JP2008509970A5 - - Google Patents

Download PDF

Info

Publication number
JP2008509970A5
JP2008509970A5 JP2007526459A JP2007526459A JP2008509970A5 JP 2008509970 A5 JP2008509970 A5 JP 2008509970A5 JP 2007526459 A JP2007526459 A JP 2007526459A JP 2007526459 A JP2007526459 A JP 2007526459A JP 2008509970 A5 JP2008509970 A5 JP 2008509970A5
Authority
JP
Japan
Prior art keywords
composition
microvesicles
gas
composition according
filled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007526459A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008509970A (ja
JP4837663B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2005/054041 external-priority patent/WO2006018433A1/en
Publication of JP2008509970A publication Critical patent/JP2008509970A/ja
Publication of JP2008509970A5 publication Critical patent/JP2008509970A5/ja
Application granted granted Critical
Publication of JP4837663B2 publication Critical patent/JP4837663B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2007526459A 2004-08-18 2005-08-17 造影画像化のためのガス充填微小胞組成物 Expired - Fee Related JP4837663B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04019557.0 2004-08-18
EP04019557 2004-08-18
PCT/EP2005/054041 WO2006018433A1 (en) 2004-08-18 2005-08-17 Gas-filled microvesicles composition for contrast imaging

Publications (3)

Publication Number Publication Date
JP2008509970A JP2008509970A (ja) 2008-04-03
JP2008509970A5 true JP2008509970A5 (enExample) 2008-05-15
JP4837663B2 JP4837663B2 (ja) 2011-12-14

Family

ID=34926209

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007526459A Expired - Fee Related JP4837663B2 (ja) 2004-08-18 2005-08-17 造影画像化のためのガス充填微小胞組成物

Country Status (7)

Country Link
US (2) US9248204B2 (enExample)
EP (1) EP1784228B1 (enExample)
JP (1) JP4837663B2 (enExample)
CN (2) CN101005858A (enExample)
AU (1) AU2005273865B2 (enExample)
CA (1) CA2575677C (enExample)
WO (1) WO2006018433A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4670083B2 (ja) 2003-02-04 2011-04-13 ブラッコ・シュイス・ソシエテ・アノニム 超音波造影剤およびその製造方法
WO2005063305A1 (en) 2003-12-22 2005-07-14 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
WO2006094951A1 (en) 2005-03-03 2006-09-14 Bracco Research Sa Medical imaging system based on a targeted contrast agent
CA2624608C (en) 2005-11-10 2016-06-07 Bracco Research Sa Detection of immobilized contrast agent in medical imaging applications based on flow dynamics analysis
EP1952349B1 (en) * 2005-11-10 2018-10-17 Bracco Suisse SA Instantaneous visualization of contrast agent concentration in imaging applications
WO2008074889A1 (en) 2006-12-21 2008-06-26 Bracco International Bv Detection of the detachment of immobilized contrast agent in medical imaging applications
JP5524860B2 (ja) 2007-12-28 2014-06-18 ブラッコ・シュイス・ソシエテ・アノニム 医療画像用途における固定化された造影剤の定量分析
US10130342B2 (en) 2007-12-28 2018-11-20 Bracco Suisse Sa Initialization of fitting parameters for perfusion assessment based on bolus administration
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
CN101745126B (zh) * 2008-12-10 2012-04-25 温州医学院 一种包载水溶性药物超声造影剂的制备方法
WO2011025893A1 (en) 2009-08-28 2011-03-03 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
EP2566459A1 (en) * 2010-05-01 2013-03-13 The Trustees of Columbia University in the City of New York Methods devices and systems of preparing targeted microbubble shells
US20130129635A1 (en) * 2010-05-24 2013-05-23 Wilson Sonsini Goodrch & Rosati Polymerized shell lipid microbubbles and uses thereof
WO2014096041A1 (en) 2012-12-21 2014-06-26 Bracco Suisse Sa Segmentation in diagnostic imaging applications based on statistical analysis over time
EP3128921B1 (en) 2014-04-07 2020-06-24 Bracco Suisse SA Estimation of acoustic level in-situ with non-fundamental analysis
KR102720431B1 (ko) 2015-12-10 2024-10-23 브라코 스위스 에스.에이. 동적 역치화에 의한 고정된 조영제의 검출
JP2020525167A (ja) * 2017-06-29 2020-08-27 インサイテック・リミテッド キャビテーション強化型の標的化薬物送達および投与
US11035740B1 (en) * 2017-07-31 2021-06-15 Prasidiux, Llc Stimulus indicating device employing thermoreversible amphiphilic gels
WO2019170606A1 (en) * 2018-03-07 2019-09-12 Bracco Suisse Sa Preparation of size-controlled microvesicles
CN113573803B (zh) * 2018-12-21 2024-05-28 博莱科瑞士股份有限公司 含有配体的充气微泡
US11246945B2 (en) 2019-06-07 2022-02-15 National Defense Medical Center Cisplatin-loaded microbubbles, pharmaceutical composition for treatment of cancer, method for preparing pharmaceutical compositions and method for treating cancer
CN116917029A (zh) * 2021-03-01 2023-10-20 国立大学法人东京大学 微颗粒和微颗粒分散液
NL2033467B1 (en) 2022-11-04 2024-05-24 Demcon Curonix B V System for generating microvesicles having a predefined size and/or size distribution
NL2037565B1 (en) 2024-04-26 2025-11-11 Demcon Curonix B V Fluid delivery system for providing a flow of microvesicle containing liquid to a subject
CN121107681A (zh) * 2025-11-07 2025-12-12 陕西新天地固体废物综合处置有限公司 一种污泥脱水处理用高效复合絮凝剂及其制备方法

