JP2008526939A5 - - Google Patents
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- JP2008526939A5 JP2008526939A5 JP2007550844A JP2007550844A JP2008526939A5 JP 2008526939 A5 JP2008526939 A5 JP 2008526939A5 JP 2007550844 A JP2007550844 A JP 2007550844A JP 2007550844 A JP2007550844 A JP 2007550844A JP 2008526939 A5 JP2008526939 A5 JP 2008526939A5
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- 髄膜炎菌により引き起こされる疾患に対してヒト患者を免疫するための方法における使用のための組成物であって、該組成物は、
（ａ）（ｉ）血清群Ａ 髄膜炎菌の莢膜糖と（ｉｉ）破傷風トキソイドとの結合体；（ｂ）（ｉ）血清群Ｃ 髄膜炎菌の莢膜糖と（ｉｉ）破傷風トキソイドとの結合体；（ｃ）（ｉ）血清群Ｗ１３５ 髄膜炎菌の莢膜糖と（ｉｉ）破傷風トキソイドとの結合体；および（ｄ）（ｉ）血清群Ｙ 髄膜炎菌の莢膜糖と（ｉｉ）破傷風トキソイドとの結合体；のうちの少なくとも２つを含み、該方法は該組成物を該ヒト患者に投与する工程を包含し、該患者は、（ａ）破傷風トキソイド；および／または（ｂ）（ｉ）髄膜炎菌以外の生物の莢膜糖と（ｉｉ）破傷風トキソイドとの結合体で予備免疫されている、組成物。 - 髄膜炎菌により引き起こされる疾患を予防するための医薬の製造における、
（ａ）（ｉ）血清群Ａ 髄膜炎菌の莢膜糖と（ｉｉ）破傷風トキソイドとの結合体；（ｂ）（ｉ）血清群Ｃ 髄膜炎菌の莢膜糖と（ｉｉ）破傷風トキソイドとの結合体；（ｃ）（ｉ）血清群Ｗ１３５ 髄膜炎菌の莢膜糖と（ｉｉ）破傷風トキソイドとの結合体；および（ｄ）（ｉ）血清群Ｙ 髄膜炎菌の莢膜糖と（ｉｉ）破傷風トキソイドとの結合体；のうちの少なくとも２つの使用であって、
該患者は、（ａ）破傷風トキソイド；および／または（ｂ）（ｉ）髄膜炎菌以外の生物の莢膜糖と（ｉｉ）破傷風トキソイドとの結合体で予備免疫されている、使用。 - 請求項１に記載の組成物であって、前記組成物は、（ａ）、（ｂ）、（ｃ）および（ｄ）の４つすべてを含む、組成物。
- 請求項２に記載の使用であって、前記使用が（ａ）、（ｂ）、（ｃ）および（ｄ）の４つすべての使用である、使用。
- 請求項３に記載の組成物または請求項４に記載の使用であって、前記結合体が、（糖の質量として測定して）１：１：１：１の比を生じるように混合される、組成物または使用。
- 請求項１〜５のうちのいずれか１項に記載の組成物または使用であって、１用量当たりの各髄膜炎菌抗原は、血清群１つ当たり（糖に関して測定すると）２μｇ〜１０μｇである、組成物または使用。
- 請求項１〜６のうちのいずれか１項に記載の組成物または使用であって、前記患者は、破傷風トキソイドを含むワクチンで予備免疫されている、組成物または使用。
- 請求項１〜７のうちのいずれか１項に記載の組成物または使用であって、前記患者は、Ｈｉｂ結合体を含むワクチンで予備免疫されている、組成物または使用。
- 請求項１〜８のうちのいずれか１項に記載の組成物または使用であって、前記患者は、少なくとも１つの肺炎球菌結合体を含むワクチンで予備免疫されている、組成物または使用。
- 請求項１〜９のうちのいずれか１項に記載の組成物または使用であって、前記患者は、前記方法または使用の少なくとも６ヶ月前に予備免疫されている、組成物または使用。
- 請求項１０に記載の組成物または使用であって、前記患者は、前記方法または使用の少なくとも８年間前に予備免疫されている、組成物または使用。
- 請求項１〜１１のうちのいずれか１項に記載の組成物または使用であって、前記予備免疫は、前記患者の出生から１年間以内に行われている、組成物または使用。
- 請求項１〜１２のうちのいずれか１項に記載の組成物または使用であって、前記髄膜炎菌結合体（ａ）〜（ｄ）中の糖は、脱重合されており、したがって髄膜炎菌において見出されるネイティブ莢膜糖よりも短い、組成物または使用。
- 請求項１〜１３のうちのいずれか１項に記載の組成物または使用であって、前記髄膜炎菌結合体は、破傷風トキソイドキャリアおよびアジピン酸リンカーを含む、組成物または使用。
- 請求項１４に記載の組成物または使用であって、６０μｇ以下の破傷風トキソイドキャリアを含む、組成物または使用。
- 請求項１〜１５のうちのいずれか１項に記載の組成物または使用であって、前記組成物または医薬は、肺炎連鎖球菌由来の結合体化莢膜糖をさらに含む、組成物または使用。
- 請求項１〜１６のうちのいずれか１項に記載の組成物または使用であって、前記組成物または医薬は、Ｂ型インフルエンザ菌由来の結合体化莢膜糖をさらに含む、組成物または使用。
- 請求項１〜１７のうちのいずれか１項に記載の組成物または使用であって、前記組成物または医薬は、血清群Ｂの髄膜炎菌由来のタンパク質抗原をさらに含む、組成物または使用。
- 請求項１〜１８のうちのいずれか１項に記載の組成物または使用であって、前記組成物または医薬は、水酸化アルミニウムアジュバントおよび／またはリン酸アルミニウムアジュバントを含む、組成物または使用。
- 請求項１〜１９のうちのいずれか１項に記載の組成物または使用であって、前記髄膜炎菌により引き起こされる疾患は、髄膜炎菌性髄膜炎である、組成物または使用。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0500787.7 | 2005-01-14 | ||
| GBGB0500787.7A GB0500787D0 (en) | 2005-01-14 | 2005-01-14 | Integration of meningococcal conjugate vaccination |
| PCT/GB2006/000120 WO2006075170A1 (en) | 2005-01-14 | 2006-01-13 | Meningococcal conjugate vaccination |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012128887A Division JP2012162580A (ja) | 2005-01-14 | 2012-06-06 | 髄膜炎菌結合体ワクチン接種 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008526939A JP2008526939A (ja) | 2008-07-24 |
| JP2008526939A5 true JP2008526939A5 (ja) | 2009-01-08 |
| JP5687405B2 JP5687405B2 (ja) | 2015-03-18 |
Family
ID=34224621
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007550844A Active JP5687405B2 (ja) | 2005-01-14 | 2006-01-13 | 髄膜炎菌結合体ワクチン接種 |
| JP2012128887A Withdrawn JP2012162580A (ja) | 2005-01-14 | 2012-06-06 | 髄膜炎菌結合体ワクチン接種 |
| JP2014104349A Withdrawn JP2014144984A (ja) | 2005-01-14 | 2014-05-20 | 髄膜炎菌結合体ワクチン接種 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012128887A Withdrawn JP2012162580A (ja) | 2005-01-14 | 2012-06-06 | 髄膜炎菌結合体ワクチン接種 |
| JP2014104349A Withdrawn JP2014144984A (ja) | 2005-01-14 | 2014-05-20 | 髄膜炎菌結合体ワクチン接種 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8529908B2 (ja) |
| EP (2) | EP2193810A1 (ja) |
| JP (3) | JP5687405B2 (ja) |
| CN (2) | CN101163508A (ja) |
| AT (1) | ATE463261T1 (ja) |
| AU (1) | AU2006205656B2 (ja) |
| BR (1) | BRPI0606523A2 (ja) |
| CA (1) | CA2595128C (ja) |
| CY (1) | CY1110140T1 (ja) |
| DE (1) | DE602006013406D1 (ja) |
| DK (1) | DK1835939T3 (ja) |
| ES (1) | ES2343855T3 (ja) |
| GB (1) | GB0500787D0 (ja) |
| MX (1) | MX2007008537A (ja) |
| NZ (1) | NZ560201A (ja) |
| PL (1) | PL1835939T3 (ja) |
| PT (1) | PT1835939E (ja) |
| RU (1) | RU2429011C2 (ja) |
| SI (1) | SI1835939T1 (ja) |
| WO (1) | WO2006075170A1 (ja) |
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| HU227613B1 (en) | 2000-06-29 | 2011-09-28 | Glaxosmithkline Biolog Sa | Vaccine composition |
| ATE384072T1 (de) | 2000-09-26 | 2008-02-15 | Idera Pharmaceuticals Inc | Modulation der immunostimulatorischen aktivität von immunostimulierenden oligonukleotidanaloga durch positionelle chemische veränderungen |
| ES2388848T3 (es) | 2001-01-23 | 2012-10-19 | Sanofi Pasteur Inc. | Vacuna meningocócica polivalente preparada con un conjugado de polisacárido y proteína |
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| RU2323002C2 (ru) | 2001-07-26 | 2008-04-27 | Чирон Срл. | Вакцины, содержащие алюминиевые адъюванты и гистидин |
| EP1425040A2 (en) | 2001-09-14 | 2004-06-09 | Cytos Biotechnology AG | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
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| WO2003035836A2 (en) | 2001-10-24 | 2003-05-01 | Hybridon Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends |
| PT1490409E (pt) | 2002-03-26 | 2009-04-03 | Novartis Vaccines & Diagnostic | Sacáridos modificados possuindo uma estabilidade melhorada em água |
| GB0302218D0 (en) * | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
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-
2005
- 2005-01-14 GB GBGB0500787.7A patent/GB0500787D0/en not_active Ceased
-
2006
- 2006-01-13 BR BRPI0606523-6A patent/BRPI0606523A2/pt not_active Application Discontinuation
- 2006-01-13 WO PCT/GB2006/000120 patent/WO2006075170A1/en active Application Filing
- 2006-01-13 EP EP10075124A patent/EP2193810A1/en not_active Ceased
- 2006-01-13 US US11/795,229 patent/US8529908B2/en active Active
- 2006-01-13 PL PL06700004T patent/PL1835939T3/pl unknown
- 2006-01-13 DK DK06700004.2T patent/DK1835939T3/da active
- 2006-01-13 RU RU2007130774/15A patent/RU2429011C2/ru active
- 2006-01-13 PT PT06700004T patent/PT1835939E/pt unknown
- 2006-01-13 JP JP2007550844A patent/JP5687405B2/ja active Active
- 2006-01-13 NZ NZ560201A patent/NZ560201A/en active Application Revival
- 2006-01-13 DE DE602006013406T patent/DE602006013406D1/de active Active
- 2006-01-13 EP EP06700004A patent/EP1835939B1/en not_active Revoked
- 2006-01-13 MX MX2007008537A patent/MX2007008537A/es active IP Right Grant
- 2006-01-13 CN CNA2006800050964A patent/CN101163508A/zh active Pending
- 2006-01-13 SI SI200630704T patent/SI1835939T1/sl unknown
- 2006-01-13 AU AU2006205656A patent/AU2006205656B2/en active Active
- 2006-01-13 CN CN201510442950.4A patent/CN105126097A/zh active Pending
- 2006-01-13 ES ES06700004T patent/ES2343855T3/es active Active
- 2006-01-13 CA CA2595128A patent/CA2595128C/en active Active
- 2006-01-13 AT AT06700004T patent/ATE463261T1/de active
-
2010
- 2010-06-28 CY CY20101100594T patent/CY1110140T1/el unknown
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2012
- 2012-06-06 JP JP2012128887A patent/JP2012162580A/ja not_active Withdrawn
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2014
- 2014-05-20 JP JP2014104349A patent/JP2014144984A/ja not_active Withdrawn
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