PT2399916E - Processo e intermediários para a preparação de inibidores de caspase de acetal de ácido aspártico - Google Patents

Processo e intermediários para a preparação de inibidores de caspase de acetal de ácido aspártico Download PDF

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Publication number
PT2399916E
PT2399916E PT11178128T PT11178128T PT2399916E PT 2399916 E PT2399916 E PT 2399916E PT 11178128 T PT11178128 T PT 11178128T PT 11178128 T PT11178128 T PT 11178128T PT 2399916 E PT2399916 E PT 2399916E
Authority
PT
Portugal
Prior art keywords
ihnhibitors
intermediates
preparation
aspartic
caspase
Prior art date
Application number
PT11178128T
Other languages
English (en)
Inventor
Philip L Nyce
Minzhang Chen
Gerald J Tanoury
Andrew D Jones
Martin Trudeau
David J Guerin
John R Snoonian
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PT2399916E publication Critical patent/PT2399916E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
PT11178128T 2004-03-12 2005-03-11 Processo e intermediários para a preparação de inibidores de caspase de acetal de ácido aspártico PT2399916E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55248004P 2004-03-12 2004-03-12

Publications (1)

Publication Number Publication Date
PT2399916E true PT2399916E (pt) 2015-03-17

Family

ID=34962478

Family Applications (3)

Application Number Title Priority Date Filing Date
PT57280927T PT1725548E (pt) 2004-03-12 2005-03-11 Processo e intermediários para a preparação de inibidores de caspase de acetal de ácido aspártico
PT11178128T PT2399916E (pt) 2004-03-12 2005-03-11 Processo e intermediários para a preparação de inibidores de caspase de acetal de ácido aspártico
PT111781266T PT2399915E (pt) 2004-03-12 2005-03-11 Processo e intermediários para a preparação de inibidores de caspase de acetal de ácido aspártico

Family Applications Before (1)

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PT57280927T PT1725548E (pt) 2004-03-12 2005-03-11 Processo e intermediários para a preparação de inibidores de caspase de acetal de ácido aspártico

Family Applications After (1)

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PT111781266T PT2399915E (pt) 2004-03-12 2005-03-11 Processo e intermediários para a preparação de inibidores de caspase de acetal de ácido aspártico

Country Status (22)

Country Link
US (4) US7381827B2 (pt)
EP (3) EP1725548B1 (pt)
JP (2) JP4898658B2 (pt)
KR (2) KR20110137409A (pt)
CN (3) CN1950364B (pt)
AR (1) AR048008A1 (pt)
AU (1) AU2005223767B2 (pt)
BR (1) BRPI0508609B8 (pt)
CA (3) CA2559303C (pt)
DK (3) DK1725548T3 (pt)
ES (3) ES2532433T3 (pt)
HK (2) HK1105955A1 (pt)
HU (1) HUE024556T2 (pt)
IL (3) IL178003A (pt)
PL (4) PL1725548T3 (pt)
PT (3) PT1725548E (pt)
RU (2) RU2433127C2 (pt)
SG (2) SG150546A1 (pt)
SI (3) SI1725548T1 (pt)
TW (3) TWI398426B (pt)
WO (1) WO2005090334A2 (pt)
ZA (1) ZA200607605B (pt)

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Also Published As

Publication number Publication date
HK1163672A1 (en) 2012-09-14
WO2005090334A2 (en) 2005-09-29
PL2399916T3 (pl) 2015-06-30
CN102225936B (zh) 2013-09-11
RU2011127174A (ru) 2013-01-10
IL178003A0 (en) 2006-12-31
CA2843066A1 (en) 2005-09-29
HUE024556T2 (hu) 2016-02-29
DK1725548T3 (en) 2015-03-23
IL218488A0 (en) 2012-04-30
US20110071298A1 (en) 2011-03-24
TWI399356B (zh) 2013-06-21
ES2532433T3 (es) 2015-03-26
US7834200B2 (en) 2010-11-16
KR101135765B1 (ko) 2012-04-23
TW201247594A (en) 2012-12-01
JP2007528904A (ja) 2007-10-18
PL381358A1 (pl) 2007-05-28
JP2012072151A (ja) 2012-04-12
RU2006136032A (ru) 2008-04-20
US20060020016A1 (en) 2006-01-26
EP2399916B1 (en) 2014-12-10
AR048008A1 (es) 2006-03-15
ES2532967T3 (es) 2015-04-06
CA2768700C (en) 2014-04-29
EP1725548A2 (en) 2006-11-29
SI1725548T1 (sl) 2015-05-29
SI2399915T1 (sl) 2015-05-29
HK1105955A1 (en) 2008-02-29
DK2399915T3 (en) 2015-03-09
CA2559303C (en) 2013-09-10
CN1950364B (zh) 2011-06-08
CN103467459A (zh) 2013-12-25
TWI398426B (zh) 2013-06-11
EP2399915B1 (en) 2014-12-17
IL218487A0 (en) 2012-04-30
SI2399916T1 (sl) 2015-05-29
US20130066083A1 (en) 2013-03-14
EP2399916A1 (en) 2011-12-28
CA2843066C (en) 2016-06-07
CN1950364A (zh) 2007-04-18
TW200602341A (en) 2006-01-16
WO2005090334A3 (en) 2005-11-17
CA2559303A1 (en) 2005-09-29
PT2399915E (pt) 2015-03-30
TW201200508A (en) 2012-01-01
PL2399915T3 (pl) 2015-07-31
JP4898658B2 (ja) 2012-03-21
AU2005223767A1 (en) 2005-09-29
US7381827B2 (en) 2008-06-03
EP1725548B1 (en) 2015-01-14
AU2005223767B2 (en) 2011-12-01
US20090048429A1 (en) 2009-02-19
PL1725548T3 (pl) 2015-08-31
CA2768700A1 (en) 2005-09-29
BRPI0508609A (pt) 2007-07-31
IL178003A (en) 2012-04-30
PT1725548E (pt) 2015-04-16
ZA200607605B (en) 2009-04-29
EP2399915A1 (en) 2011-12-28
BRPI0508609B8 (pt) 2021-05-25
US8293929B2 (en) 2012-10-23
BRPI0508609B1 (pt) 2021-03-30
KR20110137409A (ko) 2011-12-22
ES2533991T3 (es) 2015-04-16
CN102225936A (zh) 2011-10-26
SG150546A1 (en) 2009-03-30
RU2433127C2 (ru) 2011-11-10
KR20070006835A (ko) 2007-01-11
IL218487A (en) 2015-08-31
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