JP2008212150A5 - - Google Patents

Download PDF

Info

Publication number
JP2008212150A5
JP2008212150A5 JP2008040781A JP2008040781A JP2008212150A5 JP 2008212150 A5 JP2008212150 A5 JP 2008212150A5 JP 2008040781 A JP2008040781 A JP 2008040781A JP 2008040781 A JP2008040781 A JP 2008040781A JP 2008212150 A5 JP2008212150 A5 JP 2008212150A5
Authority
JP
Japan
Prior art keywords
cells
culture medium
endoderm
hps
cell culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008040781A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008212150A (ja
JP4917559B2 (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2008212150A publication Critical patent/JP2008212150A/ja
Publication of JP2008212150A5 publication Critical patent/JP2008212150A5/ja
Application granted granted Critical
Publication of JP4917559B2 publication Critical patent/JP4917559B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2008040781A 2001-12-07 2008-02-22 ヒト胚幹細胞由来の膵島細胞 Expired - Lifetime JP4917559B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33888501P 2001-12-07 2001-12-07
US60/338,885 2001-12-07

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2003551271A Division JP4666567B2 (ja) 2001-12-07 2002-12-06 ヒト胚幹細胞由来の膵島細胞

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011258931A Division JP5460677B2 (ja) 2001-12-07 2011-11-28 ヒト胚幹細胞由来の膵島細胞

Publications (3)

Publication Number Publication Date
JP2008212150A JP2008212150A (ja) 2008-09-18
JP2008212150A5 true JP2008212150A5 (https=) 2010-04-15
JP4917559B2 JP4917559B2 (ja) 2012-04-18

Family

ID=23326555

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2003551271A Expired - Lifetime JP4666567B2 (ja) 2001-12-07 2002-12-06 ヒト胚幹細胞由来の膵島細胞
JP2008040781A Expired - Lifetime JP4917559B2 (ja) 2001-12-07 2008-02-22 ヒト胚幹細胞由来の膵島細胞
JP2011258931A Expired - Lifetime JP5460677B2 (ja) 2001-12-07 2011-11-28 ヒト胚幹細胞由来の膵島細胞

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2003551271A Expired - Lifetime JP4666567B2 (ja) 2001-12-07 2002-12-06 ヒト胚幹細胞由来の膵島細胞

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011258931A Expired - Lifetime JP5460677B2 (ja) 2001-12-07 2011-11-28 ヒト胚幹細胞由来の膵島細胞

Country Status (10)

Country Link
US (8) US7033831B2 (https=)
EP (2) EP1463798A4 (https=)
JP (3) JP4666567B2 (https=)
KR (2) KR101089591B1 (https=)
CN (2) CN101240262A (https=)
AU (3) AU2002364143B2 (https=)
CA (2) CA2692325C (https=)
GB (2) GB2399823B (https=)
IL (3) IL162131A0 (https=)
WO (1) WO2003050249A2 (https=)

