JP2008504275A5 - - Google Patents
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- Publication number
- JP2008504275A5 JP2008504275A5 JP2007518277A JP2007518277A JP2008504275A5 JP 2008504275 A5 JP2008504275 A5 JP 2008504275A5 JP 2007518277 A JP2007518277 A JP 2007518277A JP 2007518277 A JP2007518277 A JP 2007518277A JP 2008504275 A5 JP2008504275 A5 JP 2008504275A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxamide
- cycloalkyl
- piperidine
- alkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 150
- 125000000753 cycloalkyl group Chemical group 0.000 claims 146
- 125000000217 alkyl group Chemical group 0.000 claims 116
- 125000001072 heteroaryl group Chemical group 0.000 claims 112
- 125000003118 aryl group Chemical group 0.000 claims 109
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 78
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 76
- 125000003710 aryl alkyl group Chemical group 0.000 claims 69
- -1 bicyclo [2.2.1] hept-2-yl Chemical group 0.000 claims 69
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 69
- 229910052799 carbon Inorganic materials 0.000 claims 60
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 53
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 52
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 52
- 125000005843 halogen group Chemical group 0.000 claims 50
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 41
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 37
- 229910052739 hydrogen Inorganic materials 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 27
- BVOCPVIXARZNQN-UHFFFAOYSA-N nipecotamide Chemical compound NC(=O)C1CCCNC1 BVOCPVIXARZNQN-UHFFFAOYSA-N 0.000 claims 26
- 125000005466 alkylenyl group Chemical group 0.000 claims 24
- 125000004432 carbon atom Chemical group C* 0.000 claims 24
- 125000003545 alkoxy group Chemical group 0.000 claims 22
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 18
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 17
- 125000003282 alkyl amino group Chemical group 0.000 claims 16
- 125000004663 dialkyl amino group Chemical group 0.000 claims 16
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 13
- 229910052760 oxygen Inorganic materials 0.000 claims 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- 125000004429 atom Chemical group 0.000 claims 12
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 12
- 125000001188 haloalkyl group Chemical group 0.000 claims 10
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 9
- 125000000304 alkynyl group Chemical group 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 125000004965 chloroalkyl group Chemical group 0.000 claims 8
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000004438 haloalkoxy group Chemical group 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 3
