CA2575677C - Gas-filled microvesicles composition for contrast imaging - Google Patents

Gas-filled microvesicles composition for contrast imaging Download PDF

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Publication number
CA2575677C
CA2575677C CA2575677A CA2575677A CA2575677C CA 2575677 C CA2575677 C CA 2575677C CA 2575677 A CA2575677 A CA 2575677A CA 2575677 A CA2575677 A CA 2575677A CA 2575677 C CA2575677 C CA 2575677C
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CA
Canada
Prior art keywords
microvesicles
gas
preparations
mhz
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2575677A
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English (en)
French (fr)
Other versions
CA2575677A1 (en
Inventor
Philippe Bussat
Peter Frinking
Christian Guillot
Michel Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
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Bracco Suisse SA
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Publication date
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Publication of CA2575677A1 publication Critical patent/CA2575677A1/en
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Publication of CA2575677C publication Critical patent/CA2575677C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
CA2575677A 2004-08-18 2005-08-17 Gas-filled microvesicles composition for contrast imaging Expired - Lifetime CA2575677C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04019557.0 2004-08-18
EP04019557 2004-08-18
PCT/EP2005/054041 WO2006018433A1 (en) 2004-08-18 2005-08-17 Gas-filled microvesicles composition for contrast imaging

Publications (2)

Publication Number Publication Date
CA2575677A1 CA2575677A1 (en) 2006-02-23
CA2575677C true CA2575677C (en) 2013-01-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2575677A Expired - Lifetime CA2575677C (en) 2004-08-18 2005-08-17 Gas-filled microvesicles composition for contrast imaging

Country Status (7)

Country Link
US (2) US9248204B2 (enExample)
EP (1) EP1784228B1 (enExample)
JP (1) JP4837663B2 (enExample)
CN (2) CN103120799A (enExample)
AU (1) AU2005273865B2 (enExample)
CA (1) CA2575677C (enExample)
WO (1) WO2006018433A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1590006B1 (en) 2003-02-04 2010-09-08 Bracco Suisse SA Ultrasound contrast agents and process for the preparation thereof
CA2547024C (en) 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
EP1866663A1 (en) 2005-03-03 2007-12-19 Bracco Research S.A. Medical imaging system based on a targeted contrast agent
CN101304690B (zh) 2005-11-10 2011-06-08 伯拉考国际股份公司 基于流体力学分析在医学成像应用中检测固定造影剂
JP2009515578A (ja) * 2005-11-10 2009-04-16 ブラッコ・リサーチ・ソシエテ・アノニム 画像化アプリケーションの造影剤濃度の即時の可視化
WO2008074889A1 (en) 2006-12-21 2008-06-26 Bracco International Bv Detection of the detachment of immobilized contrast agent in medical imaging applications
JP5524860B2 (ja) 2007-12-28 2014-06-18 ブラッコ・シュイス・ソシエテ・アノニム 医療画像用途における固定化された造影剤の定量分析
US10130342B2 (en) 2007-12-28 2018-11-20 Bracco Suisse Sa Initialization of fitting parameters for perfusion assessment based on bolus administration
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
CN101745126B (zh) * 2008-12-10 2012-04-25 温州医学院 一种包载水溶性药物超声造影剂的制备方法
US10058837B2 (en) 2009-08-28 2018-08-28 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
US20130101521A1 (en) * 2010-05-01 2013-04-25 The Trustees Of Columbia University In The City Of New York Methods devices and systems of preparing targeted microbubble shells
WO2011149985A1 (en) * 2010-05-24 2011-12-01 Nanovalent Pharmaceuticals, Inc. Polymerized shell lipid microbubbles and uses thereof
EP2936433B1 (en) 2012-12-21 2018-09-19 Bracco Suisse SA Segmentation in diagnostic imaging applications based on statistical analysis over time
BR112016022401B1 (pt) 2014-04-07 2023-04-04 Bracco Suisse S.A Método para uso com um scanner de ultrassom, meio de armazenamento legível por computador, e, sistema
WO2017097738A1 (en) 2015-12-10 2017-06-15 Bracco Suisse Sa Detection of immobilized contrast agent with dynamic thresholding
CN111032157B (zh) * 2017-06-29 2023-04-21 医视特有限公司 基于模拟的药物治疗计划
US11035740B1 (en) * 2017-07-31 2021-06-15 Prasidiux, Llc Stimulus indicating device employing thermoreversible amphiphilic gels
CN111836650B (zh) * 2018-03-07 2024-06-18 博莱科瑞士股份有限公司 尺寸可控微泡的制备
CA3120179A1 (en) 2018-12-21 2020-06-25 Bracco Suisse Sa Gas-filled microvesicles with ligand
US11246945B2 (en) 2019-06-07 2022-02-15 National Defense Medical Center Cisplatin-loaded microbubbles, pharmaceutical composition for treatment of cancer, method for preparing pharmaceutical compositions and method for treating cancer
EP3990033B1 (en) 2019-06-25 2023-12-06 Bracco Suisse SA Freeze-dried composition for preparing calibrated gas-filled microvesicles
JP7221505B2 (ja) * 2021-03-01 2023-02-14 国立大学法人 東京大学 マイクロ粒子及びマイクロ粒子分散液
NL2033467B1 (en) 2022-11-04 2024-05-24 Demcon Curonix B V System for generating microvesicles having a predefined size and/or size distribution
NL2037565B1 (en) 2024-04-26 2025-11-11 Demcon Curonix B V Fluid delivery system for providing a flow of microvesicle containing liquid to a subject
CN121107681B (zh) * 2025-11-07 2026-02-06 陕西新天地固体废物综合处置有限公司 一种污泥脱水处理用高效复合絮凝剂及其制备方法

