JP2007516941A5 - - Google Patents
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- JP2007516941A5 JP2007516941A5 JP2006517455A JP2006517455A JP2007516941A5 JP 2007516941 A5 JP2007516941 A5 JP 2007516941A5 JP 2006517455 A JP2006517455 A JP 2006517455A JP 2006517455 A JP2006517455 A JP 2006517455A JP 2007516941 A5 JP2007516941 A5 JP 2007516941A5
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- Japan
- Prior art keywords
- compound according
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- disorder
- solvate
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 54
- 150000003839 salts Chemical class 0.000 claims 29
- 239000012453 solvate Substances 0.000 claims 29
- 239000000203 mixture Substances 0.000 claims 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
- 230000002265 prevention Effects 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 208000035475 disorder Diseases 0.000 claims 12
- 150000004677 hydrates Chemical class 0.000 claims 9
- 238000002560 therapeutic procedure Methods 0.000 claims 9
- 210000003169 central nervous system Anatomy 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 241001465754 Metazoa Species 0.000 claims 6
- 208000008589 Obesity Diseases 0.000 claims 6
- 230000003542 behavioural effect Effects 0.000 claims 6
- 235000020824 obesity Nutrition 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 4
- CPPKAGUPTKIMNP-UHFFFAOYSA-N cyanogen fluoride Chemical group FC#N CPPKAGUPTKIMNP-UHFFFAOYSA-N 0.000 claims 4
- 229910052740 iodine Inorganic materials 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 208000007848 Alcoholism Diseases 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 3
- 208000020925 Bipolar disease Diseases 0.000 claims 3
- 208000032841 Bulimia Diseases 0.000 claims 3
- 206010006550 Bulimia nervosa Diseases 0.000 claims 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 3
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 3
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 3
- 206010019233 Headaches Diseases 0.000 claims 3
- 208000019695 Migraine disease Diseases 0.000 claims 3
- 208000027626 Neurocognitive disease Diseases 0.000 claims 3
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- 206010036618 Premenstrual syndrome Diseases 0.000 claims 3
- 208000028017 Psychotic disease Diseases 0.000 claims 3
- 201000001880 Sexual dysfunction Diseases 0.000 claims 3
- 206010041250 Social phobia Diseases 0.000 claims 3
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 claims 3
- 208000025748 atypical depressive disease Diseases 0.000 claims 3
- 201000010064 diabetes insipidus Diseases 0.000 claims 3
- 206010013663 drug dependence Diseases 0.000 claims 3
- 206010015037 epilepsy Diseases 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 231100000869 headache Toxicity 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 201000001881 impotence Diseases 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 206010027599 migraine Diseases 0.000 claims 3
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 3
- 208000022821 personality disease Diseases 0.000 claims 3
- 201000000484 premenstrual tension Diseases 0.000 claims 3
- 208000020016 psychiatric disease Diseases 0.000 claims 3
- XMVJITFPVVRMHC-UHFFFAOYSA-N roxarsone Chemical compound OC1=CC=C([As](O)(O)=O)C=C1[N+]([O-])=O XMVJITFPVVRMHC-UHFFFAOYSA-N 0.000 claims 3
- 201000000980 schizophrenia Diseases 0.000 claims 3
- 231100000872 sexual dysfunction Toxicity 0.000 claims 3
- 201000002859 sleep apnea Diseases 0.000 claims 3
- 208000019116 sleep disease Diseases 0.000 claims 3
- 208000020685 sleep-wake disease Diseases 0.000 claims 3
- 208000011117 substance-related disease Diseases 0.000 claims 3
- 208000026139 Memory disease Diseases 0.000 claims 2
