JP2020527152A5 - - Google Patents
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- JP2020527152A5 JP2020527152A5 JP2020502415A JP2020502415A JP2020527152A5 JP 2020527152 A5 JP2020527152 A5 JP 2020527152A5 JP 2020502415 A JP2020502415 A JP 2020502415A JP 2020502415 A JP2020502415 A JP 2020502415A JP 2020527152 A5 JP2020527152 A5 JP 2020527152A5
- Authority
- JP
- Japan
- Prior art keywords
- variable region
- chain variable
- seq
- heavy chain
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012634 fragment Substances 0.000 claims description 116
- 239000000427 antigen Substances 0.000 claims description 110
- 102000036639 antigens Human genes 0.000 claims description 110
- 108091007433 antigens Proteins 0.000 claims description 110
- 102100037632 Progranulin Human genes 0.000 claims description 29
- 101710114165 Progranulin Proteins 0.000 claims description 29
- 210000004027 cell Anatomy 0.000 claims description 26
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 210000004556 brain Anatomy 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 230000003247 decreasing effect Effects 0.000 claims description 6
- BSEYWXDBSOCPQP-UHFFFAOYSA-N Saltillin Chemical compound C1=CC(OC)=CC=C1C1=CC(=O)C2=C(O)C=C(C)C=C2O1 BSEYWXDBSOCPQP-UHFFFAOYSA-N 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 230000012202 endocytosis Effects 0.000 claims description 4
- 210000005260 human cell Anatomy 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- -1 0.5-10 nM Chemical compound 0.000 claims description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 201000008808 Fibrosarcoma Diseases 0.000 claims description 2
- 241000238631 Hexapoda Species 0.000 claims description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 210000000692 cap cell Anatomy 0.000 claims description 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 5
- 201000011240 Frontotemporal dementia Diseases 0.000 description 5
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024085982A JP2024119866A (ja) | 2017-07-20 | 2024-05-28 | 治療のための薬剤、使用及び方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201700419 | 2017-07-20 | ||
| DKPA201700419 | 2017-07-20 | ||
| PCT/EP2018/069460 WO2019016247A2 (en) | 2017-07-20 | 2018-07-18 | AGENTS, USES AND METHODS OF TREATMENT |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024085982A Division JP2024119866A (ja) | 2017-07-20 | 2024-05-28 | 治療のための薬剤、使用及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020527152A JP2020527152A (ja) | 2020-09-03 |
| JP2020527152A5 true JP2020527152A5 (https=) | 2021-07-29 |
| JP7563975B2 JP7563975B2 (ja) | 2024-10-08 |
Family
ID=63113476
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502415A Active JP7563975B2 (ja) | 2017-07-20 | 2018-07-18 | 治療のための薬剤、使用及び方法 |
| JP2024085982A Withdrawn JP2024119866A (ja) | 2017-07-20 | 2024-05-28 | 治療のための薬剤、使用及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024085982A Withdrawn JP2024119866A (ja) | 2017-07-20 | 2024-05-28 | 治療のための薬剤、使用及び方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US10894833B2 (https=) |
| EP (1) | EP3655438A2 (https=) |
| JP (2) | JP7563975B2 (https=) |
| KR (1) | KR102800556B1 (https=) |
| CN (3) | CN119161481A (https=) |
| AR (1) | AR112563A1 (https=) |
| AU (1) | AU2018303175B2 (https=) |
| BR (1) | BR112019005428A2 (https=) |
| CA (1) | CA3069391A1 (https=) |
| CL (1) | CL2020000070A1 (https=) |
| CO (1) | CO2019014090A2 (https=) |
| CR (1) | CR20200027A (https=) |
| DO (1) | DOP2020000006A (https=) |
| EA (1) | EA201992688A1 (https=) |
| EC (1) | ECSP20002935A (https=) |
| IL (1) | IL271728B2 (https=) |
| JO (1) | JOP20200007A1 (https=) |
| MA (1) | MA49633A (https=) |
| NI (1) | NI202000005A (https=) |
| PE (1) | PE20210467A1 (https=) |
| PH (1) | PH12019502869A1 (https=) |
| RU (1) | RU2019140933A (https=) |
| SG (1) | SG11201912228WA (https=) |
| TW (1) | TW201908342A (https=) |
| WO (1) | WO2019016247A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3280441T1 (sl) | 2015-04-07 | 2022-01-31 | Alector Llc | Protitelesa anti-sortilin in metoda njihove uporabe |
| GB201512215D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| LT3618928T (lt) | 2018-07-13 | 2023-04-11 | Alector Llc | Anti-sortilino antikūnai ir jų panaudojimo būdai |
| SG11202108398YA (en) * | 2019-02-01 | 2021-08-30 | Novarock Biotherapeutics Ltd | Anti-claudin 18 antibodies and methods of use thereof |
| EP3983441A1 (en) * | 2019-06-11 | 2022-04-20 | Alector LLC | Anti-sortilin antibodies for use in therapy |
| BR112022026508A2 (pt) * | 2020-06-24 | 2023-03-07 | Prothena Biosciences Ltd | Anticorpos que reconhecem sortilina |
| KR20250028349A (ko) | 2022-06-23 | 2025-02-28 | 드라우프니르 바이오 에이피에스 | 리소좀 내 세포외 표적의 분해를 선택적으로 유도하는 이작용성 분자 |
Family Cites Families (63)
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| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| DE3380726D1 (en) | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
| US4681581A (en) | 1983-12-05 | 1987-07-21 | Coates Fredrica V | Adjustable size diaper and folding method therefor |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US5776093A (en) | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
