JP2008500274A5 - - Google Patents
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- JP2008500274A5 JP2008500274A5 JP2006546489A JP2006546489A JP2008500274A5 JP 2008500274 A5 JP2008500274 A5 JP 2008500274A5 JP 2006546489 A JP2006546489 A JP 2006546489A JP 2006546489 A JP2006546489 A JP 2006546489A JP 2008500274 A5 JP2008500274 A5 JP 2008500274A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- animal
- humanized
- sequence
- animal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241001465754 Metazoa Species 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 108020004511 Recombinant DNA Proteins 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000601A ITRM20030601A1 (it) | 2003-12-24 | 2003-12-24 | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| ITRM2003A000601 | 2003-12-24 | ||
| PCT/IT2004/000722 WO2005061540A2 (en) | 2003-12-24 | 2004-12-23 | Method for the humanization of antibodies and humanized antibodies thereby obtained |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009213454A Division JP2009291211A (ja) | 2003-12-24 | 2009-09-15 | ヒト化抗ngf抗体 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2008500274A JP2008500274A (ja) | 2008-01-10 |
| JP2008500274A6 JP2008500274A6 (ja) | 2008-05-01 |
| JP2008500274A5 true JP2008500274A5 (enExample) | 2009-11-05 |
| JP4652341B2 JP4652341B2 (ja) | 2011-03-16 |
Family
ID=34708536
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006546489A Expired - Fee Related JP4652341B2 (ja) | 2003-12-24 | 2004-12-23 | 抗体のヒト化の方法およびそれによって得られるヒト化抗体 |
| JP2009213454A Pending JP2009291211A (ja) | 2003-12-24 | 2009-09-15 | ヒト化抗ngf抗体 |
| JP2012015219A Pending JP2012126726A (ja) | 2003-12-24 | 2012-01-27 | ヒト化抗ngf抗体 |
| JP2015001407A Pending JP2015110601A (ja) | 2003-12-24 | 2015-01-07 | ヒト化抗ngf抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009213454A Pending JP2009291211A (ja) | 2003-12-24 | 2009-09-15 | ヒト化抗ngf抗体 |
| JP2012015219A Pending JP2012126726A (ja) | 2003-12-24 | 2012-01-27 | ヒト化抗ngf抗体 |
| JP2015001407A Pending JP2015110601A (ja) | 2003-12-24 | 2015-01-07 | ヒト化抗ngf抗体 |
Country Status (19)
| Country | Link |
|---|---|
| US (7) | US8296079B2 (enExample) |
| EP (4) | EP2138512B8 (enExample) |
| JP (4) | JP4652341B2 (enExample) |
| CN (2) | CN1906212B (enExample) |
| AT (1) | ATE534665T1 (enExample) |
| AU (4) | AU2004303633B2 (enExample) |
| BR (1) | BRPI0418202A (enExample) |
| CA (2) | CA2551796C (enExample) |
| CY (2) | CY1112611T1 (enExample) |
| DK (3) | DK2138512T3 (enExample) |
| ES (2) | ES2377535T3 (enExample) |
| HU (1) | HUE027475T2 (enExample) |
| IL (2) | IL176495A (enExample) |
| IT (1) | ITRM20030601A1 (enExample) |
| PL (2) | PL2138512T3 (enExample) |
| PT (2) | PT2218737E (enExample) |
| SI (2) | SI2218737T1 (enExample) |
| WO (1) | WO2005061540A2 (enExample) |
| ZA (1) | ZA200605200B (enExample) |
Families Citing this family (79)
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| US10058621B2 (en) | 2015-06-25 | 2018-08-28 | Immunomedics, Inc. | Combination therapy with anti-HLA-DR antibodies and kinase inhibitors in hematopoietic cancers |
| AU2006218454B2 (en) | 2005-03-03 | 2011-11-17 | Immunomedics, Inc. | Humanized L243 antibodies |
| US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
| ITRM20050290A1 (it) * | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| ITRM20050332A1 (it) | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
| LT1976880T (lt) * | 2005-12-21 | 2016-10-10 | Amgen Research (Munich) Gmbh | Farmacinės kompozicijos, pasižyminčios atsparumu tirpiam cea |
