BRPI0508609B8 - processos e intermediários - Google Patents

processos e intermediários

Info

Publication number
BRPI0508609B8
BRPI0508609B8 BRPI0508609A BRPI0508609A BRPI0508609B8 BR PI0508609 B8 BRPI0508609 B8 BR PI0508609B8 BR PI0508609 A BRPI0508609 A BR PI0508609A BR PI0508609 A BRPI0508609 A BR PI0508609A BR PI0508609 B8 BRPI0508609 B8 BR PI0508609B8
Authority
BR
Brazil
Prior art keywords
processes
intermediaries
aspartic acid
acid derivatives
useful
Prior art date
Application number
BRPI0508609A
Other languages
English (en)
Portuguese (pt)
Inventor
D Jones Andrew
J Guerin David
J Tanoury Gerald
R Snoonian John
Trudeau Martin
Chen Minzhang
L Nyce Philip
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of BRPI0508609A publication Critical patent/BRPI0508609A/pt
Publication of BRPI0508609B1 publication Critical patent/BRPI0508609B1/pt
Publication of BRPI0508609B8 publication Critical patent/BRPI0508609B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
BRPI0508609A 2004-03-12 2005-03-11 processos e intermediários BRPI0508609B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55248004P 2004-03-12 2004-03-12
US60/552,480 2004-03-12
PCT/US2005/008251 WO2005090334A2 (en) 2004-03-12 2005-03-11 Processes and intermediates for the preparation of aspartic acetal caspase inhibitors

Publications (3)

Publication Number Publication Date
BRPI0508609A BRPI0508609A (pt) 2007-07-31
BRPI0508609B1 BRPI0508609B1 (pt) 2021-03-30
BRPI0508609B8 true BRPI0508609B8 (pt) 2021-05-25

Family

ID=34962478

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508609A BRPI0508609B8 (pt) 2004-03-12 2005-03-11 processos e intermediários

Country Status (21)

Country Link
US (4) US7381827B2 (https=)
EP (3) EP2399916B1 (https=)
JP (2) JP4898658B2 (https=)
KR (2) KR101135765B1 (https=)
CN (3) CN1950364B (https=)
AR (1) AR048008A1 (https=)
AU (1) AU2005223767B2 (https=)
BR (1) BRPI0508609B8 (https=)
CA (3) CA2843066C (https=)
DK (3) DK1725548T3 (https=)
ES (3) ES2532967T3 (https=)
HU (1) HUE024556T2 (https=)
IL (3) IL178003A (https=)
PL (4) PL381358A1 (https=)
PT (3) PT2399915E (https=)
RU (2) RU2433127C2 (https=)
SG (2) SG150547A1 (https=)
SI (3) SI1725548T1 (https=)
TW (3) TW201200508A (https=)
WO (1) WO2005090334A2 (https=)
ZA (1) ZA200607605B (https=)

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SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
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MXPA06013256A (es) * 2004-05-15 2007-02-08 Vertex Pharma Tratamiento de crisis convulsivas utilizando inhibidores ice.
US8399615B2 (en) 2005-08-19 2013-03-19 Vertex Pharmaceuticals Incorporated Processes and intermediates
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (es) * 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
AU2007217355B2 (en) 2006-02-27 2012-06-21 Vertex Pharmaceuticals Incorporated Co-crystals comprising VX-950 and pharmaceutical compositions comprising the same
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NZ583699A (en) 2007-08-30 2012-04-27 Vertex Pharma Co-crystals of vx-950 (telaprevir) other components and pharmaceutical compositions comprising the same
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US9113848B2 (en) * 2010-02-03 2015-08-25 Covidien Lp Surgical retrieval apparatus
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Also Published As

Publication number Publication date
SG150547A1 (en) 2009-03-30
JP2012072151A (ja) 2012-04-12
WO2005090334A2 (en) 2005-09-29
CN103467459A (zh) 2013-12-25
PT1725548E (pt) 2015-04-16
US7834200B2 (en) 2010-11-16
CA2559303C (en) 2013-09-10
PL381358A1 (pl) 2007-05-28
SG150546A1 (en) 2009-03-30
EP2399915B1 (en) 2014-12-17
DK2399915T3 (en) 2015-03-09
KR20110137409A (ko) 2011-12-22
CN1950364B (zh) 2011-06-08
US20060020016A1 (en) 2006-01-26
US7381827B2 (en) 2008-06-03
RU2433127C2 (ru) 2011-11-10
PL2399916T3 (pl) 2015-06-30
DK2399916T3 (en) 2015-03-02
AU2005223767A1 (en) 2005-09-29
CA2843066A1 (en) 2005-09-29
WO2005090334A3 (en) 2005-11-17
US8293929B2 (en) 2012-10-23
HUE024556T2 (hu) 2016-02-29
CN1950364A (zh) 2007-04-18
CA2768700C (en) 2014-04-29
TWI399356B (zh) 2013-06-21
EP1725548A2 (en) 2006-11-29
EP2399916A1 (en) 2011-12-28
TW201247594A (en) 2012-12-01
HK1163672A1 (en) 2012-09-14
TW200602341A (en) 2006-01-16
US20130066083A1 (en) 2013-03-14
JP2007528904A (ja) 2007-10-18
IL218487A (en) 2015-08-31
HK1105955A1 (en) 2008-02-29
PL2399915T3 (pl) 2015-07-31
ES2532433T3 (es) 2015-03-26
DK1725548T3 (en) 2015-03-23
ZA200607605B (en) 2009-04-29
PT2399916E (pt) 2015-03-17
SI2399916T1 (sl) 2015-05-29
EP1725548B1 (en) 2015-01-14
PT2399915E (pt) 2015-03-30
IL218488A0 (en) 2012-04-30
CA2843066C (en) 2016-06-07
CN102225936B (zh) 2013-09-11
CA2559303A1 (en) 2005-09-29
AU2005223767B2 (en) 2011-12-01
JP4898658B2 (ja) 2012-03-21
EP2399916B1 (en) 2014-12-10
SI2399915T1 (sl) 2015-05-29
IL178003A (en) 2012-04-30
IL178003A0 (en) 2006-12-31
TWI398426B (zh) 2013-06-11
CA2768700A1 (en) 2005-09-29
US20110071298A1 (en) 2011-03-24
RU2006136032A (ru) 2008-04-20
EP2399915A1 (en) 2011-12-28
BRPI0508609B1 (pt) 2021-03-30
KR101135765B1 (ko) 2012-04-23
RU2011127174A (ru) 2013-01-10
CN102225936A (zh) 2011-10-26
ES2533991T3 (es) 2015-04-16
TW201200508A (en) 2012-01-01
US20090048429A1 (en) 2009-02-19
AR048008A1 (es) 2006-03-15
BRPI0508609A (pt) 2007-07-31
IL218487A0 (en) 2012-04-30
SI1725548T1 (sl) 2015-05-29
PL1725548T3 (pl) 2015-08-31
KR20070006835A (ko) 2007-01-11
ES2532967T3 (es) 2015-04-06

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