Families Citing this family (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6558952B1 (en) * 1992-12-14 2003-05-06 Waratah Pharmaceuticals, Inc. Treatment for diabetes
US20040037818A1 (en) * 1998-07-30 2004-02-26 Brand Stephen J. Treatment for diabetes
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US7473555B2 (en) 2000-04-27 2009-01-06 Geron Corporation Protocols for making hepatocytes from embryonic stem cells
ATE532854T1 (de) * 2001-12-04 2011-11-15 Organogenesis Inc Kultivierte zellen aus den langerhansschen inseln
IL162131A0 (en) * 2001-12-07 2005-11-20 Geron Corp Islet cells from human embryonic stem cells
JP4374469B2 (ja) * 2002-01-09 2009-12-02 独立行政法人科学技術振興機構 記憶障害治療剤
US20050170506A1 (en) * 2002-01-16 2005-08-04 Primegen Biotech Llc Therapeutic reprogramming, hybrid stem cells and maturation
US20030134422A1 (en) * 2002-01-16 2003-07-17 Sayre Chauncey Bigelow Stem cell maturation for all tissue lines
US20050090004A1 (en) * 2003-01-16 2005-04-28 Sayre Chauncey B. Stem cell maturation for all tissue lines
WO2003068357A2 (en) * 2002-02-12 2003-08-21 Cornell Research Foundation, Inc. Identification and high-yield isolation of human pancreatic islet progenitor and stem cells
EP1543110A4 (en) 2002-05-17 2006-09-06 Sinai School Medicine POPULATION OF DEFINITIVE ENDODERMIC CELLS AND MESODERMAL
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
IL165242A0 (en) * 2002-05-24 2005-12-18 Waratah Pharmaceuticals Inc Treatment for diabetes
US20040002447A1 (en) * 2002-06-04 2004-01-01 Regents Of The University Of California Induction of insulin expression
AU2003283004A1 (en) * 2002-10-22 2004-05-13 Waratah Pharmaceuticals, Inc. Treatment of diabetes
AU2003303071B2 (en) 2002-12-16 2009-04-23 Technion Research & Development Foundation Ltd. Methods of preparing feeder cells-free, xeno-free human embryonic stem cells and stem cell cultures prepared using same
WO2004069172A2 (en) * 2003-01-30 2004-08-19 The Government of the United States of America as represented by the Department of Veterans Affairs Multilineage-inducible cells and uses thereof
WO2004099394A2 (en) 2003-05-08 2004-11-18 Cellartis Ab A method for efficient transfer of human blastocyst-derived stem cells (hbs cells) from a feeder-supported to a feeder-free culture system
US20060281136A1 (en) * 2003-05-20 2006-12-14 Shinichi Nishikawa Preparation of endodermal stem cells
EP2578676A1 (en) * 2003-06-20 2013-04-10 Axiogenesis Ag Tissue modeling in multi- or pluripotent cell systems
US8518390B2 (en) 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
WO2006071794A2 (en) 2004-12-23 2006-07-06 Ethicon Incorporated Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
WO2005001080A2 (en) 2003-06-27 2005-01-06 Ethicon, Incorporated Postpartum-derived cells for use in treatment of disease of the heart and circulatory system
US8491883B2 (en) * 2003-06-27 2013-07-23 Advanced Technologies And Regenerative Medicine, Llc Treatment of amyotrophic lateral sclerosis using umbilical derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US7875272B2 (en) * 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US8790637B2 (en) * 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
EP1668119A2 (en) * 2003-09-15 2006-06-14 Ramot at Tel Aviv University Ltd. Insulin-producing bone marrow derived cells and methods of generating and using same
US20050153446A1 (en) * 2003-11-07 2005-07-14 Steindler Dennis A. Culturing and differentiating neural precursor cells
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
CN103898047B (zh) * 2003-12-23 2020-03-03 维亚希特公司 定形内胚层
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US8586357B2 (en) * 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
AU2013200203B2 (en) * 2003-12-23 2014-11-20 Viacyte, Inc. Definitive endoderm
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
WO2005072764A2 (en) * 2004-01-16 2005-08-11 Novocell, Inc. Fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells
US20080241107A1 (en) * 2004-01-23 2008-10-02 Copland Iii John A Methods and Compositions For Preparing Pancreatic Insulin Secreting Cells
JP2007528226A (ja) * 2004-03-10 2007-10-11 リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア 胚幹細胞の増殖用組成物および方法
AU2005230832B2 (en) * 2004-04-01 2010-11-11 Wisconsin Alumni Research Foundation Differentiation of stem cells to endoderm and pancreatic lineage
EP2377922B1 (en) * 2004-04-27 2020-04-08 Viacyte, Inc. PDX1 expressing endoderm
CN103103158B (zh) * 2004-04-27 2016-08-03 韦尔赛特公司 细胞培养基
JP5128946B2 (ja) * 2004-05-21 2013-01-23 ウィセル リサーチ インスティテュート インコーポレイテッド 胚性幹細胞のフィーダー非依存性長期培養
WO2006001471A1 (ja) * 2004-06-29 2006-01-05 The University Of Tokyo グルコース応答性インスリン分泌を促進するための医薬組成物
CN102586170B (zh) * 2004-07-09 2019-11-29 维亚希特公司 前原条和中内胚层细胞
AU2011203583B2 (en) * 2004-07-09 2013-03-07 Viacyte, Inc. Methods for identifying factors for differentiating definitive endoderm
