JP2019537559A5 - - Google Patents
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- JP2019537559A5 JP2019537559A5 JP2019517991A JP2019517991A JP2019537559A5 JP 2019537559 A5 JP2019537559 A5 JP 2019537559A5 JP 2019517991 A JP2019517991 A JP 2019517991A JP 2019517991 A JP2019517991 A JP 2019517991A JP 2019537559 A5 JP2019537559 A5 JP 2019537559A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- nrr
- formula
- pyridin
- imidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662403660P | 2016-10-03 | 2016-10-03 | |
| US62/403,660 | 2016-10-03 | ||
| PCT/US2017/054668 WO2018067422A1 (en) | 2016-10-03 | 2017-09-30 | Novel jak1 selective inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019537559A JP2019537559A (ja) | 2019-12-26 |
| JP2019537559A5 true JP2019537559A5 (https=) | 2021-03-04 |
| JP7089141B2 JP7089141B2 (ja) | 2022-06-22 |
Family
ID=61831161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019517991A Active JP7089141B2 (ja) | 2016-10-03 | 2017-09-30 | 新規なｊａｋ１選択的阻害剤およびその使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | USRE50799E1 (https=) |
| EP (1) | EP3509591B1 (https=) |
| JP (1) | JP7089141B2 (https=) |
| KR (1) | KR102399848B1 (https=) |
| CN (2) | CN113214278B (https=) |
| AU (3) | AU2017339417C1 (https=) |
| DK (1) | DK3509591T3 (https=) |
| EA (1) | EA201990523A1 (https=) |
| ES (1) | ES2901216T3 (https=) |
| HK (1) | HK1253040A1 (https=) |
| HR (1) | HRP20211965T1 (https=) |
| HU (1) | HUE058120T2 (https=) |
| IL (3) | IL265358B (https=) |
| MX (1) | MX390005B (https=) |
| NZ (1) | NZ751284A (https=) |
| PL (1) | PL3509591T3 (https=) |
| PT (1) | PT3509591T (https=) |
| RS (1) | RS62695B1 (https=) |
| WO (1) | WO2018067422A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102399848B1 (ko) | 2016-10-03 | 2022-05-19 | 하이라이트ll 파머슈티컬 (하이난) 컴퍼니, 리미티드 | 신규한 jak1 선택적 억제제 및 그 용도 |
| PL3568396T3 (pl) | 2017-01-11 | 2021-05-31 | Leo Pharma A/S | Nowe pochodne aminoimidazopirydyny jako inhibitory kinaz janusowych i ich zastosowanie farmaceutyczne |
| CA3117969A1 (en) | 2018-10-31 | 2020-05-07 | Incyte Corporation | Combination therapy for treatment of hematological diseases |
| MA55201A (fr) * | 2019-03-05 | 2022-01-12 | Incyte Corp | Inhibiteurs de la voie jak1 pour le traitement d'un dysfonctionnement chronique de l'allogreffe pulmonaire |
| US11624751B2 (en) | 2019-03-19 | 2023-04-11 | Incyte Corporation | Biomarkers for vitiligo |
| IL318796A (en) * | 2019-06-06 | 2025-04-01 | Hangzhou Highlightll Pharmaceutical Co Ltd | Method for preparing a furoimidazopyridine compound, polymorph and salt polymorph |
| KR102785014B1 (ko) * | 2019-06-06 | 2025-03-20 | 항저우 하이라이트엘엘 파마슈티컬 씨오., 엘티디. | 푸로이미다조피리딘 화합물의 합성 방법, 푸로이미다조피리딘 화합물의 결정 형태, 및 그의 염의 결정 형태 |
| CN115803317B (zh) | 2020-05-19 | 2025-07-15 | 拜耳作物科学股份公司 | 作为杀真菌化合物的氮杂双环(硫代)酰胺 |
| WO2021249995A1 (en) | 2020-06-10 | 2021-12-16 | Bayer Aktiengesellschaft | Azabicyclyl-substituted heterocycles as fungicides |
| EP4351584A4 (en) * | 2021-06-07 | 2025-04-23 | The Regents of the University of California | COMPOSITIONS AND METHODS FOR TREATING CELIAC DISEASE |
| EP4419101A4 (en) * | 2021-09-13 | 2025-09-03 | Hangzhou Highlightll Pharmaceutical Co Ltd | METHODS OF TREATMENT OF CNS DISORDERS |
