JP2003507366A5 - - Google Patents
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- JP2003507366A5 JP2003507366A5 JP2001517500A JP2001517500A JP2003507366A5 JP 2003507366 A5 JP2003507366 A5 JP 2003507366A5 JP 2001517500 A JP2001517500 A JP 2001517500A JP 2001517500 A JP2001517500 A JP 2001517500A JP 2003507366 A5 JP2003507366 A5 JP 2003507366A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- disorders
- compound according
- formula
- disorder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 150000001875 compounds Chemical class 0.000 description 22
- 125000000217 alkyl group Chemical group 0.000 description 8
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 6
- 208000015114 central nervous system disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 208000008589 Obesity Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 235000020824 obesity Nutrition 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 208000018522 Gastrointestinal disease Diseases 0.000 description 2
- 230000003542 behavioural effect Effects 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 238000011321 prophylaxis Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- OBQZQQHWYDPMDY-VIFPVBQESA-N (2s)-1-(2,3,7,8-tetrahydrofuro[2,3-g]indol-1-yl)propan-2-amine Chemical compound C1=C2OCCC2=C2N(C[C@@H](N)C)CCC2=C1 OBQZQQHWYDPMDY-VIFPVBQESA-N 0.000 description 1
- FKTOLQKTYRGKNQ-VIFPVBQESA-N (2s)-1-(2,3,7,8-tetrahydrothieno[2,3-g]indol-1-yl)propan-2-amine Chemical compound C1=C2SCCC2=C2N(C[C@@H](N)C)CCC2=C1 FKTOLQKTYRGKNQ-VIFPVBQESA-N 0.000 description 1
- ISMXLYRBSVZVCO-NSHDSACASA-N (2s)-1-(2,3-dihydrobenzo[g]indol-1-yl)propan-2-amine Chemical compound C1=CC=CC2=C3N(C[C@@H](N)C)CCC3=CC=C21 ISMXLYRBSVZVCO-NSHDSACASA-N 0.000 description 1
- LCJLJRDYLZEDEL-JTQLQIEISA-N (2s)-1-(3,7,8,9-tetrahydro-2h-pyrano[2,3-g]indol-1-yl)propan-2-amine Chemical compound O1CCCC2=C3N(C[C@@H](N)C)CCC3=CC=C21 LCJLJRDYLZEDEL-JTQLQIEISA-N 0.000 description 1
- HIZVCIIORGCREW-UHFFFAOYSA-N 1,4-dioxene Chemical compound C1COC=CO1 HIZVCIIORGCREW-UHFFFAOYSA-N 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 208000000103 Anorexia Nervosa Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000020925 Bipolar disease Diseases 0.000 description 1
- 208000032841 Bulimia Diseases 0.000 description 1
- 206010006550 Bulimia nervosa Diseases 0.000 description 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- LELOWRISYMNNSU-UHFFFAOYSA-N Hydrocyanic acid Natural products N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 1
- 208000026139 Memory disease Diseases 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000027626 Neurocognitive disease Diseases 0.000 description 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010036618 Premenstrual syndrome Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 201000001880 Sexual dysfunction Diseases 0.000 description 1
- 206010041250 Social phobia Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 description 1
- 230000016571 aggressive behavior Effects 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000004104 aryloxy group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 208000025748 atypical depressive disease Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 description 1
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 description 1
- 201000010064 diabetes insipidus Diseases 0.000 description 1
- 125000004663 dialkyl amino group Chemical group 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 125000004852 dihydrofuranyl group Chemical group O1C(CC=C1)* 0.000 description 1
- 125000005043 dihydropyranyl group Chemical group O1C(CCC=C1)* 0.000 description 1
- 125000005057 dihydrothienyl group Chemical group S1C(CC=C1)* 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 201000009941 intracranial hypertension Diseases 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 208000022821 personality disease Diseases 0.000 description 1
- 201000000484 premenstrual tension Diseases 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 231100000872 sexual dysfunction Toxicity 0.000 description 1