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 3
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- NDYJWJFQPIDNLG-HDYDNRTBSA-N (3s)-1-(benzenesulfonyl)-n-(4-pyridin-4-yloxycyclohexyl)piperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)S(=O)(=O)C=1C=CC=CC=1)NC(CC1)CCC1OC1=CC=NC=C1 NDYJWJFQPIDNLG-HDYDNRTBSA-N 0.000 claims 2
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 2
- 125000006276 2-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 2
- 125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 claims 2
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000004306 triazinyl group Chemical group 0.000 claims 2
- AMBKZGFFDSCPJG-AWEZNQCLSA-N (3s)-1-(1,3-benzoxazol-2-yl)-n-cyclohexylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1OC2=CC=CC=C2N=1)NC1CCCCC1 AMBKZGFFDSCPJG-AWEZNQCLSA-N 0.000 claims 1
- AHJAIDWSOJFPJG-HNNXBMFYSA-N (3s)-1-(2-bromophenyl)sulfonyl-n-cycloheptylpiperidine-3-carboxamide Chemical compound BrC1=CC=CC=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCCCC2)CCC1 AHJAIDWSOJFPJG-HNNXBMFYSA-N 0.000 claims 1
- QJYURUPTZDMAJM-AWEZNQCLSA-N (3s)-1-(2-chlorophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound ClC1=CC=CC=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCCC2)CCC1 QJYURUPTZDMAJM-AWEZNQCLSA-N 0.000 claims 1
- FARNHWJISQHRJI-INIZCTEOSA-N (3s)-1-(2-cyanophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)S(=O)(=O)C=1C(=CC=CC=1)C#N)NC1CCCCC1 FARNHWJISQHRJI-INIZCTEOSA-N 0.000 claims 1
- ZLZOAMCBQXFVAE-ZDUSSCGKSA-N (3s)-1-(3-chloro-2-fluorophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound FC1=C(Cl)C=CC=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCCC2)CCC1 ZLZOAMCBQXFVAE-ZDUSSCGKSA-N 0.000 claims 1
- ZLPRPBUYUNTRAJ-INIZCTEOSA-N (3s)-1-(3-chloro-2-methylphenyl)sulfonyl-n-cycloheptylpiperidine-3-carboxamide Chemical compound CC1=C(Cl)C=CC=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCCCC2)CCC1 ZLPRPBUYUNTRAJ-INIZCTEOSA-N 0.000 claims 1
- ODRPEKCTTLECBX-HNNXBMFYSA-N (3s)-1-(3-chloro-2-methylphenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound CC1=C(Cl)C=CC=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCCC2)CCC1 ODRPEKCTTLECBX-HNNXBMFYSA-N 0.000 claims 1
- WTKUGAUSIFXIGA-AWEZNQCLSA-N (3s)-1-(3-chloro-2-methylphenyl)sulfonyl-n-cyclopentylpiperidine-3-carboxamide Chemical compound CC1=C(Cl)C=CC=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCC2)CCC1 WTKUGAUSIFXIGA-AWEZNQCLSA-N 0.000 claims 1
- SFFOXPSWWCTHRH-ZDUSSCGKSA-N (3s)-1-(3-chloro-4-fluorophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound C1=C(Cl)C(F)=CC=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCCC2)CCC1 SFFOXPSWWCTHRH-ZDUSSCGKSA-N 0.000 claims 1
- DSPKYDUEARCYFC-HNNXBMFYSA-N (3s)-1-(3-chlorophenyl)sulfonyl-n-cycloheptylpiperidine-3-carboxamide Chemical compound ClC1=CC=CC(S(=O)(=O)N2C[C@H](CCC2)C(=O)NC2CCCCCC2)=C1 DSPKYDUEARCYFC-HNNXBMFYSA-N 0.000 claims 1