GB2431165B (en) 2004-07-13 2009-04-01 Geron Corp Medium for growing human embryonic stem cells
US8187878B2 (en) 2004-08-13 2012-05-29 University Of Georgia Research Foundation, Inc. Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors
US20070298016A1 (en) * 2004-09-29 2007-12-27 Nico Heins Methods For The Generation Of Hepatocyte-Like Cells From Human Blastocyst-Derived Stem (Hbs)
CA2583308C (en) * 2004-10-08 2020-01-07 Georgia Tech Research Corporation Microencapsulation of cells in hydrogels using electrostatic potentials
WO2006040763A2 (en) 2004-10-12 2006-04-20 Technion Research & Development Foundation Ltd. Isolated primate embryonic cells and methods of generating and using same
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
US20060153815A1 (en) * 2004-12-21 2006-07-13 Agnieszka Seyda Tissue engineering devices for the repair and regeneration of tissue
US20060171930A1 (en) * 2004-12-21 2006-08-03 Agnieszka Seyda Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same
AU2005322007B2 (en) * 2004-12-23 2011-06-30 Viacyte, Inc. Expansion of definitive endoderm cells
WO2006071778A2 (en) 2004-12-23 2006-07-06 Ethicon Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
CA2593549C (en) * 2005-01-07 2016-04-26 Wake Forest University Health Sciences Regeneration of pancreatic islets by amniotic fluid stem cell therapy
WO2006083782A2 (en) * 2005-01-31 2006-08-10 Es Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
CN100425694C (zh) * 2005-04-15 2008-10-15 北京大学 诱导胚胎干细胞向胰腺细胞分化的方法
EP1728873A1 (en) 2005-05-30 2006-12-06 DeveloGen Aktiengesellschaft Use of an insulinoma cell for identifying pancreatic beta-cell mitogens
AU2006202209B2 (en) * 2005-05-27 2011-04-14 Lifescan, Inc. Amniotic fluid derived cells
JP2009500297A (ja) * 2005-06-08 2009-01-08 セントカー・インコーポレーテツド 眼の変性についての細胞療法
JP5560391B2 (ja) 2005-06-22 2014-07-23 アステリアス バイオセラピューティクス インコーポレイテッド ヒト胚性幹細胞の懸濁培養法
EP1962719A4 (en) 2005-08-29 2011-05-04 Technion Res And Dev Of Foundation Ltd MEDIA FOR BREEDING STEM CELLS
US20100322906A1 (en) * 2005-10-05 2010-12-23 Osaka University Method for Obtaining Pancreatic Endocrine Cells From Adipose Tissue-Origin Cells
CN101310012B (zh) 2005-10-14 2012-05-09 明尼苏达大学董事会 非胚胎干细胞分化成具有胰腺表型的细胞
US8871715B2 (en) 2005-10-14 2014-10-28 Alltech, Inc. Use of selenium compounds, especially selenium yeasts for altering cognitive function
CN101073584B (zh) * 2005-10-14 2012-10-10 全面技术公司 改变细胞功能的方法和组合物
US8865763B2 (en) 2005-10-14 2014-10-21 Alltech, Inc. Methods and compositions for altering cell function
AU2012202481B2 (en) * 2005-10-27 2015-07-02 Viacyte, Inc. PDX1-expressing dorsal and ventral foregut endoderm
WO2007051038A2 (en) * 2005-10-27 2007-05-03 Cythera, Inc. Pdx1-expressing dorsal and ventral foregut endoderm
WO2007070870A1 (en) * 2005-12-16 2007-06-21 Ethicon, Inc. Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation
JP5179376B2 (ja) * 2005-12-19 2013-04-10 エシコン・インコーポレイテッド ローラーボトルでの分娩後取り出し細胞の体外増殖
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
WO2007076522A2 (en) * 2005-12-28 2007-07-05 Ethicon, Incorporated Treatment of peripheral vascular disease using postpartum-derived cells
US11254916B2 (en) 2006-03-02 2022-02-22 Viacyte, Inc. Methods of making and using PDX1-positive pancreatic endoderm cells
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
JP6110048B2 (ja) * 2006-03-02 2017-04-05 ヴィアサイト,インコーポレイテッド 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
AU2024201016B2 (en) * 2006-03-02 2024-10-24 Viacyte, Inc. Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
AU2016213746A1 (en) * 2006-03-02 2016-08-25 Viacyte, Inc. Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
US8741643B2 (en) * 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US7989204B2 (en) * 2006-04-28 2011-08-02 Viacyte, Inc. Hepatocyte lineage cells
AU2007244675A1 (en) * 2006-04-28 2007-11-08 Lifescan, Inc. Differentiation of human embryonic stem cells
SE534150C2 (sv) * 2006-05-02 2011-05-10 Wisconsin Alumni Res Found Förfarande för differentiering av stamceller till celler av den endodermala och pankreatiska utvecklingslinjen
US8685730B2 (en) 2006-05-02 2014-04-01 Wisconsin Alumni Research Foundation Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage
US8148151B2 (en) * 2006-06-02 2012-04-03 Geron Corporation Differentiation of primate pluripotent cells to hepatocyte-lineage cells
US20090298169A1 (en) * 2006-06-02 2009-12-03 The University Of Georgia Research Foundation Pancreatic and Liver Endoderm Cells and Tissue by Differentiation of Definitive Endoderm Cells Obtained from Human Embryonic Stems
US8415153B2 (en) * 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
US8874380B2 (en) 2010-12-09 2014-10-28 Rutgers, The State University Of New Jersey Method of overcoming therapeutic limitations of nonuniform distribution of radiopharmaceuticals and chemotherapy drugs
