WO1999013916A3 - Methods and compositions for medical imaging - Google Patents

Methods and compositions for medical imaging Download PDF

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Publication number
WO1999013916A3
WO1999013916A3 PCT/GB1998/002833 GB9802833W WO9913916A3 WO 1999013916 A3 WO1999013916 A3 WO 1999013916A3 GB 9802833 W GB9802833 W GB 9802833W WO 9913916 A3 WO9913916 A3 WO 9913916A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
compositions
methods
medical imaging
material
scavenger
Prior art date
Application number
PCT/GB1998/002833
Other languages
French (fr)
Other versions
WO1999013916A2 (en )
Inventor
Paul Mark Henrichs
Vinay Chandrakant Desai
Daniel Joseph Delecki
Robert Allen Snow
Gregory Lynn Mcintire
Virginia Ann Gates
Original Assignee
Nycomed Imaging As
Towler Philip Dean
Paul Mark Henrichs
Vinay Chandrakant Desai
Daniel Joseph Delecki
Robert Allen Snow
Gregory Lynn Mcintire
Virginia Ann Gates
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0063Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0084Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure

Abstract

The invention provides a composition comprising physiologically tolerable vesicles which comprise (i) a vesicle membrane forming material, (ii) at least one chromophore material having a light absorption maximum in the range 300 to 1300 nm, and (iii) a scavenger, optionally together with at least one pharmaceutically acceptable carrier or excipient.
PCT/GB1998/002833 1997-09-18 1998-09-18 Methods and compositions for medical imaging WO1999013916A3 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB9719932A GB9719932D0 (en) 1997-09-18 1997-09-18 Composition
GB9719932.7 1997-09-18
US6926397 true 1997-09-26 1997-09-26

Publications (2)

Publication Number Publication Date
WO1999013916A2 true WO1999013916A2 (en) 1999-03-25
WO1999013916A3 true true WO1999013916A3 (en) 2001-12-20

Family

ID=26312282

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/002833 WO1999013916A3 (en) 1997-09-18 1998-09-18 Methods and compositions for medical imaging

Country Status (1)

Country Link
WO (1) WO1999013916A3 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9809217D0 (en) * 1998-04-29 1998-07-01 Nycomed Imaging As Compounds
DE10115740A1 (en) 2001-03-26 2002-10-02 Ulrich Speck Preparation for the prophylaxis of restenosis
EP2070487B1 (en) 2002-08-13 2014-03-05 NeuroArm Surgical, Ltd. Microsurgical robot system
DE10244847A1 (en) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck A medical device for drug delivery
US8355776B2 (en) 2005-05-27 2013-01-15 Board Of Regents, The University Of Texas System Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus
US7801590B2 (en) 2005-05-27 2010-09-21 Board Of Regents, The University Of Texas System Optical coherence tomographic detection of cells and killing of the same
WO2006128167A3 (en) 2005-05-27 2009-05-14 Mark D Feldman Optical coherence tomographic detection of cells and compositions
EP1815870A1 (en) * 2006-02-01 2007-08-08 DKFZ Deutsches Krebsforschungszentrum Cyanine dye compounds linked to metal chelator for bi-modal diagnostic imaging
WO2009009786A3 (en) 2007-07-12 2010-01-28 Board Of Regents, The University Of Texas System Magneto-motive ultrasound detection of magnetic nanoparticles
CN103038629B (en) * 2010-05-31 2015-07-08 卫材R&D管理有限公司 Fluorescent probe for imaging lymph nodes

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0274174A1 (en) * 1985-12-06 1988-07-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome/anthraquinone drug composition and method
DE3935257A1 (en) * 1989-10-23 1991-04-25 Langhals Heinz Liposome(s) contg. fluorescent marker and coupled to antibody - useful as diagnostic reagent and for targetted delivery of therapeutic agent for treating cancer, malaria etc.
EP0569113A1 (en) * 1992-02-05 1993-11-10 Quadra Logic Technologies Inc. Liposome compositions of porphyrin photosensitizers
US5286474A (en) * 1992-10-22 1994-02-15 Arizona Board Of Regents, A Body Corporate, Acting For And On Behalf The Arizona State University Use of carotenoporphyrins as tumor localizing agents for diagnosis
WO1994023646A1 (en) * 1993-04-20 1994-10-27 Mallinckrodt Medical, Inc. Stabilization of voltage sensitive dyes
DE4445065A1 (en) * 1994-12-07 1996-06-13 Diagnostikforschung Inst A method for in vivo diagnostics by means of NIR-radiation
WO1996023524A1 (en) * 1995-02-02 1996-08-08 Nycomed Imaging A/S Contrast media for in vivo imaging based on light transmission on reflection
WO1997004746A1 (en) * 1995-08-02 1997-02-13 Qlt Phototherapeutics, Inc. Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizers
US5650166A (en) * 1993-12-30 1997-07-22 L'oreal Moisturizing composition for the simultaneous treatment of the surface layers and deep layers of the skin, and use thereof
WO1998032468A1 (en) * 1997-01-22 1998-07-30 Nycomed Imaging As Contrast agents containing two types of gas filled microbubbles