- XOVDTJFMSZZWBV-AWEZNQCLSA-N (3s)-1-(3-chlorophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound ClC1=CC=CC(S(=O)(=O)N2C[C@H](CCC2)C(=O)NC2CCCCC2)=C1 XOVDTJFMSZZWBV-AWEZNQCLSA-N 0.000 claims 1
- SROXMWXRTDHRDS-ZDUSSCGKSA-N (3s)-1-(3-chlorophenyl)sulfonyl-n-cyclopentylpiperidine-3-carboxamide Chemical compound ClC1=CC=CC(S(=O)(=O)N2C[C@H](CCC2)C(=O)NC2CCCC2)=C1 SROXMWXRTDHRDS-ZDUSSCGKSA-N 0.000 claims 1
- JPOSBXGZRHTMRE-KRWDZBQOSA-N (3s)-1-(4-cyano-2-methylphenyl)-n-cyclohexylpiperidine-3-carboxamide Chemical compound CC1=CC(C#N)=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 JPOSBXGZRHTMRE-KRWDZBQOSA-N 0.000 claims 1
- XEDBAWHPEVFYKJ-GRTSSRMGSA-N (3s)-1-(5-bromopyridin-2-yl)-n-(4-hydroxycyclohexyl)piperidine-3-carboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C=2N=CC(Br)=CC=2)CCC1 XEDBAWHPEVFYKJ-GRTSSRMGSA-N 0.000 claims 1
- VRLHYJZLHNZLLB-ZDUSSCGKSA-N (3s)-1-(5-chloro-2-fluorophenyl)sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound FC1=CC=C(Cl)C=C1S(=O)(=O)N1C[C@@H](C(=O)NC2CCCCC2)CCC1 VRLHYJZLHNZLLB-ZDUSSCGKSA-N 0.000 claims 1
- UAUJJONANRDGHF-SFHVURJKSA-N (3s)-1-[3-(2-chlorophenoxy)phenyl]sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound ClC1=CC=CC=C1OC1=CC=CC(S(=O)(=O)N2C[C@H](CCC2)C(=O)NC2CCCCC2)=C1 UAUJJONANRDGHF-SFHVURJKSA-N 0.000 claims 1
- NNWBZHNCDBZVBJ-SFHVURJKSA-N (3s)-1-[3-(4-chlorophenoxy)phenyl]sulfonyl-n-cyclohexylpiperidine-3-carboxamide Chemical compound C1=CC(Cl)=CC=C1OC1=CC=CC(S(=O)(=O)N2C[C@H](CCC2)C(=O)NC2CCCCC2)=C1 NNWBZHNCDBZVBJ-SFHVURJKSA-N 0.000 claims 1
- UQNNZVYRXWWHGK-VIQWUECVSA-N (3s)-1-[5-(3,4-difluorophenyl)pyridin-2-yl]-n-(4-hydroxycyclohexyl)piperidine-3-carboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C=2N=CC(=CC=2)C=2C=C(F)C(F)=CC=2)CCC1 UQNNZVYRXWWHGK-VIQWUECVSA-N 0.000 claims 1
- WEJLANVJOSNDMX-PELRDEGISA-N (3s)-1-[5-(4-chlorophenyl)pyridin-2-yl]-n-(4-hydroxycyclohexyl)piperidine-3-carboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C=2N=CC(=CC=2)C=2C=CC(Cl)=CC=2)CCC1 WEJLANVJOSNDMX-PELRDEGISA-N 0.000 claims 1
- NBNZATXXBBNSND-GTPINHCMSA-N (3s)-1-benzoyl-n-(4-hydroxycyclohexyl)piperidine-3-carboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C(=O)C=2C=CC=CC=2)CCC1 NBNZATXXBBNSND-GTPINHCMSA-N 0.000 claims 1
- NKJQWRYYURKPNV-KRWDZBQOSA-N (3s)-1-phenyl-n-(2-phenylpropan-2-yl)piperidine-3-carboxamide Chemical compound C([C@@H](C1)C(=O)NC(C)(C)C=2C=CC=CC=2)CCN1C1=CC=CC=C1 NKJQWRYYURKPNV-KRWDZBQOSA-N 0.000 claims 1
- CAERBIPFBFQLQI-OOHWJJMZSA-N (3s)-3-n-(4-hydroxycyclohexyl)-1-n-phenylpiperidine-1,3-dicarboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C(=O)NC=2C=CC=CC=2)CCC1 CAERBIPFBFQLQI-OOHWJJMZSA-N 0.000 claims 1