AU2007277364B2 (en) * 2006-07-26 2010-08-12 Viacyte, Inc. Methods of producing pancreatic hormones
DK3441459T3 (da) 2006-08-02 2021-06-07 Technion Res & Dev Foundation Fremgangsmåder til ekspansion af embryonale stamceller i en suspensionskultur
KR100885854B1 (ko) 2006-09-08 2009-02-26 고려대학교 산학협력단 인간배아 줄기세포로부터 췌장전구세포로의 분화유도 방법
WO2008048647A1 (en) * 2006-10-17 2008-04-24 Cythera, Inc. Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells
WO2008063675A2 (en) 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
EP2128261B1 (en) * 2006-12-20 2012-06-06 Shenzhen Chingen Genetic Engineering Co., Ltd. A recombinant adenovirus comprising recombinant khp53 gene and preparation method and uses thereof
WO2008156708A2 (en) * 2007-06-15 2008-12-24 Massachusetts Institute Of Technology Methods and compositions for enhanced differentiation from embryonic stem cells
US9080145B2 (en) * 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
EP3957716A1 (en) 2007-07-18 2022-02-23 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CN101848993A (zh) * 2007-07-19 2010-09-29 新加坡科技研究局 使胚胎干细胞分化成表达aqp-1的细胞的方法
EP2584034B8 (en) 2007-07-31 2017-12-06 Lifescan, Inc. Pluripotent stem cell differentiation by using human feeder cells
DK2185693T3 (da) 2007-07-31 2019-09-23 Lifescan Inc Differentiering af humane embryoniske stamceller
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
JP5323845B2 (ja) * 2007-10-05 2013-10-23 エシコン・インコーポレイテッド ヒト臍帯組織由来細胞を用いた腎組織の修復および再建
DK2209888T3 (da) 2007-10-12 2020-01-20 Astellas Inst For Regenerative Medicine Forbedrede fremgangsmåder til fremstilling af rpe-celler og sammensætninger af rpe-celler
US8198083B1 (en) 2007-10-31 2012-06-12 William Gunter Loudon Organotypic slices of the central nervous system
CA2954431C (en) 2007-11-27 2021-08-24 Lifescan, Inc. Differentiation of human embryonic stem cells to pancreatic cells
US8236538B2 (en) * 2007-12-20 2012-08-07 Advanced Technologies And Regenerative Medicine, Llc Methods for sterilizing materials containing biologically active agents
JP5733986B2 (ja) 2008-02-21 2015-06-10 ヤンセン バイオテツク,インコーポレーテツド 細胞の付着、培養、及び剥離のための方法、表面改質されたプレート、並びに組成物
US20110236977A1 (en) * 2008-04-02 2011-09-29 The Trustees Of Columbia University In The City Of New York Dental stem cell differentiation
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
US7939322B2 (en) 2008-04-24 2011-05-10 Centocor Ortho Biotech Inc. Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
CA2723820A1 (en) 2008-05-09 2009-11-12 Vistagen Therapeutics, Inc. Pancreatic endocrine progenitor cells derived from pluripotent stem cells
ES2862623T3 (es) * 2008-05-22 2021-10-07 Vesta Therapeutics Inc Método de diferenciación de células progenitoras de mamíferos en células pancreáticas de los islotes productoras de insulina
GB2460552B (en) * 2008-06-05 2011-09-07 Iti Scotland Ltd Stem cell culture media and methods
EP2942392B1 (en) 2008-06-30 2018-10-03 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
AU2009267167A1 (en) * 2008-06-30 2010-01-07 Centocor Ortho Biotech Inc. Differentiation of pluripotent stem cells
US20100028307A1 (en) * 2008-07-31 2010-02-04 O'neil John J Pluripotent stem cell differentiation
KR101025880B1 (ko) * 2008-10-23 2011-03-30 공희숙 성체 줄기세포를 이용한 인슐린 분비세포로의 분화 유도방법
US9234178B2 (en) * 2008-10-31 2016-01-12 Janssen Biotech, Inc. Differentiation of human pluripotent stem cells
EP2350265B1 (en) 2008-10-31 2019-04-17 Janssen Biotech, Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
JP5390624B2 (ja) * 2008-11-04 2014-01-15 バイアサイト インク 幹細胞集合体懸濁液組成物、その分化方法
JP2012508584A (ja) 2008-11-14 2012-04-12 ヴィアサイト,インコーポレイテッド ヒト多能性幹細胞由来膵臓細胞のカプセル化
KR101687344B1 (ko) * 2008-11-20 2016-12-16 얀센 바이오테크 인코포레이티드 평면 기재상의 세포 부착 및 배양을 위한 방법 및 조성물
KR101774546B1 (ko) 2008-11-20 2017-09-04 얀센 바이오테크 인코포레이티드 마이크로-캐리어 상의 만능 줄기 세포 배양
CN102387807A (zh) 2008-12-19 2012-03-21 先进科技及再生医学有限责任公司 肺部疾病和病症的治疗
US10179900B2 (en) * 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
EP2393917B1 (en) * 2009-02-03 2016-04-06 Koninklijke Nederlandse Akademie van Wetenschappen Culture medium for epithelial stem cells and organoids comprising said stem cells.
US8507274B2 (en) 2009-02-06 2013-08-13 President And Fellows Of Harvard College Compositions and methods for promoting the generation of definitive endoderm
SG174551A1 (en) * 2009-03-26 2011-10-28 Ethicon Inc Human umbilical cord tissue cells as therapy for alzheimer' s disease
WO2010143572A1 (ja) * 2009-06-12 2010-12-16 オリンパス株式会社 被検体情報分析装置及び被検体情報分析方法
WO2010151733A1 (en) * 2009-06-25 2010-12-29 The Trustees Of Columbia University In The City Of New York Dental stem cell reprogramming
CN102803472B (zh) * 2009-06-25 2014-04-23 吉隆公司 去除了外来表型的由多能干细胞分化的子代细胞
US9388381B2 (en) 2009-07-09 2016-07-12 Massachusetts Institute Of Technology Methods and compositions for increased safety of stem cell-derived populations
CN102482643B (zh) 2009-07-20 2016-06-29 詹森生物科技公司 人胚胎干细胞的分化