- 201000002859 sleep apnea Diseases 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9918965.6 | 1999-08-11 | ||
| GBGB9918965.6A GB9918965D0 (en) | 1999-08-11 | 1999-08-11 | Chemical compounds xxi |
| PCT/GB2000/003008 WO2001012602A1 (en) | 1999-08-11 | 2000-08-04 | Condensed indoline derivatives and their use as 5ht, in particular 5ht2c, receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003507366A JP2003507366A (ja) | 2003-02-25 |
| JP2003507366A5 true JP2003507366A5 (enExample) | 2007-10-04 |
Family
ID=10858983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001517500A Abandoned JP2003507366A (ja) | 1999-08-11 | 2000-08-04 | 縮合インドール誘導体および５ｈｔ、特に５ｈｔ２ｃのレセプターリガンドとしてのこれらの使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (10) | US6962939B1 (enExample) |
| EP (1) | EP1202964B1 (enExample) |
| JP (1) | JP2003507366A (enExample) |
| KR (2) | KR20070086814A (enExample) |
| CN (1) | CN1167681C (enExample) |
| AR (1) | AR030913A1 (enExample) |
| AT (1) | ATE306470T1 (enExample) |
| AU (1) | AU774337B2 (enExample) |
| BR (1) | BR0013314A (enExample) |
| CA (1) | CA2377637A1 (enExample) |
| DE (1) | DE60023146T2 (enExample) |
| ES (1) | ES2250167T3 (enExample) |
| GB (1) | GB9918965D0 (enExample) |
| MX (1) | MXPA01013252A (enExample) |
| PE (1) | PE20010575A1 (enExample) |
| TR (1) | TR200200351T2 (enExample) |
| UY (1) | UY26290A1 (enExample) |
| WO (1) | WO2001012602A1 (enExample) |
| ZA (1) | ZA200110218B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9918965D0 (en) * | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
| SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
| JP4204315B2 (ja) | 2000-11-20 | 2009-01-07 | ビオヴィトルム・アクチボラゲット（プブリクト） | セロトニン５−ｈｔ２レセプターのアンタゴニストとしてのピペラジニルピラジン化合物 |
| JPWO2002074746A1 (ja) * | 2001-03-16 | 2004-07-08 | 山之内製薬株式会社 | ベンゾアゼピン誘導体 |
| BR0211140A (pt) * | 2001-07-13 | 2005-10-25 | Upjohn Co | Compostos e composições de indóis de hexaidroazepina (4, 5-g) e indolinas como ligantes de receptores 5-ht |
| TWI312781B (en) | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
| TW200307682A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
| TW200307540A (en) * | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
| BR0311970A (pt) | 2002-06-19 | 2005-03-29 | Biovitrum Ab | Novos compostos, seu uso e preparação |
| CL2004000826A1 (es) | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
| GB0314967D0 (en) | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
| AR046890A1 (es) * | 2003-12-15 | 2005-12-28 | Alcon Inc | [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma. |
| JP5173190B2 (ja) | 2004-08-25 | 2013-03-27 | 武田薬品工業株式会社 | 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法 |
| GT200500317A (es) | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
| WO2006062839A1 (en) * | 2004-12-08 | 2006-06-15 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
| AR054849A1 (es) | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
| US20090203750A1 (en) * | 2005-08-24 | 2009-08-13 | Alan Kozikowski | 5-HT2C Receptor Agonists as Anorectic Agents |
| JP5528699B2 (ja) | 2006-05-16 | 2014-06-25 | 武田薬品工業株式会社 | 縮合複素環化合物およびその用途 |
| DE102006033114A1 (de) * | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| JP5520051B2 (ja) | 2007-11-15 | 2014-06-11 | 武田薬品工業株式会社 | 縮合ピリジン誘導体およびその用途 |
| WO2011071136A1 (ja) | 2009-12-11 | 2011-06-16 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
| AU2011212930B2 (en) | 2010-02-04 | 2016-02-11 | The Board Of Trustees Of The University Of Illinois | Highly selective 5-HT(2C) receptor agonists having antagonist activity at the 5-HT(2B) receptor |
| PL3250549T3 (pl) | 2015-01-29 | 2021-12-13 | The Board Of Trustees Of The University Of Illinois | Cyklopropylometanoaminy jako selektywni agoniści receptora 5-HT(2C) |
| WO2018151240A1 (ja) * | 2017-02-17 | 2018-08-23 | 第一三共株式会社 | ３，６，７，８－テトラヒドロシクロペンタ［ｅ］インドール化合物 |
| WO2018151239A1 (ja) * | 2017-02-17 | 2018-08-23 | 第一三共株式会社 | ３，６－ジヒドロ－２Ｈ－フロ［２，３－ｅ］インドール化合物 |
| WO2019131902A1 (ja) | 2017-12-27 | 2019-07-04 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2541211A (en) | 1948-10-15 | 1951-02-13 | Searle & Co | Tertiary-aminoalkyl-tetrahydrocarbazoles |
