HUP0301870A2 - Imdazol és benzimidazol kaszpáz inhibitorok és alkalmazásaik - Google Patents

Imdazol és benzimidazol kaszpáz inhibitorok és alkalmazásaik

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Publication number
HUP0301870A2
HUP0301870A2 HU0301870A HUP0301870A HUP0301870A2 HU P0301870 A2 HUP0301870 A2 HU P0301870A2 HU 0301870 A HU0301870 A HU 0301870A HU P0301870 A HUP0301870 A HU P0301870A HU P0301870 A2 HUP0301870 A2 HU P0301870A2
Authority
HU
Hungary
Prior art keywords
optionally substituted
caspase inhibitors
hydrogen atom
benzimidazole
imidazole
Prior art date
Application number
HU0301870A
Other languages
English (en)
Inventor
Julian Golec
David Kay
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of HUP0301870A2 publication Critical patent/HUP0301870A2/hu
Publication of HUP0301870A3 publication Critical patent/HUP0301870A3/hu

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    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

A találmány tárgyát az általános képletű kaszpáz inhibitorok - ahol R1karboxi-, karboxi-metil-csoport, vagy észtereik, amidjaik vagyizosztereik; R2 hidrogénatom vagy adott esetben szubsztituált 1-6szénatomos alifás csoport; R3 hidrogénatom vagy adott esetbenszubsztituált 1-6 szénatomos alifás csoport; valamint R4 és R5mindegyike egymástól függetlenül hidrogénatom, adott esetbenszubsztituált 1-6 szénatomos alifás csoport, vagy R4 és R5 azzal agyűrűvel együtt, amelyhez kapcsolódik, egy adott esetben szubsztituáltbiciklusos csoportot képez, amely biciklusos csoport az vagy képletűcsoportok közül kiválasztott - és alkalmazásuk képezik. Ó
HU0301870A 2000-11-21 2001-11-19 Imidazole and benzimidazole caspase inhibitors and uses thereof HUP0301870A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25225200P 2000-11-21 2000-11-21
PCT/US2001/047688 WO2002042278A2 (en) 2000-11-21 2001-11-19 Imidazole and benzimidazole caspase inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
HUP0301870A2 true HUP0301870A2 (hu) 2003-09-29
HUP0301870A3 HUP0301870A3 (en) 2007-05-29

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HU0301870A HUP0301870A3 (en) 2000-11-21 2001-11-19 Imidazole and benzimidazole caspase inhibitors and uses thereof

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US (1) US7205327B2 (hu)
EP (1) EP1341767B1 (hu)
JP (2) JP4349802B2 (hu)
KR (1) KR20040020042A (hu)
CN (1) CN1298707C (hu)
AP (1) AP2003002811A0 (hu)
AT (1) ATE359274T1 (hu)
AU (1) AU2002232541A1 (hu)
BG (1) BG107841A (hu)
BR (1) BR0115546A (hu)
CA (1) CA2429630A1 (hu)
CO (1) CO7250442A2 (hu)
CZ (1) CZ20031730A3 (hu)
DE (1) DE60127860T2 (hu)
EA (1) EA200300601A1 (hu)
ES (1) ES2283456T3 (hu)
HK (1) HK1058672A1 (hu)
HR (1) HRP20030494A2 (hu)
HU (1) HUP0301870A3 (hu)
IL (1) IL155937A0 (hu)
IS (1) IS6822A (hu)
MX (1) MXPA03004459A (hu)
NO (1) NO20032270L (hu)
NZ (1) NZ526420A (hu)
PL (1) PL362612A1 (hu)
SK (1) SK7792003A3 (hu)
WO (1) WO2002042278A2 (hu)
ZA (1) ZA200303895B (hu)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
AU2003211052A1 (en) * 2002-02-11 2003-09-04 Vertex Pharmaceuticals Incorporated Phospholipids as caspase inhibitor prodrugs
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