US8785184B2 (en) * 2009-07-20 2014-07-22 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CN103952372B (zh) * 2009-07-20 2016-10-05 詹森生物科技公司 人胚胎干细胞的分化
PL2494035T3 (pl) * 2009-10-29 2018-07-31 Janssen Biotech, Inc. Pluripotencjalne komórki macierzyste
US9018010B2 (en) 2009-11-12 2015-04-28 Technion Research & Development Foundation Limited Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
SG10201408552YA (en) 2009-12-23 2015-02-27 Janssen Biotech Inc Differentiation of human embryonic stem cells
CN102712902B (zh) * 2009-12-23 2019-01-08 詹森生物科技公司 人胚胎干细胞的分化
CA2785966C (en) 2009-12-29 2020-10-27 Takeda Pharmaceutical Company Limited Method for manufacturing pancreatic-hormone-producing cells
PH12012501686A1 (en) 2010-03-01 2020-10-19 Janssen Biotech Inc Methods for purifying cells derived from pluripotent stem cells
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
RU2587634C2 (ru) * 2010-05-12 2016-06-20 Янссен Байотек, Инк. Дифференцирование эмбриональных стволовых клеток человека
EP2582793B1 (en) 2010-06-15 2017-09-06 Cellular Dynamics International, Inc. A compendium of ready-built stem cell models for interrogation of biological response
CA2806858C (en) 2010-08-04 2021-06-15 Cellular Dynamics International, Inc. Reprogramming immortalized b cells
KR101877077B1 (ko) 2010-08-09 2018-07-10 다케다 야쿠힌 고교 가부시키가이샤 췌호르몬-생성 세포의 제조 방법
KR20190027969A (ko) 2010-08-12 2019-03-15 얀센 바이오테크 인코포레이티드 췌장 내분비 전구 세포를 이용한 당뇨병의 치료
PL2853589T3 (pl) 2010-08-31 2018-05-30 Janssen Biotech, Inc Różnicowanie ludzkich zarodkowych komórek macierzystych
EP3372672A1 (en) 2010-08-31 2018-09-12 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CN103154237B (zh) 2010-08-31 2016-03-16 詹森生物科技公司 多能干细胞的分化
US9732128B2 (en) 2010-10-22 2017-08-15 Biotime, Inc. Methods of modifying transcriptional regulatory networks in stem cells
WO2012056997A1 (ja) * 2010-10-28 2012-05-03 国立大学法人熊本大学 多能性幹細胞の分化誘導効率を改善するための方法及び培地
WO2012068170A2 (en) 2010-11-15 2012-05-24 Jau-Nan Lee Generation of neural stem cells from human trophoblast stem cells
EP2652125B1 (en) * 2010-12-15 2017-04-26 Kadimastem Ltd. Insulin producing cells derived from pluripotent stem cells
KR20140004707A (ko) 2011-01-31 2014-01-13 독립행정법인 국립국제의료연구 센터 다능성 줄기 세포 유래 고기능 간세포와 그의 제조 방법 및 약제 대사 독성 시험 방법
WO2012135253A1 (en) 2011-03-29 2012-10-04 Geron Corporation Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells
EP2723852B1 (en) 2011-06-21 2021-11-17 Novo Nordisk A/S Efficient induction of definitive endoderm from pluripotent stem cells
US10865383B2 (en) 2011-07-12 2020-12-15 Lineage Cell Therapeutics, Inc. Methods and formulations for orthopedic cell therapy
WO2013049375A2 (en) * 2011-09-28 2013-04-04 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulating beta cell proliferation
WO2013055397A1 (en) 2011-10-14 2013-04-18 Children's Medical Center Corporation Inhibition and enhancement of reprogramming by chromatin modifying enzymes
FI2794857T3 (fi) * 2011-12-22 2026-03-25 Janssen Biotech Inc Ihmisen alkion kantasolujen erilaistaminen yksittäisiksi hormonaalisiksi insuliinipositiivisiksi soluiksi
AU2012358810B2 (en) 2011-12-23 2018-03-15 DePuy Synthes Products, Inc. Detection of human umbilical cord tissue-derived cells
CA2866590A1 (en) 2012-03-07 2013-09-12 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
EP2863026A4 (en) 2012-04-27 2016-03-02 Hino Motors Ltd BURNER AND FILTER RENEWAL DEVICE
US9447378B2 (en) 2012-04-27 2016-09-20 Massachusetts Institute Of Technology Method for differentiating human embryonic stem cells into β-cells for the treatment of type I diabetes
HRP20191677T1 (hr) * 2012-04-30 2019-12-13 Univ Health Network POSTUPCI I SASTAVI ZA GENERIRANJE PANKREASNIH PROGENITORA I FUNKCIONALNIH BETA STANICA IZ hPSC
BR112014027783A2 (pt) 2012-05-07 2017-06-27 Janssen Biotech Inc diferenciação de células-tronco embrionárias humanas em endoderma pancreático
KR20160027219A (ko) 2012-05-23 2016-03-09 에프. 호프만-라 로슈 아게 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법
EP3450544A1 (en) * 2012-06-08 2019-03-06 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endodrine cells
JP5979452B2 (ja) * 2012-06-11 2016-08-24 国立大学法人北海道大学 多能性幹細胞の選別方法
GB201216796D0 (en) * 2012-09-20 2012-11-07 Cambridge Entpr Ltd In vitro pancreatic differentiation
WO2014052458A1 (en) 2012-09-25 2014-04-03 Yale University Differentiation of human ips cells to human alveolar type ii via definitive endoderm
WO2014085493A1 (en) * 2012-11-30 2014-06-05 Jau-Nan Lee Methods of differentiating stem cells by modulating mir-124
BR112015015714A2 (pt) 2012-12-31 2017-07-11 Janssen Biotech Inc suspensão e aglomeração de células pluripotentes humanas para diferenciação em célu-las endócrinas pancreáticas
ES2837763T3 (es) 2012-12-31 2021-07-01 Janssen Biotech Inc Cultivo de células madre embrionarias humanas en la interconexión aire-líquido para la diferenciación en células endocrinas pancreáticas
