NI202000005A - Agentes, usos y métodos para el tratamiento - Google Patents

Agentes, usos y métodos para el tratamiento

Info

Publication number
NI202000005A
NI202000005A NI202000005A NI202000005A NI202000005A NI 202000005 A NI202000005 A NI 202000005A NI 202000005 A NI202000005 A NI 202000005A NI 202000005 A NI202000005 A NI 202000005A NI 202000005 A NI202000005 A NI 202000005A
Authority
NI
Nicaragua
Prior art keywords
treatment
agents
methods
antibodies
pgrn
Prior art date
Application number
NI202000005A
Other languages
English (en)
Inventor
Christian Bilmann Ronn Lars
John Malik Ibrahim
B Stavenhagen Jeffrey
Christensen Soren
Egebjerg Jan
Stummann Tina
Van Den Brink Edward
Gerritsen Arnout
Parren Paul
Trabjerg Esben
Dyberg Rand Kasper
Original Assignee
Bonasa Com S A De C V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bonasa Com S A De C V filed Critical Bonasa Com S A De C V
Publication of NI202000005A publication Critical patent/NI202000005A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a anticuerpos monoclonales anti-sortilina que se han encontrado que son útiles en la corrección de un nivel deficiente de progranulina (PGRN). En particular, estos anticuerpos pueden usarse en el tratamiento de la demencia frontotemporal (DFT) y esclerosis lateral amiotrófica (ELA) y otros trastornos neurodegenerativos, tales como la enfermedad de Alzheimer (EA).
NI202000005A 2017-07-20 2020-01-17 Agentes, usos y métodos para el tratamiento NI202000005A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA201700419 2017-07-20

Publications (1)

Publication Number Publication Date
NI202000005A true NI202000005A (es) 2020-05-20

Family

ID=63113476

Family Applications (1)

Application Number Title Priority Date Filing Date
NI202000005A NI202000005A (es) 2017-07-20 2020-01-17 Agentes, usos y métodos para el tratamiento

Country Status (25)

Country Link
US (2) US10894833B2 (es)
EP (1) EP3655438A2 (es)
JP (2) JP7563975B2 (es)
KR (1) KR20200031610A (es)
CN (1) CN110945029B (es)
AR (1) AR112563A1 (es)
AU (1) AU2018303175A1 (es)
BR (1) BR112019005428A2 (es)
CA (1) CA3069391A1 (es)
CL (1) CL2020000070A1 (es)
CO (1) CO2019014090A2 (es)
CR (1) CR20200027A (es)
DO (1) DOP2020000006A (es)
EA (1) EA201992688A1 (es)
EC (1) ECSP20002935A (es)
IL (1) IL271728B2 (es)
JO (1) JOP20200007A1 (es)
MA (1) MA49633A (es)
NI (1) NI202000005A (es)
PE (1) PE20210467A1 (es)
PH (1) PH12019502869A1 (es)
RU (1) RU2019140933A (es)
SG (1) SG11201912228WA (es)
TW (1) TW201908342A (es)
WO (1) WO2019016247A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3991748A3 (en) 2015-04-07 2022-08-24 Alector LLC Anti-sortilin antibodies and methods of use thereof
GB201512215D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
BR112019022666A2 (pt) 2018-07-13 2020-09-01 Alector Llc anticorpos antissortilina e métodos de uso dos mesmos
JP2022519118A (ja) * 2019-02-01 2022-03-18 ノヴァロック バイオセラピューティクス， リミテッド 抗クローディン１８抗体及びそれらの使用の方法
US20230235048A1 (en) * 2020-06-24 2023-07-27 Andriani IOANNOU Antibodies recognizing sortilin
WO2023247754A1 (en) 2022-06-23 2023-12-28 Draupnir Bio Aps Bifunctional molecules that selectively induce degradation of extracellular targets in lysosomes

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Also Published As

Publication number Publication date
WO2019016247A3 (en) 2019-06-20
CO2019014090A2 (es) 2020-01-17
CN110945029A (zh) 2020-03-31
SG11201912228WA (en) 2020-01-30
CA3069391A1 (en) 2019-01-24
EA201992688A1 (ru) 2020-05-20
JP2024119866A (ja) 2024-09-03
MA49633A (fr) 2020-05-27
US20190023788A1 (en) 2019-01-24
US20210292414A1 (en) 2021-09-23
CL2020000070A1 (es) 2020-06-12
PH12019502869A1 (en) 2020-09-28
RU2019140933A (ru) 2021-08-20
TW201908342A (zh) 2019-03-01
DOP2020000006A (es) 2020-07-15
CR20200027A (es) 2020-04-17
JOP20200007A1 (ar) 2020-01-15
PE20210467A1 (es) 2021-03-08
AR112563A1 (es) 2019-11-13
RU2019140933A3 (es) 2021-10-28
CN110945029B (zh) 2024-10-01
KR20200031610A (ko) 2020-03-24
WO2019016247A2 (en) 2019-01-24
JP2020527152A (ja) 2020-09-03
US10894833B2 (en) 2021-01-19
IL271728A (en) 2020-02-27
AU2018303175A1 (en) 2020-01-16
IL271728B2 (en) 2024-05-01
JP7563975B2 (ja) 2024-10-08
EP3655438A2 (en) 2020-05-27
IL271728B1 (en) 2024-01-01
ECSP20002935A (es) 2020-02-28
BR112019005428A2 (pt) 2019-07-16

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