- RCVUAUUNAWOXMV-ONUXSRJRSA-N (3s)-n-(1-adamantyl)-1-phenylpiperidine-3-carboxamide Chemical compound C([C@@H](C1)C(NC23CC4CC(CC(C4)C2)C3)=O)CCN1C1=CC=CC=C1 RCVUAUUNAWOXMV-ONUXSRJRSA-N 0.000 claims 1
- LQIWZYZIPDRHIL-INIZCTEOSA-N (3s)-n-(1-methylcyclohexyl)-1-phenylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1C=CC=CC=1)NC1(C)CCCCC1 LQIWZYZIPDRHIL-INIZCTEOSA-N 0.000 claims 1
- RAOIEIGLRGMSIY-COIXEQEXSA-N (3s)-n-(3-hydroxy-1-adamantyl)-1-phenylpiperidine-3-carboxamide Chemical compound C([C@@H](C1)C(=O)NC23CC4CC(C2)CC(C4)(C3)O)CCN1C1=CC=CC=C1 RAOIEIGLRGMSIY-COIXEQEXSA-N 0.000 claims 1
- CRAVCTWTIULTBS-AOCRQIFASA-N (3s)-n-(4-hydroxycyclohexyl)-1-(2-methylquinolin-4-yl)piperidine-3-carboxamide Chemical compound O=C([C@H]1CCCN(C1)C=1C=C(N=C2C=CC=CC2=1)C)NC1CCC(O)CC1 CRAVCTWTIULTBS-AOCRQIFASA-N 0.000 claims 1
- WGNFHUKHVIFQDE-MWXLCCTBSA-N (3s)-n-(4-hydroxycyclohexyl)-1-(5-phenylpyridin-2-yl)piperidine-3-carboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C=2N=CC(=CC=2)C=2C=CC=CC=2)CCC1 WGNFHUKHVIFQDE-MWXLCCTBSA-N 0.000 claims 1
- SUCDTMKTAUTQGF-VIQWUECVSA-N (3s)-n-(4-hydroxycyclohexyl)-1-(6-phenylpyridazin-3-yl)piperidine-3-carboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C=2N=NC(=CC=2)C=2C=CC=CC=2)CCC1 SUCDTMKTAUTQGF-VIQWUECVSA-N 0.000 claims 1
- UWXIFPXJOIDSPQ-MWXLCCTBSA-N (3s)-n-(4-hydroxycyclohexyl)-1-[5-(4-methoxyphenyl)pyridin-2-yl]piperidine-3-carboxamide Chemical compound C1=CC(OC)=CC=C1C1=CC=C(N2C[C@H](CCC2)C(=O)NC2CCC(O)CC2)N=C1 UWXIFPXJOIDSPQ-MWXLCCTBSA-N 0.000 claims 1
- QZHBVWNVTBZIDC-GTPINHCMSA-N (3s)-n-(4-hydroxycyclohexyl)-1-quinolin-4-ylpiperidine-3-carboxamide Chemical compound C1CC(O)CCC1NC(=O)[C@@H]1CN(C=2C3=CC=CC=C3N=CC=2)CCC1 QZHBVWNVTBZIDC-GTPINHCMSA-N 0.000 claims 1
- GJRDQLDITKIULZ-AWEZNQCLSA-N (3s)-n-(4-oxocyclohexyl)-1-phenylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1C=CC=CC=1)NC1CCC(=O)CC1 GJRDQLDITKIULZ-AWEZNQCLSA-N 0.000 claims 1
- AVJPZSVCXXJYJS-MLCCFXAWSA-N (3s)-n-(7-oxoazepan-4-yl)-1-phenylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1C=CC=CC=1)NC1CCNC(=O)CC1 AVJPZSVCXXJYJS-MLCCFXAWSA-N 0.000 claims 1
- XJGHZOYIEZBFLA-DAFXYXGESA-N (3s)-n-[1-(4-chlorophenyl)propan-2-yl]-1-phenylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1C=CC=CC=1)NC(C)CC1=CC=C(Cl)C=C1 XJGHZOYIEZBFLA-DAFXYXGESA-N 0.000 claims 1
- LAVCBANNERWOBE-INIZCTEOSA-N (3s)-n-cycloheptyl-1-phenylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1C=CC=CC=1)NC1CCCCCC1 LAVCBANNERWOBE-INIZCTEOSA-N 0.000 claims 1
- YBNCWRNHHHSMFD-IBGZPJMESA-N (3s)-n-cyclohexyl-1-(2-fluoro-4-pyridin-4-ylphenyl)piperidine-3-carboxamide Chemical compound O=C([C@H]1CCCN(C1)C1=CC=C(C=C1F)C=1C=CN=CC=1)NC1CCCCC1 YBNCWRNHHHSMFD-IBGZPJMESA-N 0.000 claims 1
- OCGFKWMRPDCGLG-AWEZNQCLSA-N (3s)-n-cyclohexyl-1-(2-fluorophenyl)piperidine-3-carboxamide Chemical compound FC1=CC=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 OCGFKWMRPDCGLG-AWEZNQCLSA-N 0.000 claims 1
