DE602004032481D1 - Kombinationsimpfstoffe gegen Meningitis - Google Patents
Kombinationsimpfstoffe gegen MeningitisInfo
- Publication number
- DE602004032481D1 DE602004032481D1 DE602004032481T DE602004032481T DE602004032481D1 DE 602004032481 D1 DE602004032481 D1 DE 602004032481D1 DE 602004032481 T DE602004032481 T DE 602004032481T DE 602004032481 T DE602004032481 T DE 602004032481T DE 602004032481 D1 DE602004032481 D1 DE 602004032481D1
- Authority
- DE
- Germany
- Prior art keywords
- vaccines against
- combination vaccines
- against meningitis
- meningitis
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0323102A GB0323102D0 (en) | 2003-10-02 | 2003-10-02 | Liquid vaccines for multiple meningococcal serogroups |
GB0412052A GB0412052D0 (en) | 2004-05-28 | 2004-05-28 | Liquid vaccines for multiple meningococcal serogroups |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004032481D1 true DE602004032481D1 (de) | 2011-06-09 |
Family
ID=34424891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004032481T Active DE602004032481D1 (de) | 2003-10-02 | 2004-10-04 | Kombinationsimpfstoffe gegen Meningitis |
Country Status (19)
Country | Link |
---|---|
US (2) | US8765135B2 (de) |
EP (3) | EP1670506B1 (de) |
JP (3) | JP4738339B2 (de) |
CN (2) | CN103405761A (de) |
AT (1) | ATE506963T1 (de) |
AU (2) | AU2004277758A1 (de) |
BR (2) | BRPI0415025A (de) |
CA (2) | CA2540896C (de) |
CY (2) | CY1113522T1 (de) |
DE (1) | DE602004032481D1 (de) |
DK (2) | DK1961426T3 (de) |
ES (1) | ES2397923T3 (de) |
HK (2) | HK1087946A1 (de) |
NZ (1) | NZ546430A (de) |
PL (2) | PL1670506T3 (de) |
PT (2) | PT1670506E (de) |
RU (2) | RU2378010C2 (de) |
SI (2) | SI1961426T1 (de) |
WO (1) | WO2005032583A2 (de) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070026021A1 (en) * | 1998-05-01 | 2007-02-01 | Chiron S.R.I. | Neisseria meningitidis antigens and compositions |
AU761780B2 (en) | 1998-05-01 | 2003-06-12 | Glaxosmithkline Biologicals Sa | Neisseria meningitidis antigens and compositions |
DK1079857T3 (da) | 1998-05-29 | 2007-01-29 | Novartis Vaccines & Diagnostic | Meningitidis B/C-kombinationsvacciner |
US7368261B1 (en) | 1999-04-30 | 2008-05-06 | Novartis Vaccines And Diagnostics Srl | Conserved Neisserial antigens |
ES2563677T3 (es) * | 1999-05-19 | 2016-03-15 | Glaxosmithkline Biologicals Sa | Composiciones de combinaciones de Neisseria |
ES2559317T3 (es) | 1999-10-29 | 2016-02-11 | Glaxosmithkline Biologicals Sa | Péptidos antigénicos de Neisseria |
GB9928196D0 (en) * | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
DE60142772D1 (de) * | 2000-01-17 | 2010-09-23 | Novartis Vaccines & Diagnostic | Membranvesikel (omv) impfstoff, der n. meningitidis serogruppe b membranproteine enthält |
NZ521396A (en) | 2000-02-28 | 2004-06-25 | Chiron S | Fusion proteins comprising two or more Neisseria polypeptides |
GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
EP1412381B1 (de) * | 2001-07-27 | 2010-06-02 | Novartis Vaccines and Diagnostics S.r.l. | Antikörper gegen das meningokokken adhäsin app |
GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
PT1524993E (pt) * | 2002-08-02 | 2013-06-12 | Glaxosmithkline Biolog Sa | Composições de vacina de neisseria compreendendo uma combinação de antigénios |
EP2353608B1 (de) | 2002-10-11 | 2019-12-18 | Novartis Vaccines and Diagnostics S.r.l. | Polypeptidimpstoffe zum breiten schutz gegen hypervirulente meningokokken-linien |
GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
PT1670506E (pt) * | 2003-10-02 | 2013-01-28 | Novartis Ag | Vacinas líquidas para serogrupos meningocócicos múltiplos |
GB0408977D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
AU2011204789B2 (en) * | 2004-04-22 | 2013-07-11 | Glaxosmithkline Biologicals S.A. | Immunising against meningococcal serogroup Y using proteins |
GB0413868D0 (en) | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
GB0419408D0 (en) * | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
GB0505518D0 (en) | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
AU2012203419B2 (en) * | 2005-06-27 | 2014-06-26 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