DK2938723T3 (da) 2012-12-31 2023-02-20 Janssen Biotech Inc Differentiering af humane embryonale stamceller til pancreatiske endokrine celler under anvendelse af hb9-regulatorer
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
CA2902857C (en) 2013-02-27 2022-11-29 The Regents Of The University Of California Generation of thymic epithelial progenitor cells in vitro
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
CN120796168A (zh) 2013-06-11 2025-10-17 哈佛学院校长同事会 SC-β细胞以及用于产生其的组合物和方法
JP6650393B2 (ja) 2013-06-13 2020-02-19 オージェネシス リミテッド 細胞の集団、分化転換の方法及びその使用方法
WO2014201431A1 (en) 2013-06-14 2014-12-18 Massachusetts Institute Of Technology Articles and methods for stem cell differentiation
GB201317869D0 (en) 2013-10-09 2013-11-20 Cambridge Entpr Ltd In vitro production of foregut stem cells
US9988605B2 (en) 2013-12-11 2018-06-05 Korea Advanced Institute Of Science And Technology Method for preparing endocrine aggregate of insulin-producing beta cells from human pluripotent stem cells
JP6643993B2 (ja) * 2013-12-16 2020-02-12 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング 膵島様細胞構造体及びそれを調製する方法
US9804692B2 (en) * 2014-03-28 2017-10-31 Samsung Display Co., Ltd. System and method for generating haptic feedback in stylus
KR20200138445A (ko) 2014-04-24 2020-12-09 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 입양 세포 요법 생성물을 생성하기 위한 유도 만능 줄기 세포의 응용
WO2015175307A1 (en) 2014-05-16 2015-11-19 Janssen Biotech, Inc. Use of small molecules to enhance mafa expression in pancreatic endocrine cells
CA2949171A1 (en) 2014-05-16 2015-11-19 Koninklijke Nederlandse Akademie Van Wetenschappen Improved culture method for organoids
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
WO2016043666A1 (en) * 2014-09-19 2016-03-24 Agency For Science, Technology And Research Differentiation of hepatocyte-like cells from stem cells
AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
WO2016100898A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof
CN107614678B (zh) 2014-12-18 2021-04-30 哈佛学院校长同事会 干细胞来源的β细胞的产生方法及其使用方法
EP3234110B1 (en) 2014-12-18 2024-02-28 President and Fellows of Harvard College METHODS FOR GENERATING STEM CELL-DERIVED ß CELLS AND USES THEREOF
EP3234109A4 (en) 2014-12-19 2018-06-27 Janssen Biotech, Inc. Suspension culturing of pluripotent stem cells
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
GB201603569D0 (en) 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method
US10420803B2 (en) 2016-04-14 2019-09-24 Janssen Biotech, Inc. Differentiation of pluripotent stem cells to intestinal midgut endoderm cells
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
EP4553082A3 (en) 2016-11-04 2025-08-20 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
EP3591040A4 (en) 2017-03-03 2020-11-11 Kyoto University METHOD OF PRODUCTION OF PANCREATIC PROGENITOR CELLS
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
EP3635106A4 (en) 2017-05-08 2021-01-06 Orgenesis Ltd. POPULATIONS OF TRANSDIFFERENTIATED CELLS AND THEIR METHODS OF USE
CN111565707A (zh) 2017-06-14 2020-08-21 森玛治疗公司 用于递送治疗物的装置和方法
JP2020535834A (ja) 2017-10-03 2020-12-10 エスディーエフ バイオファーマ インコーポレイテッド 遺伝子修飾されたベータ細胞による糖尿病の治療
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
EP3710021A4 (en) 2017-11-15 2021-08-11 Semma Therapeutics, Inc. ISLAND CELL MANUFACTURING COMPOSITIONS AND METHOD OF USE
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
GB201721615D0 (en) 2017-12-21 2018-02-07 Koninklijke Nederlandse Akademie Van Wetenschappen Immune cell organoid co-cultures
EP4678727A3 (en) 2018-07-26 2026-03-11 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
WO2020033879A1 (en) 2018-08-10 2020-02-13 Semma Therapeutics, Inc. Stem cell derived islet differentiation
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
GB201819224D0 (en) 2018-11-26 2019-01-09 Koninklijke Nederlandse Akademie Van Wetenschappen Hepatocyte expansion methods
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
WO2020232436A1 (en) 2019-05-16 2020-11-19 Brown University A human in vitro cardiotoxicity model
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CN112852627A (zh) * 2019-11-28 2021-05-28 中国科学院大连化学物理研究所 一种基于多器官芯片的多能干细胞来源人肝和胰岛共培养的方法
CN113106054B (zh) * 2020-01-13 2022-10-14 青岛瑞思德生物科技有限公司 一种将间充质干细胞诱导分化为胰岛细胞的诱导剂
US12188051B2 (en) 2020-05-27 2025-01-07 The Regents Of The University Of Michigan Compositions and methods for obtaining vascularized human intestinal organoid tissue, and related uses thereof
US12504423B2 (en) 2020-10-16 2025-12-23 Brown University Human in vitro cardiotoxicity model
US12076437B2 (en) 2021-07-12 2024-09-03 Brown University Proangiogenic protein cocktails delivered in custom biomaterials to revascularize ischemic tissue
WO2025117331A1 (en) 2023-12-01 2025-06-05 Eli Lilly And Company Methods of making stem cell-derived islet-like cells, as well as populations and compositions including the same

