JP2007528904A5 - - Google Patents
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- JP2007528904A5 JP2007528904A5 JP2007503066A JP2007503066A JP2007528904A5 JP 2007528904 A5 JP2007528904 A5 JP 2007528904A5 JP 2007503066 A JP2007503066 A JP 2007503066A JP 2007503066 A JP2007503066 A JP 2007503066A JP 2007528904 A5 JP2007528904 A5 JP 2007528904A5
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- HKHXMGUQAPFZOS-WRWORJQWSA-N CCO[C@@H](C(NC([C@H]1NCCC1)=O)=C1)OC1=O Chemical compound CCO[C@@H](C(NC([C@H]1NCCC1)=O)=C1)OC1=O HKHXMGUQAPFZOS-WRWORJQWSA-N 0.000 description 2
- ABYYATZCXRICQU-MAUKXSAKSA-N CCO[C@@H](C(NC([C@H](CCC1)N1C(OCc1ccccc1)=O)=O)=C1)OC1=O Chemical compound CCO[C@@H](C(NC([C@H](CCC1)N1C(OCc1ccccc1)=O)=O)=C1)OC1=O ABYYATZCXRICQU-MAUKXSAKSA-N 0.000 description 1
- GONGBLWIQFFRKY-JXHRLWIKSA-N CCO[C@@H](C(NC([C@H](CCC1)N1C([C@H](C(C)(C)C)NC(OCc1ccccc1)=O)=O)=O)=C1)OC1=O Chemical compound CCO[C@@H](C(NC([C@H](CCC1)N1C([C@H](C(C)(C)C)NC(OCc1ccccc1)=O)=O)=O)=C1)OC1=O GONGBLWIQFFRKY-JXHRLWIKSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55248004P | 2004-03-12 | 2004-03-12 | |
| US60/552,480 | 2004-03-12 | ||
| PCT/US2005/008251 WO2005090334A2 (en) | 2004-03-12 | 2005-03-11 | Processes and intermediates for the preparation of aspartic acetal caspase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011235246A Division JP2012072151A (ja) | 2004-03-12 | 2011-10-26 | アスパラギン酸アセタールカスパーゼ阻害剤の製造のための方法および中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007528904A JP2007528904A (ja) | 2007-10-18 |
| JP2007528904A5 true JP2007528904A5 (https=) | 2008-04-24 |
| JP4898658B2 JP4898658B2 (ja) | 2012-03-21 |
Family
ID=34962478
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503066A Expired - Lifetime JP4898658B2 (ja) | 2004-03-12 | 2005-03-11 | アスパラギン酸アセタールカスパーゼ阻害剤の製造のための方法および中間体 |
| JP2011235246A Pending JP2012072151A (ja) | 2004-03-12 | 2011-10-26 | アスパラギン酸アセタールカスパーゼ阻害剤の製造のための方法および中間体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011235246A Pending JP2012072151A (ja) | 2004-03-12 | 2011-10-26 | アスパラギン酸アセタールカスパーゼ阻害剤の製造のための方法および中間体 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US7381827B2 (https=) |
| EP (3) | EP2399916B1 (https=) |
| JP (2) | JP4898658B2 (https=) |
| KR (2) | KR101135765B1 (https=) |
| CN (3) | CN1950364B (https=) |
| AR (1) | AR048008A1 (https=) |
| AU (1) | AU2005223767B2 (https=) |
| BR (1) | BRPI0508609B8 (https=) |
| CA (3) | CA2843066C (https=) |
| DK (3) | DK1725548T3 (https=) |
| ES (3) | ES2532967T3 (https=) |
| HU (1) | HUE024556T2 (https=) |
| IL (3) | IL178003A (https=) |
| PL (4) | PL381358A1 (https=) |
| PT (3) | PT2399915E (https=) |
| RU (2) | RU2433127C2 (https=) |
| SG (2) | SG150547A1 (https=) |
| SI (3) | SI1725548T1 (https=) |
| TW (3) | TW201200508A (https=) |
| WO (1) | WO2005090334A2 (https=) |
| ZA (1) | ZA200607605B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP1019A (en) | 1996-10-18 | 2001-10-16 | Vertex Pharma | Inhibitors of serinre proteases, particularly hepatitis C virus NS3 protease. |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| UY28500A1 (es) | 2003-09-05 | 2005-04-29 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc. |
| EP1718639A2 (en) * | 2004-02-27 | 2006-11-08 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| MXPA06013256A (es) * | 2004-05-15 | 2007-02-08 | Vertex Pharma | Tratamiento de crisis convulsivas utilizando inhibidores ice. |
| US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
| US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| AR055395A1 (es) * | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| AU2007217355B2 (en) | 2006-02-27 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Co-crystals comprising VX-950 and pharmaceutical compositions comprising the same |
