JP2016531868A5 - - Google Patents
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- JP2016531868A5 JP2016531868A5 JP2016517332A JP2016517332A JP2016531868A5 JP 2016531868 A5 JP2016531868 A5 JP 2016531868A5 JP 2016517332 A JP2016517332 A JP 2016517332A JP 2016517332 A JP2016517332 A JP 2016517332A JP 2016531868 A5 JP2016531868 A5 JP 2016531868A5
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- JP
- Japan
- Prior art keywords
- group
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- hydrogen atom
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13186139 | 2013-09-26 | ||
| EP13186139.5 | 2013-09-26 | ||
| EP14176121.3 | 2014-07-08 | ||
| EP14176121 | 2014-07-08 | ||
| PCT/EP2014/070484 WO2015044267A1 (en) | 2013-09-26 | 2014-09-25 | NEW 1-(4-PYRIMIDINYL)-1H-PYRROLO[3,2-c]PYRIDINE DERIVATIVES AS NIK INHIBITORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531868A JP2016531868A (ja) | 2016-10-13 |
| JP2016531868A5 true JP2016531868A5 (https=) | 2017-11-02 |
| JP6402179B2 JP6402179B2 (ja) | 2018-10-10 |
Family
ID=51619194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016517332A Expired - Fee Related JP6402179B2 (ja) | 2013-09-26 | 2014-09-25 | 新規な、ＮＩＫ阻害剤としての１−（４−ピリミジニル）−１Ｈ−ピロロ［３，２−ｃ］ピリジン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10005773B2 (https=) |
| EP (1) | EP3071566B1 (https=) |
| JP (1) | JP6402179B2 (https=) |
| KR (1) | KR102317334B1 (https=) |
| CN (1) | CN105579451B (https=) |
| AU (1) | AU2014327233B2 (https=) |
| BR (1) | BR112016005914A2 (https=) |
| CA (1) | CA2922753C (https=) |
| EA (1) | EA029595B1 (https=) |
| ES (1) | ES2804595T3 (https=) |
| IL (1) | IL244706B (https=) |
| MX (1) | MX373186B (https=) |
| TW (1) | TWI704146B (https=) |
| WO (1) | WO2015044267A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| KR102523405B1 (ko) | 2014-10-23 | 2023-04-18 | 얀센 파마슈티카 엔.브이. | Ｎｉｋ 억제제로서의 신규 피라졸로피리미딘 유도체 |
| CA2960336C (en) | 2014-10-23 | 2023-03-07 | Janssen Pharmaceutica Nv | Compounds as nik inhibitors |
| EP3209654B1 (en) | 2014-10-23 | 2018-10-03 | Janssen Pharmaceutica N.V. | New pyrazole derivatives as nik inhibitors |
| EA033238B1 (ru) | 2014-10-23 | 2019-09-30 | Янссен Фармацевтика Нв | Новые производные тиенопиримидина в качестве ингибиторов nik |
| KR102720461B1 (ko) * | 2016-01-22 | 2024-10-21 | 잔센파마슈티카엔.브이. | Nik 억제제로서의 신규 6원 헤테로방향족 치환된 시아노인돌린 유도체 |
| JP6910359B2 (ja) | 2016-01-22 | 2021-07-28 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｉｋ阻害剤としての新たな置換されたシアノインドリン誘導体 |
| WO2018002219A1 (en) | 2016-06-30 | 2018-01-04 | Janssen Pharmaceutica Nv | Cyanoindoline derivatives as nik inhibitors |
| ES2805976T3 (es) * | 2016-06-30 | 2021-02-16 | Janssen Pharmaceutica Nv | Derivados heteroaromáticos en calidad de inhibidores de NIK |
| CN109863142B (zh) * | 2016-08-24 | 2022-06-10 | 豪夫迈·罗氏有限公司 | 2-氮杂双环[3.1.0]己烷-3-酮衍生物及使用方法 |
| JP7140751B2 (ja) * | 2016-08-24 | 2022-09-21 | エフ．ホフマン－ラ ロシュ アーゲー | ２－アザビシクロ［３．１．０］ヘキサン－３－オン誘導体及び使用方法 |
| UA130430C2 (uk) | 2019-05-31 | 2026-02-18 | Янссен Фармацевтика Нв | НИЗЬКОМОЛЕКУЛЯРНІ ІНГІБІТОРИ КІНАЗИ, ЩО ІНДУКУЄ NF-kB |
