JP2008543874A5 - - Google Patents
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- Publication number
- JP2008543874A5 JP2008543874A5 JP2008517192A JP2008517192A JP2008543874A5 JP 2008543874 A5 JP2008543874 A5 JP 2008543874A5 JP 2008517192 A JP2008517192 A JP 2008517192A JP 2008517192 A JP2008517192 A JP 2008517192A JP 2008543874 A5 JP2008543874 A5 JP 2008543874A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- acyl
- protecting group
- oxygen protecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *OC(CC(N[C@](CCCC1)C1O*)=O)C(O)=* Chemical compound *OC(CC(N[C@](CCCC1)C1O*)=O)C(O)=* 0.000 description 5
- LJMOAFPERYQCNH-UHFFFAOYSA-N C=CNC1CC1 Chemical compound C=CNC1CC1 LJMOAFPERYQCNH-UHFFFAOYSA-N 0.000 description 1
- CMBROMYXNDQMFP-GUDVDZBRSA-N CCOc1cc(CCO[C@H](CCCC2)[C@@H]2N(CC2)C[C@@H]2O)ccc1OC Chemical compound CCOc1cc(CCO[C@H](CCCC2)[C@@H]2N(CC2)C[C@@H]2O)ccc1OC CMBROMYXNDQMFP-GUDVDZBRSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69098905P | 2005-06-15 | 2005-06-15 | |
| US60/690,989 | 2005-06-15 | ||
| US74824805P | 2005-12-07 | 2005-12-07 | |
| US60/748,248 | 2005-12-07 | ||
| PCT/US2006/023668 WO2006138673A2 (en) | 2005-06-15 | 2006-06-15 | Synthetic processes for the preparation of aminocyclohexyl ether compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008543874A JP2008543874A (ja) | 2008-12-04 |
| JP2008543874A5 true JP2008543874A5 (https=) | 2012-02-23 |
| JP5159616B2 JP5159616B2 (ja) | 2013-03-06 |
Family
ID=37395936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008517192A Active JP5159616B2 (ja) | 2005-06-15 | 2006-06-15 | アミノシクロヘキシルエーテル化合物の調製のための合成プロセス |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US7754897B2 (https=) |
| EP (1) | EP1915340B1 (https=) |
| JP (1) | JP5159616B2 (https=) |
| BR (1) | BRPI0612138B8 (https=) |
| CA (1) | CA2612375C (https=) |
| MX (2) | MX346530B (https=) |
| WO (1) | WO2006138673A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7705036B2 (en) | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| JP4991037B2 (ja) * | 2004-04-01 | 2012-08-01 | カーディオム ファーマ コーポレイション | イオンチャネル調節化合物を含む薬物結合体 |
| US7754897B2 (en) | 2005-06-15 | 2010-07-13 | Cardiome Pharma Corp. | Synthetic processes for the preparation of aminocyclohexyl ether compounds |
| EP1828099B1 (en) | 2004-11-18 | 2020-01-22 | Correvio International Sàrl | Synthetic process for aminocyclohexyl ether compounds |
| WO2008137778A2 (en) * | 2007-05-04 | 2008-11-13 | Cardiome Pharma Corp. | Controlled release oral formulations of ion channel modulating compounds and related methods for preventing arrhythmia |
| EP2445504A4 (en) | 2009-06-23 | 2012-11-14 | Medicinova Inc | 2-AMINO-1- (2-ISOPROPYLPYRAZOLO [1,5-A] PYRIDINE-3-YL) PROPAN-1-ONE ENANTIOMER COMPOSITIONS AND METHODS THEREOF |
| WO2012024100A2 (en) | 2010-08-16 | 2012-02-23 | Merck Sharp & Dohme Corp. | Process for preparing aminocyclohexyl ether compounds |
| US8932836B2 (en) | 2010-08-16 | 2015-01-13 | Codexis, Inc. | Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine |
| BR112014017833A2 (pt) | 2012-01-20 | 2021-03-23 | Dennis Brown | Uso de hexitóis substituídos incluindo dianidrogalactitol e análogos para tratar doença neoplástica e células-tronco de câncer incluindo glioblastoma multiforme e meduloblastoma |
| US20150087687A1 (en) | 2012-03-23 | 2015-03-26 | Dennis Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
| JP6280546B2 (ja) | 2012-06-26 | 2018-02-14 | デル マー ファーマシューティカルズ | ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法 |
| EP2983674A4 (en) | 2013-04-08 | 2017-05-10 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
| KR102359214B1 (ko) | 2014-04-04 | 2022-02-07 | 델 마 파마슈티컬스 | 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체 |
| JP7262118B2 (ja) | 2016-10-06 | 2023-04-21 | オーバス セラピューティクス インコーポレイテッド | 医薬組成物およびその使用 |
| WO2018200381A1 (en) | 2017-04-25 | 2018-11-01 | Temple Otorongo Llc | Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions |
| US12605349B2 (en) | 2024-09-05 | 2026-04-21 | Orbus Therapeutics, Inc. | Methods of treating grade 3 astrocytoma |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA710830A (en) | 1965-06-01 | Moser Paul | Disodium and calcium salt of the calcium complex of 2-aminocyclohexyl 2'-aminoethyl ether-n,n,n',n'-tetraacetic acid | |
| DE2753556A1 (de) | 1977-12-01 | 1979-06-07 | Bayer Ag | Benzylaether von cyclischen 1,2-diolen, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide |
| EP0002214B1 (de) | 1977-12-01 | 1981-05-13 | Bayer Ag | Benzyläther von cyclischen 1,2-Diolen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Herbizide |
| US4684728A (en) * | 1979-01-12 | 1987-08-04 | Bayer Aktiengesellschaft | Solubilizing biologically active compounds with reactive hydrogen atoms |
