JP2008500274A5 - - Google Patents
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- JP2008500274A5 JP2008500274A5 JP2006546489A JP2006546489A JP2008500274A5 JP 2008500274 A5 JP2008500274 A5 JP 2008500274A5 JP 2006546489 A JP2006546489 A JP 2006546489A JP 2006546489 A JP2006546489 A JP 2006546489A JP 2008500274 A5 JP2008500274 A5 JP 2008500274A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- animal
- humanized
- sequence
- animal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 241001465754 Metazoa Species 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 108020004511 Recombinant DNA Proteins 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM2003A000601 | 2003-12-24 | ||
| IT000601A ITRM20030601A1 (it) | 2003-12-24 | 2003-12-24 | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| PCT/IT2004/000722 WO2005061540A2 (en) | 2003-12-24 | 2004-12-23 | Method for the humanization of antibodies and humanized antibodies thereby obtained |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009213454A Division JP2009291211A (ja) | 2003-12-24 | 2009-09-15 | ヒト化抗ngf抗体 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2008500274A JP2008500274A (ja) | 2008-01-10 |
| JP2008500274A6 JP2008500274A6 (ja) | 2008-05-01 |
| JP2008500274A5 true JP2008500274A5 (enExample) | 2009-11-05 |
| JP4652341B2 JP4652341B2 (ja) | 2011-03-16 |
Family
ID=34708536
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006546489A Expired - Fee Related JP4652341B2 (ja) | 2003-12-24 | 2004-12-23 | 抗体のヒト化の方法およびそれによって得られるヒト化抗体 |
| JP2009213454A Pending JP2009291211A (ja) | 2003-12-24 | 2009-09-15 | ヒト化抗ngf抗体 |
| JP2012015219A Pending JP2012126726A (ja) | 2003-12-24 | 2012-01-27 | ヒト化抗ngf抗体 |
| JP2015001407A Pending JP2015110601A (ja) | 2003-12-24 | 2015-01-07 | ヒト化抗ngf抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009213454A Pending JP2009291211A (ja) | 2003-12-24 | 2009-09-15 | ヒト化抗ngf抗体 |
| JP2012015219A Pending JP2012126726A (ja) | 2003-12-24 | 2012-01-27 | ヒト化抗ngf抗体 |
| JP2015001407A Pending JP2015110601A (ja) | 2003-12-24 | 2015-01-07 | ヒト化抗ngf抗体 |
Country Status (19)
| Country | Link |
|---|---|
| US (7) | US8296079B2 (enExample) |
| EP (4) | EP2138512B8 (enExample) |
| JP (4) | JP4652341B2 (enExample) |
| CN (2) | CN1906212B (enExample) |
| AT (1) | ATE534665T1 (enExample) |
| AU (4) | AU2004303633B2 (enExample) |
| BR (1) | BRPI0418202A (enExample) |
| CA (2) | CA2551796C (enExample) |
| CY (2) | CY1112611T1 (enExample) |
| DK (3) | DK2218737T3 (enExample) |
| ES (2) | ES2377535T3 (enExample) |
| HU (1) | HUE027475T2 (enExample) |
| IL (2) | IL176495A (enExample) |
| IT (1) | ITRM20030601A1 (enExample) |
| PL (2) | PL2138512T3 (enExample) |
| PT (2) | PT2138512E (enExample) |
| SI (2) | SI2218737T1 (enExample) |
| WO (1) | WO2005061540A2 (enExample) |
| ZA (1) | ZA200605200B (enExample) |
Families Citing this family (79)
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| ITRM20050332A1 (it) | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
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| BRPI0915448A2 (pt) | 2008-07-08 | 2015-11-10 | Abbott Lab | imunoglobulinas de domínio variável duplo para prostaglandina e2 e usos das mesmas |
| US9040508B2 (en) | 2008-12-08 | 2015-05-26 | Vm Pharma Llc | Compositions of protein receptor tyrosine kinase inhibitors |
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| CN102459337B (zh) | 2009-05-04 | 2015-05-20 | 雅培研究有限责任公司 | 具有增强的体内稳定性的抗神经生长因子(ngf)抗体 |
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| TW201119676A (en) * | 2009-10-15 | 2011-06-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| US20110256135A1 (en) | 2010-03-17 | 2011-10-20 | Wolfgang Fraunhofer | Anti-nerve growth factor (ngf) antibody compositions |
| EP3252072A3 (en) | 2010-08-03 | 2018-03-14 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
| JP6121903B2 (ja) | 2010-08-19 | 2017-04-26 | ゾエティス・ベルジャム・エス・アー | 抗ngf抗体およびその使用 |
| SG187938A1 (en) | 2010-08-26 | 2013-04-30 | Abbvie Inc | Dual variable domain immunoglobulins and uses thereof |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| KR20190112175A (ko) | 2010-12-01 | 2019-10-02 | 앨더바이오 홀딩스 엘엘씨 | 항―ngf 조성물 및 그의 용도 |
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| CA2835094C (en) * | 2011-05-06 | 2020-12-22 | David Gearing | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| GB2528401A (en) * | 2011-05-06 | 2016-01-20 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| ES2704007T3 (es) * | 2011-05-06 | 2019-03-13 | Nexvet Australia Pty Ltd | Anticuerpos anti-factor de crecimiento nervioso y procedimientos de preparación y uso de los mismos |
| CN103732621B (zh) * | 2011-05-06 | 2020-04-24 | 內克斯威特澳大利亚私人有限公司 | 抗神经生长因子抗体及其制备和使用方法 |
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| CN104159920A (zh) | 2011-12-30 | 2014-11-19 | 艾伯维公司 | 针对il-13和/或il-17的双重可变结构域免疫球蛋白 |
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| US9617334B2 (en) | 2012-06-06 | 2017-04-11 | Zoetis Services Llc | Caninized anti-NGF antibodies and methods thereof |
| MX362394B (es) * | 2012-06-08 | 2019-01-15 | Glenmark Pharmaceuticals Sa | Anticuerpos anti-trka humanizados con sustituciones de aminoacidos. |
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| EP2674439B1 (en) | 2012-06-13 | 2017-02-01 | Rottapharm Biotech S.r.l. | Anti-TrkA antibodies, derivatives and uses thereof |
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| CN103965357B (zh) | 2013-12-31 | 2016-08-17 | 嘉和生物药业有限公司 | 一种抗人rankl抗体 |
| AU2015204446A1 (en) * | 2014-01-13 | 2016-07-14 | Valerion Therapeutics, Llc | Internalizing moieties |
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| CN114981303B (zh) * | 2019-09-13 | 2024-01-23 | 安徽俊义医疗管理咨询有限公司 | 人源化抗Claudin18.2(CLDN18.2)抗体 |
| CN113527482B (zh) * | 2020-04-17 | 2023-07-21 | 珠海泰诺麦博制药股份有限公司 | 抗人神经生长因子的抗体 |
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2004
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