JP5159616B2 - アミノシクロヘキシルエーテル化合物の調製のための合成プロセス - Google Patents

アミノシクロヘキシルエーテル化合物の調製のための合成プロセス Download PDF

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JP5159616B2
JP5159616B2 JP2008517192A JP2008517192A JP5159616B2 JP 5159616 B2 JP5159616 B2 JP 5159616B2 JP 2008517192 A JP2008517192 A JP 2008517192A JP 2008517192 A JP2008517192 A JP 2008517192A JP 5159616 B2 JP5159616 B2 JP 5159616B2
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compound
formula
acyl
protecting group
oxygen protecting
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JP2008543874A (ja
JP2008543874A5 (https=
Inventor
グレース ユング，
ジェームス ギー ケン イー，
ダグ タ ハン チョウ，
バートランド エム． シー． プルービエ，
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カーディオム ファーマ コーポレイション
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2008517192A 2005-06-15 2006-06-15 アミノシクロヘキシルエーテル化合物の調製のための合成プロセス Active JP5159616B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US69098905P 2005-06-15 2005-06-15
US60/690,989 2005-06-15
US74824805P 2005-12-07 2005-12-07
US60/748,248 2005-12-07
PCT/US2006/023668 WO2006138673A2 (en) 2005-06-15 2006-06-15 Synthetic processes for the preparation of aminocyclohexyl ether compounds

Publications (3)

Publication Number Publication Date
JP2008543874A JP2008543874A (ja) 2008-12-04
JP2008543874A5 JP2008543874A5 (https=) 2012-02-23
JP5159616B2 true JP5159616B2 (ja) 2013-03-06

Family

ID=37395936

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008517192A Active JP5159616B2 (ja) 2005-06-15 2006-06-15 アミノシクロヘキシルエーテル化合物の調製のための合成プロセス

Country Status (7)

Country Link
US (4) US7754897B2 (https=)
EP (1) EP1915340B1 (https=)
JP (1) JP5159616B2 (https=)
BR (1) BRPI0612138B8 (https=)
CA (1) CA2612375C (https=)
MX (2) MX2007016248A (https=)
WO (1) WO2006138673A2 (https=)

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JP2013032392A (ja) * 2004-11-18 2013-02-14 Cardiome Pharma Corp アミノシクロヘキシルエーテル化合物の合成方法

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MX2007016248A (es) 2005-06-15 2008-03-07 Cardiome Pharma Corp Procedimiento sintetico para la preparacion de compuestos de eter aminociclohexilico.
EA200971025A1 (ru) * 2007-05-04 2010-04-30 Кардиом Фарма Корп. Пероральные композиции с регулируемым высвобождением соединений, модулирующих ионные каналы, и связанные с ними способы предупреждения аритмии
WO2010151551A1 (en) * 2009-06-23 2010-12-29 Medicinova, Inc. ENANTIOMERIC COMPOSITIONS OF 2-AMINO-1-(2-ISOPROPYLPYRAZOLO[1,5-a]PYRIDIN-3-YL)PROPAN-1-ONE AND RELATED METHODS
US9006460B2 (en) 2010-08-16 2015-04-14 Cardiome International Ag Process for preparing aminocyclohexyl ether compounds
EP2606139B1 (en) 2010-08-16 2015-07-15 Codexis, Inc. Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
EP2804602B1 (en) 2012-01-20 2024-12-04 Del Mar Pharmaceuticals Use of substituted hexitols including dianhydrogalactitol and analogs to treat neoplastic disease and cancer stem cells including glioblastoma multforme and medulloblastoma
CA2868302A1 (en) 2012-03-23 2013-09-26 Dennis M. Brown Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
JP6280546B2 (ja) 2012-06-26 2018-02-14 デル マー ファーマシューティカルズ ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法
KR20160061911A (ko) 2013-04-08 2016-06-01 데니스 엠. 브라운 최적하 투여된 화학 화합물의 치료 효과
SG11201608303QA (en) 2014-04-04 2016-11-29 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
IL314380A (en) 2016-10-06 2024-09-01 Orbus Therapeutics Inc Preparations for administration of aflornithine
AU2018260628A1 (en) 2017-04-25 2019-12-12 Temple Otorongo Llc Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions
US12605349B2 (en) 2024-09-05 2026-04-21 Orbus Therapeutics, Inc. Methods of treating grade 3 astrocytoma

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Also Published As

Publication number Publication date
MX346530B (es) 2017-03-22
EP1915340B1 (en) 2013-08-07
US8080673B2 (en) 2011-12-20
US20120065408A1 (en) 2012-03-15
US7754897B2 (en) 2010-07-13
WO2006138673A3 (en) 2007-03-22
US20100217014A1 (en) 2010-08-26
US20070015924A1 (en) 2007-01-18
BRPI0612138A2 (pt) 2010-10-19
US20120271057A9 (en) 2012-10-25
CA2612375A1 (en) 2006-12-28
BRPI0612138B8 (pt) 2021-05-25
WO2006138673A2 (en) 2006-12-28
EP1915340A2 (en) 2008-04-30
US8618311B2 (en) 2013-12-31
CA2612375C (en) 2013-08-06
JP2008543874A (ja) 2008-12-04
BRPI0612138B1 (pt) 2021-03-16
MX2007016248A (es) 2008-03-07
US20130090483A1 (en) 2013-04-11
US8344162B2 (en) 2013-01-01

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