JP2008512379A5 - - Google Patents
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- JP2008512379A5 JP2008512379A5 JP2007530398A JP2007530398A JP2008512379A5 JP 2008512379 A5 JP2008512379 A5 JP 2008512379A5 JP 2007530398 A JP2007530398 A JP 2007530398A JP 2007530398 A JP2007530398 A JP 2007530398A JP 2008512379 A5 JP2008512379 A5 JP 2008512379A5
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- JP
- Japan
- Prior art keywords
- formula
- compound
- alkyl
- hydrogen
- occurrence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *CCC(*)(*)N(Cc1c2c(*)c(*)c(*)c1*)C2O Chemical compound *CCC(*)(*)N(Cc1c2c(*)c(*)c(*)c1*)C2O 0.000 description 5
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60740904P | 2004-09-03 | 2004-09-03 | |
| PCT/US2005/031318 WO2006028964A1 (en) | 2004-09-03 | 2005-08-31 | Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012162375A Division JP5701824B2 (ja) | 2004-09-03 | 2012-07-23 | 置換２−（２，６−ジオキソピペリジン−３−イル）−１−オキソイソインドリン類の調製方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008512379A JP2008512379A (ja) | 2008-04-24 |
| JP2008512379A5 true JP2008512379A5 (https=) | 2008-07-10 |
Family
ID=35385616
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530398A Pending JP2008512379A (ja) | 2004-09-03 | 2005-08-31 | 置換２−（２，６−ジオキソピペリジン−３−イル）−１−オキソイソインドリン類の調製方法 |
| JP2012162375A Expired - Lifetime JP5701824B2 (ja) | 2004-09-03 | 2012-07-23 | 置換２−（２，６−ジオキソピペリジン−３−イル）−１−オキソイソインドリン類の調製方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012162375A Expired - Lifetime JP5701824B2 (ja) | 2004-09-03 | 2012-07-23 | 置換２−（２，６−ジオキソピペリジン−３−イル）−１−オキソイソインドリン類の調製方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7863451B2 (https=) |
| EP (2) | EP2479172B1 (https=) |
| JP (2) | JP2008512379A (https=) |
| KR (1) | KR20070057907A (https=) |
| CN (1) | CN101080400A (https=) |
| AR (1) | AR050724A1 (https=) |
| AU (1) | AU2005282728A1 (https=) |
| BR (1) | BRPI0514865A (https=) |
| CA (1) | CA2579291C (https=) |
| ES (2) | ES2437592T3 (https=) |
| GT (1) | GT200500242A (https=) |
| HN (1) | HN2005000508A (https=) |
| IL (1) | IL181674A0 (https=) |
| MX (1) | MX2007002521A (https=) |
| NZ (1) | NZ554068A (https=) |
| PA (1) | PA8643901A1 (https=) |
| PE (1) | PE20060648A1 (https=) |
| SV (1) | SV2007002219A (https=) |
| TW (1) | TW200621748A (https=) |
| UY (1) | UY29097A1 (https=) |
| WO (1) | WO2006028964A1 (https=) |
| ZA (1) | ZA200702382B (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7629360B2 (en) * | 1999-05-07 | 2009-12-08 | Celgene Corporation | Methods for the treatment of cachexia and graft v. host disease |
| US7323479B2 (en) * | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
| UA83504C2 (en) | 2003-09-04 | 2008-07-25 | Селджин Корпорейшн | Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| HRP20130102T1 (hr) * | 2005-06-30 | 2013-03-31 | Celgene Corporation | Postupak dobivanja spojeva 4-amino-2-(2,6-dioksopiperidin-3-il)izoindolin-1,3-diona |
| CN101186611B (zh) * | 2006-11-15 | 2011-05-18 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的吡咯啉-2-酮衍生物及其制备和应用 |
| CA2717326C (en) * | 2008-03-11 | 2018-10-23 | Dr. Reddy's Laboratories Ltd. | Preparation of lenalidomide |
| DE102008057285A1 (de) | 2008-11-14 | 2010-05-20 | Ratiopharm Gmbh | 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidindion in Form einer festen Lösung |