| US2687414A (en) | 1948-11-26 | 1954-08-24 | Searle & Co | Method for producing aromatic aminoalkyl amines |
| DE930988C (de) | 1953-01-01 | 1955-07-28 | Bayer Ag | Verfahren zur Herstellung von basisch alkylierten Tetrahydrocarbazolen oder Indolen |
| US3329571A (en) | 1961-10-24 | 1967-07-04 | American Home Prod | Methods for treating depression |
| US3142678A (en) | 1962-01-09 | 1964-07-28 | American Home Prod | Amino substituted penthienoindoles |
| TW334423B (en) * | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
| TW270114B (enExample) | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
| GB9326192D0 (en) * | 1993-12-22 | 1994-02-23 | Glaxo Group Ltd | Chemical compounds |
| TW403738B (en) | 1994-08-12 | 2000-09-01 | Hoffmann La Roche | Tricyclic pyrazole derivatives |
| FR2742047B1 (fr) * | 1995-12-06 | 1998-01-16 | Oreal | Compositions de teinture des fibres keratiniques contenant des derives n-substitues de la 4-hydroxy indoline, nouveaux derives, leur procede de synthese, leur utilisation pour la teinture, et procede de teinture |
| AU5343298A (en) | 1997-01-13 | 1998-08-03 | Yamanouchi Pharmaceutical Co., Ltd. | 5-ht2c receptor agonists and aminoalkylindazole derivatives |
| AU727654B2 (en) * | 1997-06-13 | 2000-12-21 | Yamanouchi Pharmaceutical Co., Ltd. | Tricyclic pyrazole derivative |
| GB9819035D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Res Ltd | Chemical compounds VII |
| GB9819033D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds VI |
| GB9819019D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| GB9918962D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxii |
| GB9918965D0 (en) * | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
-
1999
- 1999-08-11 GB GBGB9918965.6A patent/GB9918965D0/en not_active Ceased
-
2000
- 2000-08-04 WO PCT/GB2000/003008 patent/WO2001012602A1/en not_active Ceased
- 2000-08-04 KR KR1020077014953A patent/KR20070086814A/ko not_active Ceased
- 2000-08-04 CA CA002377637A patent/CA2377637A1/en not_active Abandoned
- 2000-08-04 JP JP2001517500A patent/JP2003507366A/ja not_active Abandoned
- 2000-08-04 CN CNB008115168A patent/CN1167681C/zh not_active Expired - Fee Related
- 2000-08-04 DE DE60023146T patent/DE60023146T2/de not_active Expired - Fee Related
- 2000-08-04 AT AT00951696T patent/ATE306470T1/de not_active IP Right Cessation
- 2000-08-04 EP EP00951696A patent/EP1202964B1/en not_active Expired - Lifetime
- 2000-08-04 TR TR2002/00351T patent/TR200200351T2/xx unknown
- 2000-08-04 AU AU64554/00A patent/AU774337B2/en not_active Ceased
- 2000-08-04 BR BR0013314-0A patent/BR0013314A/pt not_active IP Right Cessation
- 2000-08-04 ES ES00951696T patent/ES2250167T3/es not_active Expired - Lifetime
- 2000-08-04 KR KR1020027001107A patent/KR20020015077A/ko not_active Abandoned
- 2000-08-04 US US10/009,567 patent/US6962939B1/en not_active Expired - Fee Related
- 2000-08-04 MX MXPA01013252A patent/MXPA01013252A/es active IP Right Grant
- 2000-08-09 PE PE2000000808A patent/PE20010575A1/es not_active Application Discontinuation
- 2000-08-10 AR ARP000104121A patent/AR030913A1/es active IP Right Grant
- 2000-08-11 UY UY26290A patent/UY26290A1/es not_active Application Discontinuation
-
2001
- 2001-12-12 ZA ZA200110218A patent/ZA200110218B/xx unknown
-
2005
- 2005-04-29 US US11/117,460 patent/US7166632B2/en not_active Expired - Fee Related
- 2005-04-29 US US11/117,488 patent/US7173056B2/en not_active Expired - Fee Related
- 2005-04-29 US US11/117,459 patent/US7166613B2/en not_active Expired - Fee Related
-
2006
- 2006-12-12 US US11/637,082 patent/US7323487B2/en not_active Expired - Fee Related
- 2006-12-12 US US11/637,042 patent/US7323473B2/en not_active Expired - Fee Related
- 2006-12-12 US US11/637,036 patent/US7323486B2/en not_active Expired - Fee Related
-
2007
- 2007-11-21 US US11/984,735 patent/US20080114018A1/en not_active Abandoned
- 2007-11-21 US US11/984,734 patent/US20080125455A1/en not_active Abandoned
- 2007-12-04 US US11/987,774 patent/US20080090858A1/en not_active Abandoned
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