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0274174A1 (en) * 1985-12-06 1988-07-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome/anthraquinone drug composition and method
DE3935257A1 (en) * 1989-10-23 1991-04-25 Langhals Heinz Liposome(s) contg. fluorescent marker and coupled to antibody - useful as diagnostic reagent and for targetted delivery of therapeutic agent for treating cancer, malaria etc.
EP0569113A1 (en) * 1992-02-05 1993-11-10 Quadra Logic Technologies Inc. Liposome compositions of porphyrin photosensitizers
US5286474A (en) * 1992-10-22 1994-02-15 Arizona Board Of Regents, A Body Corporate, Acting For And On Behalf The Arizona State University Use of carotenoporphyrins as tumor localizing agents for diagnosis
WO1994023646A1 (en) * 1993-04-20 1994-10-27 Mallinckrodt Medical, Inc. Stabilization of voltage sensitive dyes
US5650166A (en) * 1993-12-30 1997-07-22 L'oreal Moisturizing composition for the simultaneous treatment of the surface layers and deep layers of the skin, and use thereof
DE4445065A1 (en) * 1994-12-07 1996-06-13 Diagnostikforschung Inst A method for in vivo diagnostics by means of NIR-radiation
WO1996023524A1 (en) * 1995-02-02 1996-08-08 Nycomed Imaging A/S Contrast media for in vivo imaging based on light transmission on reflection
WO1997004746A1 (en) * 1995-08-02 1997-02-13 Qlt Phototherapeutics, Inc. Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizers
WO1998032468A1 (en) * 1997-01-22 1998-07-30 Nycomed Imaging As Contrast agents containing two types of gas filled microbubbles

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
GABER M H ET AL: "Thermosensitive liposomes: extravasation and release of contents in tumor microvascular networks.", INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY, BIOLOGY, PHYSICS, (1996 DEC 1) 36 (5) 1177-87. JOURNAL CODE: G97. ISSN: 0360-3016., United States, XP002101952 *
SAKO M ET AL: "CT evaluation of extravascular perfusion of contrast medium and its potential to a new method of diagnosis: an experimental study using macro, micro-molecular contrast media.", NIPPON IGAKU HOSHASEN GAKKAI ZASSHI. NIPPON ACTA RADIOLOGICA, (1994 MAR 25) 54 (4) 289-91. JOURNAL CODE: O3G. ISSN: 0048-0428., Japan, XP002101954 *
SCHOTT, H. ET AL.: "Labeling of Liposomes with Intercalating Perylene Fluorescent Dyes", BIOCHIMICA AND BIOPHYSICA ACTA, vol. 1110, no. 2, 1992, pages 151 - 157, XP002091008 *
SINGH, A. ET AL.: "Interactions Involving the Cyanine Dye, diS-C3-(5), Cytochrome c and Liposomes and their Implications for Estimations of Delta(psi) in Cytochrome c Oxidase-Reconstituted Proteoliposomes.", JOURNAL OF MEMBRANE BIOLOGY, vol. 84, no. 2, 1985, pages 183 - 190, XP002091009 *
TERPETSCHNIG E ET AL: "AN INVESTIGATION OF SQUARAINES AS A NEW CLASS OF FLUOROPHORES WITH LONG-WAVELENGTH EXCITATION AND EMISSION", JOURNAL OF FLUORESCENCE, vol. 3, no. 3, 1 September 1993 (1993-09-01), pages 153 - 155, XP000563720 *
UNEZAKI, SAKAE ET AL: "Direct measurement of the extravasation of polyethyleneglycol-coated liposomes into solid tumor tissue by in vivo fluorescence microscopy", INT. J. PHARM. (1996), 144(1), 11-17 CODEN: IJPHDE;ISSN: 0378-5173, XP002101953 *

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