JP2007528904A5 - - Google Patents
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- JP2007528904A5 JP2007528904A5 JP2007503066A JP2007503066A JP2007528904A5 JP 2007528904 A5 JP2007528904 A5 JP 2007528904A5 JP 2007503066 A JP2007503066 A JP 2007503066A JP 2007503066 A JP2007503066 A JP 2007503066A JP 2007528904 A5 JP2007528904 A5 JP 2007528904A5
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- HKHXMGUQAPFZOS-WRWORJQWSA-N CCO[C@@H](C(NC([C@H]1NCCC1)=O)=C1)OC1=O Chemical compound CCO[C@@H](C(NC([C@H]1NCCC1)=O)=C1)OC1=O HKHXMGUQAPFZOS-WRWORJQWSA-N 0.000 description 2
- ABYYATZCXRICQU-MAUKXSAKSA-N CCO[C@@H](C(NC([C@H](CCC1)N1C(OCc1ccccc1)=O)=O)=C1)OC1=O Chemical compound CCO[C@@H](C(NC([C@H](CCC1)N1C(OCc1ccccc1)=O)=O)=C1)OC1=O ABYYATZCXRICQU-MAUKXSAKSA-N 0.000 description 1
- GONGBLWIQFFRKY-JXHRLWIKSA-N CCO[C@@H](C(NC([C@H](CCC1)N1C([C@H](C(C)(C)C)NC(OCc1ccccc1)=O)=O)=O)=C1)OC1=O Chemical compound CCO[C@@H](C(NC([C@H](CCC1)N1C([C@H](C(C)(C)C)NC(OCc1ccccc1)=O)=O)=O)=C1)OC1=O GONGBLWIQFFRKY-JXHRLWIKSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55248004P | 2004-03-12 | 2004-03-12 | |
| US60/552,480 | 2004-03-12 | ||
| PCT/US2005/008251 WO2005090334A2 (en) | 2004-03-12 | 2005-03-11 | Processes and intermediates for the preparation of aspartic acetal caspase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011235246A Division JP2012072151A (ja) | 2004-03-12 | 2011-10-26 | アスパラギン酸アセタールカスパーゼ阻害剤の製造のための方法および中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007528904A JP2007528904A (ja) | 2007-10-18 |
| JP2007528904A5 true JP2007528904A5 (https=) | 2008-04-24 |
| JP4898658B2 JP4898658B2 (ja) | 2012-03-21 |
Family
ID=34962478
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007503066A Expired - Lifetime JP4898658B2 (ja) | 2004-03-12 | 2005-03-11 | アスパラギン酸アセタールカスパーゼ阻害剤の製造のための方法および中間体 |
| JP2011235246A Pending JP2012072151A (ja) | 2004-03-12 | 2011-10-26 | アスパラギン酸アセタールカスパーゼ阻害剤の製造のための方法および中間体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011235246A Pending JP2012072151A (ja) | 2004-03-12 | 2011-10-26 | アスパラギン酸アセタールカスパーゼ阻害剤の製造のための方法および中間体 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US7381827B2 (https=) |
| EP (3) | EP2399916B1 (https=) |
| JP (2) | JP4898658B2 (https=) |
| KR (2) | KR101135765B1 (https=) |
| CN (3) | CN1950364B (https=) |
| AR (1) | AR048008A1 (https=) |
| AU (1) | AU2005223767B2 (https=) |
| BR (1) | BRPI0508609B8 (https=) |
| CA (3) | CA2843066C (https=) |
| DK (3) | DK1725548T3 (https=) |
| ES (3) | ES2532967T3 (https=) |
| HU (1) | HUE024556T2 (https=) |
| IL (3) | IL178003A (https=) |
| PL (4) | PL2399915T3 (https=) |
| PT (3) | PT2399916E (https=) |
| RU (2) | RU2433127C2 (https=) |
| SG (2) | SG150546A1 (https=) |
| SI (3) | SI2399915T1 (https=) |
| TW (3) | TW201200508A (https=) |
| WO (1) | WO2005090334A2 (https=) |
| ZA (1) | ZA200607605B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100509388B1 (ko) | 1996-10-18 | 2005-08-23 | 버텍스 파마슈티칼스 인코포레이티드 | 세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제 |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| TWI359147B (en) | 2003-09-05 | 2012-03-01 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv n |
| US7652153B2 (en) * | 2004-02-27 | 2010-01-26 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| WO2005115362A1 (en) * | 2004-05-15 | 2005-12-08 | Vertex Pharmaceuticals Incorporated | Treating seizures using ice inhibitors |
| US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
| AR055395A1 (es) * | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| EP1991229A2 (en) | 2006-02-27 | 2008-11-19 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| EP1993994A2 (en) | 2006-03-16 | 2008-11-26 | Vertex Pharmceuticals Incorporated | Deuterated hepatitis c protease inhibitors |
