PL1758596T3 - Pochodne purynowe jako agoniści receptora adenozynowgo A1, oraz sposoby ich zastosowania - Google Patents
Pochodne purynowe jako agoniści receptora adenozynowgo A1, oraz sposoby ich zastosowaniaInfo
- Publication number
- PL1758596T3 PL1758596T3 PL05757108T PL05757108T PL1758596T3 PL 1758596 T3 PL1758596 T3 PL 1758596T3 PL 05757108 T PL05757108 T PL 05757108T PL 05757108 T PL05757108 T PL 05757108T PL 1758596 T3 PL1758596 T3 PL 1758596T3
- Authority
- PL
- Poland
- Prior art keywords
- methods
- animal
- adenosine
- purine derivatives
- receptor agonists
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57480504P | 2004-05-26 | 2004-05-26 | |
US58826304P | 2004-07-15 | 2004-07-15 | |
EP05757108A EP1758596B9 (en) | 2004-05-26 | 2005-05-25 | Purine derivatives as adenosine a1 receptor agonists and methods of use thereof |
PCT/US2005/018381 WO2005117910A2 (en) | 2004-05-26 | 2005-05-25 | Purine derivatives as adenosine a1 receptor agonists and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1758596T3 true PL1758596T3 (pl) | 2011-01-31 |
Family
ID=35463332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL05757108T PL1758596T3 (pl) | 2004-05-26 | 2005-05-25 | Pochodne purynowe jako agoniści receptora adenozynowgo A1, oraz sposoby ich zastosowania |
Country Status (25)
Country | Link |
---|---|
US (3) | US7423144B2 (pl) |
EP (2) | EP1758596B9 (pl) |
JP (3) | JP4484928B2 (pl) |
KR (2) | KR101167342B1 (pl) |
CN (1) | CN103087133B (pl) |
AT (1) | ATE462704T1 (pl) |
AU (1) | AU2005249430B2 (pl) |
BR (1) | BRPI0510406A (pl) |
CA (1) | CA2567289C (pl) |
CY (1) | CY1110159T1 (pl) |
DE (1) | DE602005020286D1 (pl) |
DK (1) | DK1758596T3 (pl) |
EA (1) | EA011826B1 (pl) |
ES (1) | ES2343421T3 (pl) |
HK (1) | HK1104457A1 (pl) |
HR (1) | HRP20100344T2 (pl) |
IL (1) | IL179400A (pl) |
ME (1) | ME01072B (pl) |
MX (1) | MXPA06013560A (pl) |
NO (1) | NO339450B1 (pl) |
NZ (1) | NZ551951A (pl) |
PL (1) | PL1758596T3 (pl) |
PT (1) | PT1758596E (pl) |
RS (1) | RS51261B (pl) |
WO (1) | WO2005117910A2 (pl) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101167342B1 (ko) * | 2004-05-26 | 2012-07-19 | 이노텍 파마슈티컬스 코포레이션 | 아데노신 a1 수용체 아고니스트로서의 퓨린 유도체 및 이것의 사용 방법 |
AU2005286946B2 (en) * | 2004-09-20 | 2012-03-15 | Inotek Pharmaceuticals Corporation | Purine derivatives and methods of use thereof |
AU2006320578B2 (en) * | 2005-11-30 | 2013-01-31 | Inotek Pharmaceuticals Corporation | Purine derivatives and methods of use thereof |
MX2008012185A (es) * | 2006-03-23 | 2008-10-02 | Inotek Pharmaceuticals Corp | Compuestos de purina y metodos de uso de los mismos. |
DE502007002185D1 (de) * | 2006-04-04 | 2010-01-14 | Emodys Gmbh | Verwendung von zusammensetzungen enthaltend kappa-opioidrezeptor-antagonisten zur behandlung von dissoziativen störungen |
SG175346A1 (en) | 2009-05-01 | 2011-11-28 | Inotek Pharmaceuticals Corp | Method of reducing intraocular pressure in humans |
MX2012000113A (es) | 2009-06-30 | 2012-02-29 | Forest Lab Holdings Ltd | Compuestos alcoxi-carbonil-amino-alquinil-adenosina y derivados de los mismos como agonistas a2ar. |
WO2011053569A1 (en) * | 2009-10-26 | 2011-05-05 | Inotek Pharmaceuticals Corporation | Ophthalmic formulation and method of manufacture thereof |
WO2011085361A1 (en) * | 2010-01-11 | 2011-07-14 | Inotek Pharmaceuticals Corporation | Combination, kit and method of reducing intraocular pressure |
RS55616B1 (sr) * | 2010-03-19 | 2017-06-30 | Inotek Pharmaceuticals Corp | Kombinovane kompozicije adenozinskih a1 agonista i ne-selektivnih beta-adrenergičnih receptor blokera za snižavanje intraokularnog pritiska |
EP2555775B1 (en) * | 2010-03-19 | 2016-12-07 | Inotek Pharmaceuticals Corporation | Combination compositions of adenosine a1 agonists and carbonic anhydrase inhibitors for reducing intraocular pressure |
US8476247B2 (en) | 2010-03-26 | 2013-07-02 | Inotek Pharmaceuticals Corporation | Method of reducing intraocular pressure in humans |
US8501708B2 (en) | 2010-03-26 | 2013-08-06 | Inotek Pharmaceuticals Corporation | Adenosine compounds and their use thereof |
AU2013211957B2 (en) * | 2012-01-26 | 2017-08-10 | Inotek Pharmaceuticals Corporation | Anhydrous polymorphs of (2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl) } methyl nitrate and processes of preparation thereof |
CA2903114A1 (en) | 2013-03-15 | 2014-09-25 | Inotek Pharmaceuticals Corporation | Ophthalmic formulations |
GB2582361A (en) * | 2019-03-21 | 2020-09-23 | Univ Warwick | Adenosine receptor agonists |
DE102021120112A1 (de) | 2021-08-03 | 2023-02-09 | Bayerische Motoren Werke Aktiengesellschaft | Schnittwerkzeug für ein Metallblech und ein Verfahren zum Betreiben eines Schnittwerkzeugs für ein Metallblech |
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JPS4935635B1 (pl) | 1970-12-28 | 1974-09-25 | ||
CH563405A5 (pl) * | 1971-09-10 | 1975-06-30 | Duschinsky Robert Dr Schweiz I | |
DE2226295A1 (de) * | 1972-05-30 | 1973-12-20 | Henning Berlin Gmbh | Salpetersaeureester von purinnucleosiden und verfahren zur herstellung derselben |
DE2342479A1 (de) * | 1973-08-23 | 1975-03-13 | Merck Patent Gmbh | Ribonucleosid-5'-nitrate und verfahren zu ihrer herstellung |
JPS5126882A (en) * | 1974-08-21 | 1976-03-05 | Yamasa Shoyu Kk | Nukureoshido 55 monosurupponsanesuteruno seizoho |
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