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
JPS60501759A (ja) 1983-07-01 1985-10-17 バテル　メモリアル　インステイチユ−ト 生物分解性ポリペプチド及び薬剤の緩慢な放出のためのその使用
SE463651B (sv) 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
DE3581471D1 (de) 1984-10-19 1991-02-28 Battelle Memorial Institute Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten.
CH667874A5 (fr) 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
IN172208B (enExample) 1990-04-02 1993-05-01 Sint Sa
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5562099A (en) 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
US5487390A (en) 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
JP2974083B2 (ja) 1990-11-26 1999-11-08 株式会社 小松製作所 静油圧―機械式伝動機の制御装置
AU2317592A (en) 1991-07-05 1993-02-11 University Of Rochester Ultrasmall non-aggregated porous particles entrapping gas-bubbles
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
DE4208527A1 (de) 1992-03-17 1993-09-23 Max Planck Gesellschaft Liposomen mit negativer ueberschussladung
AU4563093A (en) 1992-07-03 1994-01-31 Byk Gulden Lomberg Chemische Fabrik Gmbh Echographic contrast agent composition
US5464696A (en) 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
ES2231775T5 (es) 1993-07-30 2011-02-02 Imcor Pharmaceutical Co. Composición de microburbujas estabilizadas para ecografía.
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
PL182223B1 (pl) * 1993-12-15 2001-11-30 Bracco Research Sa Biokompatybilna faza rozproszona do otrzymywania srodka kontrastowego do badan ultradzwiekowych, srodek kontrastowy do badan ultradzwiekowych, suchy preparat srodka kontrastowego oraz dwuskladnikowy zestaw do otrzymywania srodka kontrastowego do badan ultradzwiekowych PL PL PL
NO940711D0 (no) 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
EP0699445A3 (en) * 1994-08-04 1996-04-17 Gakko Houjin Toin Gakuen Process for the preparation of an ultrasonic microbubble contrast agent with a surfactant
GB9417941D0 (en) * 1994-09-06 1994-10-26 Nycomed Imaging As Improvements in or relating to contrast agents
WO1996009037A1 (en) 1994-09-23 1996-03-28 The Liposome Company, Inc. Method of producing a lyophilized liposome product
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
IL116328A (en) 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5833948A (en) 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
DE69721235T2 (de) 1996-02-19 2004-02-05 Amersham Health As Verbesserungen an (oder im bezug auf) kontrastmittel
US6165442A (en) 1996-02-19 2000-12-26 Nycomed Imaging As Thermally stabilized ultrasound contrast agent
DE69720979T2 (de) 1996-02-19 2004-02-26 Amersham Health As Thermostabilisiertes kontrastmittel
US6263032B1 (en) 1996-07-22 2001-07-17 Seagate Technology Llc Phase detector estimator
KR100593873B1 (ko) 1996-08-02 2006-07-03 지이 헬스케어 에이에스 조영제
MXPA99003664A (es) 1996-10-21 2002-06-11 Nycomed Imaging As Mejoras relacionadas con agentes de contraste.
US6331289B1 (en) 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
CA2269985A1 (en) 1996-10-28 1998-05-07 Aslak Godal Improvements in or relating to diagnostic/therapeutic agents
EP0973552B1 (en) 1996-10-28 2006-03-01 Amersham Health AS Improvements in or relating to diagnostic/therapeutic agents
GB9701237D0 (en) 1997-01-22 1997-03-12 Nycomed Imaging As Improvements in or relating to contrast agents
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6245318B1 (en) 1997-05-27 2001-06-12 Mallinckrodt Inc. Selectively binding ultrasound contrast agents