| WO2007109080A2 (en) | 2006-03-16 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis c protease inhibitors |
| CA2669917A1 (en) * | 2006-11-17 | 2008-05-22 | Dawn M. George | Aminopyrrolidines as chemokine receptor antagonists |
| HRP20120330T1 (hr) * | 2007-02-27 | 2012-05-31 | Vertex Pharmaceuticals Incorporated | Sukristali i farmaceutski pripravci koji ih sadrže |
| WO2008106058A2 (en) | 2007-02-27 | 2008-09-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| NZ583699A (en) | 2007-08-30 | 2012-04-27 | Vertex Pharma | Co-crystals of vx-950 (telaprevir) other components and pharmaceutical compositions comprising the same |
| WO2010017408A1 (en) | 2008-08-06 | 2010-02-11 | The Buck Institute For Age Research | Caspase inhibitors and uses thereof |
| US9113848B2 (en) * | 2010-02-03 | 2015-08-25 | Covidien Lp | Surgical retrieval apparatus |
| JP5769655B2 (ja) * | 2012-03-30 | 2015-08-26 | ユニ・チャーム株式会社 | 吸収性物品 |
| CN103193572B (zh) * | 2013-04-07 | 2015-06-17 | 山东大学 | 一种拉唑类化合物单一对映体的分离方法 |
| ES2950100T3 (es) | 2016-12-23 | 2023-10-05 | Casp Aid Inc | Inhibición de la caspasa-1 y usos de esta para la prevención y el tratamiento de afecciones neurológicas |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5874424A (en) | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| GB9123326D0 (en) | 1991-11-04 | 1991-12-18 | Sandoz Ltd | Improvements in or relating to organic compounds |
| BE1008343A3 (nl) | 1994-05-06 | 1996-04-02 | Dsm Nv | Bidentaat fosfineligand |
| US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5716929A (en) | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5756466A (en) | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5847135A (en) | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
| AU704318B2 (en) * | 1995-11-09 | 1999-04-22 | Pq Nederland B.V. | Compacted sodium silicate |
| US5843904A (en) | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
| US6200969B1 (en) | 1996-09-12 | 2001-03-13 | Idun Pharmaceuticals, Inc. | Inhibition of apoptosis using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors |
| KR20000036056A (ko) | 1996-09-12 | 2000-06-26 | 아이디유엔 파마슈티칼즈, 인코포레이티드 | 인터루킨-1β 전환 효소 및 관련 프로테아제의 억제제로서의 Ｃ-말단 변형된 (Ｎ-치환된)-2-인돌릴 디펩티드 |
| EP0929311B8 (en) | 1996-09-12 | 2006-02-01 | Idun Pharmaceuticals, Inc. | INHIBITION OF APOPTOSIS USING INTERLEUKIN-1 beta-CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS |
| NZ330451A (https=) | 1996-09-12 | 2000-01-28 | Idun Pharmaceuticals Inc | |
| US5968927A (en) | 1996-09-20 | 1999-10-19 | Idun Pharmaceuticals, Inc. | Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes |
| WO1998016502A1 (en) | 1996-10-11 | 1998-04-23 | Warner-Lambert Company | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
| NZ334906A (en) | 1996-10-11 | 2000-09-29 | Basf Ag | A sulphonamido pentanoic acid derivative useful as an interleukin-1-beta converting enzyme inhibitor |
| US5919790A (en) | 1996-10-11 | 1999-07-06 | Warner-Lambert Company | Hydroxamate inhibitors of interleukin-1β converting enzyme |
| AP1019A (en) | 1996-10-18 | 2001-10-16 | Vertex Pharma | Inhibitors of serinre proteases, particularly hepatitis C virus NS3 protease. |
| US6184244B1 (en) | 1996-12-16 | 2001-02-06 | Idun Pharmaceuticals, Inc. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| FR2766188B1 (fr) | 1997-07-15 | 2000-02-11 | Hoechst Marion Roussel Inc | Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes |
| US6184210B1 (en) | 1997-10-10 | 2001-02-06 | Cytovia, Inc. | Dipeptide apoptosis inhibitors and the use thereof |
| ATE388139T1 (de) | 1997-12-18 | 2008-03-15 | Boehringer Ingelheim Pharma | Pyridone als hemmer der sh2-domäne der src- familie |
| JP2002509153A (ja) | 1998-01-20 | 2002-03-26 | ワーナー−ランバート・カンパニー | インターロイキン−１β変換酵素（ＩＣＥ）のインビボ阻害剤としてのＮ−［２−（５−ベンジルオキシカルボニル−アミノ−６−オキソ−２−（４−フルオロフェニル）−１，６−ジヒドロ−１−ピリミジニル）アセトキシル］−Ｌ−アスパラギン酸アルデヒド |
