JP2016531858A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016531858A5 JP2016531858A5 JP2016516870A JP2016516870A JP2016531858A5 JP 2016531858 A5 JP2016531858 A5 JP 2016531858A5 JP 2016516870 A JP2016516870 A JP 2016516870A JP 2016516870 A JP2016516870 A JP 2016516870A JP 2016531858 A5 JP2016531858 A5 JP 2016531858A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- substituted
- hydrogen atom
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13186148.6 | 2013-09-26 | ||
| EP13186148 | 2013-09-26 | ||
| EP14176125.4 | 2014-07-08 | ||
| EP14176125 | 2014-07-08 | ||
| PCT/EP2014/070489 WO2015044269A1 (en) | 2013-09-26 | 2014-09-25 | NEW 3-(1H-PYRAZOL-4-YL)-1H-PYRROLO[2,3-c]PYRIDINE DERIVATIVES AS NIK INHIBITORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531858A JP2016531858A (ja) | 2016-10-13 |
| JP2016531858A5 true JP2016531858A5 (https=) | 2017-11-02 |
| JP6404332B2 JP6404332B2 (ja) | 2018-10-10 |
Family
ID=51626028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016516870A Expired - Fee Related JP6404332B2 (ja) | 2013-09-26 | 2014-09-25 | 新規な、ＮＩＫ阻害剤としての３−（１Ｈ−ピラゾール−４−イル）−１Ｈ−ピロロ［２，３−ｃ］ピリジン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9981963B2 (https=) |
| EP (1) | EP3049412B1 (https=) |
| JP (1) | JP6404332B2 (https=) |
| KR (1) | KR102317335B1 (https=) |
| CN (1) | CN105579452B (https=) |
| AU (1) | AU2014327235B2 (https=) |
| BR (1) | BR112016006232B1 (https=) |
| CA (1) | CA2922633C (https=) |
| EA (1) | EA028101B1 (https=) |
| ES (1) | ES2643070T3 (https=) |
| IL (1) | IL244702B (https=) |
| MX (1) | MX365739B (https=) |
| TW (1) | TWI627173B (https=) |
| WO (1) | WO2015044269A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| TWI704146B (zh) * | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| KR102523405B1 (ko) | 2014-10-23 | 2023-04-18 | 얀센 파마슈티카 엔.브이. | Ｎｉｋ 억제제로서의 신규 피라졸로피리미딘 유도체 |
| CA2960336C (en) | 2014-10-23 | 2023-03-07 | Janssen Pharmaceutica Nv | Compounds as nik inhibitors |
| EP3209654B1 (en) | 2014-10-23 | 2018-10-03 | Janssen Pharmaceutica N.V. | New pyrazole derivatives as nik inhibitors |
| EA033238B1 (ru) | 2014-10-23 | 2019-09-30 | Янссен Фармацевтика Нв | Новые производные тиенопиримидина в качестве ингибиторов nik |
| CN108883103A (zh) * | 2015-12-02 | 2018-11-23 | 阿斯特来亚治疗有限责任公司 | 哌啶基痛敏肽受体化合物 |
| US10112924B2 (en) | 2015-12-02 | 2018-10-30 | Astraea Therapeutics, Inc. | Piperdinyl nociceptin receptor compounds |
| JP6910359B2 (ja) | 2016-01-22 | 2021-07-28 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｉｋ阻害剤としての新たな置換されたシアノインドリン誘導体 |
| KR102720461B1 (ko) | 2016-01-22 | 2024-10-21 | 잔센파마슈티카엔.브이. | Nik 억제제로서의 신규 6원 헤테로방향족 치환된 시아노인돌린 유도체 |
| WO2018002219A1 (en) | 2016-06-30 | 2018-01-04 | Janssen Pharmaceutica Nv | Cyanoindoline derivatives as nik inhibitors |
| ES2805976T3 (es) | 2016-06-30 | 2021-02-16 | Janssen Pharmaceutica Nv | Derivados heteroaromáticos en calidad de inhibidores de NIK |
| WO2020162638A1 (ja) * | 2019-02-08 | 2020-08-13 | 学校法人近畿大学 | 悪性腫瘍疾患の改善用組成物 |
| UA130430C2 (uk) | 2019-05-31 | 2026-02-18 | Янссен Фармацевтика Нв | НИЗЬКОМОЛЕКУЛЯРНІ ІНГІБІТОРИ КІНАЗИ, ЩО ІНДУКУЄ NF-kB |
| CN110156766A (zh) * | 2019-06-04 | 2019-08-23 | 南京工业大学 | 一种银催化的氘代五元芳香杂环化合物的制备方法 |
| EP4253372A4 (en) | 2020-12-22 | 2024-11-13 | Kinki University | PHARMACEUTICAL COMPOSITION FOR THE RELIEF OF MALIGNANT DISEASES |
| TW202402269A (zh) * | 2022-05-26 | 2024-01-16 | 大陸商迪哲（江蘇）醫藥股份有限公司 | ＲＯＣＫ（Ｒｈｏ相關激酶）抑制劑及其用途 |
| WO2024029528A1 (ja) | 2022-08-02 | 2024-02-08 | 学校法人近畿大学 | アレルギー性疾患の改善用医薬組成物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3990061B2 (ja) * | 1998-01-05 | 2007-10-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | プリン誘導体および糖尿病の予防・治療剤としてのアデノシンａ２受容体拮抗剤 |
| DE19948417A1 (de) * | 1999-10-07 | 2001-04-19 | Morphochem Ag | Imidazol-Derivate und ihre Verwendung als Arzneimittel |
