HUP0301870A2 - Imdazol és benzimidazol kaszpáz inhibitorok és alkalmazásaik - Google Patents
Imdazol és benzimidazol kaszpáz inhibitorok és alkalmazásaikInfo
- Publication number
- HUP0301870A2 HUP0301870A2 HU0301870A HUP0301870A HUP0301870A2 HU P0301870 A2 HUP0301870 A2 HU P0301870A2 HU 0301870 A HU0301870 A HU 0301870A HU P0301870 A HUP0301870 A HU P0301870A HU P0301870 A2 HUP0301870 A2 HU P0301870A2
- Authority
- HU
- Hungary
- Prior art keywords
- optionally substituted
- caspase inhibitors
- hydrogen atom
- benzimidazole
- imidazole
- Prior art date
Links
- 102000011727 Caspases Human genes 0.000 title abstract 2
- 108010076667 Caspases Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 3
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- -1 carboxy, carboxymethyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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Abstract
A találmány tárgyát az általános képletű kaszpáz inhibitorok - ahol R1karboxi-, karboxi-metil-csoport, vagy észtereik, amidjaik vagyizosztereik; R2 hidrogénatom vagy adott esetben szubsztituált 1-6szénatomos alifás csoport; R3 hidrogénatom vagy adott esetbenszubsztituált 1-6 szénatomos alifás csoport; valamint R4 és R5mindegyike egymástól függetlenül hidrogénatom, adott esetbenszubsztituált 1-6 szénatomos alifás csoport, vagy R4 és R5 azzal agyűrűvel együtt, amelyhez kapcsolódik, egy adott esetben szubsztituáltbiciklusos csoportot képez, amely biciklusos csoport az vagy képletűcsoportok közül kiválasztott - és alkalmazásuk képezik. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25225200P | 2000-11-21 | 2000-11-21 | |
PCT/US2001/047688 WO2002042278A2 (en) | 2000-11-21 | 2001-11-19 | Imidazole and benzimidazole caspase inhibitors and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0301870A2 true HUP0301870A2 (hu) | 2003-09-29 |
HUP0301870A3 HUP0301870A3 (en) | 2007-05-29 |
Family
ID=22955229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301870A HUP0301870A3 (en) | 2000-11-21 | 2001-11-19 | Imidazole and benzimidazole caspase inhibitors and uses thereof |
Country Status (28)
Country | Link |
---|---|
US (1) | US7205327B2 (hu) |
EP (1) | EP1341767B1 (hu) |
JP (2) | JP4349802B2 (hu) |
KR (1) | KR20040020042A (hu) |
CN (1) | CN1298707C (hu) |
AP (1) | AP2003002811A0 (hu) |
AT (1) | ATE359274T1 (hu) |
AU (1) | AU2002232541A1 (hu) |
BG (1) | BG107841A (hu) |
BR (1) | BR0115546A (hu) |
CA (1) | CA2429630A1 (hu) |
CO (1) | CO7250442A2 (hu) |
CZ (1) | CZ20031730A3 (hu) |
DE (1) | DE60127860T2 (hu) |
EA (1) | EA200300601A1 (hu) |
ES (1) | ES2283456T3 (hu) |
HK (1) | HK1058672A1 (hu) |
HR (1) | HRP20030494A2 (hu) |
HU (1) | HUP0301870A3 (hu) |
IL (1) | IL155937A0 (hu) |
IS (1) | IS6822A (hu) |
MX (1) | MXPA03004459A (hu) |
NO (1) | NO20032270L (hu) |
NZ (1) | NZ526420A (hu) |
PL (1) | PL362612A1 (hu) |
SK (1) | SK7792003A3 (hu) |
WO (1) | WO2002042278A2 (hu) |
ZA (1) | ZA200303895B (hu) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
AU2003211052A1 (en) * | 2002-02-11 | 2003-09-04 | Vertex Pharmaceuticals Incorporated | Phospholipids as caspase inhibitor prodrugs |
US7960398B2 (en) | 2002-04-19 | 2011-06-14 | Vertex Pharmaceuticals Incorporated | Regulation of TNF-alpha |
US20060217299A1 (en) * | 2003-02-24 | 2006-09-28 | Hirofumi Doi | Degradation inhibitor for hepatitis b virus x interacting protein |
AU2003902704A0 (en) * | 2003-05-29 | 2003-06-19 | Crc For Waste Management And Pollution Control Limited Of Unsw | Process for producing a nanoscale zero-valent metal |
US7297714B2 (en) * | 2003-10-21 | 2007-11-20 | Irm Llc | Inhibitors of cathepsin S |
ES2532433T3 (es) * | 2004-03-12 | 2015-03-26 | Vertex Pharmaceuticals Incorporated | Proceso y productos intermedios para la preparación de inhibidores de la acetal caspasa aspártica |
CA2566362C (en) * | 2004-05-15 | 2013-09-10 | Vertex Pharmaceuticals Incorporated | Treating seizures using ice inhibitors |
CN1980658A (zh) * | 2004-05-27 | 2007-06-13 | 沃泰克斯药物股份有限公司 | 治疗自身炎性疾病的ice抑制剂 |
PT1796660T (pt) | 2004-09-17 | 2017-02-13 | Biomas Ltd | Utilização de tricloro(dioxietileno-o,o¿)telurato de amónio (as101) para a inibição da enzima de conversão da interleucina-1 beta |