- 241000287462 Phalacrocorax carbo Species 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 206010016256 fatigue Diseases 0.000 claims 2
- 201000009941 intracranial hypertension Diseases 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 230000003287 optical effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- YGLDQFWPUCURIP-UHFFFAOYSA-N 3h-3-benzazepine Chemical compound C1=CNC=CC2=CC=CC=C21 YGLDQFWPUCURIP-UHFFFAOYSA-N 0.000 claims 1
- APEKSNHUILZZDC-UHFFFAOYSA-N 6,7-dichloro-3,5-dimethyl-1,2,4,5-tetrahydro-3-benzazepine Chemical compound CC1CN(C)CCC2=CC=C(Cl)C(Cl)=C12 APEKSNHUILZZDC-UHFFFAOYSA-N 0.000 claims 1
- QXXFCLLJUAFAFV-UHFFFAOYSA-N 6-bromo-7-chloro-5-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical compound CC1CNCCC2=CC=C(Cl)C(Br)=C12 QXXFCLLJUAFAFV-UHFFFAOYSA-N 0.000 claims 1
- LVDZEHWRCDOGFA-UHFFFAOYSA-N 7,9-dichloro-5-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical compound CC1CNCCC2=C(Cl)C=C(Cl)C=C12 LVDZEHWRCDOGFA-UHFFFAOYSA-N 0.000 claims 1
- LSYBMYCVSJZAMI-UHFFFAOYSA-N 7-chloro-6-fluoro-5-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical compound CC1CNCCC2=CC=C(Cl)C(F)=C12 LSYBMYCVSJZAMI-UHFFFAOYSA-N 0.000 claims 1
- HMGASYPJYKHVCW-UHFFFAOYSA-N 9-chloro-5-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine Chemical compound CC1CNCCC2=C(Cl)C=CC=C12 HMGASYPJYKHVCW-UHFFFAOYSA-N 0.000 claims 1
- 206010001488 Aggression Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 206010022773 Intracranial pressure increased Diseases 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 230000037406 food intake Effects 0.000 claims 1
- 235000012631 food intake Nutrition 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 230000036186 satiety Effects 0.000 claims 1
- 235000019627 satiety Nutrition 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47928003P | 2003-06-17 | 2003-06-17 | |
| US60/479,280 | 2003-06-17 | ||
| PCT/US2004/019670 WO2005003096A1 (en) | 2003-06-17 | 2004-06-16 | Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011118521A Division JP2011162564A (ja) | 2003-06-17 | 2011-05-26 | ５ｈｔ２ｃレセプター関連疾患の処置に有用なベンズアゼピン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007516941A JP2007516941A (ja) | 2007-06-28 |
| JP2007516941A5 true JP2007516941A5 (enExample) | 2007-08-09 |
| JP4782003B2 JP4782003B2 (ja) | 2011-09-28 |
Family
ID=33563791
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006517455A Expired - Fee Related JP4782003B2 (ja) | 2003-06-17 | 2004-06-16 | ５ｈｔ２ｃレセプター関連疾患の処置に有用なベンズアゼピン誘導体 |
| JP2011118521A Pending JP2011162564A (ja) | 2003-06-17 | 2011-05-26 | ５ｈｔ２ｃレセプター関連疾患の処置に有用なベンズアゼピン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011118521A Pending JP2011162564A (ja) | 2003-06-17 | 2011-05-26 | ５ｈｔ２ｃレセプター関連疾患の処置に有用なベンズアゼピン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7704993B2 (enExample) |
| EP (2) | EP2332920A3 (enExample) |
| JP (2) | JP4782003B2 (enExample) |
| KR (1) | KR101152521B1 (enExample) |
| CN (4) | CN1805939B (enExample) |
| AU (1) | AU2004253888B2 (enExample) |
| BR (1) | BRPI0411470A (enExample) |
| CA (2) | CA2529320C (enExample) |
| EA (1) | EA016558B1 (enExample) |
| IL (1) | IL172334A (enExample) |
| MX (1) | MXPA05013366A (enExample) |
| NZ (1) | NZ578503A (enExample) |
| WO (1) | WO2005003096A1 (enExample) |
| ZA (2) | ZA200510194B (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| AU2004253888B2 (en) | 2003-06-17 | 2010-11-11 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases |
| MXPA05013364A (es) * | 2003-06-17 | 2006-03-17 | Arena Pharm Inc | Procedimiento para preparar 3-benzazepinas. |
| WO2005042490A1 (en) * | 2003-10-22 | 2005-05-12 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
| EP2400300A1 (en) | 2004-08-25 | 2011-12-28 | Takeda Pharmaceutical Company Limited | Method of screening preventives/remedies for stress urinary incontinence |
