WO1998032468A1 - Contrast agents containing two types of gas filled microbubbles - Google Patents
Contrast agents containing two types of gas filled microbubbles Download PDFInfo
- Publication number
- WO1998032468A1 WO1998032468A1 PCT/GB1998/000189 GB9800189W WO9832468A1 WO 1998032468 A1 WO1998032468 A1 WO 1998032468A1 GB 9800189 W GB9800189 W GB 9800189W WO 9832468 A1 WO9832468 A1 WO 9832468A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gas
- preparation
- types
- microparticle
- phospholipid
- Prior art date
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- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000008227 sterile water for injection Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU56740/98A AU5674098A (en) | 1997-01-22 | 1998-01-22 | Contrast agents containing two types of gas filled microbubbles |
JP53172098A JP2001508454A (en) | 1997-01-22 | 1998-01-22 | Contrast agents containing two types of gas-filled microbubbles |
EP98900940A EP0966305A1 (en) | 1997-01-22 | 1998-01-22 | Contrast agents containing two types of gas filled microbubbles |
CA002278750A CA2278750A1 (en) | 1997-01-22 | 1998-01-22 | Contrast agents containing two types of gas filled microbubbles |
US09/078,274 US6054118A (en) | 1997-01-22 | 1998-05-14 | Contrast agents comprising two types of gas-containing microparticles |
NO993438A NO993438D0 (en) | 1997-01-22 | 1999-07-13 | Ultrasound contrast agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9701237.1A GB9701237D0 (en) | 1997-01-22 | 1997-01-22 | Improvements in or relating to contrast agents |
GB9701237.1 | 1997-01-22 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/078,274 Continuation US6054118A (en) | 1997-01-22 | 1998-05-14 | Contrast agents comprising two types of gas-containing microparticles |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998032468A1 true WO1998032468A1 (en) | 1998-07-30 |
Family
ID=10806374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1998/000189 WO1998032468A1 (en) | 1997-01-22 | 1998-01-22 | Contrast agents containing two types of gas filled microbubbles |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0966305A1 (en) |
JP (1) | JP2001508454A (en) |
CN (1) | CN1244131A (en) |
AU (1) | AU5674098A (en) |
CA (1) | CA2278750A1 (en) |
GB (1) | GB9701237D0 (en) |
NO (1) | NO993438D0 (en) |
WO (1) | WO1998032468A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999013916A2 (en) * | 1997-09-18 | 1999-03-25 | Nycomed Imaging As | Methods and compositions for medical imaging |
WO2006018433A1 (en) * | 2004-08-18 | 2006-02-23 | Bracco Research Sa | Gas-filled microvesicles composition for contrast imaging |
US8569233B2 (en) | 2008-09-26 | 2013-10-29 | Eli Lilly And Company | Modified animal erythropoietin polypeptides and their uses |
US9364569B2 (en) | 2003-02-04 | 2016-06-14 | Bracco Suisse S.A. | Ultrasound contrast agents and process for the preparation thereof |
US9750821B2 (en) | 2003-12-22 | 2017-09-05 | Bracco Suisse S.A. | Gas-filled microvesicle assembly for contrast imaging |
CN113521317A (en) * | 2021-07-01 | 2021-10-22 | 中国科学院深圳先进技术研究院 | Ultrasonic molecular composite imaging method for double-targeting tumor |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5689416B2 (en) * | 2008-07-23 | 2015-03-25 | コーニンクレッカ フィリップス エヌ ヴェ | Ultrasound-mediated drug delivery |
CN109529033A (en) * | 2018-07-09 | 2019-03-29 | 彭盛 | A kind of stable oxygen carrier microvesicle and its preparation method and application |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0494615A1 (en) * | 1991-01-09 | 1992-07-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Echo contrast agent |
WO1996007434A1 (en) * | 1994-09-06 | 1996-03-14 | Marsden, John, Christopher | Improvements in or relating to contrast agents |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5585112A (en) * | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
DK0711179T3 (en) * | 1993-07-30 | 2005-02-14 | Imcor Pharmaceutical Co | Stabilized ultrasound microbubble compositions |
-
1997
- 1997-01-22 GB GBGB9701237.1A patent/GB9701237D0/en active Pending
-
1998
- 1998-01-22 CN CN 98801948 patent/CN1244131A/en active Pending
- 1998-01-22 CA CA002278750A patent/CA2278750A1/en not_active Abandoned