| DE102008057284A1 (de) | 2008-11-14 | 2010-05-20 | Ratiopharm Gmbh | Tabletten enthaltend Lenalidomid und Adhäsionsverstärker |
| DE102008057335A1 (de) | 2008-11-14 | 2010-05-20 | Ratiopharm Gmbh | Amorphes Lenalidomid |
| WO2010056384A1 (en) * | 2008-11-17 | 2010-05-20 | Dr. Reddy's Laboratories Ltd. | Lenalidomide solvates and processes |
| WO2010093434A1 (en) | 2009-02-11 | 2010-08-19 | Celgene Corporation | Isotopologues of lenalidomide |
| CN102414196A (zh) * | 2009-03-02 | 2012-04-11 | 基因里克斯(英国)有限公司 | 改进的方法 |
| CN101580501B (zh) | 2009-06-01 | 2011-03-09 | 南京卡文迪许生物工程技术有限公司 | 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体 |
| EA201270261A1 (ru) * | 2009-08-12 | 2012-07-30 | Синтон Б. В. | Соли леналидомида |
| WO2011033468A1 (en) * | 2009-09-16 | 2011-03-24 | Ranbaxy Laboratories Limited | Process for the preparation of a crystalline form of lenalidomid |
| TWI475014B (zh) * | 2009-09-17 | 2015-03-01 | Scinopharm Taiwan Ltd | 固體形態的３－（４－胺基－１－側氧基－１，３－二氫－異吲哚－２－基）－哌啶－２，６－二酮及其製造方法 |
| WO2011050962A1 (en) | 2009-10-29 | 2011-05-05 | Ratiopharm Gmbh | Acid addition salts of lenalidomide |
| CN102060842B (zh) * | 2009-11-02 | 2013-05-08 | 南京卡文迪许生物工程技术有限公司 | 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物 |
| CN102127054B (zh) * | 2009-11-02 | 2013-04-03 | 南京卡文迪许生物工程技术有限公司 | 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物 |
| CN101696205B (zh) * | 2009-11-02 | 2011-10-19 | 南京卡文迪许生物工程技术有限公司 | 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物 |
| WO2011069608A1 (en) * | 2009-12-09 | 2011-06-16 | Ratiopharm Gmbh | S-lenalidomide, polymorphic forms thereof and blend comprising s- und r-lenalidomide |
| CN101817813B (zh) * | 2010-01-15 | 2013-04-10 | 南京卡文迪许生物工程技术有限公司 | 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮晶体ⅳ及其药用组合物 |
| EP2536706B1 (en) * | 2010-02-11 | 2017-06-14 | Celgene Corporation | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same |
| CN102453021A (zh) * | 2010-10-22 | 2012-05-16 | 重庆医药工业研究院有限责任公司 | 来那度胺的新晶型及其制备方法 |
| WO2012079075A1 (en) | 2010-12-10 | 2012-06-14 | Concert Pharmaceuticals, Inc. | Deuterated phthalimide derivatives |
| US9540341B2 (en) | 2011-07-19 | 2017-01-10 | Amplio Pharma, Llc | Crystalline forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| JP2015524811A (ja) * | 2012-07-27 | 2015-08-27 | セルジーン コーポレイション | イソインドリン−１，３−ジオン化合物の調製プロセス |
| ES2712652T3 (es) * | 2012-08-09 | 2019-05-14 | Celgene Corp | Procesos para la preparación de (S)-3-4-((4-(morfolinometil) bencil) oxi) -1-oxoisoindolin-2il-) piperidin-2, 6-diona y formas farmacéuticas aceptables de las mismas |
| WO2014110322A2 (en) | 2013-01-11 | 2014-07-17 | Concert Pharmaceuticals, Inc. | Substituted dioxopiperidinyl phthalimide derivatives |
| CN103242215A (zh) * | 2013-05-27 | 2013-08-14 | 合肥医工医药有限公司 | 一种来那度胺中间体的制备方法 |
| WO2016024286A2 (en) | 2014-08-11 | 2016-02-18 | Avra Laboratories Pvt. Ltd. | An improved process for synthesis of lenalidomide |
| CN111205268B (zh) * | 2014-10-30 | 2021-01-26 | 康朴生物医药技术（上海）有限公司 | 异吲哚啉衍生物、其中间体、制备方法、药物组合物及应用 |
| CN104447689B (zh) * | 2014-12-22 | 2016-07-20 | 上海迈柏医药科技有限公司 | 来那度胺的晶型及其制备方法 |
| TWI793151B (zh) | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
| CN108191826A (zh) * | 2018-01-08 | 2018-06-22 | 浙江省医学科学院 | 一种来那度胺晶体及其制备方法 |
