JP7563975B2 - 治療のための薬剤、使用及び方法 - Google Patents

治療のための薬剤、使用及び方法 Download PDF

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Publication number
JP7563975B2
JP7563975B2 JP2020502415A JP2020502415A JP7563975B2 JP 7563975 B2 JP7563975 B2 JP 7563975B2 JP 2020502415 A JP2020502415 A JP 2020502415A JP 2020502415 A JP2020502415 A JP 2020502415A JP 7563975 B2 JP7563975 B2 JP 7563975B2
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Japan
Prior art keywords
antibody
seq
chain variable
variable region
antigen
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Japanese (ja)
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JP2020527152A (ja
JP2020527152A5 (https=
Inventor
ロン，ラーズ，クリスチャン ビルマン
マリク，イブラヒム，ジョン
スタヴェンハーゲン，ジェフリー，ビー
クリステンセン，セーレン
エゲブジャーグ，ジャン
スツマン，ティナ
ジェリッツェン，アーノウト
デン ブリンク，エドワード ヴァン
パレン，ポール
トラブジャーグ，エスベン
ダイアバーグ ランド，カスパー
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ハー・ルンドベック・アクチエゼルスカベット
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Publication of JP2020527152A publication Critical patent/JP2020527152A/ja
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Priority to JP2024085982A priority Critical patent/JP2024119866A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2020502415A 2017-07-20 2018-07-18 治療のための薬剤、使用及び方法 Active JP7563975B2 (ja)

Priority Applications (1)

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JP2024085982A JP2024119866A (ja) 2017-07-20 2024-05-28 治療のための薬剤、使用及び方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201700419 2017-07-20
DKPA201700419 2017-07-20
PCT/EP2018/069460 WO2019016247A2 (en) 2017-07-20 2018-07-18 AGENTS, USES AND METHODS OF TREATMENT

Related Child Applications (1)

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JP2024085982A Division JP2024119866A (ja) 2017-07-20 2024-05-28 治療のための薬剤、使用及び方法

Publications (3)

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JP2020527152A JP2020527152A (ja) 2020-09-03
JP2020527152A5 JP2020527152A5 (https=) 2021-07-29
JP7563975B2 true JP7563975B2 (ja) 2024-10-08

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JP2020502415A Active JP7563975B2 (ja) 2017-07-20 2018-07-18 治療のための薬剤、使用及び方法
JP2024085982A Withdrawn JP2024119866A (ja) 2017-07-20 2024-05-28 治療のための薬剤、使用及び方法

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Country Status (25)

Country Link
US (2) US10894833B2 (https=)
EP (1) EP3655438A2 (https=)
JP (2) JP7563975B2 (https=)
KR (1) KR102800556B1 (https=)
CN (3) CN119161481A (https=)
AR (1) AR112563A1 (https=)
AU (1) AU2018303175B2 (https=)
BR (1) BR112019005428A2 (https=)
CA (1) CA3069391A1 (https=)
CL (1) CL2020000070A1 (https=)
CO (1) CO2019014090A2 (https=)
CR (1) CR20200027A (https=)
DO (1) DOP2020000006A (https=)
EA (1) EA201992688A1 (https=)
EC (1) ECSP20002935A (https=)
IL (1) IL271728B2 (https=)
JO (1) JOP20200007A1 (https=)
MA (1) MA49633A (https=)
NI (1) NI202000005A (https=)
PE (1) PE20210467A1 (https=)
PH (1) PH12019502869A1 (https=)
RU (1) RU2019140933A (https=)
SG (1) SG11201912228WA (https=)
TW (1) TW201908342A (https=)
WO (1) WO2019016247A2 (https=)

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LT3618928T (lt) 2018-07-13 2023-04-11 Alector Llc Anti-sortilino antikūnai ir jų panaudojimo būdai
SG11202108398YA (en) * 2019-02-01 2021-08-30 Novarock Biotherapeutics Ltd Anti-claudin 18 antibodies and methods of use thereof
EP3983441A1 (en) * 2019-06-11 2022-04-20 Alector LLC Anti-sortilin antibodies for use in therapy
BR112022026508A2 (pt) * 2020-06-24 2023-03-07 Prothena Biosciences Ltd Anticorpos que reconhecem sortilina
KR20250028349A (ko) 2022-06-23 2025-02-28 드라우프니르 바이오 에이피에스 리소좀 내 세포외 표적의 분해를 선택적으로 유도하는 이작용성 분자

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Also Published As

Publication number Publication date
KR102800556B1 (ko) 2025-04-24
RU2019140933A3 (https=) 2021-10-28
CN119161480A (zh) 2024-12-20
CN110945029A (zh) 2020-03-31
WO2019016247A2 (en) 2019-01-24
AU2018303175B2 (en) 2025-01-23
JOP20200007A1 (ar) 2020-01-15
CA3069391A1 (en) 2019-01-24
CR20200027A (es) 2020-04-17
JP2020527152A (ja) 2020-09-03
ECSP20002935A (es) 2020-02-28
EA201992688A1 (ru) 2020-05-20
DOP2020000006A (es) 2020-07-15
BR112019005428A2 (pt) 2019-07-16
CO2019014090A2 (es) 2020-01-17
PE20210467A1 (es) 2021-03-08
IL271728B1 (en) 2024-01-01
IL271728A (en) 2020-02-27
US20190023788A1 (en) 2019-01-24
CN119161481A (zh) 2024-12-20
EP3655438A2 (en) 2020-05-27
MA49633A (fr) 2020-05-27
AU2018303175A1 (en) 2020-01-16
TW201908342A (zh) 2019-03-01
US10894833B2 (en) 2021-01-19
IL271728B2 (en) 2024-05-01
NI202000005A (es) 2020-05-20
US20210292414A1 (en) 2021-09-23
CN110945029B (zh) 2024-10-01
SG11201912228WA (en) 2020-01-30
AR112563A1 (es) 2019-11-13
KR20200031610A (ko) 2020-03-24
JP2024119866A (ja) 2024-09-03
CL2020000070A1 (es) 2020-06-12
RU2019140933A (ru) 2021-08-20
PH12019502869A1 (en) 2020-09-28
WO2019016247A3 (en) 2019-06-20

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