JP2008512987A - 結合分子 - Google Patents

結合分子 Download PDF

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Publication number
JP2008512987A
JP2008512987A JP2007522034A JP2007522034A JP2008512987A JP 2008512987 A JP2008512987 A JP 2008512987A JP 2007522034 A JP2007522034 A JP 2007522034A JP 2007522034 A JP2007522034 A JP 2007522034A JP 2008512987 A JP2008512987 A JP 2008512987A
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Japan
Prior art keywords
heavy chain
domain
antibody
binding
polypeptide complex
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JP2007522034A
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Japanese (ja)
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JP2008512987A5 (https=
Inventor
クレイグ，ロジャー・キングドン
フロスフェルト，フランクリン・ヘラルドゥス
ヤンセンス，リハルト・ウィルヘルム
ドラベク，ドゥブラヴカ
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35431831&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2008512987(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0416392A external-priority patent/GB2416768A/en
Priority claimed from GB0511881A external-priority patent/GB0511881D0/en
Application filed by Individual filed Critical Individual
Publication of JP2008512987A publication Critical patent/JP2008512987A/ja
Publication of JP2008512987A5 publication Critical patent/JP2008512987A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
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    • C07K16/114—Lentivirus (G), e.g. human immunodeficiency virus [HIV], feline immunodeficiency virus [FIV] or simian immunodeficiency virus [SIV]
    • C07K16/1143—Gag-pol proteins, e.g. p17or p24
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
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    • C07K16/112—Retroviridae (F), e.g. leukemia viruses
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    • C07K16/1145—Env proteins, e.g. gp41, gp110/120, gp160, V3, principal neutralising domain [PND] or CD4-binding site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
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    • C07K16/1228—Enterobacterales (O), e.g. Citrobacter (G), Serratia (G), Proteus (G), Providencia (G), Morganella (G) or Yersinia (G)
    • C07K16/1232—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
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  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
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JP2007522034A 2004-07-22 2005-07-22 結合分子 Pending JP2008512987A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0416392A GB2416768A (en) 2004-07-22 2004-07-22 Heavy chain immunoglobulin complexes
GB0511881A GB0511881D0 (en) 2005-06-10 2005-06-10 Binding molecules
PCT/GB2005/002892 WO2006008548A2 (en) 2004-07-22 2005-07-22 Binding molecules

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2011166561A Division JP5855381B2 (ja) 2004-07-22 2011-07-29 結合分子
JP2011166562A Division JP5888893B2 (ja) 2004-07-22 2011-07-29 結合分子

Publications (2)

Publication Number Publication Date
JP2008512987A true JP2008512987A (ja) 2008-05-01
JP2008512987A5 JP2008512987A5 (https=) 2008-11-13

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ID=35431831

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JP2007522034A Pending JP2008512987A (ja) 2004-07-22 2005-07-22 結合分子
JP2011166562A Expired - Fee Related JP5888893B2 (ja) 2004-07-22 2011-07-29 結合分子
JP2011166561A Expired - Lifetime JP5855381B2 (ja) 2004-07-22 2011-07-29 結合分子

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JP2011166562A Expired - Fee Related JP5888893B2 (ja) 2004-07-22 2011-07-29 結合分子
JP2011166561A Expired - Lifetime JP5855381B2 (ja) 2004-07-22 2011-07-29 結合分子

Country Status (21)

Country Link
US (7) US20090285805A1 (https=)
EP (6) EP1864998B2 (https=)
JP (3) JP2008512987A (https=)
KR (4) KR101422286B1 (https=)
CN (2) CN102659940B (https=)
AU (2) AU2005263994B2 (https=)
BR (1) BRPI0513577A (https=)
CA (1) CA2580336C (https=)
CY (2) CY1115762T1 (https=)
DK (3) DK2311874T3 (https=)
ES (3) ES2635497T3 (https=)
HU (1) HUE034335T2 (https=)
LT (1) LT2311874T (https=)
MX (2) MX2007000921A (https=)
PL (2) PL1776383T3 (https=)
PT (2) PT1776383E (https=)
RU (1) RU2398882C2 (https=)
SG (1) SG188080A1 (https=)
SI (2) SI2311874T1 (https=)
WO (1) WO2006008548A2 (https=)
ZA (3) ZA200701186B (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012521211A (ja) * 2009-03-24 2012-09-13 エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム 結合分子
JP2015519055A (ja) * 2012-05-17 2015-07-09 カイマブ・リミテッド 二重特異性免疫グロブリンまたは超変異重鎖のみの免疫グロブリンのｉｎｖｉｖｏでの生成のためのトランスジェニック非ヒト脊椎動物
JP2016531924A (ja) * 2013-09-05 2016-10-13 アイジーエム バイオサイエンス， インコーポレイテッド 定常領域が修飾された（ｃｏｎｓｔａｎｔ ｃｈａｉｎ ｍｏｄｉｆｉｅｄ）二重特異性五価及び六価Ｉｇ−Ｍ抗体
JP2017511152A (ja) * 2014-03-21 2017-04-20 エックス−ボディ インコーポレイテッド 二重特異性抗原結合ポリペプチド
JP2017512208A (ja) * 2014-02-10 2017-05-18 アイジーエム バイオサイエンス， インコーポレイテッド ＩｇＡ多重特異性結合分子
JP2017140058A (ja) * 2009-12-10 2017-08-17 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 重鎖抗体を作製するマウス
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