JP2008500361A5 - - Google Patents
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- Publication number
- JP2008500361A5 JP2008500361A5 JP2007515304A JP2007515304A JP2008500361A5 JP 2008500361 A5 JP2008500361 A5 JP 2008500361A5 JP 2007515304 A JP2007515304 A JP 2007515304A JP 2007515304 A JP2007515304 A JP 2007515304A JP 2008500361 A5 JP2008500361 A5 JP 2008500361A5
- Authority
- JP
- Japan
- Prior art keywords
- monocyclic
- bicyclic
- cycloalkenyl
- aryl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 50
- 125000000217 alkyl group Chemical group 0.000 claims 29
- 125000002619 bicyclic group Chemical group 0.000 claims 29
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 24
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 23
- 125000000753 cycloalkyl group Chemical group 0.000 claims 20
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 17
- 125000001475 halogen functional group Chemical group 0.000 claims 10
- 125000002950 monocyclic group Chemical group 0.000 claims 10
- 239000000546 pharmaceutical excipient Substances 0.000 claims 10
- 230000017105 transposition Effects 0.000 claims 10
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 8
- 230000002107 myocardial effect Effects 0.000 claims 8
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims 8
- 239000003223 protective agent Substances 0.000 claims 8
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 6
- -1 neoheptyl Chemical group 0.000 claims 6
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 5
- CHNUOJQWGUIOLD-NFZZJPOKSA-N epalrestat Chemical compound C=1C=CC=CC=1\C=C(/C)\C=C1/SC(=S)N(CC(O)=O)C1=O CHNUOJQWGUIOLD-NFZZJPOKSA-N 0.000 claims 5
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 4
- IVVNZDGDKPTYHK-JTQLQIEISA-N 1-cyano-2-[(2s)-3,3-dimethylbutan-2-yl]-3-pyridin-4-ylguanidine Chemical compound CC(C)(C)[C@H](C)N=C(NC#N)NC1=CC=NC=C1 IVVNZDGDKPTYHK-JTQLQIEISA-N 0.000 claims 4
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 4
- 229960003150 bupivacaine Drugs 0.000 claims 4
- FSEUPUDHEBLWJY-HWKANZROSA-N diacetylmonoxime Chemical compound CC(=O)C(\C)=N\O FSEUPUDHEBLWJY-HWKANZROSA-N 0.000 claims 4
- AQNDDEOPVVGCPG-UHFFFAOYSA-N esmolol Chemical compound COC(=O)CCC1=CC=C(OCC(O)CNC(C)C)C=C1 AQNDDEOPVVGCPG-UHFFFAOYSA-N 0.000 claims 4
- 229960003745 esmolol Drugs 0.000 claims 4
- BCQZXOMGPXTTIC-UHFFFAOYSA-N halothane Chemical compound FC(F)(F)C(Cl)Br BCQZXOMGPXTTIC-UHFFFAOYSA-N 0.000 claims 4
- 229960003132 halothane Drugs 0.000 claims 4
- 229960004194 lidocaine Drugs 0.000 claims 4
- LBHIOVVIQHSOQN-UHFFFAOYSA-N nicorandil Chemical compound [O-][N+](=O)OCCNC(=O)C1=CC=CN=C1 LBHIOVVIQHSOQN-UHFFFAOYSA-N 0.000 claims 4
- 229960002497 nicorandil Drugs 0.000 claims 4
- 229940053973 novocaine Drugs 0.000 claims 4
- 229960002310 pinacidil Drugs 0.000 claims 4
- 235000011164 potassium chloride Nutrition 0.000 claims 4
- 239000001103 potassium chloride Substances 0.000 claims 4
- 229960002816 potassium chloride Drugs 0.000 claims 4
- 229960004919 procaine Drugs 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 claims 2
- 125000003229 2-methylhexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 claims 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000005244 neohexyl group Chemical group [H]C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 0 C*C[C@](*[C@@](C1c(ncnc2*C3CCCC3)c2N=C1)[C@@]1O)[C@@]1O Chemical compound C*C[C@](*[C@@](C1c(ncnc2*C3CCCC3)c2N=C1)[C@@]1O)[C@@]1O 0.000 description 4
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57480504P | 2004-05-26 | 2004-05-26 | |
| US58826304P | 2004-07-15 | 2004-07-15 | |