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391909A (en) 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4378016A (en) 1981-07-15 1983-03-29 Biotek, Inc. Artificial endocrine gland containing hormone-producing cells
US4439521A (en) 1981-10-21 1984-03-27 Ontario Cancer Institute Method for producing self-reproducing mammalian pancreatic islet-like structures
GB8604497D0 (en) 1986-02-24 1986-04-03 Connaught Lab Separation of islets of langerhans
GB2197915B (en) 1986-11-19 1990-11-14 Rolls Royce Plc Improvements in or relating to fluid bearings
EP0605428B9 (en) 1991-06-24 2003-01-02 hCell Technology, Inc. Hormone-secreting pancreatic cells maintained in long-term culture
US5425764A (en) 1992-07-30 1995-06-20 The University Of Toledo Bioartificial pancreas
AU687386B2 (en) 1993-04-08 1998-02-26 Human Cell Cultures, Inc. Cell culturing method and medium
FR2710654B1 (fr) 1993-09-30 1995-12-22 Maryam Asfari Nouvelles lignées de cellules sécrétrices d'insuline, leurs procédés d'obtention par voie de manipulation génétique et leur utilisation chez des sujets diabétiques sous forme protégée.
US5834308A (en) 1994-04-28 1998-11-10 University Of Florida Research Foundation, Inc. In vitro growth of functional islets of Langerhans
US5587309A (en) 1994-04-29 1996-12-24 The United States Of America As Represented By The Department Of Health And Human Services Method of stimulating proliferation and differentiation of human fetal pancreatic cells ex vivo
US5849989A (en) 1994-10-07 1998-12-15 Ontogeny, Inc. Insulin promoter factor, and uses related thereto
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5679565A (en) 1995-04-10 1997-10-21 The Regents Of The University Of California Method of preserving pancreatic islets
CA2218623A1 (en) 1996-02-23 1997-08-28 Circe Biomedical, Inc. Novel artificial pancreas
US5869243A (en) 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
IL129222A0 (en) 1996-10-01 2000-02-17 Geron Corp Telomerase reverse transcriptase
CA2277278A1 (en) 1997-01-10 1998-07-16 Life Technologies, Inc. Embryonic stem cell serum replacement
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US5935852A (en) * 1997-07-03 1999-08-10 Genetics Institute, Inc. DNA molecules encoding mammalian cerberus-like proteins
CA2307807C (en) 1997-10-23 2008-09-02 Andrea G. Bodnar Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
WO2000047720A2 (en) * 1999-02-10 2000-08-17 Curis, Inc. Pancreatic progenitor cells, methods and uses related thereto
US6946293B1 (en) * 1999-02-10 2005-09-20 Es Cell International Pte Ltd. Progenitor cells, methods and uses related thereto
AU3227000A (en) 1999-02-10 2000-08-29 Ontogeny, Inc. Methods of inducing insulin positive progenitor cells
US6774120B1 (en) 1999-06-01 2004-08-10 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
CA2375509A1 (en) 1999-06-23 2000-12-28 Joslin Diabetes Center, Inc Methods of making pancreatic islet cells
WO2001011011A2 (en) 1999-08-05 2001-02-15 Mcl Llc Multipotent adult stem cells and methods for isolation
AU7445800A (en) 1999-09-27 2001-04-30 Chugai Seiyaku Kabushiki Kaisha Method of prolonging normal cell life span
CA2392615A1 (en) * 1999-12-06 2001-06-07 The General Hospital Corporation Pancreatic stem cells and their use in transplantation
CA2397292A1 (en) 2000-01-14 2001-07-19 Bresagen Limited Cell production
US6610535B1 (en) 2000-02-10 2003-08-26 Es Cell International Pte Ltd. Progenitor cells and methods and uses related thereto
US6436704B1 (en) 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
EP1366148A2 (en) 2001-01-24 2003-12-03 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES Differentiation of stem cells to pancreatic endocrine cells
AU2002235728A1 (en) 2001-02-26 2002-10-03 Novo Nordisk A/S Method for generating insulin-secreting cells suitable for transplantation
AU2002242538B2 (en) 2001-03-21 2007-06-28 Geron Corporation Animal tissue with carbohydrate antigens compatible for human transplantation
CA2442177A1 (en) 2001-03-29 2002-10-10 Ixion Biotechnology, Inc. Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway
WO2002086107A2 (en) * 2001-04-19 2002-10-31 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung A method for differentiating stem cells into insulin-producing cells
EP1393066A4 (en) * 2001-05-15 2006-01-25 Rappaport Family Inst For Res INSULIN-PRODUCING CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS
CA2451838A1 (en) 2001-05-25 2002-12-05 Cythera, Inc. Stem cell differentiation
EP1298201A1 (en) * 2001-09-27 2003-04-02 Cardion AG Process for the production of cells exhibiting an islet-beta-cell-like state
EP1448763A4 (en) 2001-11-09 2006-11-29 Es Cell Int Pte Ltd CHARACTERIZATION AND ISOLATION OF SUBSETS OF HUMAN EMBRYONIC STEM CELLS (HES) AND CELLS ASSOCIATED THERETO OR DERIVED THEREFROM
IL162131A0 (en) * 2001-12-07 2005-11-20 Geron Corp Islet cells from human embryonic stem cells
US20060003446A1 (en) * 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
EP1543110A4 (en) 2002-05-17 2006-09-06 Sinai School Medicine POPULATION OF DEFINITIVE ENDODERMIC CELLS AND MESODERMAL
WO2003102171A1 (en) * 2002-05-28 2003-12-11 Becton, Dickinson And Company Expansion and transdifferentiation of human acinar cells
US20050266554A1 (en) * 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
CN103898047B (zh) * 2003-12-23 2020-03-03 维亚希特公司 定形内胚层
US7541185B2 (en) * 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
WO2006083782A2 (en) * 2005-01-31 2006-08-10 Es Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
WO2007075807A2 (en) 2005-12-20 2007-07-05 Es Cell International Pte Ltd. Methods for the directed differentiation of embryonic stem cell
US8415153B2 (en) 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells

Similar Documents

Publication Publication Date Title
JP2008212150A5 (https=)
RU2011124900A (ru) Культура плюрипотентных стволовых клеток на микроносителях
EP2896690A3 (en) Use of RNA for reprogramming somatic cells
JP2017500013A5 (https=)
WO2008036447A3 (en) Pluripotent stem cell culture
SE0850111L (sv) Förfarande för differentiering av stamceller till celler av den endodermala och pankreatiska utvecklingslinjen
WO2007115337A8 (en) Chondrocyte differentiation from human embryonic stem cells and their use in tissue engineering
WO2007077217A3 (en) Oligopeptide-free cell culture media
SI1646715T1 (sl) Pridobivanje poksvirusov z adherentnimi ali ne adherentnimi linijami ptičjih celic
EP2727998A3 (en) Methods for purifying pancreatic endoderm cells derived from human embryonic stem cells
JP2005501554A5 (https=)
JP2008525039A5 (https=)
WO2008148105A8 (en) Endometrial stem cells and methods of making and using same
WO2015054526A3 (en) Methods of mammalian retinal stem cell production and applications
EP4368701A3 (en) Feeder-free culture system
WO2007030469A3 (en) Transplantable cell growth niche and related compositions and methods
WO2011119507A3 (en) Method of altering the differentiative state of a cell and compositions thereof
WO2007149182A3 (en) Differentiation and enrichment of islet-like cells from human pluripotent stem cells
IL320421A (en) Stem cell aggregate suspension compositions and methods for differentiation thereof
WO2006070370A3 (en) Stem cells culture systems
MY157524A (en) Culturing embryonic stem cells, embryonic stem-like cells, or induced pluripotent stem cells with a muc1 or muc1* ligand
WO2007146123A3 (en) Placental niche and use thereof to culture stem cells
WO2010088456A3 (en) Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
JP2014501518A5 (https=)
WO2008058273A3 (en) Dedifferentiation of adult mammalian cardiomyocytes into cardiac stem cells