CN101268084A (zh) * | 2005-07-28 | 2008-09-17 | 沃泰克斯药物股份有限公司 | 天冬氨酸特异性半胱氨酸蛋白酶抑制剂前体药物 |
SG191591A1 (en) | 2008-05-21 | 2013-07-31 | New World Lab Inc | Selective caspase inhibitors and uses thereof |
LT2380881T (lt) * | 2008-12-26 | 2017-04-10 | Sumitomo Dainippon Pharma Co., Ltd. | Naujas biciklinis heterociklinis junginys |
WO2010133000A1 (en) | 2009-05-21 | 2010-11-25 | New World Laboratories Inc. | Selective caspase inhibitors and uses thereof |
US9365612B2 (en) | 2010-01-29 | 2016-06-14 | United States Of America As Represented By The Secretary, Department Of Health And Human Services | Caspase inhibitors |
TWI402072B (zh) | 2010-10-19 | 2013-07-21 | Lilly Co Eli | 組織蛋白酶s抑制劑化合物 |
US20140309172A1 (en) | 2010-11-05 | 2014-10-16 | Dagmar Ringe | Ice inhibiting compounds and uses thereof |
DK2697246T3 (en) | 2011-04-15 | 2018-05-28 | Genesis Tech Limited | SELECTIVE CYSTEIN PROTEASE INHIBITORS AND USES THEREOF |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
CA2906194A1 (en) * | 2013-03-15 | 2014-09-18 | Whitehead Institute For Biomedical Research | Benzimidazole derivatives and uses thereof |
US11434212B2 (en) | 2017-01-23 | 2022-09-06 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Bicyclic compound as a caspase inhibitor |
BR112021000183A8 (pt) * | 2018-07-19 | 2022-12-06 | Sumitomo Dainippon Pharma Co Ltd | Preparação medicinal para uso externo |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US5714484A (en) * | 1993-12-08 | 1998-02-03 | Prototek, Inc. | α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
DE69718012T2 (de) * | 1996-09-12 | 2003-09-25 | Idun Pharmaceuticals Inc | C-terminale modifizierte (n-substituierte)-2-indolyl dipeptide als inhibitoren von der ice/ced-3 cysteinprotease familie |
JP2006518738A (ja) * | 2003-02-12 | 2006-08-17 | トランス テック ファーマ,インコーポレイテッド | 治療薬としての置換アゾール誘導体 |
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2001
- 2001-11-19 WO PCT/US2001/047688 patent/WO2002042278A2/en active IP Right Grant
- 2001-11-19 KR KR10-2003-7006781A patent/KR20040020042A/ko not_active Application Discontinuation
- 2001-11-19 IL IL15593701A patent/IL155937A0/xx unknown
- 2001-11-19 JP JP2002544413A patent/JP4349802B2/ja not_active Expired - Fee Related
- 2001-11-19 CZ CZ20031730A patent/CZ20031730A3/cs unknown
- 2001-11-19 CN CNB018210813A patent/CN1298707C/zh not_active Expired - Fee Related
- 2001-11-19 AU AU2002232541A patent/AU2002232541A1/en not_active Abandoned
- 2001-11-19 BR BR0115546-6A patent/BR0115546A/pt not_active IP Right Cessation
- 2001-11-19 HU HU0301870A patent/HUP0301870A3/hu unknown
- 2001-11-19 SK SK779-2003A patent/SK7792003A3/sk unknown
- 2001-11-19 US US10/012,722 patent/US7205327B2/en not_active Expired - Fee Related
- 2001-11-19 MX MXPA03004459A patent/MXPA03004459A/es not_active Application Discontinuation
- 2001-11-19 DE DE60127860T patent/DE60127860T2/de not_active Expired - Lifetime
- 2001-11-19 CA CA002429630A patent/CA2429630A1/en not_active Abandoned
- 2001-11-19 AT AT01992067T patent/ATE359274T1/de not_active IP Right Cessation
- 2001-11-19 EP EP01992067A patent/EP1341767B1/en not_active Expired - Lifetime
- 2001-11-19 PL PL01362612A patent/PL362612A1/xx unknown
- 2001-11-19 AP APAP/P/2003/002811A patent/AP2003002811A0/en unknown
- 2001-11-19 NZ NZ526420A patent/NZ526420A/en unknown
- 2001-11-19 EA EA200300601A patent/EA200300601A1/ru unknown
- 2001-11-19 ES ES01992067T patent/ES2283456T3/es not_active Expired - Lifetime
-
2003
- 2003-05-20 IS IS6822A patent/IS6822A/is unknown
- 2003-05-20 NO NO20032270A patent/NO20032270L/no unknown
- 2003-05-20 ZA ZA200303895A patent/ZA200303895B/en unknown
- 2003-05-22 BG BG107841A patent/BG107841A/bg unknown
- 2003-06-16 CO CO03050947A patent/CO7250442A2/es unknown
- 2003-06-17 HR HR20030494A patent/HRP20030494A2/hr not_active Application Discontinuation
-
2004
- 2004-03-01 HK HK04101501A patent/HK1058672A1/xx not_active IP Right Cessation
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2008
- 2008-10-08 JP JP2008262291A patent/JP2009046511A/ja not_active Withdrawn
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