| PT1838677E (pt) | 2004-12-21 | 2009-11-16 | Arena Pharm Inc | Formas cristalinas do cloridrato de (r)-8-cloro-1-metil- 2,3,4,5-tetra-hidro-1h-3-benzazepina |
| SI1833473T1 (sl) * | 2004-12-23 | 2010-01-29 | Arena Pharm Inc | Sestavki modulatorjev 5HT2C receptorjev in postopki uporabe |
| ES2397400T3 (es) | 2005-09-01 | 2013-03-06 | Eli Lilly & Company | 6-arilalquilamino-2,3,4,5-tetrahidro-1H-benzo[D]azepinas como agonistas del receptor 5-HT2C |
| CA2619287C (en) * | 2005-09-01 | 2013-10-22 | Eli Lilly And Company | 6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists |
| PL1924560T3 (pl) * | 2005-09-01 | 2009-12-31 | Lilly Co Eli | 6 podstawione - 2,3,4,5 - tetrahydro-1h-benzo[d]azepiny jako agoniści receptora 5-ht2c |
| WO2007028132A2 (en) * | 2005-09-01 | 2007-03-08 | Eli Lilly And Company | 6-N-LINKED HETEROCYCLE-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS |
| BRPI0707183A2 (pt) | 2006-01-19 | 2011-04-26 | Athersys Inc | composto, composição farmacêutica, e, método de tratar uma doença, distúrbio e/ou condição em um paciente |
| WO2007120517A2 (en) | 2006-04-03 | 2007-10-25 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto |
| WO2007132841A1 (ja) | 2006-05-16 | 2007-11-22 | Takeda Pharmaceutical Company Limited | 縮合複素環化合物およびその用途 |
| WO2007140213A1 (en) | 2006-05-26 | 2007-12-06 | Forest Laboratories Holdings Limited | Pyridoazepine derivatives |
| US8299241B2 (en) | 2006-12-05 | 2012-10-30 | Arena Pharmaceuticals, Inc. | Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof |
| CL2008000596A1 (es) * | 2007-03-01 | 2008-09-05 | Glaxo Group Ltd | Forma de dosificacion que comprende 1-(6-[(3-ciclobutil-2,3,4,5-tetrahidro-1h-3-benzazepin-7-il)oxi]-3-piridinil)-2-pirrolidinona, un estabilizador, un excipiente; procedimiento de preparacion; y su uso para tratar enfermedades neurologicas. |
| JP5520051B2 (ja) | 2007-11-15 | 2014-06-11 | 武田薬品工業株式会社 | 縮合ピリジン誘導体およびその用途 |
| JP5491421B2 (ja) * | 2008-03-04 | 2014-05-14 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス |
| UA108357C2 (xx) | 2009-06-15 | 2015-04-27 | Похідні піразинооксазепіну | |
| CN102648170A (zh) | 2009-06-18 | 2012-08-22 | 艾尼纳制药公司 | 制备5-ht2c受体激动剂的方法 |
| JPWO2011071136A1 (ja) | 2009-12-11 | 2013-04-22 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
| US20110269744A1 (en) * | 2010-03-12 | 2011-11-03 | Astellas Pharma Inc. | Benzazepine Compound |
| KR20130112848A (ko) | 2010-06-02 | 2013-10-14 | 아레나 파마슈티칼스, 인크. | 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법 |
| SG188361A1 (en) * | 2010-09-01 | 2013-04-30 | Arena Pharm Inc | Non-hygroscopic salts of 5-ht2c agonists |
| CA2808890A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Administration of lorcaserin to individuals with renal impairment |
| US20130267500A1 (en) | 2010-09-01 | 2013-10-10 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
| WO2012030938A1 (en) * | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Salts of lorcaserin with optically active acids |
| JP6272695B2 (ja) | 2010-09-01 | 2018-01-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 体重管理のために有用な５−ｈｔ２ｃアゴニストの改変放出剤形 |
| JP2013536858A (ja) * | 2010-09-01 | 2013-09-26 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ｈｔ２ｃアゴニストの速く溶解する剤形 |
| CN102895233B (zh) * | 2012-09-04 | 2015-06-24 | 苏州大学 | 苯并氮杂卓类化合物在制备预防或治疗癫痫的药物中的应用 |
| JP2015534563A (ja) | 2012-10-09 | 2015-12-03 | アリーナ ファーマシューティカルズ， インコーポレイテッド | 体重管理の方法 |
| WO2014060575A2 (en) * | 2012-10-19 | 2014-04-24 | Medichem S.A. | Process for the enantioselective synthesis of a tetrahydrobenzazepine compound |
| EP2938345B1 (en) | 2012-12-21 | 2018-08-22 | ABT Holding Company | Benzazepines as serotonin 5-ht2c receptor ligands and uses thereof |
| US9309262B2 (en) | 2013-03-13 | 2016-04-12 | Abt Holding Company | Thienylindole azepines as serotonin 5-HT2C receptor ligands and uses thereof |