| DK1064298T3 (da) * | 1998-03-19 | 2009-01-19 | Vertex Pharma | Inhibitorer af caspaser |
| US6197750B1 (en) | 1998-07-02 | 2001-03-06 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| US6242422B1 (en) | 1998-10-22 | 2001-06-05 | Idun Pharmacueticals, Inc. | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
| CA2367862A1 (en) | 1999-03-16 | 2000-09-21 | Merck Frosst Canada & Co. | Gamma-ketoacid dipeptides as inhibitors of caspase-3 |
| JP2002539183A (ja) | 1999-03-16 | 2002-11-19 | サイトビア インコーポレイテッド | 置換２−アミノベンズアミドカスパーゼインヒビターおよびその使用 |
| CN1176941C (zh) | 1999-04-09 | 2004-11-24 | 西托维亚公司 | Caspase抑制剂及其应用 |
| ES2274795T3 (es) | 1999-07-19 | 2007-06-01 | Merck Frosst Canada Ltd. | Pirazinonas, composiciones que contienen tales compuestos. |
| EP1163208B1 (en) | 1999-08-06 | 2004-05-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| CN1235875C (zh) | 1999-08-27 | 2006-01-11 | 西托维亚公司 | 取代的α－羟基酸天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途 |
| AR026748A1 (es) | 1999-12-08 | 2003-02-26 | Vertex Pharma | Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis |
| PE20011267A1 (es) | 2000-03-29 | 2001-12-15 | Vertex Pharma | Carbamato como inhibidores de caspasa |
| AU2001251165A1 (en) | 2000-04-03 | 2001-10-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
| CA2402128A1 (en) * | 2000-04-24 | 2001-11-01 | Vertex Pharmaceuticals Incorporated | Process and intermediates for making substituted aspartic acid acetals |
| TWI291462B (en) | 2000-04-25 | 2007-12-21 | Daiichi Sankyo Co Ltd | Hydrate crystal of neuraminic acid compound |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| TR200200767T1 (tr) | 2000-05-23 | 2002-09-23 | Vertex Pharmaceuticals Incorporated | Kaspaz engelleyiciler ve kullanımları |
| EP1289993B9 (en) | 2000-06-07 | 2008-08-20 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| CN1498224A (zh) | 2000-07-21 | 2004-05-19 | ���鹫˾ | 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽 |
| WO2002022611A2 (en) | 2000-09-13 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| US6846806B2 (en) | 2000-10-23 | 2005-01-25 | Bristol-Myers Squibb Company | Peptide inhibitors of Hepatitis C virus NS3 protein |
| AU2002232541A1 (en) | 2000-11-21 | 2002-06-03 | Vertex Pharmaceuticals Incorporated | Imidazole and benzimidazole caspase inhibitors and uses thereof |
| GB0107924D0 (en) | 2001-03-29 | 2001-05-23 | Angeletti P Ist Richerche Bio | Inhibitor of hepatitis C virus NS3 protease |
| US20030096737A1 (en) | 2001-04-19 | 2003-05-22 | Anita Diu-Hercend | Caspase inhibitors and uses thereof |
| JP4428926B2 (ja) | 2001-05-23 | 2010-03-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼインヒビターおよびそれらの使用 |
| IL159087A0 (en) | 2001-07-11 | 2004-05-12 | Vertex Pharma | Bridged bicyclic compounds and pharmaceutical compositions containing the same |
| AU2002348533A1 (en) | 2001-10-09 | 2003-05-26 | Vertex Pharmaceuticals Incorporated | Process for synthesizing aspartic and glutamic acid derivatives and diazoketone intermediates thereof |
| US7410956B2 (en) | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
| US7960398B2 (en) | 2002-04-19 | 2011-06-14 | Vertex Pharmaceuticals Incorporated | Regulation of TNF-alpha |
| US7138395B2 (en) | 2002-06-10 | 2006-11-21 | The Procter & Gamble Company | Interleukin-1β converting enzyme inhibitors |
| US7001899B2 (en) | 2002-06-10 | 2006-02-21 | The Procter & Gamble Company | Interleukin converting enzyme inhibitors |
| US7041696B2 (en) | 2002-06-17 | 2006-05-09 | The Procter & Gamble Company | Interleukin-1β converting enzyme inhibitors |
| PE20040728A1 (es) | 2002-06-28 | 2004-10-23 | Vertex Pharma | Inhibidores de caspasa |
| TW200500343A (en) | 2002-12-20 | 2005-01-01 | Vertex Pharma | Caspase inhibitors and uses thereof |