| CN101534824A (zh) * | 2006-11-17 | 2009-09-16 | 艾博特公司 | 作为化学活素受体拮抗剂的氨基吡咯烷 |
| DK2114924T3 (da) * | 2007-02-27 | 2012-04-10 | Vertex Pharma | Co-krystaller og farmaceutiske sammensætninger omfattende disse |
| JP2010519329A (ja) | 2007-02-27 | 2010-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | セリンプロテアーゼ阻害剤 |
| CN101835774B (zh) | 2007-08-30 | 2014-09-17 | 弗特克斯药品有限公司 | 共晶体和包含该共晶体的药物组合物 |
| WO2010017408A1 (en) | 2008-08-06 | 2010-02-11 | The Buck Institute For Age Research | Caspase inhibitors and uses thereof |
| US9113848B2 (en) * | 2010-02-03 | 2015-08-25 | Covidien Lp | Surgical retrieval apparatus |
| JP5769655B2 (ja) * | 2012-03-30 | 2015-08-26 | ユニ・チャーム株式会社 | 吸収性物品 |
| CN103193572B (zh) * | 2013-04-07 | 2015-06-17 | 山东大学 | 一种拉唑类化合物单一对映体的分离方法 |
| PT3558335T (pt) | 2016-12-23 | 2023-07-20 | Casp Aid Inc | Inibição da caspase-1 e sua utilização na prevenção e tratamento de doenças neurológicas |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| US5874424A (en) | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| GB9123326D0 (en) | 1991-11-04 | 1991-12-18 | Sandoz Ltd | Improvements in or relating to organic compounds |
| BE1008343A3 (nl) | 1994-05-06 | 1996-04-02 | Dsm Nv | Bidentaat fosfineligand |
| US5716929A (en) | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5847135A (en) | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5756466A (en) | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| ES2150696T3 (es) * | 1995-11-09 | 2000-12-01 | Akzo Pq Silica Vof | Silicato de sodio compactado. |
| US5843904A (en) | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
| DE69718012T2 (de) | 1996-09-12 | 2003-09-25 | Idun Pharmaceuticals, Inc. | C-terminale modifizierte (n-substituierte)-2-indolyl dipeptide als inhibitoren von der ice/ced-3 cysteinprotease familie |
| AU738048B2 (en) | 1996-09-12 | 2001-09-06 | Idun Pharmaceuticals, Inc. | Inhibition of apoptosis using interleukin-1beta-converting enzyme (ICE)/CED-3 family inhibitors |
| US6200969B1 (en) | 1996-09-12 | 2001-03-13 | Idun Pharmaceuticals, Inc. | Inhibition of apoptosis using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors |
| NZ330451A (https=) | 1996-09-12 | 2000-01-28 | Idun Pharmaceuticals Inc | |
| US5968927A (en) | 1996-09-20 | 1999-10-19 | Idun Pharmaceuticals, Inc. | Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes |
| US5919790A (en) | 1996-10-11 | 1999-07-06 | Warner-Lambert Company | Hydroxamate inhibitors of interleukin-1β converting enzyme |
| CA2268086A1 (en) | 1996-10-11 | 1998-04-23 | Warner-Lambert Company | Sulfonamide interleukin-1.beta. converting enzyme inhibitors |
| AU738341B2 (en) | 1996-10-11 | 2001-09-13 | Abbott Gmbh & Co. Kg | Asparate ester inhibitors of interleukin-1beta converting enzyme |
| KR100509388B1 (ko) | 1996-10-18 | 2005-08-23 | 버텍스 파마슈티칼스 인코포레이티드 | 세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제 |
| US6184244B1 (en) | 1996-12-16 | 2001-02-06 | Idun Pharmaceuticals, Inc. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| FR2766188B1 (fr) | 1997-07-15 | 2000-02-11 | Hoechst Marion Roussel Inc | Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes |
| US6184210B1 (en) | 1997-10-10 | 2001-02-06 | Cytovia, Inc. | Dipeptide apoptosis inhibitors and the use thereof |
| WO1999031066A1 (en) | 1997-12-18 | 1999-06-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pyridones as src family sh2 domain inhibitors |
| PT1049703E (pt) | 1998-01-20 | 2003-06-30 | Warner Lambert Co | Aldeido do acido n-¬2-(5-benziloxicarbonilamino-6-oxo-2-(4-fluorofenil)-1,6-di-hidro-1-pirimidinil)acetoxil|-l-aspartico como inibidor da enzima de conversao da interleucina-1beta in vivo |
| TWI243828B (en) * | 1998-03-19 | 2005-11-21 | Vertex Pharma | Inhibitors of caspases |
