JP2017531678A5 - - Google Patents
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- JP2017531678A5 JP2017531678A5 JP2017522086A JP2017522086A JP2017531678A5 JP 2017531678 A5 JP2017531678 A5 JP 2017531678A5 JP 2017522086 A JP2017522086 A JP 2017522086A JP 2017522086 A JP2017522086 A JP 2017522086A JP 2017531678 A5 JP2017531678 A5 JP 2017531678A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- substituted
- groups
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14190073.8 | 2014-10-23 | ||
| EP14190073 | 2014-10-23 | ||
| PCT/EP2015/074431 WO2016062790A1 (en) | 2014-10-23 | 2015-10-22 | New pyrazolopyrimidine derivatives as nik inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017531678A JP2017531678A (ja) | 2017-10-26 |
| JP2017531678A5 true JP2017531678A5 (https=) | 2019-11-21 |
| JP6616412B2 JP6616412B2 (ja) | 2019-12-04 |
Family
ID=51846471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017522086A Expired - Fee Related JP6616412B2 (ja) | 2014-10-23 | 2015-10-22 | Ｎｉｋ阻害剤としての新規のピラゾロピリミジン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10221180B2 (https=) |
| EP (1) | EP3209663B1 (https=) |
| JP (1) | JP6616412B2 (https=) |
| KR (1) | KR102523405B1 (https=) |
| CN (1) | CN107074882B (https=) |
| AU (1) | AU2015334915B2 (https=) |
| BR (1) | BR112017007704B1 (https=) |
| CA (1) | CA2960574C (https=) |
| EA (1) | EA033237B1 (https=) |
| ES (1) | ES2715104T3 (https=) |
| IL (1) | IL251778B (https=) |
| MX (1) | MX371152B (https=) |
| WO (1) | WO2016062790A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| BR112017008039B1 (pt) | 2014-10-23 | 2023-04-11 | Janssen Pharmaceutica N.V. | Derivados de pirazol como inibidores de nik, seu uso no tratamento ou prevenção de câncer e composição farmacêutica que os compreende |
| AU2015334917B2 (en) | 2014-10-23 | 2019-08-29 | Janssen Pharmaceutica Nv | New compounds as NIK inhibitors |
| MX371151B (es) | 2014-10-23 | 2020-01-20 | Janssen Pharmaceutica Nv | NUEVOS DERIVADOS DE TIENOPIRIMIDINA EN CALIDAD DE INHIBIDORES DE LA CINASA INDUCTORA DE NF-kB (NIK). |
| JP6616412B2 (ja) | 2014-10-23 | 2019-12-04 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｉｋ阻害剤としての新規のピラゾロピリミジン誘導体 |
| US12448374B2 (en) | 2018-06-07 | 2025-10-21 | Disarm Therapeutics, Inc. | Inhibitors of SARM1 |
| ES2992431T3 (es) * | 2018-06-18 | 2024-12-12 | Janssen Pharmaceutica Nv | Derivados de pirazol como inhibidores de MALT1 |
| WO2020132045A1 (en) | 2018-12-19 | 2020-06-25 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 in combination with neuroprotective agents |
| KR20210146320A (ko) * | 2019-03-29 | 2021-12-03 | 교와 가부시키가이샤 | 신규 아자인돌 유도체 |
| CN114222737B (zh) | 2019-05-31 | 2024-07-26 | 詹森药业有限公司 | NF-κB诱导激酶的小分子抑制剂 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX19185A (es) * | 1989-01-20 | 1993-12-01 | Pfizer | Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas. |
| WO2005103003A2 (en) | 2004-04-26 | 2005-11-03 | Pfizer Inc. | Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors |
| TW200736260A (en) | 2005-11-10 | 2007-10-01 | Smithkline Beecham Corp | Inhibitors of Akt activity |
| DE102008005493A1 (de) | 2008-01-22 | 2009-07-23 | Merck Patent Gmbh | 4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate |
| AU2009263037B2 (en) * | 2008-06-26 | 2011-10-06 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
| CN102143746A (zh) | 2008-07-03 | 2011-08-03 | 埃克塞利希斯股份有限公司 | Cdk 调节剂 |
| WO2010042337A1 (en) | 2008-10-07 | 2010-04-15 | Merck Sharp & Dohme Corp. | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
| CN101723936B (zh) | 2008-10-27 | 2014-01-15 | 上海睿星基因技术有限公司 | 激酶抑制剂及其在药学中的用途 |
| WO2011050245A1 (en) | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
| MX2013010513A (es) | 2011-03-16 | 2013-10-07 | Hoffmann La Roche | Compuestos de alcohol 6,5-heterociclil-propargilico y usos de los mismos. |
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| BR112017008039B1 (pt) | 2014-10-23 | 2023-04-11 | Janssen Pharmaceutica N.V. | Derivados de pirazol como inibidores de nik, seu uso no tratamento ou prevenção de câncer e composição farmacêutica que os compreende |
| AU2015334917B2 (en) | 2014-10-23 | 2019-08-29 | Janssen Pharmaceutica Nv | New compounds as NIK inhibitors |
| MX371151B (es) | 2014-10-23 | 2020-01-20 | Janssen Pharmaceutica Nv | NUEVOS DERIVADOS DE TIENOPIRIMIDINA EN CALIDAD DE INHIBIDORES DE LA CINASA INDUCTORA DE NF-kB (NIK). |
| JP6616412B2 (ja) | 2014-10-23 | 2019-12-04 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｉｋ阻害剤としての新規のピラゾロピリミジン誘導体 |
-
2015
- 2015-10-22 JP JP2017522086A patent/JP6616412B2/ja not_active Expired - Fee Related
- 2015-10-22 EP EP15784050.5A patent/EP3209663B1/en active Active
- 2015-10-22 CA CA2960574A patent/CA2960574C/en active Active
- 2015-10-22 AU AU2015334915A patent/AU2015334915B2/en not_active Ceased
- 2015-10-22 BR BR112017007704-3A patent/BR112017007704B1/pt not_active IP Right Cessation
- 2015-10-22 WO PCT/EP2015/074431 patent/WO2016062790A1/en not_active Ceased
- 2015-10-22 MX MX2017005284A patent/MX371152B/es active IP Right Grant
- 2015-10-22 ES ES15784050T patent/ES2715104T3/es active Active
- 2015-10-22 KR KR1020177010805A patent/KR102523405B1/ko active Active
- 2015-10-22 CN CN201580057545.9A patent/CN107074882B/zh not_active Expired - Fee Related
- 2015-10-22 US US15/520,346 patent/US10221180B2/en active Active
- 2015-10-22 EA EA201790907A patent/EA033237B1/ru not_active IP Right Cessation
-
2017
- 2017-04-19 IL IL251778A patent/IL251778B/en active IP Right Grant
-
2019
- 2019-02-01 US US16/265,679 patent/US10822342B2/en active Active
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