SI2399916T1 - Postopek in intermediati za pripravo inhibitorjev asparagin-acetal-kaspaze - Google Patents

Postopek in intermediati za pripravo inhibitorjev asparagin-acetal-kaspaze

Info

Publication number
SI2399916T1
SI2399916T1 SI200531941T SI200531941T SI2399916T1 SI 2399916 T1 SI2399916 T1 SI 2399916T1 SI 200531941 T SI200531941 T SI 200531941T SI 200531941 T SI200531941 T SI 200531941T SI 2399916 T1 SI2399916 T1 SI 2399916T1
Authority
SI
Slovenia
Prior art keywords
ihnhibitors
intermediates
preparation
aspartic
caspase
Prior art date
Application number
SI200531941T
Other languages
English (en)
Inventor
Gerald J. Tanoury
Minzhang Chen
Andrew D Jones
Philip L. Nyce
Martin Trudeau
David J. Guerin
John R. Snoonian
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of SI2399916T1 publication Critical patent/SI2399916T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
SI200531941T 2004-03-12 2005-03-11 Postopek in intermediati za pripravo inhibitorjev asparagin-acetal-kaspaze SI2399916T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55248004P 2004-03-12 2004-03-12
EP11178128.2A EP2399916B1 (en) 2004-03-12 2005-03-11 Process and intermediates for the preparation of aspartic acetal caspase ihnhibitors

Publications (1)

Publication Number Publication Date
SI2399916T1 true SI2399916T1 (sl) 2015-05-29

Family

ID=34962478

Family Applications (3)

Application Number Title Priority Date Filing Date
SI200531945T SI2399915T1 (sl) 2004-03-12 2005-03-11 Postopek in intermediati za pripravo inhibitorjev asparagin-acetal-kaspaze
SI200531959T SI1725548T1 (sl) 2004-03-12 2005-03-11 Postopki in intermediati za pripravo inhibitorjev asparagin-acetal-kaspaze
SI200531941T SI2399916T1 (sl) 2004-03-12 2005-03-11 Postopek in intermediati za pripravo inhibitorjev asparagin-acetal-kaspaze

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SI200531945T SI2399915T1 (sl) 2004-03-12 2005-03-11 Postopek in intermediati za pripravo inhibitorjev asparagin-acetal-kaspaze
SI200531959T SI1725548T1 (sl) 2004-03-12 2005-03-11 Postopki in intermediati za pripravo inhibitorjev asparagin-acetal-kaspaze

Country Status (22)

Country Link
US (4) US7381827B2 (sl)
EP (3) EP2399916B1 (sl)
JP (2) JP4898658B2 (sl)
KR (2) KR101135765B1 (sl)
CN (3) CN1950364B (sl)
AR (1) AR048008A1 (sl)
AU (1) AU2005223767B2 (sl)
BR (1) BRPI0508609B8 (sl)
CA (3) CA2559303C (sl)
DK (3) DK2399915T3 (sl)
ES (3) ES2532967T3 (sl)
HK (2) HK1105955A1 (sl)
HU (1) HUE024556T2 (sl)
IL (3) IL178003A (sl)
PL (4) PL2399916T3 (sl)
PT (3) PT1725548E (sl)
RU (2) RU2433127C2 (sl)
SG (2) SG150547A1 (sl)
SI (3) SI2399915T1 (sl)
TW (3) TWI398426B (sl)
WO (1) WO2005090334A2 (sl)
ZA (1) ZA200607605B (sl)

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CA2679426A1 (en) 2007-02-27 2008-09-04 Luc Farmer Inhibitors of serine proteases
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Also Published As

Publication number Publication date
EP2399915B1 (en) 2014-12-17
TW200602341A (en) 2006-01-16
PT2399915E (pt) 2015-03-30
ZA200607605B (en) 2009-04-29
BRPI0508609A (pt) 2007-07-31
KR20070006835A (ko) 2007-01-11
EP1725548B1 (en) 2015-01-14
HK1105955A1 (en) 2008-02-29
KR101135765B1 (ko) 2012-04-23
BRPI0508609B1 (pt) 2021-03-30
TW201200508A (en) 2012-01-01
CA2559303C (en) 2013-09-10
IL218488A0 (en) 2012-04-30
PT2399916E (pt) 2015-03-17
CA2843066C (en) 2016-06-07
JP4898658B2 (ja) 2012-03-21
BRPI0508609B8 (pt) 2021-05-25
RU2011127174A (ru) 2013-01-10
CN103467459A (zh) 2013-12-25
ES2532967T3 (es) 2015-04-06
PL381358A1 (pl) 2007-05-28
EP1725548A2 (en) 2006-11-29
EP2399916A1 (en) 2011-12-28
RU2433127C2 (ru) 2011-11-10
DK2399916T3 (en) 2015-03-02
CA2768700A1 (en) 2005-09-29
CN1950364A (zh) 2007-04-18
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US7834200B2 (en) 2010-11-16
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IL178003A0 (en) 2006-12-31
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US20130066083A1 (en) 2013-03-14
JP2012072151A (ja) 2012-04-12
IL218487A0 (en) 2012-04-30
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ES2533991T3 (es) 2015-04-16
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IL218487A (en) 2015-08-31
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CA2559303A1 (en) 2005-09-29
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PL1725548T3 (pl) 2015-08-31
PL2399916T3 (pl) 2015-06-30
DK1725548T3 (en) 2015-03-23
WO2005090334A2 (en) 2005-09-29
JP2007528904A (ja) 2007-10-18
SI1725548T1 (sl) 2015-05-29
PL2399915T3 (pl) 2015-07-31
US20090048429A1 (en) 2009-02-19
AR048008A1 (es) 2006-03-15
SG150546A1 (en) 2009-03-30
CA2843066A1 (en) 2005-09-29
AU2005223767B2 (en) 2011-12-01
DK2399915T3 (en) 2015-03-09
AU2005223767A1 (en) 2005-09-29
US8293929B2 (en) 2012-10-23
US20060020016A1 (en) 2006-01-26
EP2399915A1 (en) 2011-12-28
SI2399915T1 (sl) 2015-05-29
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SG150547A1 (en) 2009-03-30
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