GB9717589D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
WO1999020312A1 (en) 1997-10-21 1999-04-29 Nycomed Imaging As Ultrasound imaging with contrast agent targeted to microvasculature and a vasodilator drug
US20020169138A1 (en) 1997-10-24 2002-11-14 Southern Research Institute Delivery vehicles for bioactive agents and uses thereof
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
AU753196B2 (en) * 1998-02-09 2002-10-10 Bracco Research S.A. Targeted delivery of biologically active media
GB9808599D0 (en) 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
FR2782006B1 (fr) 1998-08-07 2002-04-19 Gattefosse Ets Sa Composition a liberation prolongee apte a former une micro-emulsion
JP2000143550A (ja) 1998-11-10 2000-05-23 Toin Gakuen 超音波造影剤
DE10013850A1 (de) 2000-03-15 2001-09-20 Schering Ag Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung
AU2002248222B2 (en) 2000-12-23 2006-04-27 Dyax Corp. Fibrin binding polypeptides useful inter alia in medical imaging processes
US6793626B2 (en) 2001-01-17 2004-09-21 Fuji Photo Film Co., Ltd. Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus
JP2002212108A (ja) 2001-01-17 2002-07-31 Fuji Photo Film Co Ltd 超音波散乱体
US7179449B2 (en) 2001-01-30 2007-02-20 Barnes-Jewish Hospital Enhanced ultrasound detection with temperature-dependent contrast agents
ES2243350T3 (es) 2001-01-31 2005-12-01 Bracco International B.V. Agente de contraste liofizable que comprende microburbujas de gas.
WO2003005029A2 (en) 2001-07-03 2003-01-16 Governors Of The University Of Alberta Magnetic nanoparticles for bioseparation application and methods for producing same
CN1620314A (zh) 2001-08-16 2005-05-25 布里斯托尔-迈尔斯斯奎布药品公司 气体微球脂质体复合体
JP2005519980A (ja) 2002-03-01 2005-07-07 ブラッコ インターナショナル ビー．ヴイ． 治療および診断用途の多価構成物
SI2301587T1 (sl) 2002-03-01 2014-11-28 Dyax Corp. KDR in VEGF/KDR vezavni peptidi in njihova uporaba pri diagnozi
AU2002344871A1 (en) 2002-06-19 2004-01-06 Dimitrios Patsalaridis Support device designed to be anchored in the ground
WO2004083902A2 (en) 2002-10-25 2004-09-30 Georgia Tech Research Corporation Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
EP1590006B1 (en) 2003-02-04 2010-09-08 Bracco Suisse SA Ultrasound contrast agents and process for the preparation thereof
ES2531751T3 (es) 2003-12-22 2015-03-18 Bracco Suisse Sa Montaje de microvesícula rellena de gas con componente activo para imagenología de contraste
CA2547024C (en) 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
EP1715897B2 (en) 2004-01-20 2013-10-30 Sunnybrook and Women's College Health Sciences Centre High frequency ultrasound imaging using contrast agents

Also Published As

Publication number Publication date
JP2008509970A (ja) 2008-04-03
US10076580B2 (en) 2018-09-18
US20160184464A1 (en) 2016-06-30
AU2005273865B2 (en) 2011-02-24
US20080008657A1 (en) 2008-01-10
CN101005858A (zh) 2007-07-25
CN103120799A (zh) 2013-05-29
EP1784228A1 (en) 2007-05-16
JP4837663B2 (ja) 2011-12-14
AU2005273865A1 (en) 2006-02-23
WO2006018433A1 (en) 2006-02-23
EP1784228B1 (en) 2016-10-05
US9248204B2 (en) 2016-02-02
CA2575677A1 (en) 2006-02-23

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Legal Events

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EEER Examination request
H11 Ip right ceased following rejected request for revival

Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED

Effective date: 20250219