AU2004303633B2 - Method for the humanization of antibodies and humanized antibodies thereby obtained - Google Patents

Method for the humanization of antibodies and humanized antibodies thereby obtained Download PDF

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Publication number
AU2004303633B2
AU2004303633B2 AU2004303633A AU2004303633A AU2004303633B2 AU 2004303633 B2 AU2004303633 B2 AU 2004303633B2 AU 2004303633 A AU2004303633 A AU 2004303633A AU 2004303633 A AU2004303633 A AU 2004303633A AU 2004303633 B2 AU2004303633 B2 AU 2004303633B2
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AU
Australia
Prior art keywords
antibody
humanized
antibodies
trka
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004303633A
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English (en)
Other versions
AU2004303633A1 (en
Inventor
Antonino Cattaneo
Sonia Covaceuszach
Doriano Lamba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scuola Internazionale Superiore di Studi Avanzati SISSA
Lay Line Genomics SpA
Original Assignee
Scuola Internazionale Superiore di Studi Avanzati SISSA
Lay Line Genomics SpA
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Filing date
Publication date
Application filed by Scuola Internazionale Superiore di Studi Avanzati SISSA, Lay Line Genomics SpA filed Critical Scuola Internazionale Superiore di Studi Avanzati SISSA
Publication of AU2004303633A1 publication Critical patent/AU2004303633A1/en
Priority to AU2009245889A priority Critical patent/AU2009245889B2/en
Application granted granted Critical
Publication of AU2004303633B2 publication Critical patent/AU2004303633B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Neurology (AREA)
AU2004303633A 2003-12-24 2004-12-23 Method for the humanization of antibodies and humanized antibodies thereby obtained Ceased AU2004303633B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2009245889A AU2009245889B2 (en) 2003-12-24 2009-11-25 Method for the humanization of antibodies and humanized antibodies thereby obtained

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000601A ITRM20030601A1 (it) 2003-12-24 2003-12-24 Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti.
ITRM2003000601 2003-12-24
PCT/IT2004/000722 WO2005061540A2 (en) 2003-12-24 2004-12-23 Method for the humanization of antibodies and humanized antibodies thereby obtained

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2009245889A Division AU2009245889B2 (en) 2003-12-24 2009-11-25 Method for the humanization of antibodies and humanized antibodies thereby obtained

Publications (2)

Publication Number Publication Date
AU2004303633A1 AU2004303633A1 (en) 2005-07-07
AU2004303633B2 true AU2004303633B2 (en) 2011-12-08

Family

ID=34708536

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2004303633A Ceased AU2004303633B2 (en) 2003-12-24 2004-12-23 Method for the humanization of antibodies and humanized antibodies thereby obtained
AU2009245889A Ceased AU2009245889B2 (en) 2003-12-24 2009-11-25 Method for the humanization of antibodies and humanized antibodies thereby obtained
AU2012261567A Ceased AU2012261567B2 (en) 2003-12-24 2012-12-07 Method for the humanization of antibodies and humanized antibodies thereby obtained
AU2016269485A Abandoned AU2016269485A1 (en) 2003-12-24 2016-12-07 Method for the humanization of antibodies and humanized antibodies thereby obtained

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2009245889A Ceased AU2009245889B2 (en) 2003-12-24 2009-11-25 Method for the humanization of antibodies and humanized antibodies thereby obtained
AU2012261567A Ceased AU2012261567B2 (en) 2003-12-24 2012-12-07 Method for the humanization of antibodies and humanized antibodies thereby obtained
AU2016269485A Abandoned AU2016269485A1 (en) 2003-12-24 2016-12-07 Method for the humanization of antibodies and humanized antibodies thereby obtained

Country Status (19)

Country Link
US (7) US8296079B2 (enExample)
EP (4) EP2138512B8 (enExample)
JP (4) JP4652341B2 (enExample)
CN (2) CN1906212B (enExample)
AT (1) ATE534665T1 (enExample)
AU (4) AU2004303633B2 (enExample)
BR (1) BRPI0418202A (enExample)
CA (2) CA2551796C (enExample)
CY (2) CY1112611T1 (enExample)
DK (3) DK2138512T3 (enExample)
ES (2) ES2377535T3 (enExample)
HU (1) HUE027475T2 (enExample)
IL (2) IL176495A (enExample)
IT (1) ITRM20030601A1 (enExample)
PL (2) PL2138512T3 (enExample)
PT (2) PT2218737E (enExample)
SI (2) SI2218737T1 (enExample)
WO (1) WO2005061540A2 (enExample)
ZA (1) ZA200605200B (enExample)

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