| CN114213424B (zh) | 2021-12-30 | 2023-05-26 | 杭州高光制药有限公司 | 一种呋喃[3，2-b]并吡啶衍生物的合成方法 |
| WO2025224600A1 (en) * | 2024-04-21 | 2025-10-30 | Biohaven Therapeutics Ltd. | Treatment of alpha-synucleinopathies and neuroprotection |
| WO2025248468A1 (en) | 2024-05-28 | 2025-12-04 | Biohaven Therapeutics Ltd. | Use of tyk2/jak1 inhibitors to treat amyloid-related imaging abnormalities (aria) |
| WO2026002028A1 (zh) * | 2024-06-26 | 2026-01-02 | 杭州多域生物技术有限公司 | 稠杂芳环类化合物、其药物组合物及其应用 |
| WO2026032213A1 (zh) * | 2024-08-08 | 2026-02-12 | 普罗思特(南京)生物科技有限公司 | 取代的三环衍生物及其应用 |
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| US3983092A (en) | 1975-01-20 | 1976-09-28 | Ciba-Geigy Corporation | Phenylindane diamine mixture and epoxy resin therewith |
| US4369172A (en) | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| DE3583799D1 (de) | 1985-01-11 | 1991-09-19 | Abbott Lab Ltd | Feste zubereitung mit langsamer freisetzung. |
| JP2773959B2 (ja) | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
| UA73092C2 (uk) | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| DE69924735T2 (de) | 1998-07-28 | 2006-01-19 | Tanabe Seiyaku Co., Ltd. | Zur wirkstoffabgabe an zielorten im darm fähige zubereitung |
| JP2000119271A (ja) | 1998-08-12 | 2000-04-25 | Hokuriku Seiyaku Co Ltd | １ｈ―イミダゾピリジン誘導体 |
| US6461631B1 (en) | 1999-11-16 | 2002-10-08 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| US6800663B2 (en) | 2002-10-18 | 2004-10-05 | Alkermes Controlled Therapeutics Inc. Ii, | Crosslinked hydrogel copolymers |
| US20070185152A1 (en) | 2004-03-02 | 2007-08-09 | Smithkline Beecham Corporation | Inhibitors of akt activity |
| CN101282974A (zh) * | 2005-08-04 | 2008-10-08 | 西特里斯药业公司 | 作为sirtuin调节剂的咪唑并吡啶衍生物 |
| CN101238186B (zh) | 2005-08-11 | 2012-10-24 | 3M创新有限公司 | 作为金属基底涂层的互穿聚合物网络及其制造方法 |
| WO2007039146A1 (en) | 2005-09-23 | 2007-04-12 | Smithkline Beecham Corporation | 4-carboxy pyrazole derivatives as anti-viral agents |
| US7879968B2 (en) | 2006-10-17 | 2011-02-01 | Taylor Made Golf Company, Inc. | Polymer compositions and golf balls with reduced yellowing |
| US20100280151A1 (en) | 2009-05-04 | 2010-11-04 | Toray Industries, Inc. | Toughened fiber reinforced polymer composite with core-shell particles |
| KR20120081164A (ko) * | 2009-09-29 | 2012-07-18 | 엑스커버리 홀딩 컴퍼니 엘엘씨 | Ｐｉ3ｋ(델타) 선택적 억제제 |
| WO2011138657A1 (en) | 2010-05-04 | 2011-11-10 | Glenmark Pharmaceuticals S.A. | Aryl substituted olefinic compounds as pde10a inhibitors |
| WO2012022045A1 (en) * | 2010-08-20 | 2012-02-23 | Hutchison Medipharma Limited | Pyrrolopyrimidine compounds and uses thereof |
| RU2013120966A (ru) | 2010-10-08 | 2014-11-20 | Эббви Инк. | ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ |
| WO2013007768A1 (en) | 2011-07-13 | 2013-01-17 | F. Hoffmann-La Roche Ag | Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors |
| AU2012295802B2 (en) | 2011-08-12 | 2017-03-30 | Nissan Chemical Industries, Ltd. | Tricyclic heterocyclic compounds and JAK inhibitors |
| JP6057907B2 (ja) | 2011-10-04 | 2017-01-11 | 株式会社ヤクルト本社 | チアゾリジン誘導体又はその塩を有効成分とする医薬品 |
| CN104918945B (zh) | 2012-11-01 | 2018-01-05 | 因赛特公司 | 作为jak抑制剂的三环稠合噻吩衍生物 |
| CN103450125B (zh) | 2013-07-18 | 2016-01-13 | 嘉兴中科化学有限公司 | 一种5-取代苯丙呋喃-2-羧酸及其衍生物的合成方法 |
| EP3060234A1 (en) | 2013-10-24 | 2016-08-31 | AbbVie Inc. | Jak1 selective inhibitor and uses thereof |