| ATE76292T1 (de) | 1987-11-25 | 1992-06-15 | American Cyanamid Co | System fuer die verzoegerte (kontrollierte) freisetzung von substituierten dihydropyridincalciumantagonisten. |
| DE3836917A1 (de) * | 1988-10-29 | 1990-05-17 | Bayer Ag | Verfahren zur herstellung von cyclopropylamin |
| US5215919A (en) * | 1991-02-25 | 1993-06-01 | Takeda Chemical Industries, Ltd. | Process for producing optically active 2-hydroxycycloalkanecarboxylic acid esters using microbially derived reductase |
| CN1087725C (zh) * | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| US6214608B1 (en) | 1995-02-03 | 2001-04-10 | Basf Aktiengesellschaft | Resolution of racemates of primary and secondary heteroatom-substitued amines by enzyme-catalyzed acylation |
| DE19523868A1 (de) * | 1995-06-30 | 1997-01-02 | Huels Chemische Werke Ag | Verfahren zur Herstellung von Cyclopropanamin |
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| DE69735057T2 (de) | 1996-03-12 | 2006-08-31 | PG-TXL Co., L.P., Houston | Wasserlösliche paclitaxel-prodrogen |
| US6342507B1 (en) * | 1997-09-05 | 2002-01-29 | Isotechnika, Inc. | Deuterated rapamycin compounds, method and uses thereof |
| EP0991660B8 (en) * | 1997-10-08 | 2006-04-05 | Isotechnika,Inc. | DEUTERATED and undeuterated CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS |
| CA2326777C (en) | 1998-04-01 | 2011-12-20 | Nortran Pharmaceuticals Inc. | Aminocyclohexyl ether compounds and uses thereof |
| EP1143896B1 (en) | 1998-10-20 | 2006-12-13 | The University of North Carolina at Chapel Hill | Methods of hydrating the nasal mucosal surface |
| AU2899400A (en) * | 1999-03-04 | 2000-09-21 | Nortran Pharmaceuticals Inc. | Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics |
| CA2311483A1 (en) | 2000-06-12 | 2001-12-12 | Gregory N Beatch | IMIDAZO [1,2-A] PYRIDINIC ETHERS AND USES THEREOF |
| JP2004501191A (ja) * | 2000-06-28 | 2004-01-15 | テバ ファーマシューティカル インダストリーズ リミティド | カルベジロール |
| US7524879B2 (en) | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| EP1291336A3 (en) * | 2001-09-05 | 2003-10-08 | Solvias AG | Preparation of optically active alpha-hydroxyethers |
| JP2003250577A (ja) * | 2001-12-27 | 2003-09-09 | Sumitomo Chem Co Ltd | ２‐ヒドロキシシクロアルカンカルボン酸エステルの製造方法 |
| US20040049049A1 (en) | 2002-06-14 | 2004-03-11 | Johnson Matthey Pharmaceutical Materials, Inc. | Stereoselective synthesis of 1,2-disubstituted cycloalkyls |
| WO2004014973A2 (en) | 2002-08-13 | 2004-02-19 | Sirus Pharmaceuticals Ltd | Biodegradable polymer |
| US7056540B2 (en) * | 2002-10-29 | 2006-06-06 | Council Of Scientific And Industrial Research | Enzymatic process for the preparation of optically active alcohols from ketones using tuberous root Daucus carota |
| WO2004098525A2 (en) | 2003-05-02 | 2004-11-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| CA2524323C (en) | 2003-05-02 | 2012-05-15 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| WO2005016242A2 (en) | 2003-06-04 | 2005-02-24 | Cardiome Pharma Corp. | Synthetic process for trans-aminocyclohexyl ether compounds |
| US7345087B2 (en) * | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| US7754897B2 (en) * | 2005-06-15 | 2010-07-13 | Cardiome Pharma Corp. | Synthetic processes for the preparation of aminocyclohexyl ether compounds |
| MXPA06011419A (es) * | 2004-04-01 | 2007-04-20 | Cardiome Pharma Corp | Profarmacos de compuestos moduladores de canales ionicos y usos de los mismos. |
| WO2005097087A2 (en) | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| JP4991037B2 (ja) * | 2004-04-01 | 2012-08-01 | カーディオム ファーマ コーポレイション | イオンチャネル調節化合物を含む薬物結合体 |
| US7705036B2 (en) * | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| EP1828099B1 (en) | 2004-11-18 | 2020-01-22 | Correvio International Sàrl | Synthetic process for aminocyclohexyl ether compounds |
| US20090069404A1 (en) * | 2007-09-09 | 2009-03-12 | Protia, Llc | Deuterium-enriched vernakalant |
-
2006
- 2006-06-15 US US11/455,280 patent/US7754897B2/en active Active
- 2006-06-15 CA CA2612375A patent/CA2612375C/en active Active
- 2006-06-15 JP JP2008517192A patent/JP5159616B2/ja active Active
- 2006-06-15 MX MX2014009461A patent/MX346530B/es unknown
- 2006-06-15 BR BRPI0612138A patent/BRPI0612138B8/pt active IP Right Grant
- 2006-06-15 WO PCT/US2006/023668 patent/WO2006138673A2/en not_active Ceased
- 2006-06-15 MX MX2007016248A patent/MX2007016248A/es active IP Right Grant
- 2006-06-15 EP EP06785062.8A patent/EP1915340B1/en active Active
-
2010
- 2010-02-19 US US12/709,355 patent/US8080673B2/en active Active
-
2011
- 2011-11-16 US US13/297,846 patent/US8344162B2/en active Active
-
2012
- 2012-09-12 US US13/612,539 patent/US8618311B2/en active Active
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