- 1998-01-22 JP JP53172098A patent/JP2001508454A/en not_active Ceased
- 1998-01-22 AU AU56740/98A patent/AU5674098A/en not_active Abandoned
- 1998-01-22 WO PCT/GB1998/000189 patent/WO1998032468A1/en active Application Filing
- 1998-01-22 EP EP98900940A patent/EP0966305A1/en not_active Ceased
-
1999
- 1999-07-13 NO NO993438A patent/NO993438D0/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0494615A1 (en) * | 1991-01-09 | 1992-07-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Echo contrast agent |
WO1996007434A1 (en) * | 1994-09-06 | 1996-03-14 | Marsden, John, Christopher | Improvements in or relating to contrast agents |
Non-Patent Citations (7)
Title |
---|
ALEXANDER A L ET AL: "MICROBUBBLES AS NOVEL PRESSURE-SENSITIVE MR CONTRAST AGENTS", MAGNETIC RESONANCE IN MEDICINE, vol. 35, no. 6, 1 June 1996 (1996-06-01), pages 801 - 806, XP000594132 * |
JONG DE N: "IMPROVEMENTS IN ULTRASOUND CONTRAST AGENTS", IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, vol. 15, no. 6, November 1996 (1996-11-01), pages 72 - 82, XP000638030 * |
MARUYAMA, KAZUO ET AL: "Lipid composition is important for highly efficient target binding and retention of immunoliposomes", PROC. NATL. ACAD. SCI. U. S. A., 1990, VOL. 87, NO. 15, PAGES 5744-5748, XP002060195 * |
OPHIR J ET AL: "CONTRAST AGENTS IN DIAGNOSTIC ULTRASOUND", ULTRASOUND IN MEDICINE AND BIOLOGY, vol. 15, no. 4, 1989, pages 319 - 333, XP000611239 * |
PORTE T R ET AL: "A SUB-THERAPEUTIC QUANTITY OF AMINOPHYLLINE MIXED WITH PERFLUOROPROPANE-ENHANCED SONICATED DEXTROSE ALBUMIN PRODUCES SIGNIFICANTLY IMPROVED MYOCARDIAL ULTRASOUND OPACIFICATION FOLLOWING INTRAVENOUS INJECTION", CIRCULATION, vol. 90, no. 4, PART 02, 14 November 1994 (1994-11-14), pages 1556, XP000577053 * |
PORTER T K ET AL: "Effect of microbubble gas molecular weight on myocardial contrast produced from an intravenous injection", 68TH SCIENTIFIC SESSION OF THE AMERICAN HEART ASSOCIATION, ANAHEIM, CALIFORNIA, USA, NOVEMBER 13-16, 1995. CIRCULATION, 1995, VOL. 92, NO. 8 SUPPL., PAGE(S) I463., XP002060196 * |
SCHNEIDER M ET AL: "BR1:A NEW ULTRASONOGRAPHIC CONTRAST AGENT BASED ON SULFUR HEXAFLUORIDE-FILLED MICROBUBBLES", INVESTIGATIVE RADIOLOGY, vol. 30, no. 8, August 1995 (1995-08-01), pages 451 - 457, XP002018821 * |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999013916A2 (en) * | 1997-09-18 | 1999-03-25 | Nycomed Imaging As | Methods and compositions for medical imaging |
WO1999013916A3 (en) * | 1997-09-18 | 2001-12-20 | Nycomed Imaging As | Methods and compositions for medical imaging |
US9364569B2 (en) | 2003-02-04 | 2016-06-14 | Bracco Suisse S.A. | Ultrasound contrast agents and process for the preparation thereof |
US9750821B2 (en) | 2003-12-22 | 2017-09-05 | Bracco Suisse S.A. | Gas-filled microvesicle assembly for contrast imaging |
WO2006018433A1 (en) * | 2004-08-18 | 2006-02-23 | Bracco Research Sa | Gas-filled microvesicles composition for contrast imaging |
US20080008657A1 (en) * | 2004-08-18 | 2008-01-10 | Bracco Research S.A. | Gas- Filled Microvesicles Composition for Contrast Imaging |
AU2005273865B2 (en) * | 2004-08-18 | 2011-02-24 | Bracco Suisse S.A. | Gas-filled microvesicles composition for contrast imaging |
CN103120799A (en) * | 2004-08-18 | 2013-05-29 | 博莱科瑞士股份有限公司 | Gas-filled microvesicles composition for contrast imaging |
US9248204B2 (en) | 2004-08-18 | 2016-02-02 | Bracco Suisse S.A. | Gas-filled microvesicles composition for contrast imaging |
US10076580B2 (en) | 2004-08-18 | 2018-09-18 | Bracco Suisse S.A. | Gas-filled microvesicles composition for contrast imaging |
US8569233B2 (en) | 2008-09-26 | 2013-10-29 | Eli Lilly And Company | Modified animal erythropoietin polypeptides and their uses |
CN113521317A (en) * | 2021-07-01 | 2021-10-22 | 中国科学院深圳先进技术研究院 | Ultrasonic molecular composite imaging method for double-targeting tumor |
Also Published As
Publication number | Publication date |
---|---|
NO993438L (en) | 1999-07-13 |
AU5674098A (en) | 1998-08-18 |
GB9701237D0 (en) | 1997-03-12 |
CA2278750A1 (en) | 1998-07-30 |
NO993438D0 (en) | 1999-07-13 |
JP2001508454A (en) | 2001-06-26 |
CN1244131A (en) | 2000-02-09 |
EP0966305A1 (en) | 1999-12-29 |
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