| CN103333111A (zh) * | 2013-06-14 | 2013-10-02 | 苏州汇和药业有限公司 | 氯卡色林盐酸盐的制备方法 |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| CN104936947B (zh) * | 2013-12-27 | 2017-03-08 | 杭州普晒医药科技有限公司 | 氯卡色林盐及其晶体、其制备方法和用途 |
| WO2015170346A1 (en) | 2014-05-09 | 2015-11-12 | Council Of Scientific & Industrial Research | A process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-benzo[d]azepine its enantiomers |
| EA022748B1 (ru) * | 2014-06-02 | 2016-02-29 | Делкростон Менеджмент Лимитед | Способы получения двойных солей лоркасерина (варианты), продукты способов, двойные соли, фармацевтические композиции для лечения и/или профилактики нарушений, связанных с ожирением, их применение и способ лечения и/или профилактики нарушений, связанных с ожирением |
| CN104016919A (zh) * | 2014-06-18 | 2014-09-03 | 安徽省逸欣铭医药科技有限公司 | 一种绿卡色林类似物及其制备方法和用途 |
| CN104130188B (zh) * | 2014-08-05 | 2016-08-31 | 南京工业大学 | 8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的制备方法 |
| CN105693610B (zh) * | 2014-11-28 | 2019-01-11 | 国药集团宜宾制药有限责任公司 | 氯卡色林中间体的制备方法 |
| EP3288946B1 (en) * | 2015-04-27 | 2019-08-21 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| CA3002525A1 (en) * | 2015-07-31 | 2017-02-09 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| CN105777638B (zh) * | 2016-01-06 | 2019-07-30 | 北京修正创新药物研究院有限公司 | 氯卡色林杂质的制备方法 |
| CN106631823B (zh) * | 2016-12-20 | 2022-04-26 | 天津泰普制药有限公司 | 一种氯卡色林中间体的制备方法 |
| CN107353250B (zh) * | 2016-12-27 | 2019-11-12 | 开封制药(集团)有限公司 | 一种氯卡色林的合成方法 |
| US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
| CN108358796B (zh) * | 2018-02-23 | 2021-03-23 | 广州同隽医药科技有限公司 | 一种绿卡色林关键中间体ⅰ的制备方法 |
| CN110590695B (zh) * | 2019-10-22 | 2023-03-21 | 南华大学 | 苯并氮杂环类化合物及其应用 |
| CN115784911A (zh) * | 2022-10-19 | 2023-03-14 | 山东省药学科学院 | 一种1-[2-(4-氯苯基)-乙基氨基]-2-丙醇的合成方法 |
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-
2004
- 2004-06-16 AU AU2004253888A patent/AU2004253888B2/en not_active Ceased
- 2004-06-16 EP EP10010300A patent/EP2332920A3/en not_active Withdrawn
- 2004-06-16 EA EA200600048A patent/EA016558B1/ru not_active IP Right Cessation
- 2004-06-16 US US10/561,071 patent/US7704993B2/en not_active Expired - Fee Related
- 2004-06-16 CA CA2529320A patent/CA2529320C/en not_active Expired - Fee Related
- 2004-06-16 CN CN2004800167803A patent/CN1805939B/zh not_active Expired - Lifetime
- 2004-06-16 CN CN2004800167733A patent/CN1805938B/zh not_active Expired - Fee Related
- 2004-06-16 CN CN2008100073149A patent/CN101274911B/zh not_active Expired - Fee Related
- 2004-06-16 EP EP04776811A patent/EP1633720A1/en not_active Withdrawn
- 2004-06-16 JP JP2006517455A patent/JP4782003B2/ja not_active Expired - Fee Related
- 2004-06-16 CN CN201010003763A patent/CN101792417A/zh active Pending
- 2004-06-16 NZ NZ578503A patent/NZ578503A/en not_active IP Right Cessation
- 2004-06-16 WO PCT/US2004/019670 patent/WO2005003096A1/en not_active Ceased
- 2004-06-16 MX MXPA05013366A patent/MXPA05013366A/es active IP Right Grant
- 2004-06-16 BR BRPI0411470-1A patent/BRPI0411470A/pt active Search and Examination
- 2004-06-16 CA CA2888392A patent/CA2888392A1/en not_active Withdrawn
-
2005
- 2005-12-02 IL IL172334A patent/IL172334A/en not_active IP Right Cessation
- 2005-12-14 ZA ZA200510194A patent/ZA200510194B/en unknown
- 2005-12-15 ZA ZA200510255A patent/ZA200510255B/xx unknown
- 2005-12-16 KR KR1020057024149A patent/KR101152521B1/ko not_active Expired - Fee Related
-
2010
- 2010-03-22 US US12/729,026 patent/US8404675B2/en not_active Expired - Fee Related
-
2011
- 2011-05-26 JP JP2011118521A patent/JP2011162564A/ja active Pending
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2012
- 2012-09-14 US US13/616,784 patent/US20130172322A1/en not_active Abandoned
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