CO2019014090A2 - Agentes, usos y métodos para el tratamiento - Google Patents

Agentes, usos y métodos para el tratamiento

Info

Publication number
CO2019014090A2
CO2019014090A2 CONC2019/0014090A CO2019014090A CO2019014090A2 CO 2019014090 A2 CO2019014090 A2 CO 2019014090A2 CO 2019014090 A CO2019014090 A CO 2019014090A CO 2019014090 A2 CO2019014090 A2 CO 2019014090A2
Authority
CO
Colombia
Prior art keywords
treatment
agents
methods
antibodies
pgrn
Prior art date
Application number
CONC2019/0014090A
Other languages
English (en)
Inventor
Rønn Lars Christian Biilmann
Ibrahim John Malik
Jeffrey B Stavenhagen
Søren Christensen
Jan Egebjerg
Tina Stummann
Arnout Gerritsen
Den Brink Edward Van
Paul Parren
Esben Trabjerg
Kasper Dyrberg Rand
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of CO2019014090A2 publication Critical patent/CO2019014090A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

RESUMEN La presente invención se refiere a anticuerpos monoclonales anti-sortilina que se ha encontrado que son útiles en la corrección de un nivel deficiente de progranulina (PGRN). En particular, estos anticuerpos pueden usarse en el tratamiento de la demencia frontotemporal (DFT) y la esclerosis lateral amiotrófica (ELA) y otros trastornos neurodegenerativos, tales como la enfermedad de Alzheimer (EA).
CONC2019/0014090A 2017-07-20 2019-12-13 Agentes, usos y métodos para el tratamiento CO2019014090A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201700419 2017-07-20
PCT/EP2018/069460 WO2019016247A2 (en) 2017-07-20 2018-07-18 AGENTS, USES AND METHODS OF TREATMENT

Publications (1)

Publication Number Publication Date
CO2019014090A2 true CO2019014090A2 (es) 2020-01-17

Family

ID=63113476

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0014090A CO2019014090A2 (es) 2017-07-20 2019-12-13 Agentes, usos y métodos para el tratamiento

Country Status (25)

Country Link
US (2) US10894833B2 (es)
EP (1) EP3655438A2 (es)
JP (1) JP2020527152A (es)
KR (1) KR20200031610A (es)
CN (1) CN110945029A (es)
AR (1) AR112563A1 (es)
AU (1) AU2018303175A1 (es)
BR (1) BR112019005428A2 (es)
CA (1) CA3069391A1 (es)
CL (1) CL2020000070A1 (es)
CO (1) CO2019014090A2 (es)
CR (1) CR20200027A (es)
DO (1) DOP2020000006A (es)
EA (1) EA201992688A1 (es)
EC (1) ECSP20002935A (es)
IL (1) IL271728B2 (es)
JO (1) JOP20200007A1 (es)
MA (1) MA49633A (es)
NI (1) NI202000005A (es)
PE (1) PE20210467A1 (es)
PH (1) PH12019502869A1 (es)
RU (1) RU2019140933A (es)
SG (1) SG11201912228WA (es)
TW (1) TW201908342A (es)
WO (1) WO2019016247A2 (es)

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* Cited by examiner, † Cited by third party
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CA2981851A1 (en) 2015-04-07 2016-10-13 Alector Llc Anti-sortilin antibodies and methods of use thereof
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BR112019022666A2 (pt) 2018-07-13 2020-09-01 Alector Llc anticorpos antissortilina e métodos de uso dos mesmos
SG11202108398YA (en) * 2019-02-01 2021-08-30 Novarock Biotherapeutics Ltd Anti-claudin 18 antibodies and methods of use thereof
WO2023247754A1 (en) 2022-06-23 2023-12-28 Draupnir Bio Aps Bifunctional molecules that selectively induce degradation of extracellular targets in lysosomes

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Also Published As

Publication number Publication date
CN110945029A (zh) 2020-03-31
PE20210467A1 (es) 2021-03-08
CR20200027A (es) 2020-04-17
PH12019502869A1 (en) 2020-09-28
CA3069391A1 (en) 2019-01-24
AU2018303175A1 (en) 2020-01-16
US20210292414A1 (en) 2021-09-23
IL271728B2 (en) 2024-05-01
AR112563A1 (es) 2019-11-13
RU2019140933A (ru) 2021-08-20
KR20200031610A (ko) 2020-03-24
BR112019005428A2 (pt) 2019-07-16
MA49633A (fr) 2020-05-27
US10894833B2 (en) 2021-01-19
CL2020000070A1 (es) 2020-06-12
NI202000005A (es) 2020-05-20
WO2019016247A2 (en) 2019-01-24
US20190023788A1 (en) 2019-01-24
ECSP20002935A (es) 2020-02-28
EA201992688A1 (ru) 2020-05-20
IL271728A (en) 2020-02-27
WO2019016247A3 (en) 2019-06-20
JP2020527152A (ja) 2020-09-03
RU2019140933A3 (es) 2021-10-28
DOP2020000006A (es) 2020-07-15
TW201908342A (zh) 2019-03-01
JOP20200007A1 (ar) 2020-01-15
EP3655438A2 (en) 2020-05-27
IL271728B1 (en) 2024-01-01
SG11201912228WA (en) 2020-01-30

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