| US5101827A (en) | 1985-07-05 | 1992-04-07 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
| US4735210A (en) | 1985-07-05 | 1988-04-05 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5750172A (en) | 1987-06-23 | 1998-05-12 | Pharming B.V. | Transgenic non human mammal milk |
| US5648471A (en) | 1987-12-03 | 1997-07-15 | Centocor, Inc. | One vial method for labeling antibodies with Technetium-99m |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| DK0486622T3 (da) | 1989-08-09 | 1999-07-19 | Rhomed Inc | Direkte radiomærkning af antistoffer og andre proteiner med technetium eller rhenium |
| US5633076A (en) | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
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| US5101990A (en) | 1990-03-23 | 1992-04-07 | Continental Pet Technologies, Inc. | Stretch blow molded oblong or oval container |
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| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
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| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
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| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
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| WO1994019935A1 (en) | 1993-03-09 | 1994-09-15 | Genzyme Corporation | Isolation of components of interest from milk |
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| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US6077835A (en) | 1994-03-23 | 2000-06-20 | Case Western Reserve University | Delivery of compacted nucleic acid to cells |
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| WO2009154995A2 (en) * | 2008-05-27 | 2009-12-23 | Kyowa Hakko Kirin Co., Ltd. | Interleukin 10 receptor (il-10r) antibodies and methods of use |
| US20120039865A1 (en) | 2008-08-19 | 2012-02-16 | Yale University | Identification of sortilin as a neuronal receptor for the frontotemporal dementia protein, progranulin |
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| JP6239635B2 (ja) | 2012-11-02 | 2017-11-29 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | 血管石灰化の誘導因子であるソルチリン１ |
| WO2015143300A1 (en) * | 2014-03-21 | 2015-09-24 | The Board Of Regents Of The University Of Texas System | Isoxazole treatments for frontotemporal dementia |
| US10428158B2 (en) * | 2014-03-27 | 2019-10-01 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
| SI3280441T1 (sl) * | 2015-04-07 | 2022-01-31 | Alector Llc | Protitelesa anti-sortilin in metoda njihove uporabe |
| GB201512215D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| UA129904C2 (uk) * | 2017-04-05 | 2025-09-10 | Ле Лаборатуар Сервьє | Комбінація антитіла до tim-3 й антитіла до pd-1 для лікування раку |
| LT3618928T (lt) * | 2018-07-13 | 2023-04-11 | Alector Llc | Anti-sortilino antikūnai ir jų panaudojimo būdai |
| CN113151432A (zh) * | 2020-04-14 | 2021-07-23 | 郁金泰 | 神经退行性疾病检测和治疗的新靶标 |
-
2018
- 2018-07-17 US US16/037,790 patent/US10894833B2/en active Active
- 2018-07-18 JO JOP/2020/0007A patent/JOP20200007A1/ar unknown
- 2018-07-18 SG SG11201912228WA patent/SG11201912228WA/en unknown
- 2018-07-18 BR BR112019005428A patent/BR112019005428A2/pt not_active IP Right Cessation
- 2018-07-18 JP JP2020502415A patent/JP7563975B2/ja active Active
- 2018-07-18 MA MA049633A patent/MA49633A/fr unknown
- 2018-07-18 CA CA3069391A patent/CA3069391A1/en active Pending
- 2018-07-18 CN CN202411383796.3A patent/CN119161481A/zh active Pending
- 2018-07-18 AU AU2018303175A patent/AU2018303175B2/en active Active
- 2018-07-18 EP EP18750343.8A patent/EP3655438A2/en active Pending
- 2018-07-18 RU RU2019140933A patent/RU2019140933A/ru unknown
- 2018-07-18 CR CR20200027A patent/CR20200027A/es unknown
- 2018-07-18 IL IL271728A patent/IL271728B2/en unknown
- 2018-07-18 CN CN201880047918.8A patent/CN110945029B/zh active Active
- 2018-07-18 KR KR1020207001250A patent/KR102800556B1/ko active Active
- 2018-07-18 WO PCT/EP2018/069460 patent/WO2019016247A2/en not_active Ceased
- 2018-07-18 PE PE2020000100A patent/PE20210467A1/es unknown
- 2018-07-18 EA EA201992688A patent/EA201992688A1/ru unknown
- 2018-07-18 CN CN202411383695.6A patent/CN119161480A/zh active Pending
- 2018-07-19 TW TW107124976A patent/TW201908342A/zh unknown
- 2018-07-20 AR ARP180102043 patent/AR112563A1/es not_active Application Discontinuation
-
2019
- 2019-12-13 CO CONC2019/0014090A patent/CO2019014090A2/es unknown
- 2019-12-18 PH PH12019502869A patent/PH12019502869A1/en unknown
-
2020
- 2020-01-09 DO DO2020000006A patent/DOP2020000006A/es unknown
- 2020-01-09 CL CL2020000070A patent/CL2020000070A1/es unknown
- 2020-01-16 EC ECSENADI20202935A patent/ECSP20002935A/es unknown
- 2020-01-17 NI NI202000005A patent/NI202000005A/es unknown
- 2020-12-11 US US17/118,934 patent/US20210292414A1/en active Pending
-
2024
- 2024-05-28 JP JP2024085982A patent/JP2024119866A/ja not_active Withdrawn
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