| US6197750B1 (en) | 1998-07-02 | 2001-03-06 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| US6242422B1 (en) | 1998-10-22 | 2001-06-05 | Idun Pharmacueticals, Inc. | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
| JP2002539193A (ja) | 1999-03-16 | 2002-11-19 | メルク フロスト カナダ アンド カンパニー | カスパーゼ−３阻害薬としてのγ−ケト酸ジペプチド類 |
| AU3876600A (en) | 1999-03-16 | 2000-10-04 | Cytovia, Inc. | Substituted 2-aminobenzamide caspase inhibitors and the use thereof |
| US6355618B1 (en) | 1999-04-09 | 2002-03-12 | Cytovia, Inc. | Caspase inhibitors and the use thereof |
| ATE344249T1 (de) | 1999-07-19 | 2006-11-15 | Merck Frosst Canada Ltd | Pyrazinone, diese verbindungen enthaltende zusammenstellungen |
| DE60010675T2 (de) | 1999-08-06 | 2005-06-16 | Vertex Pharmaceuticals Inc., Cambridge | Caspase inhibitoren und deren verwendung |
| US6495522B1 (en) | 1999-08-27 | 2002-12-17 | Cytovia, Inc. | Substituted alpha-hydroxy acid caspase inhibitors and the use thereof |
| AR026748A1 (es) | 1999-12-08 | 2003-02-26 | Vertex Pharma | Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis |
| AU2001249619B2 (en) | 2000-03-29 | 2006-08-17 | Vertex Pharmaceuticals Incorporated | Carbamate caspase inhibitors and uses thereof |
| ES2240446T3 (es) | 2000-04-03 | 2005-10-16 | Vertex Pharma | Inhibidores de serina proteasas, particularmente la proteasa ns3 del virus de la hepatitis c. |
| EP1278737B1 (en) * | 2000-04-24 | 2010-06-30 | Vertex Pharmaceuticals Incorporated | Process and intermediates for making substituted aspartic acid acetals |
| TWI291462B (en) | 2000-04-25 | 2007-12-21 | Daiichi Sankyo Co Ltd | Hydrate crystal of neuraminic acid compound |
| PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
| KR20020025959A (ko) | 2000-05-23 | 2002-04-04 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제 억제제 및 이의 용도 |
| WO2001094351A1 (en) | 2000-06-07 | 2001-12-13 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| DK1385870T3 (da) | 2000-07-21 | 2010-07-05 | Schering Corp | Peptider som inhibitorer af NS3-serinprotease fra hepatitis C-virus |
| CA2418720A1 (en) | 2000-09-13 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| US6846806B2 (en) | 2000-10-23 | 2005-01-25 | Bristol-Myers Squibb Company | Peptide inhibitors of Hepatitis C virus NS3 protein |
| DE60127860T2 (de) | 2000-11-21 | 2008-01-17 | Vertex Pharmaceuticals Inc., Cambridge | Imidazol- und benzimidazol- caspase inhibitoren und deren verwendung |
| GB0107924D0 (en) | 2001-03-29 | 2001-05-23 | Angeletti P Ist Richerche Bio | Inhibitor of hepatitis C virus NS3 protease |
| US20030096737A1 (en) | 2001-04-19 | 2003-05-22 | Anita Diu-Hercend | Caspase inhibitors and uses thereof |
| WO2002094263A2 (en) | 2001-05-23 | 2002-11-28 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| CA2449504A1 (en) | 2001-07-11 | 2003-01-23 | Vertex Pharmaceuticals Incorporated | Bridged bicyclic serine protease inhibitors |
| JP2005509028A (ja) | 2001-10-09 | 2005-04-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | アスパラギン酸およびグルタミン酸誘導体ならびにそのジアゾケトン中間体を合成するための方法 |
| US7410956B2 (en) | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
| AU2003225088A1 (en) | 2002-04-19 | 2003-11-03 | Vertex Pharmaceuticals Incorporated | Regulation of tnf-alpha |
| US7138395B2 (en) | 2002-06-10 | 2006-11-21 | The Procter & Gamble Company | Interleukin-1β converting enzyme inhibitors |
| US7001899B2 (en) | 2002-06-10 | 2006-02-21 | The Procter & Gamble Company | Interleukin converting enzyme inhibitors |
| US7041696B2 (en) | 2002-06-17 | 2006-05-09 | The Procter & Gamble Company | Interleukin-1β converting enzyme inhibitors |
| PL374598A1 (en) | 2002-06-28 | 2005-10-31 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| US7612091B2 (en) | 2002-12-20 | 2009-11-03 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| PE20050159A1 (es) | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
