JP2008509970A5 - - Google Patents
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- Publication number
- JP2008509970A5 JP2008509970A5 JP2007526459A JP2007526459A JP2008509970A5 JP 2008509970 A5 JP2008509970 A5 JP 2008509970A5 JP 2007526459 A JP2007526459 A JP 2007526459A JP 2007526459 A JP2007526459 A JP 2007526459A JP 2008509970 A5 JP2008509970 A5 JP 2008509970A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- microvesicles
- gas
- composition according
- filled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 34
- 238000009472 formulation Methods 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 239000008365 aqueous carrier Substances 0.000 claims 3
- 230000005540 biological transmission Effects 0.000 claims 3
- 238000009826 distribution Methods 0.000 claims 3
- 238000003384 imaging method Methods 0.000 claims 3
- 238000007689 inspection Methods 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 239000000843 powder Substances 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 239000012867 bioactive agent Substances 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000003094 microcapsule Substances 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 239000002872 contrast media Substances 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000004530 micro-emulsion Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 229920000771 poly (alkylcyanoacrylate) Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000003223 protective agent Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04019557.0 | 2004-08-18 | ||
| EP04019557 | 2004-08-18 | ||
| PCT/EP2005/054041 WO2006018433A1 (en) | 2004-08-18 | 2005-08-17 | Gas-filled microvesicles composition for contrast imaging |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008509970A JP2008509970A (ja) | 2008-04-03 |
| JP2008509970A5 true JP2008509970A5 (enExample) | 2008-05-15 |
| JP4837663B2 JP4837663B2 (ja) | 2011-12-14 |
Family
ID=34926209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007526459A Expired - Fee Related JP4837663B2 (ja) | 2004-08-18 | 2005-08-17 | 造影画像化のためのガス充填微小胞組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9248204B2 (enExample) |
| EP (1) | EP1784228B1 (enExample) |
| JP (1) | JP4837663B2 (enExample) |
| CN (2) | CN103120799A (enExample) |
| AU (1) | AU2005273865B2 (enExample) |
| CA (1) | CA2575677C (enExample) |
| WO (1) | WO2006018433A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1590006T3 (da) | 2003-02-04 | 2010-12-20 | Bracco Suisse Sa | Ultralydskontrastmidler og fremgangsmåde til frembringelse deraf |
| WO2005063305A1 (en) | 2003-12-22 | 2005-07-14 | Bracco Research Sa | Gas-filled microvesicle assembly for contrast imaging |
| WO2006094951A1 (en) | 2005-03-03 | 2006-09-14 | Bracco Research Sa | Medical imaging system based on a targeted contrast agent |
| US8634608B2 (en) * | 2005-11-10 | 2014-01-21 | Bracco Suisse S.A. | Instantaneous visualization of contrast agent concentration in imaging applications |
| US9198639B2 (en) | 2005-11-10 | 2015-12-01 | Bracco Suisse S.A. | Detection of immobilized contrast agent in medical imaging applications based on flow dynamics analysis |
| CA2670932C (en) | 2006-12-21 | 2016-03-22 | Bracco International Bv | Detection of the detachment of immobilized contrast agent in medical imaging applications |
| US10130342B2 (en) | 2007-12-28 | 2018-11-20 | Bracco Suisse Sa | Initialization of fitting parameters for perfusion assessment based on bolus administration |
| CN101917908B (zh) | 2007-12-28 | 2012-10-03 | 博莱科瑞士股份有限公司 | 医学成像应用中对固定造影剂的量化分析 |
| JP2010005512A (ja) * | 2008-06-25 | 2010-01-14 | Kao Corp | 微細気泡前駆体組成物 |
| GB0811856D0 (en) | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
| CN101745126B (zh) * | 2008-12-10 | 2012-04-25 | 温州医学院 | 一种包载水溶性药物超声造影剂的制备方法 |
| WO2011025893A1 (en) | 2009-08-28 | 2011-03-03 | The Trustees Of Columbia University In The City Of New York | Systems, methods, and devices for production of gas-filled microbubbles |
| EP2566459A1 (en) * | 2010-05-01 | 2013-03-13 | The Trustees of Columbia University in the City of New York | Methods devices and systems of preparing targeted microbubble shells |
| WO2011149985A1 (en) * | 2010-05-24 | 2011-12-01 | Nanovalent Pharmaceuticals, Inc. | Polymerized shell lipid microbubbles and uses thereof |
| BR112015014164B1 (pt) | 2012-12-21 | 2021-12-07 | Bracco Suisse Sa | Método de segmentação de processamento de dados e sistema para aplicações de formação de imagem de diagnóstico. |
| BR112016022401B1 (pt) | 2014-04-07 | 2023-04-04 | Bracco Suisse S.A | Método para uso com um scanner de ultrassom, meio de armazenamento legível por computador, e, sistema |
| KR102720431B1 (ko) | 2015-12-10 | 2024-10-23 | 브라코 스위스 에스.에이. | 동적 역치화에 의한 고정된 조영제의 검출 |