| CN106687462A (zh) | 2014-04-30 | 2017-05-17 | 因赛特公司 | Jak1抑制剂的制备方法以及其新形式 |
| EP2940022B1 (en) | 2014-04-30 | 2020-09-02 | Masarykova Univerzita | Furopyridines as inhibitors of protein kinases |
| US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
| CN105418620B (zh) | 2014-09-23 | 2018-05-04 | 天津药明康德新药开发有限公司 | 一种4-(叔丁氧羰基)八氢呋喃并[3,2-b]吡啶-6-羧酸的合成方法 |
| WO2016100349A2 (en) | 2014-12-16 | 2016-06-23 | Rugen Holdings (Cayman) Limited | Bicyclic azaheterocyclic compounds as nr2b nmda receptor antagonists |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| CN106432232A (zh) | 2016-09-18 | 2017-02-22 | 苏州汉德创宏生化科技有限公司 | 1‑哌啶‑4‑基‑1,3‑二氢‑咪唑[4,5‑b]吡啶‑2‑酮的合成方法 |
| KR102399848B1 (ko) | 2016-10-03 | 2022-05-19 | 하이라이트ll 파머슈티컬 (하이난) 컴퍼니, 리미티드 | 신규한 jak1 선택적 억제제 및 그 용도 |
| LT3555097T (lt) | 2016-12-16 | 2022-08-25 | Janssen Pharmaceutica Nv | Imidazo[4,5-d]pirolo[2,3-b]piridino junginiai kaip janus kinazės inhibitoriai |
| CN107216334A (zh) | 2017-06-29 | 2017-09-29 | 上海吉尔多肽有限公司 | 一种6‑氯呋喃[3,2‑b]吡啶的合成方法 |
| KR102785014B1 (ko) | 2019-06-06 | 2025-03-20 | 항저우 하이라이트엘엘 파마슈티컬 씨오., 엘티디. | 푸로이미다조피리딘 화합물의 합성 방법, 푸로이미다조피리딘 화합물의 결정 형태, 및 그의 염의 결정 형태 |
| IL318796A (en) | 2019-06-06 | 2025-04-01 | Hangzhou Highlightll Pharmaceutical Co Ltd | Method for preparing a furoimidazopyridine compound, polymorph and salt polymorph |
| CN118619944A (zh) | 2019-06-06 | 2024-09-10 | 北京泰德制药股份有限公司 | 作为atr激酶抑制剂的2,4,6-三取代的嘧啶化合物 |
| CN114213424B (zh) | 2021-12-30 | 2023-05-26 | 杭州高光制药有限公司 | 一种呋喃[3，2-b]并吡啶衍生物的合成方法 |
-
2017
- 2017-09-30 KR KR1020197009016A patent/KR102399848B1/ko active Active
- 2017-09-30 AU AU2017339417A patent/AU2017339417C1/en active Active
- 2017-09-30 HR HRP20211965TT patent/HRP20211965T1/hr unknown
- 2017-09-30 EP EP17858944.6A patent/EP3509591B1/en active Active
- 2017-09-30 EA EA201990523A patent/EA201990523A1/ru unknown
- 2017-09-30 DK DK17858944.6T patent/DK3509591T3/da active
- 2017-09-30 PT PT178589446T patent/PT3509591T/pt unknown
- 2017-09-30 US US18/122,295 patent/USRE50799E1/en active Active
- 2017-09-30 JP JP2019517991A patent/JP7089141B2/ja active Active
- 2017-09-30 HU HUE17858944A patent/HUE058120T2/hu unknown
- 2017-09-30 CN CN202110514751.5A patent/CN113214278B/zh active Active
- 2017-09-30 RS RS20211521A patent/RS62695B1/sr unknown
- 2017-09-30 NZ NZ751284A patent/NZ751284A/en unknown
- 2017-09-30 PL PL17858944T patent/PL3509591T3/pl unknown
- 2017-09-30 CN CN201780004442.5A patent/CN108366994B/zh active Active
- 2017-09-30 HK HK18112420.5A patent/HK1253040A1/zh unknown
- 2017-09-30 ES ES17858944T patent/ES2901216T3/es active Active
- 2017-09-30 US US16/333,994 patent/US10738060B2/en not_active Ceased
- 2017-09-30 WO PCT/US2017/054668 patent/WO2018067422A1/en not_active Ceased
- 2017-09-30 US US17/526,799 patent/USRE49834E1/en active Active
- 2017-09-30 MX MX2019003649A patent/MX390005B/es unknown
-
2019
- 2019-03-13 IL IL265358A patent/IL265358B/en unknown
-
2022
- 2022-02-17 AU AU2022201061A patent/AU2022201061B2/en active Active
- 2022-02-17 AU AU2022201058A patent/AU2022201058B2/en active Active
- 2022-03-10 IL IL291265A patent/IL291265B2/en unknown
- 2022-03-10 IL IL291267A patent/IL291267B2/en unknown
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