NO20066012L - Purinderivater som adenosin A1-reseptoragonister og fremgangsmater for anvendelse derav - Google Patents

Purinderivater som adenosin A1-reseptoragonister og fremgangsmater for anvendelse derav

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Publication number
NO20066012L
NO20066012L NO20066012A NO20066012A NO20066012L NO 20066012 L NO20066012 L NO 20066012L NO 20066012 A NO20066012 A NO 20066012A NO 20066012 A NO20066012 A NO 20066012A NO 20066012 L NO20066012 L NO 20066012L
Authority
NO
Norway
Prior art keywords
methods
animal
adenosine
purine derivatives
receptor agonists
Prior art date
Application number
NO20066012A
Other languages
English (en)
Other versions
NO339450B1 (no
Inventor
Andrew L Salzman
Prakash Jagtap
Caaba Szabo
Original Assignee
Inotek Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inotek Pharmaceuticals Corp filed Critical Inotek Pharmaceuticals Corp
Publication of NO20066012L publication Critical patent/NO20066012L/no
Publication of NO339450B1 publication Critical patent/NO339450B1/no

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    • C—CHEMISTRY; METALLURGY
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/08—Vasodilators for multiple indications
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

Abstract

Foreliggende oppfinnelse gjelder purinderivater, preparater som omfatter en effektiv mengde av et purinderivat og fremgangsmåter for reduksjon av et dyrs metabolske aktivitet, beskyttelse av et dyrs hjerte mot myokardskader under kardioplegi eller for behandling eller forebyggelse av en hjerte-karsykdom, en nevrologisk forstyrrelse, en iskemisk tilstand, en reperfusjonsskade, fedme, en tærende sykdom eller diabetes, som omfatter tilførsel av en effektiv mengde av et purinderivat til et dyr med behov for dette.
NO20066012A 2004-05-26 2006-12-27 Purinderivater som adenosin A1-reseptoragonister, preparater inneholdende slike og anvendelser derav NO339450B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57480504P 2004-05-26 2004-05-26
US58826304P 2004-07-15 2004-07-15
PCT/US2005/018381 WO2005117910A2 (en) 2004-05-26 2005-05-25 Purine derivatives as adenosine a1 receptor agonists and methods of use thereof

Publications (2)

Publication Number Publication Date
NO20066012L true NO20066012L (no) 2007-02-21
NO339450B1 NO339450B1 (no) 2016-12-12

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NO20066012A NO339450B1 (no) 2004-05-26 2006-12-27 Purinderivater som adenosin A1-reseptoragonister, preparater inneholdende slike og anvendelser derav

Country Status (25)

Country Link
US (3) US7423144B2 (no)
EP (2) EP2221307A1 (no)
JP (3) JP4484928B2 (no)
KR (2) KR101267202B1 (no)
CN (1) CN103087133B (no)
AT (1) ATE462704T1 (no)
AU (1) AU2005249430B2 (no)
BR (1) BRPI0510406A (no)
CA (1) CA2567289C (no)
CY (1) CY1110159T1 (no)
DE (1) DE602005020286D1 (no)
DK (1) DK1758596T3 (no)
EA (1) EA011826B1 (no)
ES (1) ES2343421T3 (no)
HK (1) HK1104457A1 (no)
HR (1) HRP20100344T2 (no)
IL (1) IL179400A (no)
ME (1) ME01072B (no)
MX (1) MXPA06013560A (no)
NO (1) NO339450B1 (no)
NZ (1) NZ551951A (no)
PL (1) PL1758596T3 (no)
PT (1) PT1758596E (no)
RS (1) RS51261B (no)
WO (1) WO2005117910A2 (no)

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BR112012023747A2 (pt) 2010-03-26 2016-08-23 Inotek Pharmaceuticals Corp compostos de adenosina e seu uso
JP2013523739A (ja) 2010-03-26 2013-06-17 イノテック ファーマシューティカルズ コーポレイション Ｎ６−シクロペンチルアデノシン（ｃｐａ）、ｃｐａ誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法
BR112014018413A8 (pt) * 2012-01-26 2017-07-11 Inotek Pharmaceuticals Corp Polimorfos anidros de nitrato de metila [(2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-diidroxitetraidrofuran-2-il)] e processos de preparação do mesmo
CN105188714A (zh) 2013-03-15 2015-12-23 伊诺泰克制药公司 眼用配制品
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IL179400A0 (en) 2007-05-15
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