| CA2564356A1 (en) | 2004-04-26 | 2005-11-03 | Pfizer Inc. | Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors |
| AR056786A1 (es) | 2005-11-10 | 2007-10-24 | Smithkline Beecham Corp | Compuesto de 1h- imidazo ( 4,5-c) piridin-2-ilo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion, su uso para preparar unmedicamento, uso de una combinacion que omprende al compuesto y al menos un agente antineoplasico para preparar un medicamento y dicha com |
| DE102008005493A1 (de) | 2008-01-22 | 2009-07-23 | Merck Patent Gmbh | 4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate |
| JP2011525915A (ja) * | 2008-06-26 | 2011-09-29 | アムジエン・インコーポレーテツド | キナーゼ阻害薬としてのアルキニルアルコール類 |
| US20110201599A1 (en) | 2008-07-03 | 2011-08-18 | Exelixis, Inc. | CDK Modulators |
| US20110183975A1 (en) * | 2008-10-07 | 2011-07-28 | Yasuhiro Goto | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
| CN101723936B (zh) | 2008-10-27 | 2014-01-15 | 上海睿星基因技术有限公司 | 激酶抑制剂及其在药学中的用途 |
| WO2011050245A1 (en) | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
| MX2013010513A (es) | 2011-03-16 | 2013-10-07 | Hoffmann La Roche | Compuestos de alcohol 6,5-heterociclil-propargilico y usos de los mismos. |
| TWI663166B (zh) * | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| KR102523405B1 (ko) | 2014-10-23 | 2023-04-18 | 얀센 파마슈티카 엔.브이. | Ｎｉｋ 억제제로서의 신규 피라졸로피리미딘 유도체 |
| EP3209654B1 (en) | 2014-10-23 | 2018-10-03 | Janssen Pharmaceutica N.V. | New pyrazole derivatives as nik inhibitors |
| CA2960336C (en) | 2014-10-23 | 2023-03-07 | Janssen Pharmaceutica Nv | Compounds as nik inhibitors |
| EA033238B1 (ru) | 2014-10-23 | 2019-09-30 | Янссен Фармацевтика Нв | Новые производные тиенопиримидина в качестве ингибиторов nik |
-
2014
- 2014-09-24 TW TW103132895A patent/TWI627173B/zh not_active IP Right Cessation
- 2014-09-25 CA CA2922633A patent/CA2922633C/en active Active
- 2014-09-25 EP EP14776635.6A patent/EP3049412B1/en active Active
- 2014-09-25 EA EA201690657A patent/EA028101B1/ru not_active IP Right Cessation
- 2014-09-25 AU AU2014327235A patent/AU2014327235B2/en not_active Ceased
- 2014-09-25 WO PCT/EP2014/070489 patent/WO2015044269A1/en not_active Ceased
- 2014-09-25 JP JP2016516870A patent/JP6404332B2/ja not_active Expired - Fee Related
- 2014-09-25 BR BR112016006232-9A patent/BR112016006232B1/pt not_active IP Right Cessation
- 2014-09-25 MX MX2016003863A patent/MX365739B/es active IP Right Grant
- 2014-09-25 ES ES14776635.6T patent/ES2643070T3/es active Active
- 2014-09-25 US US15/024,724 patent/US9981963B2/en active Active
- 2014-09-25 KR KR1020167007902A patent/KR102317335B1/ko not_active Expired - Fee Related
- 2014-09-25 CN CN201480052798.2A patent/CN105579452B/zh not_active Expired - Fee Related
-
2016
- 2016-03-22 IL IL244702A patent/IL244702B/en active IP Right Grant
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016531858A5 (https=) | ||
| JP2016531868A5 (https=) | ||
| JP2017531677A5 (https=) | ||
| JP2014518286A5 (https=) | ||
| ES2817902T3 (es) | N-acil-N'-(piridin-2-il) ureas y análogos que presentan actividades anticancerosas y antiproliferativas | |
| JP2018500343A5 (https=) | ||
| JP2013528204A5 (https=) | ||
| JP2017511357A5 (https=) | ||
| JP2019514874A5 (https=) | ||
| JP2016506369A5 (https=) | ||
| JP2015514808A5 (https=) | ||
| JP2018529739A5 (https=) | ||
| JP2016540742A5 (https=) | ||
| JP2013533883A5 (https=) | ||
| JP2016523270A5 (https=) | ||
| JP2013527136A5 (https=) | ||
| JP2016514719A5 (https=) | ||
| JP2017531678A5 (https=) | ||
| JP2018537413A5 (ja) | 化合物、医薬的に許容される塩又はその立体異性体及び医薬組成物 | |
| JP2014516074A5 (https=) | ||
| JP2017504631A5 (https=) | ||
| JP2014501766A5 (https=) | ||
| JP2015520140A5 (https=) | ||
| JP2016507581A5 (https=) | ||
| MX375556B (es) | Compuestos de benzoxaborol tricíclicos y usos de los mismos. |