| CN118344338A (zh) | 2018-04-23 | 2024-07-16 | 细胞基因公司 | 取代的4-氨基异吲哚啉-1,3-二酮化合物以及它们用于治疗淋巴瘤的用途 |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| DK3820573T3 (da) | 2018-07-10 | 2023-10-23 | Novartis Ag | 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidin-2,6-dion-derivativer og anvendelse deraf ved behandling af ikaros family zinc finger 2 (ikzf2)-afhængige sygdomme |
| WO2020048546A1 (zh) * | 2018-09-07 | 2020-03-12 | 南京明德新药研发有限公司 | 三环取代哌啶二酮类化合物 |
| JP2022507267A (ja) | 2018-11-13 | 2022-01-18 | バイオセリックス， インコーポレイテッド | 置換イソインドリノン |
| CN109369504B (zh) * | 2018-12-06 | 2020-05-12 | 温州大学 | 含硫3-亚甲基异吲哚啉-1-酮衍生物的制备方法 |
| WO2025118133A1 (zh) * | 2023-12-05 | 2025-06-12 | 浙江普洛家园药业有限公司 | 一种(s)-来那度胺-5-位衍生物及其合成方法和应用 |
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|---|---|---|---|---|
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| DE4236880A1 (de) * | 1992-10-31 | 1994-05-05 | Basf Ag | N-Phenyl substituierte Glutarimide und N-Phenylglutarsäureamide, deren Herstellung und Verwendung |
| US6114355A (en) | 1993-03-01 | 2000-09-05 | D'amato; Robert | Methods and compositions for inhibition of angiogenesis |
| US5629327A (en) | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
| US5463063A (en) | 1993-07-02 | 1995-10-31 | Celgene Corporation | Ring closure of N-phthaloylglutamines |
| US5698579A (en) | 1993-07-02 | 1997-12-16 | Celgene Corporation | Cyclic amides |
| DE19601303A1 (de) * | 1996-01-16 | 1997-07-17 | Boehringer Ingelheim Kg | Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln |
| US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| US5798368A (en) | 1996-08-22 | 1998-08-25 | Celgene Corporation | Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels |
| NZ333903A (en) * | 1996-07-24 | 2000-02-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1oxoisoindolines and method of reducing TNF-alpha levels in a mammal |
| HU228769B1 (en) * | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| RU2188819C2 (ru) | 1996-08-12 | 2002-09-10 | Селджин Корпорейшн | НОВЫЕ ИММУНОТЕРАПЕВТИЧЕСКИЕ СОЕДИНЕНИЯ, СОДЕРЖАЩАЯ ИХ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ СНИЖЕНИЯ УРОВНЕЙ ФДЭ, TNFα И NFκB |
| US5874448A (en) | 1997-11-18 | 1999-02-23 | Celgene Corporation | Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels |
| US5955476A (en) | 1997-11-18 | 1999-09-21 | Celgene Corporation | Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels |
| EP1064277B1 (en) | 1998-03-16 | 2005-06-15 | Celgene Corporation | 2-(2,6-dioxopiperidin-3-yl)isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines |
| KR100672892B1 (ko) | 1999-03-18 | 2007-01-23 | 셀진 코오퍼레이션 | 치환된 1-옥소- 및 1,3-디옥소이소인돌린스 및 염증성사이토킨 수치를 감소시키기 위한 약학적 조성물로서의이들의 사용 |
| EP1193248A1 (en) * | 2000-09-30 | 2002-04-03 | Aventis Pharma Deutschland GmbH | Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation and their use |
| US6458810B1 (en) | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
| AU2002253795B2 (en) | 2000-11-30 | 2007-02-01 | The Children's Medical Center Corporation | Synthesis of 4-Amino-Thalidomide enantiomers |
| US20030045552A1 (en) | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
| US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
| JP2002284761A (ja) * | 2001-01-17 | 2002-10-03 | Toray Ind Inc | 光学活性３−アミノピロリジン−２，５−ジオン誘導体および光学活性３−アミノピロリジン誘導体の製造方法 |