- QZBDPAMWZLSFIX-INIZCTEOSA-N (3s)-n-cyclohexyl-1-(2-methylphenyl)piperidine-3-carboxamide Chemical compound CC1=CC=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 QZBDPAMWZLSFIX-INIZCTEOSA-N 0.000 claims 1
- LZFNWPKAIZQXGJ-HNNXBMFYSA-N (3s)-n-cyclohexyl-1-(3-methoxyphenyl)piperidine-3-carboxamide Chemical compound COC1=CC=CC(N2C[C@H](CCC2)C(=O)NC2CCCCC2)=C1 LZFNWPKAIZQXGJ-HNNXBMFYSA-N 0.000 claims 1
- SWNUHFZBHNAAPU-INIZCTEOSA-N (3s)-n-cyclohexyl-1-(3-methylphenyl)piperidine-3-carboxamide Chemical compound CC1=CC=CC(N2C[C@H](CCC2)C(=O)NC2CCCCC2)=C1 SWNUHFZBHNAAPU-INIZCTEOSA-N 0.000 claims 1
- OUHNBYHPDLSUQE-HNNXBMFYSA-N (3s)-n-cyclohexyl-1-(4-fluoro-2-methylphenyl)piperidine-3-carboxamide Chemical compound CC1=CC(F)=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 OUHNBYHPDLSUQE-HNNXBMFYSA-N 0.000 claims 1
- ZZTWAHRKAKIKNH-HNNXBMFYSA-N (3s)-n-cyclohexyl-1-(4-methoxyphenyl)piperidine-3-carboxamide Chemical compound C1=CC(OC)=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 ZZTWAHRKAKIKNH-HNNXBMFYSA-N 0.000 claims 1
- FSXIJYMGOITPDX-IBGZPJMESA-N (3s)-n-cyclohexyl-1-(4-phenoxyphenyl)piperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1C=CC(OC=2C=CC=CC=2)=CC=1)NC1CCCCC1 FSXIJYMGOITPDX-IBGZPJMESA-N 0.000 claims 1
- ICUMADNJQZSPPG-AWEZNQCLSA-N (3s)-n-cyclohexyl-1-[2-(trifluoromethyl)phenyl]piperidine-3-carboxamide Chemical compound FC(F)(F)C1=CC=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 ICUMADNJQZSPPG-AWEZNQCLSA-N 0.000 claims 1
- RKMJNYJFZLPULL-AWEZNQCLSA-N (3s)-n-cyclohexyl-1-[3-(trifluoromethyl)phenyl]piperidine-3-carboxamide Chemical compound FC(F)(F)C1=CC=CC(N2C[C@H](CCC2)C(=O)NC2CCCCC2)=C1 RKMJNYJFZLPULL-AWEZNQCLSA-N 0.000 claims 1
- ZSQBFLPIYJOWES-AWEZNQCLSA-N (3s)-n-cyclohexyl-1-[4-(trifluoromethyl)phenyl]piperidine-3-carboxamide Chemical compound C1=CC(C(F)(F)F)=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 ZSQBFLPIYJOWES-AWEZNQCLSA-N 0.000 claims 1
- JDDUYMMKDTZDBF-ZDUSSCGKSA-N (3s)-n-cyclohexyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperidine-3-carboxamide Chemical compound N1=CC(C(F)(F)F)=CC=C1N1C[C@@H](C(=O)NC2CCCCC2)CCC1 JDDUYMMKDTZDBF-ZDUSSCGKSA-N 0.000 claims 1
- OPXWDPIAYYNTMY-HNNXBMFYSA-N (3s)-n-cyclohexyl-1-phenylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1C=CC=CC=1)NC1CCCCC1 OPXWDPIAYYNTMY-HNNXBMFYSA-N 0.000 claims 1
- JYQSCBJDTKZOKU-ZDUSSCGKSA-N (3s)-n-cyclohexyl-1-pyrazin-2-ylpiperidine-3-carboxamide Chemical compound O=C([C@@H]1CN(CCC1)C=1N=CC=NC=1)NC1CCCCC1 JYQSCBJDTKZOKU-ZDUSSCGKSA-N 0.000 claims 1
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- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
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| TWI400239B (zh) * | 2004-11-10 | 2013-07-01 | Incyte Corp | 內醯胺化合物及其作為醫藥品之用途 |