| CN110831665B (zh) * | 2017-06-29 | 2022-03-04 | 医视特有限公司 | 用于破坏靶组织以进行治疗以及评估靶组织破坏的系统 |
| US11035740B1 (en) * | 2017-07-31 | 2021-06-15 | Prasidiux, Llc | Stimulus indicating device employing thermoreversible amphiphilic gels |
| CN111836650B (zh) * | 2018-03-07 | 2024-06-18 | 博莱科瑞士股份有限公司 | 尺寸可控微泡的制备 |
| CN113573803B (zh) * | 2018-12-21 | 2024-05-28 | 博莱科瑞士股份有限公司 | 含有配体的充气微泡 |
| US11246945B2 (en) | 2019-06-07 | 2022-02-15 | National Defense Medical Center | Cisplatin-loaded microbubbles, pharmaceutical composition for treatment of cancer, method for preparing pharmaceutical compositions and method for treating cancer |
| WO2022186224A1 (ja) * | 2021-03-01 | 2022-09-09 | 国立大学法人 東京大学 | マイクロ粒子及びマイクロ粒子分散液 |
| NL2033467B1 (en) | 2022-11-04 | 2024-05-24 | Demcon Curonix B V | System for generating microvesicles having a predefined size and/or size distribution |
| NL2037565B1 (en) | 2024-04-26 | 2025-11-11 | Demcon Curonix B V | Fluid delivery system for providing a flow of microvesicle containing liquid to a subject |
| CN121107681B (zh) * | 2025-11-07 | 2026-02-06 | 陕西新天地固体废物综合处置有限公司 | 一种污泥脱水处理用高效复合絮凝剂及其制备方法 |
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| US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
| WO1985000372A1 (fr) | 1983-07-01 | 1985-01-31 | Battelle Memorial Institute | Polypeptide biodegradable et son utilisation pour le relargage progressif de medicaments |
| SE463651B (sv) * | 1983-12-21 | 1991-01-07 | Nycomed As | Diagnostikum och kontrastmedel |
| DE3581471D1 (de) | 1984-10-19 | 1991-02-28 | Battelle Memorial Institute | Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten. |
| CH667874A5 (fr) * | 1985-12-19 | 1988-11-15 | Battelle Memorial Institute | Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments. |
| IE61591B1 (en) | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
| US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| US6088613A (en) * | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
| US5733572A (en) * | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
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| US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
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| US5556610A (en) | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
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| US5487390A (en) | 1990-10-05 | 1996-01-30 | Massachusetts Institute Of Technology | Gas-filled polymeric microbubbles for ultrasound imaging |
| US5562099A (en) * | 1990-10-05 | 1996-10-08 | Massachusetts Institute Of Technology | Polymeric microparticles containing agents for imaging |
| JP2974083B2 (ja) | 1990-11-26 | 1999-11-08 | 株式会社 小松製作所 | 静油圧―機械式伝動機の制御装置 |
| CA2112905A1 (en) * | 1991-07-05 | 1993-01-21 | Michael R. Violante | Ultrasmall non-aggregated porous particles entrapping gas-bubbles |
| IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
| DE4208527A1 (de) | 1992-03-17 | 1993-09-23 | Max Planck Gesellschaft | Liposomen mit negativer ueberschussladung |
| AU4563093A (en) | 1992-07-03 | 1994-01-31 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Echographic contrast agent composition |
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| SI1482987T1 (sl) | 2002-03-01 | 2014-12-31 | Bracco Suisse Sa | Večvalentni konstrukti za terapevtske in diagnostične aplikacije |
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| DK1590006T3 (da) | 2003-02-04 | 2010-12-20 | Bracco Suisse Sa | Ultralydskontrastmidler og fremgangsmåde til frembringelse deraf |
| EP1696965B1 (en) | 2003-12-22 | 2014-12-10 | Bracco Suisse SA | Assembly of gas-filled microvesicle with active component for contrast imaging |
| WO2005063305A1 (en) | 2003-12-22 | 2005-07-14 | Bracco Research Sa | Gas-filled microvesicle assembly for contrast imaging |
| ATE466596T1 (de) | 2004-01-20 | 2010-05-15 | Sunnybrook & Womens College | Hochfrequenz-ultraschall-darstellung mit kontrastmitteln |
-
2005
- 2005-08-17 US US11/660,188 patent/US9248204B2/en active Active
- 2005-08-17 CN CN201310032548XA patent/CN103120799A/zh active Pending
- 2005-08-17 EP EP05772044.3A patent/EP1784228B1/en not_active Expired - Lifetime
- 2005-08-17 WO PCT/EP2005/054041 patent/WO2006018433A1/en not_active Ceased
- 2005-08-17 CA CA2575677A patent/CA2575677C/en not_active Expired - Lifetime
- 2005-08-17 JP JP2007526459A patent/JP4837663B2/ja not_active Expired - Fee Related
- 2005-08-17 CN CNA2005800280529A patent/CN101005858A/zh active Pending
- 2005-08-17 AU AU2005273865A patent/AU2005273865B2/en not_active Ceased
-
2015
- 2015-12-28 US US14/981,745 patent/US10076580B2/en not_active Expired - Lifetime
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