JP2008515889A5 - - Google Patents

Info

Publication number

JP2008515889A5

JP2008515889A5 JP2007535700A JP2007535700A JP2008515889A5 JP 2008515889 A5 JP2008515889 A5 JP 2008515889A5 JP 2007535700 A JP2007535700 A JP 2007535700A JP 2007535700 A JP2007535700 A JP 2007535700A JP 2008515889 A5 JP2008515889 A5 JP 2008515889A5

Authority

JP

Japan

Prior art keywords

seq

xaa

conjugate molecule

cys

sabm

Prior art date

2005-09-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 239000003814 drug Substances 0.000 claims 6
• 229940124597 therapeutic agent Drugs 0.000 claims 6
• 125000003275 alpha amino acid group Chemical group 0.000 claims 5
• 241000124008 Mammalia Species 0.000 claims 4
• 108010052285 Membrane Proteins Proteins 0.000 claims 4
• 102000018697 Membrane Proteins Human genes 0.000 claims 4
• 102000007562 Serum Albumin Human genes 0.000 claims 4
• 108010071390 Serum Albumin Proteins 0.000 claims 4
• 125000000539 amino acid group Chemical group 0.000 claims 3
• 210000003719 b-lymphocyte Anatomy 0.000 claims 3
• 239000003145 cytotoxic factor Substances 0.000 claims 3
• 230000001988 toxicity Effects 0.000 claims 3
• 231100000419 toxicity Toxicity 0.000 claims 3
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 239000002458 cell surface marker Substances 0.000 claims 2
• 230000008685 targeting Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
• 101100381481 Caenorhabditis elegans baz-2 gene Proteins 0.000 claims 1
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 1
• 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 1
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
• 102000008100 Human Serum Albumin Human genes 0.000 claims 1
• 108091006905 Human Serum Albumin Proteins 0.000 claims 1
• 101100372762 Rattus norvegicus Flt1 gene Proteins 0.000 claims 1
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims 1
• 108010044540 auristatin Proteins 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000005647 linker group Chemical group 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 1
• 229920002776 polycyclohexyl methacrylate Polymers 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1