| US8309088B2 (en) | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
| ES2517872T3 (es) | 2007-08-10 | 2014-11-04 | Regeneron Pharmaceuticals, Inc. | Anticuerpos humanos de alta afinidad para el factor de crecimiento nervioso humano |
| EP2388323B1 (en) * | 2008-01-11 | 2016-04-13 | Gene Techno Science Co., Ltd. | Humanized anti-9 integrin antibodies and the uses thereof |
| AU2009211340B2 (en) * | 2008-02-04 | 2013-09-12 | Lay Line Genomics S.P.A. | Anti-TrkA antibodies and derivatives thereof |
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| NZ589436A (en) | 2008-06-03 | 2012-12-21 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| RU2010153580A (ru) | 2008-06-03 | 2012-07-20 | Эбботт Лэборетриз (Us) | Иммуноглобулины с двумя вариабельными доменами и их применение |
| RU2011104348A (ru) | 2008-07-08 | 2012-08-20 | Эбботт Лэборетриз (Us) | Иммуноглобулины с двойным вариабельным доменом против простагландина е2 и их применение |
| KR101805754B1 (ko) * | 2008-12-08 | 2017-12-07 | 먼디파머 인터내셔널 코포레이션 리미티드 | 단백질 수용체 티로신 키나아제 억제제의 조성물 |
| CN112690250B (zh) * | 2008-12-18 | 2024-03-08 | 伊拉兹马斯大学鹿特丹医学中心 | 表达人源化抗体的非人转基因动物及其用途 |
| NZ594315A (en) | 2009-02-17 | 2013-05-31 | Ucb Pharma Sa | Antibody molecules having specificity for human ox40 |
| SG175436A1 (en) | 2009-05-04 | 2011-12-29 | Abbott Res Bv | Antibodies against nerve growth factor (ngf) with enhanced in vivo stability |
| TWI614267B (zh) | 2009-05-13 | 2018-02-11 | 建新公司 | 抗人類cd52免疫球蛋白 |
| JP2013507928A (ja) | 2009-10-15 | 2013-03-07 | アボット・ラボラトリーズ | 二重可変ドメイン免疫グロブリンおよびその使用 |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| UY33280A (es) | 2010-03-17 | 2011-10-31 | Abbott Res Bv | Composiciones de anticuerpos anti-factor de crecimiento nervioso (ngf) |
| MX341579B (es) | 2010-08-03 | 2016-08-25 | Abbvie Inc * | Inmunoglobulinas de dominio variable doble y usos de las mismas. |
| EP2606067B1 (en) | 2010-08-19 | 2018-02-21 | Zoetis Belgium S.A. | Anti-ngf antibodies and their use |
| CA2809433A1 (en) | 2010-08-26 | 2012-03-01 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| CA2821515A1 (en) | 2010-12-01 | 2012-06-07 | Alder Biopharmaceuticals, Inc. | Anti-ngf compositions and use thereof |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| GB2528811A (en) * | 2011-05-06 | 2016-02-03 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| CA2835094C (en) * | 2011-05-06 | 2020-12-22 | David Gearing | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| GB201114858D0 (en) * | 2011-08-29 | 2011-10-12 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of using the same |
| US20140170136A1 (en) * | 2011-05-06 | 2014-06-19 | Nvip Pty Ltd. | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| EP3498732B1 (en) * | 2011-05-06 | 2021-11-17 | Zoetis Services LLC | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| GB2505352B (en) * | 2011-05-06 | 2016-01-27 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| SI3498732T1 (sl) * | 2011-05-06 | 2022-04-29 | Zoetis Services Llc | Protitelesa proti živčnemu rastnemu faktorju ter postopki za pripravo in uporabo le-teh |
| US9580496B2 (en) | 2011-05-06 | 2017-02-28 | Nexvet Australia Pty Ltd | Therapeutic canine immunoglobulins and methods of using same |
| US9102673B2 (en) | 2011-07-12 | 2015-08-11 | Merck Sharp & Dohme Corp. | Substituted pyrrolo[3,2-c]pyridines as TrkA kinase inhibitors |
| US8986952B2 (en) | 2011-08-11 | 2015-03-24 | Astellas Pharma Inc. | Anti-human NGF antibody |
