JP4837663B2 - 造影画像化のためのガス充填微小胞組成物 - Google Patents

造影画像化のためのガス充填微小胞組成物 Download PDF

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Publication number
JP4837663B2
JP4837663B2 JP2007526459A JP2007526459A JP4837663B2 JP 4837663 B2 JP4837663 B2 JP 4837663B2 JP 2007526459 A JP2007526459 A JP 2007526459A JP 2007526459 A JP2007526459 A JP 2007526459A JP 4837663 B2 JP4837663 B2 JP 4837663B2
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Prior art keywords
microvesicles
gas
particle size
microvesicle
composition
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Japanese (ja)
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JP2008509970A (ja
JP2008509970A5 (enExample
Inventor
フィリップ・ビュサ
ペーテル・フリンキング
クリスティアン・ギヨ
ミシェル・シュナイダー
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Bracco Suisse SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
JP2007526459A 2004-08-18 2005-08-17 造影画像化のためのガス充填微小胞組成物 Expired - Fee Related JP4837663B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04019557.0 2004-08-18
EP04019557 2004-08-18
PCT/EP2005/054041 WO2006018433A1 (en) 2004-08-18 2005-08-17 Gas-filled microvesicles composition for contrast imaging

Publications (3)

Publication Number Publication Date
JP2008509970A JP2008509970A (ja) 2008-04-03
JP2008509970A5 JP2008509970A5 (enExample) 2008-05-15
JP4837663B2 true JP4837663B2 (ja) 2011-12-14

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JP2007526459A Expired - Fee Related JP4837663B2 (ja) 2004-08-18 2005-08-17 造影画像化のためのガス充填微小胞組成物

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US (2) US9248204B2 (enExample)
EP (1) EP1784228B1 (enExample)
JP (1) JP4837663B2 (enExample)
CN (2) CN101005858A (enExample)
AU (1) AU2005273865B2 (enExample)
CA (1) CA2575677C (enExample)
WO (1) WO2006018433A1 (enExample)

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JP4670083B2 (ja) 2003-02-04 2011-04-13 ブラッコ・シュイス・ソシエテ・アノニム 超音波造影剤およびその製造方法
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JP5524860B2 (ja) 2007-12-28 2014-06-18 ブラッコ・シュイス・ソシエテ・アノニム 医療画像用途における固定化された造影剤の定量分析
US10130342B2 (en) 2007-12-28 2018-11-20 Bracco Suisse Sa Initialization of fitting parameters for perfusion assessment based on bolus administration
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
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CN101745126B (zh) * 2008-12-10 2012-04-25 温州医学院 一种包载水溶性药物超声造影剂的制备方法
WO2011025893A1 (en) 2009-08-28 2011-03-03 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
EP2566459A1 (en) * 2010-05-01 2013-03-13 The Trustees of Columbia University in the City of New York Methods devices and systems of preparing targeted microbubble shells
US20130129635A1 (en) * 2010-05-24 2013-05-23 Wilson Sonsini Goodrch & Rosati Polymerized shell lipid microbubbles and uses thereof
WO2014096041A1 (en) 2012-12-21 2014-06-26 Bracco Suisse Sa Segmentation in diagnostic imaging applications based on statistical analysis over time
EP3128921B1 (en) 2014-04-07 2020-06-24 Bracco Suisse SA Estimation of acoustic level in-situ with non-fundamental analysis
KR102720431B1 (ko) 2015-12-10 2024-10-23 브라코 스위스 에스.에이. 동적 역치화에 의한 고정된 조영제의 검출
JP2020525167A (ja) * 2017-06-29 2020-08-27 インサイテック・リミテッド キャビテーション強化型の標的化薬物送達および投与
US11035740B1 (en) * 2017-07-31 2021-06-15 Prasidiux, Llc Stimulus indicating device employing thermoreversible amphiphilic gels
WO2019170606A1 (en) * 2018-03-07 2019-09-12 Bracco Suisse Sa Preparation of size-controlled microvesicles
CN113573803B (zh) * 2018-12-21 2024-05-28 博莱科瑞士股份有限公司 含有配体的充气微泡
US11246945B2 (en) 2019-06-07 2022-02-15 National Defense Medical Center Cisplatin-loaded microbubbles, pharmaceutical composition for treatment of cancer, method for preparing pharmaceutical compositions and method for treating cancer
CN116917029A (zh) * 2021-03-01 2023-10-20 国立大学法人东京大学 微颗粒和微颗粒分散液
NL2033467B1 (en) 2022-11-04 2024-05-24 Demcon Curonix B V System for generating microvesicles having a predefined size and/or size distribution
NL2037565B1 (en) 2024-04-26 2025-11-11 Demcon Curonix B V Fluid delivery system for providing a flow of microvesicle containing liquid to a subject
CN121107681A (zh) * 2025-11-07 2025-12-12 陕西新天地固体废物综合处置有限公司 一种污泥脱水处理用高效复合絮凝剂及其制备方法

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Also Published As

Publication number Publication date
EP1784228B1 (en) 2016-10-05
AU2005273865A1 (en) 2006-02-23
JP2008509970A (ja) 2008-04-03
CA2575677A1 (en) 2006-02-23
AU2005273865B2 (en) 2011-02-24
WO2006018433A1 (en) 2006-02-23
US10076580B2 (en) 2018-09-18
US9248204B2 (en) 2016-02-02
CN103120799A (zh) 2013-05-29
CA2575677C (en) 2013-01-22
EP1784228A1 (en) 2007-05-16
US20160184464A1 (en) 2016-06-30
US20080008657A1 (en) 2008-01-10
CN101005858A (zh) 2007-07-25

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