| PCT/US2005/018381 WO2005117910A2 (en) | 2004-05-26 | 2005-05-25 | Purine derivatives as adenosine a1 receptor agonists and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010015618A Division JP2010090177A (ja) | 2004-05-26 | 2010-01-27 | アデノシンａ１レセプター・アゴニストとしてのプリン誘導体およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008500361A JP2008500361A (ja) | 2008-01-10 |
| JP2008500361A5 true JP2008500361A5 (https=) | 2009-08-13 |
| JP4484928B2 JP4484928B2 (ja) | 2010-06-16 |
Family
ID=35463332
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007515304A Expired - Fee Related JP4484928B2 (ja) | 2004-05-26 | 2005-05-25 | アデノシンａ１レセプター・アゴニストとしてのプリン誘導体およびその使用方法 |
| JP2010015618A Pending JP2010090177A (ja) | 2004-05-26 | 2010-01-27 | アデノシンａ１レセプター・アゴニストとしてのプリン誘導体およびその使用方法 |
| JP2013055535A Pending JP2013116920A (ja) | 2004-05-26 | 2013-03-18 | アデノシンａ１レセプター・アゴニストとしてのプリン誘導体およびその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010015618A Pending JP2010090177A (ja) | 2004-05-26 | 2010-01-27 | アデノシンａ１レセプター・アゴニストとしてのプリン誘導体およびその使用方法 |
| JP2013055535A Pending JP2013116920A (ja) | 2004-05-26 | 2013-03-18 | アデノシンａ１レセプター・アゴニストとしてのプリン誘導体およびその使用方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US7423144B2 (https=) |
| EP (2) | EP2221307A1 (https=) |
| JP (3) | JP4484928B2 (https=) |
| KR (2) | KR101167342B1 (https=) |
| CN (1) | CN103087133B (https=) |
| AT (1) | ATE462704T1 (https=) |
| AU (1) | AU2005249430B2 (https=) |
| BR (1) | BRPI0510406A (https=) |
| CA (1) | CA2567289C (https=) |
| CY (1) | CY1110159T1 (https=) |
| DE (1) | DE602005020286D1 (https=) |
| DK (1) | DK1758596T3 (https=) |
| EA (1) | EA011826B1 (https=) |
| ES (1) | ES2343421T3 (https=) |
| HR (1) | HRP20100344T2 (https=) |
| IL (1) | IL179400A (https=) |
| ME (1) | ME01072B (https=) |
| MX (1) | MXPA06013560A (https=) |
| NO (1) | NO339450B1 (https=) |
| NZ (1) | NZ551951A (https=) |
| PL (1) | PL1758596T3 (https=) |
| PT (1) | PT1758596E (https=) |
| RS (1) | RS51261B (https=) |
| WO (1) | WO2005117910A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103087133B (zh) * | 2004-05-26 | 2016-09-14 | 伊诺泰克制药公司 | 嘌呤衍生物作为腺苷a1受体激动剂及其用法 |
| CN101437526A (zh) * | 2004-09-20 | 2009-05-20 | 伊诺泰克制药公司 | 嘌呤衍生物及其用法 |
| EA015683B1 (ru) * | 2005-11-30 | 2011-10-31 | Инотек Фармасьютикалз Корпорейшн | Производные пурина и способы их применения |
| BRPI0709124A2 (pt) * | 2006-03-23 | 2011-06-28 | Inotek Pharmaceuticals Corp | composto purina e métodos de uso dos mesmos |
| JP5128578B2 (ja) * | 2006-04-04 | 2013-01-23 | エモディス ゲーエムベーハー | 解離性障害の治療のためのκ−オピオイド受容体アンタゴニスト含有組成物の利用 |
| NZ596428A (en) | 2009-05-01 | 2014-03-28 | Inotek Pharmaceuticals Corp | Method of reducing intraocular pressure in humans |
| EA201270102A1 (ru) | 2009-06-30 | 2012-08-30 | Форест Лэборетериз Холдингз Лимитед | Соединения алкокси-карбонил-амино-алкинил-аденозина и их производные в качестве агонистов ar |
| WO2011053569A1 (en) * | 2009-10-26 | 2011-05-05 | Inotek Pharmaceuticals Corporation | Ophthalmic formulation and method of manufacture thereof |
| LT2523669T (lt) * | 2010-01-11 | 2017-04-25 | Inotek Pharmaceuticals Corporation | Akispūdžio mažinimo būdas, derinys ir rinkinys |
| US8455457B2 (en) * | 2010-03-19 | 2013-06-04 | Inotek Pharmaceuticals Corporation | Combination compositions for reducing intraocular pressure |
| JP2013522322A (ja) * | 2010-03-19 | 2013-06-13 | イノテック ファーマシューティカルズ コーポレイション | 眼内圧を下げるためのアデノシンａ１受容体アゴニストと炭酸脱水酵素阻害剤との組合せ組成物 |
| PH12012501906A1 (en) | 2010-03-26 | 2013-01-14 | Inotek Pharmaceuticals Corp | Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof |
| KR20130029049A (ko) | 2010-03-26 | 2013-03-21 | 이노텍 파마슈티컬스 코포레이션 | 아데노신 화합물 및 이의 용도 |
