ATE359274T1 - Imidazol- und benzimidazol- caspase inhibitoren und deren verwendung - Google Patents

Imidazol- und benzimidazol- caspase inhibitoren und deren verwendung

Info

Publication number
ATE359274T1
ATE359274T1 AT01992067T AT01992067T ATE359274T1 AT E359274 T1 ATE359274 T1 AT E359274T1 AT 01992067 T AT01992067 T AT 01992067T AT 01992067 T AT01992067 T AT 01992067T AT E359274 T1 ATE359274 T1 AT E359274T1
Authority
AT
Austria
Prior art keywords
benzimidazole
imidazole
caspase inhibitors
caspase
inhibitors
Prior art date
Application number
AT01992067T
Other languages
English (en)
Inventor
David Kay
Julian Golec
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE359274T1 publication Critical patent/ATE359274T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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AT01992067T 2000-11-21 2001-11-19 Imidazol- und benzimidazol- caspase inhibitoren und deren verwendung ATE359274T1 (de)

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US25225200P 2000-11-21 2000-11-21

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ATE359274T1 true ATE359274T1 (de) 2007-05-15

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US (1) US7205327B2 (de)
EP (1) EP1341767B1 (de)
JP (2) JP4349802B2 (de)
KR (1) KR20040020042A (de)
CN (1) CN1298707C (de)
AP (1) AP2003002811A0 (de)
AT (1) ATE359274T1 (de)
AU (1) AU2002232541A1 (de)
BG (1) BG107841A (de)
BR (1) BR0115546A (de)
CA (1) CA2429630A1 (de)
CO (1) CO7250442A2 (de)
CZ (1) CZ20031730A3 (de)
DE (1) DE60127860T2 (de)
EA (1) EA200300601A1 (de)
ES (1) ES2283456T3 (de)
HR (1) HRP20030494A2 (de)
HU (1) HUP0301870A3 (de)
IL (1) IL155937A0 (de)
IS (1) IS6822A (de)
MX (1) MXPA03004459A (de)
NO (1) NO20032270L (de)
NZ (1) NZ526420A (de)
PL (1) PL362612A1 (de)
SK (1) SK7792003A3 (de)
WO (1) WO2002042278A2 (de)
ZA (1) ZA200303895B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
US7410956B2 (en) * 2002-02-11 2008-08-12 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
US7960398B2 (en) 2002-04-19 2011-06-14 Vertex Pharmaceuticals Incorporated Regulation of TNF-alpha
WO2004073742A1 (ja) * 2003-02-24 2004-09-02 Daiichi Pharmaceutical Co.,Ltd. Ｂ型肝炎ウイルスx相互作用蛋白質の分解阻害剤
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