DK1758596T3 - Purinderivater som adenosin-A1-receptoragonister og fremgangsmåder til anvendelse deraf - Google Patents

Purinderivater som adenosin-A1-receptoragonister og fremgangsmåder til anvendelse deraf

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Publication number
DK1758596T3
DK1758596T3 DK05757108.5T DK05757108T DK1758596T3 DK 1758596 T3 DK1758596 T3 DK 1758596T3 DK 05757108 T DK05757108 T DK 05757108T DK 1758596 T3 DK1758596 T3 DK 1758596T3
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Prior art keywords
methods
animal
adenosine
purine derivatives
receptor agonists
Prior art date
Application number
DK05757108.5T
Other languages
Danish (da)
English (en)
Inventor
Csaba Szabo
Andrew L Salzman
Prakash Jagtap
Original Assignee
Inotek Pharmaceuticals Corp
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Publication date
Application filed by Inotek Pharmaceuticals Corp filed Critical Inotek Pharmaceuticals Corp
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Publication of DK1758596T3 publication Critical patent/DK1758596T3/da

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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

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DK05757108.5T 2004-05-26 2005-05-25 Purinderivater som adenosin-A1-receptoragonister og fremgangsmåder til anvendelse deraf DK1758596T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57480504P 2004-05-26 2004-05-26
US58826304P 2004-07-15 2004-07-15
PCT/US2005/018381 WO2005117910A2 (en) 2004-05-26 2005-05-25 Purine derivatives as adenosine a1 receptor agonists and methods of use thereof

Publications (1)

Publication Number Publication Date
DK1758596T3 true DK1758596T3 (da) 2010-07-26

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ID=35463332

Family Applications (1)

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DK05757108.5T DK1758596T3 (da) 2004-05-26 2005-05-25 Purinderivater som adenosin-A1-receptoragonister og fremgangsmåder til anvendelse deraf

Country Status (24)

Country Link
US (3) US7423144B2 (https=)
EP (2) EP2221307A1 (https=)
JP (3) JP4484928B2 (https=)
KR (2) KR101167342B1 (https=)
CN (1) CN103087133B (https=)
AT (1) ATE462704T1 (https=)
AU (1) AU2005249430B2 (https=)
BR (1) BRPI0510406A (https=)
CA (1) CA2567289C (https=)
CY (1) CY1110159T1 (https=)
DE (1) DE602005020286D1 (https=)
DK (1) DK1758596T3 (https=)
EA (1) EA011826B1 (https=)
ES (1) ES2343421T3 (https=)
HR (1) HRP20100344T2 (https=)
IL (1) IL179400A (https=)
ME (1) ME01072B (https=)
MX (1) MXPA06013560A (https=)
NO (1) NO339450B1 (https=)
NZ (1) NZ551951A (https=)
PL (1) PL1758596T3 (https=)
PT (1) PT1758596E (https=)
RS (1) RS51261B (https=)
WO (1) WO2005117910A2 (https=)

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CN103087133B (zh) * 2004-05-26 2016-09-14 伊诺泰克制药公司 嘌呤衍生物作为腺苷a1受体激动剂及其用法
CN101437526A (zh) * 2004-09-20 2009-05-20 伊诺泰克制药公司 嘌呤衍生物及其用法
EA015683B1 (ru) * 2005-11-30 2011-10-31 Инотек Фармасьютикалз Корпорейшн Производные пурина и способы их применения
BRPI0709124A2 (pt) * 2006-03-23 2011-06-28 Inotek Pharmaceuticals Corp composto purina e métodos de uso dos mesmos
JP5128578B2 (ja) * 2006-04-04 2013-01-23 エモディス ゲーエムベーハー 解離性障害の治療のためのκ−オピオイド受容体アンタゴニスト含有組成物の利用
NZ596428A (en) 2009-05-01 2014-03-28 Inotek Pharmaceuticals Corp Method of reducing intraocular pressure in humans
EA201270102A1 (ru) 2009-06-30 2012-08-30 Форест Лэборетериз Холдингз Лимитед Соединения алкокси-карбонил-амино-алкинил-аденозина и их производные в качестве агонистов ar
WO2011053569A1 (en) * 2009-10-26 2011-05-05 Inotek Pharmaceuticals Corporation Ophthalmic formulation and method of manufacture thereof
LT2523669T (lt) * 2010-01-11 2017-04-25 Inotek Pharmaceuticals Corporation Akispūdžio mažinimo būdas, derinys ir rinkinys
US8455457B2 (en) * 2010-03-19 2013-06-04 Inotek Pharmaceuticals Corporation Combination compositions for reducing intraocular pressure
JP2013522322A (ja) * 2010-03-19 2013-06-13 イノテック ファーマシューティカルズ コーポレイション 眼内圧を下げるためのアデノシンａ１受容体アゴニストと炭酸脱水酵素阻害剤との組合せ組成物
PH12012501906A1 (en) 2010-03-26 2013-01-14 Inotek Pharmaceuticals Corp Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
KR20130029049A (ko) 2010-03-26 2013-03-21 이노텍 파마슈티컬스 코포레이션 아데노신 화합물 및 이의 용도
PT2807178T (pt) 2012-01-26 2017-08-08 Inotek Pharmaceuticals Corp Polimorfos anidros de nitrato de (2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-dihidroxitetrahidrofuran-2-il)}metilo e seus processos de preparação
NZ630759A (en) 2013-03-15 2017-07-28 Inotek Pharmaceuticals Corp Ophthalmic formulations comprising an a1 agonist
GB2582361A (en) * 2019-03-21 2020-09-23 Univ Warwick Adenosine receptor agonists
JP2022538408A (ja) * 2019-06-21 2022-09-02 アカデミー オブ ミリタリー メディカル サイエンシズ Ａ２ａアデノシン受容体アゴニスト活性を有する６－ヒドラジノアデノシン化合物
DE102021120112A1 (de) 2021-08-03 2023-02-09 Bayerische Motoren Werke Aktiengesellschaft Schnittwerkzeug für ein Metallblech und ein Verfahren zum Betreiben eines Schnittwerkzeugs für ein Metallblech

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