| US8926978B2 (en) | 2011-10-25 | 2015-01-06 | Anaptysbio, Inc. | Antibodies directed against nerve growth factor (NGF) |
| UA112203C2 (uk) | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
| BR112014015851A2 (pt) | 2011-12-30 | 2019-09-24 | Abbvie Inc | proteínas de ligação específicas duplas direcionadas contra il-13 e/ou il-17 |
| WO2013176970A1 (en) | 2012-05-22 | 2013-11-28 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
| WO2013184871A1 (en) | 2012-06-06 | 2013-12-12 | Zoetis Llc | Caninized anti-ngf antibodies and methods thereof |
| KR20150023679A (ko) * | 2012-06-08 | 2015-03-05 | 그렌마크 파머수티칼스 에스. 아. | 아미노산 치환을 갖는 인간화된 항-TrkA 항체 |
| US20150183885A1 (en) * | 2012-06-08 | 2015-07-02 | Glenmark Pharmaceuticals S.A. | Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof |
| EP2674439B1 (en) | 2012-06-13 | 2017-02-01 | Rottapharm Biotech S.r.l. | Anti-TrkA antibodies, derivatives and uses thereof |
| BR112015009961B1 (pt) | 2012-11-01 | 2020-10-20 | Abbvie Inc. | proteína de ligação capaz de se ligar a dll4 e vegf, bem como composição que a compreende como composição que a compreende |
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| AR095199A1 (es) * | 2013-03-15 | 2015-09-30 | Genzyme Corp | Anticuerpos anti-cd52 |
| WO2015039333A1 (en) | 2013-09-22 | 2015-03-26 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
| WO2015039334A1 (en) | 2013-09-22 | 2015-03-26 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
| CN103965357B (zh) | 2013-12-31 | 2016-08-17 | 嘉和生物药业有限公司 | 一种抗人rankl抗体 |
| EP3094646B1 (en) | 2014-01-13 | 2020-04-15 | Valerion Therapeutics, LLC | Internalizing moieties |
| JP6197125B2 (ja) | 2014-02-05 | 2017-09-13 | ブイエム オンコロジー リミテッド ライアビリティ カンパニー | 化合物の組成物およびその使用 |
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| MA41097A (fr) * | 2014-12-05 | 2017-10-10 | Glenmark Pharmaceuticals Sa | Anticorps anti-trka à propriétés inhibitrices améliorées et dérivés desdits anticorps destinés à être utilisés pour traiter les douleurs osseuses |
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| UA123209C2 (uk) * | 2015-05-22 | 2021-03-03 | Астеллас Фарма Інк. | Fab-ФРАГМЕНТ АНТИТІЛА ДО ЛЮДСЬКОГО NGF |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
| US11680110B2 (en) | 2017-07-31 | 2023-06-20 | Hoffmann-La Roche Inc. | Three-dimensional structure-based humanization method |
| WO2019164970A1 (en) * | 2018-02-20 | 2019-08-29 | Emory University | Hpv proteins, antibodies, and uses in managing abnormal epithelial cell growth |
| AR114110A1 (es) | 2018-02-28 | 2020-07-22 | Lilly Co Eli | Anticuerpo anti-trka |
| JP2021517461A (ja) | 2018-03-12 | 2021-07-26 | ゾエティス・サービシーズ・エルエルシー | 抗ngf抗体およびその方法 |
| CN113365697B (zh) * | 2018-09-25 | 2024-07-19 | 百进生物科技公司 | 抗tlr9药剂和组合物及其制备方法和使用方法 |
| KR102265434B1 (ko) * | 2019-08-20 | 2021-06-15 | 주식회사 케어젠 | 피부 미백 활성을 갖는 펩타이드 및 이의 용도 |
| TW202124442A (zh) * | 2019-09-13 | 2021-07-01 | 大陸商北京軒義醫藥科技有限公司 | 人源化抗cldn18.2抗體、編碼其的核酸分子、其產生方法、包含其的組合物、試劑盒及其用途 |
| CN117186219B (zh) * | 2020-04-17 | 2024-07-12 | 珠海泰诺麦博制药股份有限公司 | 抗人神经生长因子的抗体 |
| CN116003590A (zh) * | 2020-08-06 | 2023-04-25 | 熙源安健医药(上海)有限公司 | 抗ngf抗体及其抗原结合片段、其制备方法和应用 |
| CN114516917B (zh) * | 2020-11-20 | 2022-11-18 | 广东东阳光药业有限公司 | 人源化抗TrkA的抗体及其应用 |
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-
2003
- 2003-12-24 IT IT000601A patent/ITRM20030601A1/it unknown
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2004
- 2004-12-23 EP EP09008366A patent/EP2138512B8/en not_active Expired - Lifetime
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