AU2005273865B2 - Gas-filled microvesicles composition for contrast imaging - Google Patents

Gas-filled microvesicles composition for contrast imaging Download PDF

Info

Publication number
AU2005273865B2
AU2005273865B2 AU2005273865A AU2005273865A AU2005273865B2 AU 2005273865 B2 AU2005273865 B2 AU 2005273865B2 AU 2005273865 A AU2005273865 A AU 2005273865A AU 2005273865 A AU2005273865 A AU 2005273865A AU 2005273865 B2 AU2005273865 B2 AU 2005273865B2
Authority
AU
Australia
Prior art keywords
microvesicles
gas
composition according
mhz
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005273865A
Other languages
English (en)
Other versions
AU2005273865A1 (en
Inventor
Philippe Bussat
Peter Frinking
Christian Guillot
Michel Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco Suisse SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse SA filed Critical Bracco Suisse SA
Publication of AU2005273865A1 publication Critical patent/AU2005273865A1/en
Application granted granted Critical
Publication of AU2005273865B2 publication Critical patent/AU2005273865B2/en
Assigned to BRACCO SUISSE S.A. reassignment BRACCO SUISSE S.A. Request to Amend Deed and Register Assignors: BRACCO RESEARCH SA
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
AU2005273865A 2004-08-18 2005-08-17 Gas-filled microvesicles composition for contrast imaging Ceased AU2005273865B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04019557.0 2004-08-18
EP04019557 2004-08-18
PCT/EP2005/054041 WO2006018433A1 (en) 2004-08-18 2005-08-17 Gas-filled microvesicles composition for contrast imaging

Publications (2)

Publication Number Publication Date
AU2005273865A1 AU2005273865A1 (en) 2006-02-23
AU2005273865B2 true AU2005273865B2 (en) 2011-02-24

Family

ID=34926209

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005273865A Ceased AU2005273865B2 (en) 2004-08-18 2005-08-17 Gas-filled microvesicles composition for contrast imaging

Country Status (7)

Country Link
US (2) US9248204B2 (enExample)
EP (1) EP1784228B1 (enExample)
JP (1) JP4837663B2 (enExample)
CN (2) CN101005858A (enExample)
AU (1) AU2005273865B2 (enExample)
CA (1) CA2575677C (enExample)
WO (1) WO2006018433A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4670083B2 (ja) 2003-02-04 2011-04-13 ブラッコ・シュイス・ソシエテ・アノニム 超音波造影剤およびその製造方法
WO2005063305A1 (en) 2003-12-22 2005-07-14 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
WO2006094951A1 (en) 2005-03-03 2006-09-14 Bracco Research Sa Medical imaging system based on a targeted contrast agent
CA2624608C (en) 2005-11-10 2016-06-07 Bracco Research Sa Detection of immobilized contrast agent in medical imaging applications based on flow dynamics analysis
EP1952349B1 (en) * 2005-11-10 2018-10-17 Bracco Suisse SA Instantaneous visualization of contrast agent concentration in imaging applications
WO2008074889A1 (en) 2006-12-21 2008-06-26 Bracco International Bv Detection of the detachment of immobilized contrast agent in medical imaging applications
JP5524860B2 (ja) 2007-12-28 2014-06-18 ブラッコ・シュイス・ソシエテ・アノニム 医療画像用途における固定化された造影剤の定量分析
US10130342B2 (en) 2007-12-28 2018-11-20 Bracco Suisse Sa Initialization of fitting parameters for perfusion assessment based on bolus administration
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
CN101745126B (zh) * 2008-12-10 2012-04-25 温州医学院 一种包载水溶性药物超声造影剂的制备方法
WO2011025893A1 (en) 2009-08-28 2011-03-03 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
EP2566459A1 (en) * 2010-05-01 2013-03-13 The Trustees of Columbia University in the City of New York Methods devices and systems of preparing targeted microbubble shells
US20130129635A1 (en) * 2010-05-24 2013-05-23 Wilson Sonsini Goodrch & Rosati Polymerized shell lipid microbubbles and uses thereof
WO2014096041A1 (en) 2012-12-21 2014-06-26 Bracco Suisse Sa Segmentation in diagnostic imaging applications based on statistical analysis over time
EP3128921B1 (en) 2014-04-07 2020-06-24 Bracco Suisse SA Estimation of acoustic level in-situ with non-fundamental analysis
KR102720431B1 (ko) 2015-12-10 2024-10-23 브라코 스위스 에스.에이. 동적 역치화에 의한 고정된 조영제의 검출
JP2020525167A (ja) * 2017-06-29 2020-08-27 インサイテック・リミテッド キャビテーション強化型の標的化薬物送達および投与
US11035740B1 (en) * 2017-07-31 2021-06-15 Prasidiux, Llc Stimulus indicating device employing thermoreversible amphiphilic gels
WO2019170606A1 (en) * 2018-03-07 2019-09-12 Bracco Suisse Sa Preparation of size-controlled microvesicles
CN113573803B (zh) * 2018-12-21 2024-05-28 博莱科瑞士股份有限公司 含有配体的充气微泡
US11246945B2 (en) 2019-06-07 2022-02-15 National Defense Medical Center Cisplatin-loaded microbubbles, pharmaceutical composition for treatment of cancer, method for preparing pharmaceutical compositions and method for treating cancer
CN116917029A (zh) * 2021-03-01 2023-10-20 国立大学法人东京大学 微颗粒和微颗粒分散液
NL2033467B1 (en) 2022-11-04 2024-05-24 Demcon Curonix B V System for generating microvesicles having a predefined size and/or size distribution
NL2037565B1 (en) 2024-04-26 2025-11-11 Demcon Curonix B V Fluid delivery system for providing a flow of microvesicle containing liquid to a subject
CN121107681A (zh) * 2025-11-07 2025-12-12 陕西新天地固体废物综合处置有限公司 一种污泥脱水处理用高效复合絮凝剂及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
WO1996007434A1 (en) * 1994-09-06 1996-03-14 Marsden, John, Christopher Improvements in or relating to contrast agents
WO1998032468A1 (en) * 1997-01-22 1998-07-30 Nycomed Imaging As Contrast agents containing two types of gas filled microbubbles
WO2001068150A1 (en) * 2000-03-15 2001-09-20 Schering Aktiengesellschaft Microcapsules comprising functionalised polyalkylcyanoacrylates