| PE20050159A1 (es) | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
| EP1718639A2 (en) * | 2004-02-27 | 2006-11-08 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
-
2005
- 2005-03-11 SG SG200901309-5A patent/SG150547A1/en unknown
- 2005-03-11 PT PT111781266T patent/PT2399915E/pt unknown
- 2005-03-11 DK DK05728092.7T patent/DK1725548T3/en active
- 2005-03-11 PT PT11178128T patent/PT2399916E/pt unknown
- 2005-03-11 PL PL381358A patent/PL381358A1/pl not_active Application Discontinuation
- 2005-03-11 ES ES11178126.6T patent/ES2532967T3/es not_active Expired - Lifetime
- 2005-03-11 ES ES11178128.2T patent/ES2532433T3/es not_active Expired - Lifetime
- 2005-03-11 CA CA2843066A patent/CA2843066C/en not_active Expired - Fee Related
- 2005-03-11 WO PCT/US2005/008251 patent/WO2005090334A2/en not_active Ceased
- 2005-03-11 RU RU2006136032/04A patent/RU2433127C2/ru active
- 2005-03-11 AR ARP050100964A patent/AR048008A1/es not_active Application Discontinuation
- 2005-03-11 SG SG200901306-1A patent/SG150546A1/en unknown
- 2005-03-11 SI SI200531959T patent/SI1725548T1/sl unknown
- 2005-03-11 CA CA2768700A patent/CA2768700C/en not_active Expired - Fee Related
- 2005-03-11 DK DK11178126T patent/DK2399915T3/en active
- 2005-03-11 AU AU2005223767A patent/AU2005223767B2/en not_active Ceased
- 2005-03-11 US US11/078,147 patent/US7381827B2/en active Active
- 2005-03-11 PL PL05728092T patent/PL1725548T3/pl unknown
- 2005-03-11 BR BRPI0508609A patent/BRPI0508609B8/pt not_active IP Right Cessation
- 2005-03-11 DK DK11178128T patent/DK2399916T3/en active
- 2005-03-11 SI SI200531945T patent/SI2399915T1/sl unknown
- 2005-03-11 CN CN2005800144933A patent/CN1950364B/zh not_active Expired - Lifetime
- 2005-03-11 HU HUE05728092A patent/HUE024556T2/hu unknown
- 2005-03-11 KR KR1020067021136A patent/KR101135765B1/ko not_active Expired - Fee Related
- 2005-03-11 CN CN2013103410022A patent/CN103467459A/zh active Pending
- 2005-03-11 CA CA2559303A patent/CA2559303C/en not_active Expired - Fee Related
- 2005-03-11 PT PT57280927T patent/PT1725548E/pt unknown
- 2005-03-11 EP EP11178128.2A patent/EP2399916B1/en not_active Expired - Lifetime
- 2005-03-11 ES ES05728092.7T patent/ES2533991T3/es not_active Expired - Lifetime
- 2005-03-11 KR KR1020117029981A patent/KR20110137409A/ko not_active Ceased
- 2005-03-11 PL PL11178126T patent/PL2399915T3/pl unknown
- 2005-03-11 EP EP11178126.6A patent/EP2399915B1/en not_active Expired - Lifetime
- 2005-03-11 JP JP2007503066A patent/JP4898658B2/ja not_active Expired - Lifetime
- 2005-03-11 EP EP05728092.7A patent/EP1725548B1/en not_active Expired - Lifetime
- 2005-03-11 CN CN2011100999799A patent/CN102225936B/zh not_active Expired - Lifetime
- 2005-03-11 SI SI200531941T patent/SI2399916T1/sl unknown
- 2005-03-11 PL PL11178128T patent/PL2399916T3/pl unknown
- 2005-03-14 TW TW100133524A patent/TW201200508A/zh unknown
- 2005-03-14 TW TW101124668A patent/TWI399356B/zh not_active IP Right Cessation
- 2005-03-14 TW TW094107737A patent/TWI398426B/zh not_active IP Right Cessation
-
2006
- 2006-09-11 IL IL178003A patent/IL178003A/en active IP Right Grant
- 2006-09-11 ZA ZA200607605A patent/ZA200607605B/xx unknown
-
2008
- 2008-03-07 US US12/074,983 patent/US7834200B2/en not_active Expired - Lifetime
-
2010
- 2010-10-12 US US12/902,811 patent/US8293929B2/en not_active Expired - Lifetime
-
2011
- 2011-07-01 RU RU2011127174/04A patent/RU2011127174A/ru not_active Application Discontinuation
- 2011-10-26 JP JP2011235246A patent/JP2012072151A/ja active Pending
-
2012
- 2012-03-05 IL IL218488A patent/IL218488A0/en unknown
- 2012-03-05 IL IL218487A patent/IL218487A/en active IP Right Grant
- 2012-09-20 US US13/623,563 patent/US20130066083A1/en not_active Abandoned
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