JP2008501509A - 非凝集性コア／シェル型ナノコンポジット粒子 - Google Patents

非凝集性コア／シェル型ナノコンポジット粒子 Download PDF

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Publication number
JP2008501509A
JP2008501509A JP2007515527A JP2007515527A JP2008501509A JP 2008501509 A JP2008501509 A JP 2008501509A JP 2007515527 A JP2007515527 A JP 2007515527A JP 2007515527 A JP2007515527 A JP 2007515527A JP 2008501509 A JP2008501509 A JP 2008501509A
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JP
Japan
Prior art keywords
nanocomposite
suspension
sio
nanocomposite particles
microemulsion
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JP2007515527A
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Japanese (ja)
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JP2008501509A5 (enExample
Inventor
ジェームス エイチ アデアー
サラ エム ルース
ジュン ワン
マーク ケスター
クリストファー シードレクキ
ウィリアム ビー ホワイト
アーウィン ヴォグラー
アラン スナイダー
カルロ パンタノ
ローレンス シノウェイ
ヴィクター ルイズ−ヴェラスコ
Original Assignee
ザ ペン ステイト リサーチ ファウンデーション
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Publication of JP2008501509A publication Critical patent/JP2008501509A/ja
Publication of JP2008501509A5 publication Critical patent/JP2008501509A5/ja
Pending legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2995—Silane, siloxane or silicone coating

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Ceramic Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Composite Materials (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Colloid Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Pigments, Carbon Blacks, Or Wood Stains (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2007515527A 2004-06-01 2005-06-01 非凝集性コア／シェル型ナノコンポジット粒子 Pending JP2008501509A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57588704P 2004-06-01 2004-06-01
US57921404P 2004-06-14 2004-06-14
PCT/US2005/019239 WO2005118702A2 (en) 2004-06-01 2005-06-01 Unagglomerated core/shell nanocomposite particles

Publications (2)

Publication Number Publication Date
JP2008501509A true JP2008501509A (ja) 2008-01-24
JP2008501509A5 JP2008501509A5 (enExample) 2008-07-17

Family

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JP2007515527A Pending JP2008501509A (ja) 2004-06-01 2005-06-01 非凝集性コア／シェル型ナノコンポジット粒子

Country Status (7)

Country Link
US (1) US8071132B2 (enExample)
EP (1) EP1773936B1 (enExample)
JP (1) JP2008501509A (enExample)
KR (1) KR20070028478A (enExample)
AU (1) AU2005250464B2 (enExample)
CA (1) CA2569067C (enExample)
WO (1) WO2005118702A2 (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
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WO2008114532A1 (ja) * 2007-03-16 2008-09-25 Konica Minolta Medical & Graphic, Inc. コア／シェル型半導体ナノ粒子の製造方法とそれを用いて製造された半導体ナノ粒子集合体
JP2013515670A (ja) * 2009-12-29 2013-05-09 ダブリュー・アール・グレース・アンド・カンパニー−コーン 複合無機粒子及びそれを製造及び使用する方法
JP2013520491A (ja) * 2010-02-23 2013-06-06 ソウルテハクサンハクヒョリョクタン 表面改質された酸化タンタルナノ粒子、その製造方法、それを用いたｘ線コンピュータ断層撮影造影剤及び高誘電薄膜
JP2013527792A (ja) * 2010-03-08 2013-07-04 ビーエーエスエフ ソシエタス・ヨーロピア ナノ粒子懸濁液の製造方法
JP2015530962A (ja) * 2012-07-18 2015-10-29 ジ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンティッド バイ ザ セクレタリー，デパートメント オブ ヘルス アンド ヒューマン サービシズ シリカ被覆ナノダイヤモンドの調製方法
JP2018021929A (ja) * 2009-12-15 2018-02-08 ウオーターズ・テクノロジーズ・コーポレイシヨン サイズ排除クロマトグラフィーを行うための装置および方法
JP2018035031A (ja) * 2016-08-31 2018-03-08 国立大学法人 名古屋工業大学 ナノシリカ中空粒子の製造方法
KR20210097419A (ko) * 2020-01-30 2021-08-09 창원대학교 산학협력단 우수한 분산성 및 균일한 입도를 가지는 나노분말의 제조방법