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE26584T1 (de) 1983-07-01 1987-05-15 Battelle Memorial Institute In-vivo abbaubares polypeptid und dessen anwendung zur verzoegerten freigabe von medikamenten.
SE463651B (sv) * 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
ATE60340T1 (de) 1984-10-19 1991-02-15 Battelle Memorial Institute Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten.
CH667874A5 (fr) * 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US6146657A (en) * 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US6088613A (en) * 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
IN172208B (enExample) 1990-04-02 1993-05-01 Sint Sa
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5487390A (en) 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
JP2974083B2 (ja) 1990-11-26 1999-11-08 株式会社 小松製作所 静油圧―機械式伝動機の制御装置
AU2317592A (en) * 1991-07-05 1993-02-11 University Of Rochester Ultrasmall non-aggregated porous particles entrapping gas-bubbles
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
DE4208527A1 (de) 1992-03-17 1993-09-23 Max Planck Gesellschaft Liposomen mit negativer ueberschussladung
WO1994001140A1 (de) 1992-07-03 1994-01-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Echokontrastmittelzubereitung
US5464696A (en) 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
ES2231775T5 (es) 1993-07-30 2011-02-02 Imcor Pharmaceutical Co. Composición de microburbujas estabilizadas para ecografía.
US5798091A (en) * 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
HU225495B1 (en) * 1993-12-15 2007-01-29 Bracco Research Sa Gas mixtures useful as ultrasound contrast media
NO940711D0 (no) 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
US5876697A (en) * 1994-08-04 1999-03-02 Gakko Houjin Toin Gakuen Method for the production of microbubble-type ultrasonic contrast agent using fatty acid surfactants
EP0783295A1 (en) 1994-09-23 1997-07-16 The Liposome Company, Inc. Method of producing a lyophilized liposome product
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
IL116328A (en) 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5833948A (en) 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
US6165442A (en) * 1996-02-19 2000-12-26 Nycomed Imaging As Thermally stabilized ultrasound contrast agent
NZ331509A (en) * 1996-02-19 2000-04-28 Nycomed Imaging As Aqueous dispersions of stabilised gas microbubbles and their use as contrast agents
NZ331372A (en) 1996-02-19 2000-01-28 Nycomed Imaging As freeze-dried vesicle containing a thermally stabilized ultrasound contrast agent
WO1998004074A1 (en) 1996-07-22 1998-01-29 Seagate Technology, Inc. Phase detector estimator
DE69739047D1 (de) 1996-08-02 2008-11-27 Ge Healthcare As Verbesserungen für oder in bezug auf kontrastmittel
RU2204415C2 (ru) * 1996-10-21 2003-05-20 Амершем Хелт АС Комбинированный препарат для использования в качестве контрастного агента и способ получения изображения
NZ335799A (en) 1996-10-28 2000-11-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
WO1998018501A2 (en) 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
US6331289B1 (en) * 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6245318B1 (en) * 1997-05-27 2001-06-12 Mallinckrodt Inc. Selectively binding ultrasound contrast agents
GB9717589D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
AU9550498A (en) 1997-10-21 1999-05-10 Nycomed Imaging As Ultrasound imaging with contrast agent targeted to microvasculature and a vasodilator drug
US20020169138A1 (en) * 1997-10-24 2002-11-14 Southern Research Institute Delivery vehicles for bioactive agents and uses thereof
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
ES2244169T3 (es) * 1998-02-09 2005-12-01 Bracco International B.V. Suministro direccionado de medios biologicamente activos.
GB9808599D0 (en) 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
FR2782006B1 (fr) 1998-08-07 2002-04-19 Gattefosse Ets Sa Composition a liberation prolongee apte a former une micro-emulsion
JP2000143550A (ja) 1998-11-10 2000-05-23 Toin Gakuen 超音波造影剤
JP3991086B2 (ja) 2000-12-23 2007-10-17 ダイアックス、コープ 造影剤として有用なフィブリン結合部分
US6793626B2 (en) * 2001-01-17 2004-09-21 Fuji Photo Film Co., Ltd. Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus
JP2002212108A (ja) 2001-01-17 2002-07-31 Fuji Photo Film Co Ltd 超音波散乱体
US7179449B2 (en) * 2001-01-30 2007-02-20 Barnes-Jewish Hospital Enhanced ultrasound detection with temperature-dependent contrast agents
ATE299378T1 (de) 2001-01-31 2005-07-15 Bracco Research Sa Lyophilisierbares kontrastmittel, gasgefüllte mikrobläschen enthaltend
WO2003005029A2 (en) 2001-07-03 2003-01-16 Governors Of The University Of Alberta Magnetic nanoparticles for bioseparation application and methods for producing same
CA2456988A1 (en) 2001-08-16 2003-02-27 Alan P. Carpenter, Jr. Gas microsphere liposome composites
EP2014310B8 (en) 2002-03-01 2012-12-26 Dyax Corp. KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
EP1482987B1 (en) 2002-03-01 2014-08-13 Bracco Suisse SA Multivalent constructs for therapeutic and diagnostic applications
EP1518028B1 (fr) 2002-06-19 2011-11-09 Dimitrios Patsalaridis Dispositif de support ancrable dans le sol
US7459145B2 (en) * 2002-10-25 2008-12-02 Georgia Tech Research Corporation Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
JP4670083B2 (ja) 2003-02-04 2011-04-13 ブラッコ・シュイス・ソシエテ・アノニム 超音波造影剤およびその製造方法
CA2545362C (en) 2003-12-22 2013-02-12 Bracco Research Sa Assembly of gas-filled microvesicle with active component for contrast imaging
WO2005063305A1 (en) 2003-12-22 2005-07-14 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
US8708909B2 (en) 2004-01-20 2014-04-29 Fujifilm Visualsonics, Inc. High frequency ultrasound imaging using contrast agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
WO1996007434A1 (en) * 1994-09-06 1996-03-14 Marsden, John, Christopher Improvements in or relating to contrast agents
WO1998032468A1 (en) * 1997-01-22 1998-07-30 Nycomed Imaging As Contrast agents containing two types of gas filled microbubbles
WO2001068150A1 (en) * 2000-03-15 2001-09-20 Schering Aktiengesellschaft Microcapsules comprising functionalised polyalkylcyanoacrylates