| ATE538124T1 (de) | 2004-11-12 | 2012-01-15 | Bristol Myers Squibb Co | Imidazokondensierte tricyclische verbindungen auf thiazoloä4,5-büpyridin-basis und pharmazeutische zusammensetzungen damit |
| CA2587153A1 (en) * | 2004-11-18 | 2006-05-26 | Incyte Corporation | Inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1 and methods of using the same |
| US7217838B2 (en) * | 2005-01-05 | 2007-05-15 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| KR100979577B1 (ko) * | 2005-03-03 | 2010-09-01 | 에프. 호프만-라 로슈 아게 | 2형 진성 당뇨병의 치료를 위한11-베타-하이드록시스테로이드 탈수소효소의 억제제로서1-설폰일-피페리딘-3-카복실산 아마이드 유도체 |
| JP2009508963A (ja) * | 2005-09-21 | 2009-03-05 | インサイト・コーポレイション | アミド化合物および医薬組成物としてのその使用 |
| TW200804382A (en) * | 2005-12-05 | 2008-01-16 | Incyte Corp | Lactam compounds and methods of using the same |
| WO2007084314A2 (en) * | 2006-01-12 | 2007-07-26 | Incyte Corporation | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| TW200804341A (en) | 2006-01-31 | 2008-01-16 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| JP2007219880A (ja) * | 2006-02-17 | 2007-08-30 | Fujitsu Ltd | 評判情報処理プログラム、方法及び装置 |
| WO2007101270A1 (en) | 2006-03-02 | 2007-09-07 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| WO2007103719A2 (en) * | 2006-03-03 | 2007-09-13 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| WO2007130898A1 (en) * | 2006-05-01 | 2007-11-15 | Incyte Corporation | TETRASUBSTITUTED UREAS AS MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1 |
| CA2652375A1 (en) * | 2006-05-17 | 2007-11-29 | Incyte Corporation | Heterocyclic inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type i and methods of using the same |
| CL2008001839A1 (es) * | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
-
2005
- 2005-06-23 BR BRPI0512535-9A patent/BRPI0512535A/pt not_active IP Right Cessation
- 2005-06-23 EP EP05763380A patent/EP1758580A4/en not_active Withdrawn
- 2005-06-23 CA CA002570637A patent/CA2570637A1/en not_active Abandoned
- 2005-06-23 NZ NZ551603A patent/NZ551603A/en not_active IP Right Cessation
- 2005-06-23 EA EA200700117A patent/EA200700117A1/ru unknown
- 2005-06-23 MX MXPA06014574A patent/MXPA06014574A/es not_active Application Discontinuation
- 2005-06-23 AU AU2005267289A patent/AU2005267289A1/en not_active Abandoned
- 2005-06-23 WO PCT/US2005/022307 patent/WO2006012226A2/en not_active Ceased
- 2005-06-23 US US11/159,448 patent/US8071624B2/en active Active
- 2005-06-23 JP JP2007518277A patent/JP2008504275A/ja active Pending
-
2006
- 2006-11-23 IL IL179520A patent/IL179520A0/en unknown
- 2006-12-06 CR CR8793A patent/CR8793A/es unknown
- 2006-12-26 EC EC2006007114A patent/ECSP067114A/es unknown
-
2011
- 2011-10-24 US US13/279,700 patent/US8288417B2/en not_active Expired - Lifetime
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