| CN113816957B (zh) * | 2021-10-29 | 2023-04-07 | 浙江工业大学 | 4-(7-氮杂吲哚)-2-氨基嘧啶类化合物及其应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3990061B2 (ja) * | 1998-01-05 | 2007-10-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | プリン誘導体および糖尿病の予防・治療剤としてのアデノシンａ２受容体拮抗剤 |
| CA2564356A1 (en) | 2004-04-26 | 2005-11-03 | Pfizer Inc. | Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors |
| AR056786A1 (es) * | 2005-11-10 | 2007-10-24 | Smithkline Beecham Corp | Compuesto de 1h- imidazo ( 4,5-c) piridin-2-ilo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion, su uso para preparar unmedicamento, uso de una combinacion que omprende al compuesto y al menos un agente antineoplasico para preparar un medicamento y dicha com |
| DE102008005493A1 (de) | 2008-01-22 | 2009-07-23 | Merck Patent Gmbh | 4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate |
| JP2011525915A (ja) | 2008-06-26 | 2011-09-29 | アムジエン・インコーポレーテツド | キナーゼ阻害薬としてのアルキニルアルコール類 |
| US20110201599A1 (en) | 2008-07-03 | 2011-08-18 | Exelixis, Inc. | CDK Modulators |
| US20110183975A1 (en) * | 2008-10-07 | 2011-07-28 | Yasuhiro Goto | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
| CN101723936B (zh) | 2008-10-27 | 2014-01-15 | 上海睿星基因技术有限公司 | 激酶抑制剂及其在药学中的用途 |
| WO2011050245A1 (en) * | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
| MX2013010513A (es) * | 2011-03-16 | 2013-10-07 | Hoffmann La Roche | Compuestos de alcohol 6,5-heterociclil-propargilico y usos de los mismos. |
| TWI663166B (zh) * | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| KR102523405B1 (ko) | 2014-10-23 | 2023-04-18 | 얀센 파마슈티카 엔.브이. | Ｎｉｋ 억제제로서의 신규 피라졸로피리미딘 유도체 |
| EP3209654B1 (en) | 2014-10-23 | 2018-10-03 | Janssen Pharmaceutica N.V. | New pyrazole derivatives as nik inhibitors |
| EA033238B1 (ru) | 2014-10-23 | 2019-09-30 | Янссен Фармацевтика Нв | Новые производные тиенопиримидина в качестве ингибиторов nik |
| CA2960336C (en) | 2014-10-23 | 2023-03-07 | Janssen Pharmaceutica Nv | Compounds as nik inhibitors |
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2014
- 2014-09-24 TW TW103132898A patent/TWI704146B/zh not_active IP Right Cessation
- 2014-09-25 US US15/024,603 patent/US10005773B2/en active Active
- 2014-09-25 ES ES14772372T patent/ES2804595T3/es active Active
- 2014-09-25 EA EA201690645A patent/EA029595B1/ru not_active IP Right Cessation
- 2014-09-25 CN CN201480052786.XA patent/CN105579451B/zh not_active Expired - Fee Related
- 2014-09-25 WO PCT/EP2014/070484 patent/WO2015044267A1/en not_active Ceased
- 2014-09-25 AU AU2014327233A patent/AU2014327233B2/en not_active Ceased
- 2014-09-25 MX MX2016003861A patent/MX373186B/es active IP Right Grant
- 2014-09-25 KR KR1020167007899A patent/KR102317334B1/ko not_active Expired - Fee Related
- 2014-09-25 BR BR112016005914A patent/BR112016005914A2/pt not_active Application Discontinuation
- 2014-09-25 CA CA2922753A patent/CA2922753C/en active Active
- 2014-09-25 JP JP2016517332A patent/JP6402179B2/ja not_active Expired - Fee Related
- 2014-09-25 EP EP14772372.0A patent/EP3071566B1/en active Active
-
2016
- 2016-03-22 IL IL244706A patent/IL244706B/en active IP Right Grant