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DE JONG N et al: Ultrasonics, GB, vol. 30, no. 2, 1 March 1992, pages 95-103 *
GORCE JEAN-MARIE et al: Investigative Radiology, vol. 35, no. 11, November 2000, pages 661-671, *
SCHNEIDER M et al:Investigative Radiology, vol. 30, no. 8, 1 August 1995, pages 451-457 *

Also Published As

Publication number Publication date
EP1784228B1 (en) 2016-10-05
AU2005273865A1 (en) 2006-02-23
JP2008509970A (ja) 2008-04-03
JP4837663B2 (ja) 2011-12-14
CA2575677A1 (en) 2006-02-23
WO2006018433A1 (en) 2006-02-23
US10076580B2 (en) 2018-09-18
US9248204B2 (en) 2016-02-02
CN103120799A (zh) 2013-05-29
CA2575677C (en) 2013-01-22
EP1784228A1 (en) 2007-05-16
US20160184464A1 (en) 2016-06-30
US20080008657A1 (en) 2008-01-10
CN101005858A (zh) 2007-07-25

Similar Documents

Publication Publication Date Title
US10076580B2 (en) Gas-filled microvesicles composition for contrast imaging
JP5513708B2 (ja) 造影イメージング用の気体封入マイクロベシクル・アセンブリー
EP1590006B1 (en) Ultrasound contrast agents and process for the preparation thereof
AU2007293888B2 (en) Gas-filled microvesicles with polymer-modified lipids
EP1696965B1 (en) Assembly of gas-filled microvesicle with active component for contrast imaging

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired