JP2007507487A5 - - Google Patents
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- JP2007507487A5 JP2007507487A5 JP2006530762A JP2006530762A JP2007507487A5 JP 2007507487 A5 JP2007507487 A5 JP 2007507487A5 JP 2006530762 A JP2006530762 A JP 2006530762A JP 2006530762 A JP2006530762 A JP 2006530762A JP 2007507487 A5 JP2007507487 A5 JP 2007507487A5
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- JP
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- Prior art keywords
- serogroup
- composition
- conjugated
- capsular saccharide
- composition according
- Prior art date
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- 239000000427 antigen Substances 0.000 claims 18
- 102000038129 antigens Human genes 0.000 claims 18
- 108091007172 antigens Proteins 0.000 claims 18
- 150000001720 carbohydrates Chemical class 0.000 claims 16
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 230000028993 immune response Effects 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000000844 anti-bacterial Effects 0.000 claims 3
- 208000006572 Human Influenza Diseases 0.000 claims 2
- 206010022000 Influenza Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K Aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 108060007869 BAH1 Proteins 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 102100019937 DHRS2 Human genes 0.000 claims 1
- 240000003598 Fraxinus ornus Species 0.000 claims 1
- 241000588650 Neisseria meningitidis Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 229940031000 Streptococcus pneumoniae Drugs 0.000 claims 1
- 230000000240 adjuvant Effects 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 229960003983 diphtheria toxoid Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 200000000004 influenza B Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000002772 monosaccharides Chemical group 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Polymers 0.000 claims 1
- 230000001681 protective Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
Claims (20)
- 被験体への投与後に、N.meningitidisの血清群B、血清群C、血清群W135および血清群Yに対して殺菌性である免疫応答を誘導し得る、水性免疫原性組成物であって、該組成物は、(i)結合体化した血清群C莢膜サッカリド抗原;(ii)結合体化した血清群W135莢膜サッカリド抗原;(iii)結合体化した血清群Y莢膜サッカリド抗原;および(iv)血清群B由来の1以上のポリペプチド抗原を含む、組成物。
- (v)結合体化した血清群A莢膜サッカリド抗原をさらに含む、請求項1に記載の組成物。
- 前記血清群A莢膜サッカリドが、そのモノサッカリド単位の少なくとも20%は3位および4位のいずれかに−OHを有さないように改変される、請求項2に記載の組成物。
- 前記組成物が、37℃にて28日間保存され得、この期間の後、結合体化したMenAサッカリドの初期合計量の20%未満が結合されていない、請求項2または請求項3に記載の組成物。
- 前記結合体化したサッカリドがオリゴサッカリドである、請求項1〜請求項4のいずれかに記載の組成物。
- 前記サッカリドが、ジフテリアトキソイド、破傷風トキソイド、H.influenzaeプロテインD、およびCRM197から選択されるキャリアタンパク質に結合体化される、請求項1〜請求項5のいずれかに記載の組成物。
- 前記組成物が、1〜10の規定された血清群Bポリペプチド抗原をさらに含み、該組成物が、少数の超毒性系統A4、ET 5およびN.meningitidis血清群Bの系統3に対して殺菌性である免疫応答を誘導し得る、請求項1〜請求項6のいずれかに記載の組成物。
- 以下の5つの抗原:(i)オリゴマー形態の「NadA」タンパク質;(ii)「741」タンパク質;(iii)「936」タンパク質;(iv)「953」タンパク質;および(v)「287」タンパク質のうちの1以上を含む、請求項7に記載の組成物。
- 配列番号2のアミノ酸配列を含む第1ポリペプチド;配列番号7のアミノ酸配列を含む第2ポリペプチド;および配列番号8のアミノ酸配列を含む第3ポリペプチドを含む、請求項8に記載の組成物。
- H.influenzae B型(Hib)に対して防御するサッカリド抗原をさらに含む、請求項1〜請求項9のいずれかに記載の組成物。
- Streptococcus pneumoniaeに対して防御する抗原をさらに含む、請求項1〜請求項10のいずれかに記載の組成物。
- リン酸アルミニウムアジュバントを含む、請求項1〜請求項11のいずれかに記載の組成物。
- 気密シールした容器に包装された、請求項1〜請求項12のいずれかに記載の組成物。
- 前記容器がバイアルまたは注射器である、請求項13に記載の組成物。
- 医薬として使用するための、請求項1〜請求項14のいずれかに記載の組成物。
- 哺乳動物において免疫応答を惹起するための医薬の製造における、(i)結合体化した血清群C莢膜サッカリド抗原;(ii)結合体化した血清群W135莢膜サッカリド抗原;(iii)結合体化した血清群Y莢膜サッカリド抗原;(iv)血清群B由来の1以上のポリペプチド抗原;および必要に応じて(v)結合体化した血清群A莢膜サッカリド抗原の使用。
- 哺乳動物において抗体応答を惹起するための、請求項1〜請求項15のいずれかに記載の組成物。
- 水性免疫原性組成物であって、該組成物は、被験体への投与後に、(a)N.meningitidisの少なくとも血清群W135に対して殺菌性であり、そして(b)H.influenzae b型疾患に対して防御性である、免疫応答を誘導し得、ここで、該組成物は、(i)結合体化した血清群W135莢膜サッカリド抗原;(ii)結合体化したH.influenzae b型莢膜サッカリド抗原を含む、組成物。
- 血清群Cおよび血清群Y、必要に応じて血清群A由来の結合体化した莢膜サッカリド抗原をさらに含む、請求項18に記載の組成物。
- N.meningitidis由来の血清群B由来の1以上のポリペプチド抗原をさらに含む、請求項18または請求項19に記載の組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0323102.4 | 2003-10-02 | ||
GB0323102A GB0323102D0 (en) | 2003-10-02 | 2003-10-02 | Liquid vaccines for multiple meningococcal serogroups |
GB0412052.3 | 2004-05-28 | ||
GB0412052A GB0412052D0 (en) | 2004-05-28 | 2004-05-28 | Liquid vaccines for multiple meningococcal serogroups |
PCT/IB2004/003373 WO2005032583A2 (en) | 2003-10-02 | 2004-10-04 | Liquid vaccines for multiple meningococcal serogroups |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011003484A Division JP5618842B2 (ja) | 2003-10-02 | 2011-01-11 | 複数の髄膜炎菌血清群についての液体ワクチン |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007507487A JP2007507487A (ja) | 2007-03-29 |
JP2007507487A5 true JP2007507487A5 (ja) | 2007-11-22 |
JP4738339B2 JP4738339B2 (ja) | 2011-08-03 |
Family
ID=34424891
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006530762A Active JP4738339B2 (ja) | 2003-10-02 | 2004-10-04 | 複数の髄膜炎菌血清群についての液体ワクチン |
JP2011003484A Active JP5618842B2 (ja) | 2003-10-02 | 2011-01-11 | 複数の髄膜炎菌血清群についての液体ワクチン |
JP2014148501A Withdrawn JP2014196362A (ja) | 2003-10-02 | 2014-07-22 | 複数の髄膜炎菌血清群についての液体ワクチン |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011003484A Active JP5618842B2 (ja) | 2003-10-02 | 2011-01-11 | 複数の髄膜炎菌血清群についての液体ワクチン |
JP2014148501A Withdrawn JP2014196362A (ja) | 2003-10-02 | 2014-07-22 | 複数の髄膜炎菌血清群についての液体ワクチン |
Country Status (19)
Country | Link |
---|---|
US (2) | US8765135B2 (ja) |
EP (3) | EP1670506B1 (ja) |
JP (3) | JP4738339B2 (ja) |
CN (2) | CN103405761A (ja) |
AT (1) | ATE506963T1 (ja) |
AU (2) | AU2004277758A1 (ja) |
BR (2) | BR122017002991B1 (ja) |
CA (2) | CA2885040C (ja) |
CY (2) | CY1113522T1 (ja) |
DE (1) | DE602004032481D1 (ja) |
DK (2) | DK1670506T3 (ja) |
ES (1) | ES2397923T3 (ja) |
HK (2) | HK1087946A1 (ja) |
NZ (1) | NZ546430A (ja) |
PL (2) | PL1961426T3 (ja) |
PT (2) | PT1670506E (ja) |
RU (2) | RU2378010C2 (ja) |
SI (2) | SI1670506T1 (ja) |
WO (1) | WO2005032583A2 (ja) |
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