| PT2807178T (pt) | 2012-01-26 | 2017-08-08 | Inotek Pharmaceuticals Corp | Polimorfos anidros de nitrato de (2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-dihidroxitetrahidrofuran-2-il)}metilo e seus processos de preparação |
| NZ630759A (en) | 2013-03-15 | 2017-07-28 | Inotek Pharmaceuticals Corp | Ophthalmic formulations comprising an a1 agonist |
| GB2582361A (en) * | 2019-03-21 | 2020-09-23 | Univ Warwick | Adenosine receptor agonists |
| JP2022538408A (ja) * | 2019-06-21 | 2022-09-02 | アカデミー オブ ミリタリー メディカル サイエンシズ | Ａ２ａアデノシン受容体アゴニスト活性を有する６－ヒドラジノアデノシン化合物 |
| DE102021120112A1 (de) | 2021-08-03 | 2023-02-09 | Bayerische Motoren Werke Aktiengesellschaft | Schnittwerkzeug für ein Metallblech und ein Verfahren zum Betreiben eines Schnittwerkzeugs für ein Metallblech |
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| DE2342479A1 (de) * | 1973-08-23 | 1975-03-13 | Merck Patent Gmbh | Ribonucleosid-5'-nitrate und verfahren zu ihrer herstellung |
| JPS5126882A (en) * | 1974-08-21 | 1976-03-05 | Yamasa Shoyu Kk | Nukureoshido 55 monosurupponsanesuteruno seizoho |
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| CN103087133B (zh) * | 2004-05-26 | 2016-09-14 | 伊诺泰克制药公司 | 嘌呤衍生物作为腺苷a1受体激动剂及其用法 |
| BRPI0709124A2 (pt) * | 2006-03-23 | 2011-06-28 | Inotek Pharmaceuticals Corp | composto purina e métodos de uso dos mesmos |
-
2005
- 2005-05-25 CN CN201210444152.1A patent/CN103087133B/zh not_active Expired - Fee Related
- 2005-05-25 DK DK05757108.5T patent/DK1758596T3/da active
- 2005-05-25 JP JP2007515304A patent/JP4484928B2/ja not_active Expired - Fee Related
- 2005-05-25 CA CA2567289A patent/CA2567289C/en not_active Expired - Fee Related
- 2005-05-25 ES ES05757108T patent/ES2343421T3/es not_active Expired - Lifetime
- 2005-05-25 PT PT05757108T patent/PT1758596E/pt unknown
- 2005-05-25 KR KR1020067027319A patent/KR101167342B1/ko not_active Expired - Fee Related
- 2005-05-25 KR KR1020117027975A patent/KR101267202B1/ko not_active Expired - Fee Related
- 2005-05-25 ME MEP-2010-87A patent/ME01072B/me unknown
- 2005-05-25 EP EP10003479A patent/EP2221307A1/en not_active Withdrawn
- 2005-05-25 BR BRPI0510406-8A patent/BRPI0510406A/pt not_active Application Discontinuation
- 2005-05-25 HR HR20100344T patent/HRP20100344T2/hr unknown
- 2005-05-25 RS RSP-2010/0241A patent/RS51261B/sr unknown
- 2005-05-25 MX MXPA06013560A patent/MXPA06013560A/es active IP Right Grant
- 2005-05-25 AT AT05757108T patent/ATE462704T1/de active
- 2005-05-25 NZ NZ551951A patent/NZ551951A/en not_active IP Right Cessation
- 2005-05-25 EA EA200602197A patent/EA011826B1/ru not_active IP Right Cessation
- 2005-05-25 US US11/137,632 patent/US7423144B2/en not_active Expired - Fee Related
- 2005-05-25 DE DE602005020286T patent/DE602005020286D1/de not_active Expired - Lifetime
- 2005-05-25 PL PL05757108T patent/PL1758596T3/pl unknown
- 2005-05-25 AU AU2005249430A patent/AU2005249430B2/en not_active Ceased
- 2005-05-25 EP EP05757108A patent/EP1758596B9/en not_active Expired - Lifetime
- 2005-05-25 WO PCT/US2005/018381 patent/WO2005117910A2/en not_active Ceased
-
2006
- 2006-11-20 IL IL179400A patent/IL179400A/en not_active IP Right Cessation
- 2006-12-27 NO NO20066012A patent/NO339450B1/no not_active IP Right Cessation
-
2008
- 2008-08-04 US US12/221,539 patent/US8183224B2/en not_active Expired - Fee Related
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2010
- 2010-01-27 JP JP2010015618A patent/JP2010090177A/ja active Pending
- 2010-06-25 CY CY20101100585T patent/CY1110159T1/el unknown
-
2012
- 2012-04-20 US US13/451,613 patent/US8609833B2/en not_active Expired - Fee Related
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2013
- 2013-03-18 JP JP2013055535A patent/JP2013116920A/ja active Pending
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