1992-12-03 2000-08-21 Transkaryotic Therapies Inc Protein production and protein delivery
US6569681B1 (en) 2000-03-14 2003-05-27 Transkaryotic Therapies, Inc. Methods of improving homologous recombination
EP3263581B2 (en) 2005-05-17 2025-07-09 University of Connecticut Compositions and methods for immunomodulation in an organism
US8021668B2 (en) 2005-12-12 2011-09-20 Immune Disease Institute, Inc. Integrin alpha L I domain mutants with increased binding affinity
NZ569541A (en) 2006-01-13 2012-05-25 Us Gov Health & Human Serv Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells
CN101743249B (zh) 2007-05-11 2017-08-08 阿尔托生物科学有限公司 融合分子与il‑15变异体
CA2727953C (en) 2008-08-22 2017-05-16 Magna Seating Inc. Disc recliner with reduced backlash
US8507222B2 (en) 2010-09-21 2013-08-13 Altor Bioscience Corporation Multimeric IL-15 soluble fusion molecules and methods of making and using same
US20150359853A1 (en) * 2012-10-24 2015-12-17 Admune Therapeutics Llc Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes
PE20170255A1 (es) 2014-01-24 2017-03-22 Dana Farber Cancer Inst Inc Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas
KR102762243B1 (ko) * 2014-06-30 2025-02-05 알토 바이오사이언스 엘엘씨 Il-15-베이즈드 분자 및 이의 사용 방법
EP4245376A3 (en) * 2014-10-14 2023-12-13 Novartis AG Antibody molecules to pd-l1 and uses thereof

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