| US7652153B2 (en) * | 2004-02-27 | 2010-01-26 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
-
2005
- 2005-03-11 EP EP11178128.2A patent/EP2399916B1/en not_active Expired - Lifetime
- 2005-03-11 HU HUE05728092A patent/HUE024556T2/hu unknown
- 2005-03-11 EP EP11178126.6A patent/EP2399915B1/en not_active Expired - Lifetime
- 2005-03-11 CA CA2843066A patent/CA2843066C/en not_active Expired - Fee Related
- 2005-03-11 PT PT11178128T patent/PT2399916E/pt unknown
- 2005-03-11 DK DK05728092.7T patent/DK1725548T3/en active
- 2005-03-11 PL PL11178126T patent/PL2399915T3/pl unknown
- 2005-03-11 SG SG200901306-1A patent/SG150546A1/en unknown
- 2005-03-11 PL PL11178128T patent/PL2399916T3/pl unknown
- 2005-03-11 AU AU2005223767A patent/AU2005223767B2/en not_active Ceased
- 2005-03-11 ES ES11178126.6T patent/ES2532967T3/es not_active Expired - Lifetime
- 2005-03-11 PT PT57280927T patent/PT1725548E/pt unknown
- 2005-03-11 PT PT111781266T patent/PT2399915E/pt unknown
- 2005-03-11 ES ES05728092.7T patent/ES2533991T3/es not_active Expired - Lifetime
- 2005-03-11 RU RU2006136032/04A patent/RU2433127C2/ru active
- 2005-03-11 CA CA2768700A patent/CA2768700C/en not_active Expired - Fee Related
- 2005-03-11 EP EP05728092.7A patent/EP1725548B1/en not_active Expired - Lifetime
- 2005-03-11 KR KR1020067021136A patent/KR101135765B1/ko not_active Expired - Fee Related
- 2005-03-11 CN CN2005800144933A patent/CN1950364B/zh not_active Expired - Lifetime
- 2005-03-11 BR BRPI0508609A patent/BRPI0508609B8/pt not_active IP Right Cessation
- 2005-03-11 SI SI200531945T patent/SI2399915T1/sl unknown
- 2005-03-11 US US11/078,147 patent/US7381827B2/en active Active
- 2005-03-11 JP JP2007503066A patent/JP4898658B2/ja not_active Expired - Lifetime
- 2005-03-11 PL PL05728092T patent/PL1725548T3/pl unknown
- 2005-03-11 DK DK11178126T patent/DK2399915T3/en active
- 2005-03-11 WO PCT/US2005/008251 patent/WO2005090334A2/en not_active Ceased
- 2005-03-11 AR ARP050100964A patent/AR048008A1/es not_active Application Discontinuation
- 2005-03-11 SG SG200901309-5A patent/SG150547A1/en unknown
- 2005-03-11 DK DK11178128T patent/DK2399916T3/en active
- 2005-03-11 CN CN2013103410022A patent/CN103467459A/zh active Pending
- 2005-03-11 ES ES11178128.2T patent/ES2532433T3/es not_active Expired - Lifetime
- 2005-03-11 CA CA2559303A patent/CA2559303C/en not_active Expired - Fee Related
- 2005-03-11 PL PL381358A patent/PL381358A1/pl not_active Application Discontinuation
- 2005-03-11 KR KR1020117029981A patent/KR20110137409A/ko not_active Ceased
- 2005-03-11 SI SI200531959T patent/SI1725548T1/sl unknown
- 2005-03-11 CN CN2011100999799A patent/CN102225936B/zh not_active Expired - Lifetime
- 2005-03-11 SI SI200531941T patent/SI2399916T1/sl unknown
- 2005-03-14 TW TW100133524A patent/TW201200508A/zh unknown
- 2005-03-14 TW TW094107737A patent/TWI398426B/zh not_active IP Right Cessation
- 2005-03-14 TW TW101124668A patent/TWI399356B/zh not_active IP Right Cessation
-
2006
- 2006-09-11 IL IL178003A patent/IL178003A/en active IP Right Grant
- 2006-09-11 ZA ZA200607605A patent/ZA200607605B/xx unknown
-
2008
- 2008-03-07 US US12/074,983 patent/US7834200B2/en not_active Expired - Lifetime
-
2010
- 2010-10-12 US US12/902,811 patent/US8293929B2/en not_active Expired - Lifetime
-
2011
- 2011-07-01 RU RU2011127174/04A patent/RU2011127174A/ru not_active Application Discontinuation
- 2011-10-26 JP JP2011235246A patent/JP2012072151A/ja active Pending
-
2012
- 2012-03-05 IL IL218487A patent/IL218487A/en active IP Right Grant
- 2012-03-05 IL IL218488A patent/IL218488A0/en unknown
- 2012-09-20 US US13/623,563 patent/US20130066083A1/en not_active Abandoned
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