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* Cited by examiner, † Cited by third party
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AUPQ573300A0 (en) * 2000-02-21 2000-03-16 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
WO2005118702A2 (en) 2004-06-01 2005-12-15 The Penn State Research Foundation Unagglomerated core/shell nanocomposite particles
EP1991203A2 (en) * 2006-02-13 2008-11-19 Advanced Materials Technology, Inc. Porous microparticles solid cores
KR100745745B1 (ko) * 2006-02-21 2007-08-02 삼성전기주식회사 나노복합재료 및 그 제조방법
JP2007269770A (ja) * 2006-03-09 2007-10-18 Mitsubishi Chemicals Corp 機能性磁気超ナノ微粒子及びその用途
US7670679B2 (en) 2006-05-30 2010-03-02 General Electric Company Core-shell ceramic particulate and method of making
US20100258759A1 (en) * 2006-06-06 2010-10-14 Cornell Research Foundation, Inc. Nanostructured Metal Oxides Comprising Internal Voids and Methods of Use Thereof
EP2061583B1 (en) * 2006-09-14 2019-04-10 Yissum Research Development Company, of The Hebrew University of Jerusalem Organic nanoparticles obtained from microemulsions by solvent evaporation
AR063704A1 (es) 2006-09-14 2009-02-11 Makhteshim Chem Works Ltd Nanoparticulas de pesticida obtenida obtenidas a partir de microemulsiones y nanoemulsiones
JP5486147B2 (ja) * 2006-11-08 2014-05-07 富士フイルム株式会社 顔料分散組成物、それを含有する着色感光性樹脂組成物及び感光性樹脂転写材料、並びにそれらを用いたカラーフィルタ及び液晶表示装置
JP4493044B2 (ja) * 2006-11-27 2010-06-30 株式会社豊田中央研究所 ナノ複合粒子および分子のラッピング方法
KR100791731B1 (ko) * 2007-01-04 2008-01-03 고려대학교 산학협력단 자성체 코어 - 세라믹 쉘 나노 결정 및 그의 제조방법
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WO2009079056A2 (en) * 2007-09-22 2009-06-25 Boise State University Fluorescent particles comprising nanoscale zno layer and exhibiting cell-specific toxicity
KR100954612B1 (ko) * 2007-12-14 2010-04-26 한국화학연구원 양자점을 이용한 약물전달체
KR101466407B1 (ko) * 2008-07-22 2014-12-02 엘지전자 주식회사 압축기
GB0818864D0 (en) * 2008-10-15 2008-11-19 Dow Corning Fabric and fibre conditioning additives
WO2010055529A2 (en) * 2008-11-14 2010-05-20 Indian Association For The Cultivation Of Science Nontoxic, water-soluble and functionalized transition metal ion doped semiconductor nanocrystals and a process for the preparation thereof
CN101531827B (zh) * 2009-04-16 2013-01-09 西安工程大学 活性橙/ZnO核壳结构纳米复合材料及制备方法
US11291974B2 (en) 2009-06-01 2022-04-05 Waters Technologies Corporation Hybrid inorganic/organic materials having novel surface modification; process for the preparation of inorganic/organic hybrid materials; and use of said particles for chromatographic separations
US11439977B2 (en) 2009-06-01 2022-09-13 Waters Technologies Corporation Hybrid material for chromatographic separations comprising a superficially porous core and a surrounding material
CN101580710B (zh) * 2009-06-22 2012-12-05 暨南大学 一种荧光纳米复合粒子及其制备方法和应用
US8685755B2 (en) * 2009-07-20 2014-04-01 The Board Of Regents Of The University Of Texas System Combinatorial multidomain mesoporous chips and a method for fractionation, stabilization, and storage of biomolecules
US20110046239A1 (en) * 2009-08-24 2011-02-24 Keiser Bruce A Calcium based carrier particles
US20110046238A1 (en) * 2009-08-24 2011-02-24 Keiser Bruce A Calcium based carrier particles
US20110046241A1 (en) * 2009-08-24 2011-02-24 Keizer Timothy S Calcium based carrier particles
US20110046240A1 (en) * 2009-08-24 2011-02-24 Keizer Timothy S Calcium-based carrier particles
US9149544B2 (en) * 2009-11-06 2015-10-06 The Penn State Research Foundation Bioconjugation of calcium phosphosilicate nanoparticles for selective targeting of cells in vivo
WO2011063371A1 (en) * 2009-11-23 2011-05-26 University Of Medicine And Dentistry Of New Jersey Dentinal drug delivery composition
US8513031B2 (en) * 2009-12-25 2013-08-20 Konica Minolta Medical & Graphic, Inc. Fluorescent substance-containing silica nanoparticles with coating having high bulk refractive index
WO2011109214A2 (en) * 2010-03-01 2011-09-09 University Of Florida Research Foundation, Inc. Near-ir indocyanine green doped multimodal silica nanoparticles and methods for making the same
JP6199184B2 (ja) 2010-07-26 2017-09-20 ウオーターズ・テクノロジーズ・コーポレイシヨン 粒度分布の狭い実質的に非多孔質のコアを含む表面多孔質材料、その製造方法及びクロマトグラフィー分離用としてのその使用
US8518288B2 (en) 2010-07-27 2013-08-27 Toyota Motor Engineering & Manufacturing North America, Inc. Synthesis of nanocomposite thermoelectric material
JP6343147B2 (ja) 2010-08-30 2018-06-13 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 狭窄病変および血栓溶解療法のための剪断による制御放出
US20120208026A1 (en) * 2011-02-10 2012-08-16 Xerox Corporation Silica-Coated Magnetic Nanoparticles and Process for Making Same
US20140154296A1 (en) * 2011-04-04 2014-06-05 Robert L. Karlinsey Dental compositions containing silica microbeads
US9724277B2 (en) * 2011-04-04 2017-08-08 Robert L. Karlinsey Microbeads for dental use
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