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
ATE26584T1 (de) 1983-07-01 1987-05-15 Battelle Memorial Institute In-vivo abbaubares polypeptid und dessen anwendung zur verzoegerten freigabe von medikamenten.
SE463651B (sv) * 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
ATE60340T1 (de) 1984-10-19 1991-02-15 Battelle Memorial Institute Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten.
CH667874A5 (fr) * 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US6146657A (en) * 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US6088613A (en) * 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
IN172208B (enExample) 1990-04-02 1993-05-01 Sint Sa
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5487390A (en) 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
JP2974083B2 (ja) 1990-11-26 1999-11-08 株式会社 小松製作所 静油圧―機械式伝動機の制御装置
AU2317592A (en) * 1991-07-05 1993-02-11 University Of Rochester Ultrasmall non-aggregated porous particles entrapping gas-bubbles
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
DE4208527A1 (de) 1992-03-17 1993-09-23 Max Planck Gesellschaft Liposomen mit negativer ueberschussladung
WO1994001140A1 (de) 1992-07-03 1994-01-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Echokontrastmittelzubereitung
US5464696A (en) 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
ES2231775T5 (es) 1993-07-30 2011-02-02 Imcor Pharmaceutical Co. Composición de microburbujas estabilizadas para ecografía.
US5798091A (en) * 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
HU225495B1 (en) * 1993-12-15 2007-01-29 Bracco Research Sa Gas mixtures useful as ultrasound contrast media
NO940711D0 (no) 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
US5876697A (en) * 1994-08-04 1999-03-02 Gakko Houjin Toin Gakuen Method for the production of microbubble-type ultrasonic contrast agent using fatty acid surfactants
GB9417941D0 (en) 1994-09-06 1994-10-26 Nycomed Imaging As Improvements in or relating to contrast agents
EP0783295A1 (en) 1994-09-23 1997-07-16 The Liposome Company, Inc. Method of producing a lyophilized liposome product
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
IL116328A (en) 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5833948A (en) 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
US6165442A (en) * 1996-02-19 2000-12-26 Nycomed Imaging As Thermally stabilized ultrasound contrast agent
NZ331509A (en) * 1996-02-19 2000-04-28 Nycomed Imaging As Aqueous dispersions of stabilised gas microbubbles and their use as contrast agents
NZ331372A (en) 1996-02-19 2000-01-28 Nycomed Imaging As freeze-dried vesicle containing a thermally stabilized ultrasound contrast agent
WO1998004074A1 (en) 1996-07-22 1998-01-29 Seagate Technology, Inc. Phase detector estimator
DE69739047D1 (de) 1996-08-02 2008-11-27 Ge Healthcare As Verbesserungen für oder in bezug auf kontrastmittel
RU2204415C2 (ru) * 1996-10-21 2003-05-20 Амершем Хелт АС Комбинированный препарат для использования в качестве контрастного агента и способ получения изображения
NZ335799A (en) 1996-10-28 2000-11-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
WO1998018501A2 (en) 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
US6331289B1 (en) * 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
GB9701237D0 (en) * 1997-01-22 1997-03-12 Nycomed Imaging As Improvements in or relating to contrast agents
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6245318B1 (en) * 1997-05-27 2001-06-12 Mallinckrodt Inc. Selectively binding ultrasound contrast agents
GB9717589D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
AU9550498A (en) 1997-10-21 1999-05-10 Nycomed Imaging As Ultrasound imaging with contrast agent targeted to microvasculature and a vasodilator drug
US20020169138A1 (en) * 1997-10-24 2002-11-14 Southern Research Institute Delivery vehicles for bioactive agents and uses thereof
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
ES2244169T3 (es) * 1998-02-09 2005-12-01 Bracco International B.V. Suministro direccionado de medios biologicamente activos.
GB9808599D0 (en) 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
FR2782006B1 (fr) 1998-08-07 2002-04-19 Gattefosse Ets Sa Composition a liberation prolongee apte a former une micro-emulsion
JP2000143550A (ja) 1998-11-10 2000-05-23 Toin Gakuen 超音波造影剤
DE10013850A1 (de) * 2000-03-15 2001-09-20 Schering Ag Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung
JP3991086B2 (ja) 2000-12-23 2007-10-17 ダイアックス、コープ 造影剤として有用なフィブリン結合部分
US6793626B2 (en) * 2001-01-17 2004-09-21 Fuji Photo Film Co., Ltd. Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus
JP2002212108A (ja) 2001-01-17 2002-07-31 Fuji Photo Film Co Ltd 超音波散乱体
US7179449B2 (en) * 2001-01-30 2007-02-20 Barnes-Jewish Hospital Enhanced ultrasound detection with temperature-dependent contrast agents
ATE299378T1 (de) 2001-01-31 2005-07-15 Bracco Research Sa Lyophilisierbares kontrastmittel, gasgefüllte mikrobläschen enthaltend
WO2003005029A2 (en) 2001-07-03 2003-01-16 Governors Of The University Of Alberta Magnetic nanoparticles for bioseparation application and methods for producing same
CA2456988A1 (en) 2001-08-16 2003-02-27 Alan P. Carpenter, Jr. Gas microsphere liposome composites
EP2014310B8 (en) 2002-03-01 2012-12-26 Dyax Corp. KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
EP1482987B1 (en) 2002-03-01 2014-08-13 Bracco Suisse SA Multivalent constructs for therapeutic and diagnostic applications
EP1518028B1 (fr) 2002-06-19 2011-11-09 Dimitrios Patsalaridis Dispositif de support ancrable dans le sol
US7459145B2 (en) * 2002-10-25 2008-12-02 Georgia Tech Research Corporation Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
JP4670083B2 (ja) 2003-02-04 2011-04-13 ブラッコ・シュイス・ソシエテ・アノニム 超音波造影剤およびその製造方法
CA2545362C (en) 2003-12-22 2013-02-12 Bracco Research Sa Assembly of gas-filled microvesicle with active component for contrast imaging
WO2005063305A1 (en) 2003-12-22 2005-07-14 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
US8708909B2 (en) 2004-01-20 2014-04-29 Fujifilm Visualsonics, Inc. High frequency ultrasound imaging using contrast agents