| WO2003014315A2 (en) * | 2001-08-06 | 2003-02-20 | The Children's Medical Center Corporation | Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs |
| EP1485100B1 (en) | 2002-03-15 | 2010-05-05 | Vertex Pharmaceuticals Incorporated | Azinylaminoazoles as inhibitors of protein kinases |
| US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| US7189740B2 (en) | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
| US20040091455A1 (en) | 2002-10-31 | 2004-05-13 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for treatment and management of macular degeneration |
| US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| CH696542A5 (de) * | 2003-07-09 | 2007-07-31 | Siegfried Ltd | Verfahren zur Herstellung von substituierten 2,6-Dioxopiperidin-3-yl-Verbindungen. |
| HRP20130102T1 (hr) | 2005-06-30 | 2013-03-31 | Celgene Corporation | Postupak dobivanja spojeva 4-amino-2-(2,6-dioksopiperidin-3-il)izoindolin-1,3-diona |
| KR20080042158A (ko) | 2005-08-31 | 2008-05-14 | 셀진 코포레이션 | 이소인돌-이미드 화합물과 이를 포함하는 조성물 및 이를이용한 방법 |
| PL2076260T3 (pl) | 2006-09-15 | 2011-08-31 | Celgene Corp | Związki N-metyloaminometylo-izoindolu, kompozycje zawierające te związki, oraz metody ich stosowania |
| CA2717326C (en) | 2008-03-11 | 2018-10-23 | Dr. Reddy's Laboratories Ltd. | Preparation of lenalidomide |
| CN101531653B (zh) | 2008-03-13 | 2014-07-09 | 峡江和美药业有限公司 | 3-(4-氨基-1-氧代-1,3-二氢异吲哚-2-基)哌啶-2,6-二酮及其衍生物的盐或盐的多晶型物及其制备和应用 |
-
2005
- 2005-08-31 BR BRPI0514865-0A patent/BRPI0514865A/pt not_active IP Right Cessation
- 2005-08-31 CN CNA2005800372200A patent/CN101080400A/zh active Pending
- 2005-08-31 AU AU2005282728A patent/AU2005282728A1/en not_active Abandoned
- 2005-08-31 WO PCT/US2005/031318 patent/WO2006028964A1/en not_active Ceased
- 2005-08-31 EP EP12164781.2A patent/EP2479172B1/en not_active Expired - Lifetime
- 2005-08-31 NZ NZ554068A patent/NZ554068A/en not_active IP Right Cessation
- 2005-08-31 ZA ZA200702382A patent/ZA200702382B/xx unknown
- 2005-08-31 CA CA2579291A patent/CA2579291C/en not_active Expired - Lifetime
- 2005-08-31 ES ES05793314.5T patent/ES2437592T3/es not_active Expired - Lifetime
- 2005-08-31 MX MX2007002521A patent/MX2007002521A/es active IP Right Grant
- 2005-08-31 KR KR1020077007538A patent/KR20070057907A/ko not_active Withdrawn
- 2005-08-31 ES ES12164781.2T patent/ES2438725T3/es not_active Expired - Lifetime
- 2005-08-31 EP EP05793314.5A patent/EP1797068B1/en not_active Expired - Lifetime
- 2005-08-31 JP JP2007530398A patent/JP2008512379A/ja active Pending
- 2005-09-01 US US11/219,589 patent/US7863451B2/en active Active
- 2005-09-02 PA PA20058643901A patent/PA8643901A1/es unknown
- 2005-09-02 UY UY29097A patent/UY29097A1/es not_active Application Discontinuation
- 2005-09-02 PE PE2005001015A patent/PE20060648A1/es not_active Application Discontinuation
- 2005-09-02 SV SV2005002219A patent/SV2007002219A/es not_active Application Discontinuation
- 2005-09-02 GT GT200500242A patent/GT200500242A/es unknown
- 2005-09-02 HN HN2005000508A patent/HN2005000508A/es unknown
- 2005-09-02 AR ARP050103695A patent/AR050724A1/es unknown
- 2005-09-02 TW TW094130010A patent/TW200621748A/zh unknown
-
2007
- 2007-03-01 IL IL181674A patent/IL181674A0/en unknown
-
2012
- 2012-07-23 JP JP2012162375A patent/JP5701824B2/ja not_active Expired - Lifetime
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