BRPI0514865A - processo para preparar um composto - Google Patents

processo para preparar um composto

Info

Publication number
BRPI0514865A
BRPI0514865A BRPI0514865-0A BRPI0514865A BRPI0514865A BR PI0514865 A BRPI0514865 A BR PI0514865A BR PI0514865 A BRPI0514865 A BR PI0514865A BR PI0514865 A BRPI0514865 A BR PI0514865A
Authority
BR
Brazil
Prior art keywords
oxo
preparing
compound
indolines
dioxo
Prior art date
Application number
BRPI0514865-0A
Other languages
English (en)
Portuguese (pt)
Inventor
George W Muller
Roger Chen
Manohar Tukaram Saindane
Chuansheng Ge
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35385616&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0514865(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of BRPI0514865A publication Critical patent/BRPI0514865A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0514865-0A 2004-09-03 2005-08-31 processo para preparar um composto BRPI0514865A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60740904P 2004-09-03 2004-09-03
PCT/US2005/031318 WO2006028964A1 (en) 2004-09-03 2005-08-31 Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines

Publications (1)

Publication Number Publication Date
BRPI0514865A true BRPI0514865A (pt) 2008-06-24

Family

ID=35385616

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514865-0A BRPI0514865A (pt) 2004-09-03 2005-08-31 processo para preparar um composto

Country Status (22)

Country Link
US (1) US7863451B2 (https=)
EP (2) EP1797068B1 (https=)
JP (2) JP2008512379A (https=)
KR (1) KR20070057907A (https=)
CN (1) CN101080400A (https=)
AR (1) AR050724A1 (https=)
AU (1) AU2005282728A1 (https=)
BR (1) BRPI0514865A (https=)
CA (1) CA2579291C (https=)
ES (2) ES2438725T3 (https=)
GT (1) GT200500242A (https=)
HN (1) HN2005000508A (https=)
IL (1) IL181674A0 (https=)
MX (1) MX2007002521A (https=)
NZ (1) NZ554068A (https=)
PA (1) PA8643901A1 (https=)
PE (1) PE20060648A1 (https=)
SV (1) SV2007002219A (https=)
TW (1) TW200621748A (https=)
UY (1) UY29097A1 (https=)
WO (1) WO2006028964A1 (https=)
ZA (1) ZA200702382B (https=)

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DE102008057335A1 (de) 2008-11-14 2010-05-20 Ratiopharm Gmbh Amorphes Lenalidomid
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WO2011050962A1 (en) 2009-10-29 2011-05-05 Ratiopharm Gmbh Acid addition salts of lenalidomide
CN102060842B (zh) * 2009-11-02 2013-05-08 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物
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CN102127054B (zh) * 2009-11-02 2013-04-03 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物
WO2011069608A1 (en) * 2009-12-09 2011-06-16 Ratiopharm Gmbh S-lenalidomide, polymorphic forms thereof and blend comprising s- und r-lenalidomide
CN101817813B (zh) * 2010-01-15 2013-04-10 南京卡文迪许生物工程技术有限公司 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮晶体ⅳ及其药用组合物
PL3202460T3 (pl) 2010-02-11 2019-12-31 Celgene Corporation Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania
CN102453021A (zh) * 2010-10-22 2012-05-16 重庆医药工业研究院有限责任公司 来那度胺的新晶型及其制备方法
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CN103242215A (zh) * 2013-05-27 2013-08-14 合肥医工医药有限公司 一种来那度胺中间体的制备方法
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CN104447689B (zh) * 2014-12-22 2016-07-20 上海迈柏医药科技有限公司 来那度胺的晶型及其制备方法
TWI793151B (zh) * 2017-08-23 2023-02-21 瑞士商諾華公司 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途
CN108191826A (zh) * 2018-01-08 2018-06-22 浙江省医学科学院 一种来那度胺晶体及其制备方法
FI3784663T3 (fi) 2018-04-23 2023-10-06 Celgene Corp Substituoituja 4-aminoisoindoliini-1,3-dioniyhdisteitä ja niiden käyttö lymfooman hoitamiseksi
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KR20210056397A (ko) * 2018-09-07 2021-05-18 메드샤인 디스커버리 아이엔씨. 삼환식 치환 피페리딘 디온계 화합물
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Also Published As

Publication number Publication date
EP2479172B1 (en) 2013-10-09
ZA200702382B (en) 2008-08-27
KR20070057907A (ko) 2007-06-07
AR050724A1 (es) 2006-11-15
WO2006028964A1 (en) 2006-03-16
CA2579291C (en) 2011-11-29
CA2579291A1 (en) 2006-03-16
JP2012207040A (ja) 2012-10-25
MX2007002521A (es) 2007-05-09
EP1797068B1 (en) 2013-10-09
UY29097A1 (es) 2006-03-31
PA8643901A1 (es) 2006-05-16
IL181674A0 (en) 2007-07-04
CN101080400A (zh) 2007-11-28
NZ554068A (en) 2009-07-31
ES2438725T3 (es) 2014-01-20
SV2007002219A (es) 2007-03-20
JP5701824B2 (ja) 2015-04-15
JP2008512379A (ja) 2008-04-24
TW200621748A (en) 2006-07-01
ES2437592T3 (es) 2014-01-13
PE20060648A1 (es) 2006-07-14
US20060052609A1 (en) 2006-03-09
EP2479172A1 (en) 2012-07-25
US7863451B2 (en) 2011-01-04
EP1797068A1 (en) 2007-06-20
GT200500242A (es) 2006-06-22
AU2005282728A1 (en) 2006-03-16
HN2005000508A (es) 2010-10-08

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