Similar Documents

Publication Publication Date Title
JP2008509970A5 (enExample)
JP4901469B2 (ja) 生物学的利用能および/または溶解度を増大させるための含浸粉末とその製造方法
DE69535203T2 (de) Mikrokapseln, verfahren zur herstellung und ihre anwendung
US10076580B2 (en) Gas-filled microvesicles composition for contrast imaging
JP2523069B2 (ja) 経口投与用薬物の微細カプセル化方法
KR101330096B1 (ko) 구연산, 산화 마그네슘, 중탄산칼륨 및 피코황산나트륨을 포함하는 의약품의 제조 방법, 이러한 방법에 의해 제조된 과립을 포함하는 약제학적 조성물 및 중간체
CN109316440A (zh) 一种温敏性液晶纳米水凝胶及其制备方法与应用
JPWO2006115198A1 (ja) 多孔質セルロース凝集体及びその成型体組成物
WO1995007072A2 (de) Wirkstoffe und gas enthaltende mikropartikel
JP2002080398A (ja) pHに依存する多相的な放出を伴う経口用の固体の薬学的組成物
WO2005073286A1 (ja) 多孔質セルロース凝集体及びその成型体組成物
Zhou et al. Folate-targeted perfluorohexane nanoparticles carrying bismuth sulfide for use in US/CT dual-mode imaging and synergistic high-intensity focused ultrasound ablation of cervical cancer
CN105079829B (zh) 一种口服高回声腹部胃肠道超声检查助显剂及其制备方法
CN112055581B (zh) 利用包含纳米气泡和药物的药物载体的超声波诱导药物传递系统
CN102764456A (zh) 血管栓塞剂及其用途、制备方法
JPS61227520A (ja) マイクロスフエア
US20220288227A1 (en) Ultrasound Responsive Microbubbles And Related Methods
CN108498849A (zh) 一种液晶凝胶肝动脉栓塞剂及其制备方法
CN101721719B (zh) 超声造影剂及其制备方法
CN105106963B (zh) 马来酸曲美布汀缓释制剂及其制备方法
KR100646446B1 (ko) 나노캡슐화된 생리활성물질의 필름제제 및 그 제조방법
CN101015701A (zh) 在体反应式微气泡超声造影剂及其制备方法
CN102125610A (zh) 小金缓释微丸及其组合物
CN115068421A (zh) 一种瑞卢戈利纳米混悬液及其制备方法和应用
CN100500223C (zh) 高分子聚合材料声学造影剂及其制备方法