KR20130122810A (ko) * | 2005-06-27 | 2013-11-08 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 제조 방법 |
GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
WO2007066226A2 (en) * | 2005-12-06 | 2007-06-14 | Universita Degli Studi Di Padova | Methods and compositions relating to adhesins as adjuvants |
AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
IN2009KN04098A (de) | 2007-06-04 | 2015-08-28 | Novartis Ag | |
BR122016015627A2 (pt) * | 2007-10-19 | 2018-10-30 | Novartis Ag | kit, composição antigênica liofilizada e método para preparação de uma composição imunogênica |
RU2475496C2 (ru) | 2008-02-21 | 2013-02-20 | Новартис Аг | МЕНИНГОКОККОВЫЕ ПОЛИПЕПТИДЫ fHBP |
WO2009143168A2 (en) * | 2008-05-19 | 2009-11-26 | Novartis Ag | Vaccine assays |
CA2726512A1 (en) * | 2008-06-09 | 2009-12-17 | Novartis Ag | Antibodies against neisserial factor h binding protein |
GB0816447D0 (en) * | 2008-09-08 | 2008-10-15 | Glaxosmithkline Biolog Sa | Vaccine |
US20100330117A1 (en) * | 2008-09-26 | 2010-12-30 | Salubrious Pharmaceutical, Llc | Process for treatment of amyotrophic lateral sclerosis, rheumatoid arthritis, tremors/parkinson's disease, multiple sclerosis, non-viral based cancers, alzheimers's disease, muscular dystrophy, attention deficit disorder, attention deficit hyperactivity disorder, complex regional pain syndrome, diabetes, neuropathic pain, spider arthritis, west nile virus, fibromyalgia, shingles, gout, migraine headaches, senile dementia, post polio syndrome, central virus deafness, asthma, chronic pain of unknown origin and hepatitis c |
US20110020392A1 (en) * | 2008-10-14 | 2011-01-27 | Salubrious Pharmaceutical, Llc | Process for treatment of rheumatoid arthritis, tremors/parkinson's disease, multiple sclerosis and non-viral based cancers |
GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
CA2756522C (en) | 2009-03-24 | 2018-06-26 | Novartis Ag | Adjuvanting meningococcal factor h binding protein |
WO2011161653A1 (en) | 2010-06-25 | 2011-12-29 | Novartis Ag | Combinations of meningococcal factor h binding proteins |
PL3246044T5 (pl) | 2010-08-23 | 2024-06-17 | Wyeth Llc | Stabilne preparaty antygenów rLP2086 Neisseria meningitidis |
WO2012031271A1 (en) | 2010-09-04 | 2012-03-08 | Novartis Ag | Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines |
ES2759484T3 (es) * | 2010-09-10 | 2020-05-11 | Glaxosmithkline Biologicals Sa | Meningococo que sobreexpresa NadA y/o NHBA y vesículas de la membrana externa derivadas del mismo |
MY166172A (en) | 2010-09-10 | 2018-06-07 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
BR112014018815B1 (pt) * | 2012-01-30 | 2022-07-12 | Serum Institute Of India Ltd. | Composição imunogênica compreendendo conjugado proteína-polissacarídeo x de n. meningitidis |
ES2750366T3 (es) | 2012-03-08 | 2020-03-25 | Glaxosmithkline Biologicals Sa | Ensayo de potencia in vitro para vacunas meningocócicas basadas en proteína |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
NZ628449A (en) | 2012-03-09 | 2016-04-29 | Pfizer | Neisseria meningitidis compositions and methods thereof |
JP5698693B2 (ja) * | 2012-03-13 | 2015-04-08 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 髄膜炎菌特異的抗血清に対する血清殺菌アッセイ |
CA2876138C (en) | 2012-06-14 | 2023-09-19 | Novartis Ag | Vaccines for serogroup x meningococcus |
EP2877492A1 (de) | 2012-07-27 | 2015-06-03 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Cd147 als rezeptor für pilusvermittelte adhäsion von meningokokken an gefässendothelzellen |
ES2685894T3 (es) | 2013-03-08 | 2018-10-15 | Pfizer Inc. | Polipéptidos de fusión inmunogénicos |
KR101905278B1 (ko) | 2013-09-08 | 2018-10-08 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
WO2016091902A1 (en) * | 2014-12-09 | 2016-06-16 | Sanofi Pasteur | Compositions comprising n. meningitidis proteins |
EP3270959A1 (de) | 2015-02-19 | 2018-01-24 | Pfizer Inc | Neisseria meningitidis-zusammensetzungen und verfahren dafür |
US10374088B2 (en) * | 2015-06-16 | 2019-08-06 | International Business Machines Corporation | Low parasitic capacitance and resistance finFET device |
KR20180040567A (ko) * | 2015-07-28 | 2018-04-20 | 엠에스디 웰컴 트러스트 힐레맨 랩스 피브이티. 리미티드 | 신규한 나이세리아 메닌지티디스 혈청군 y 올리고머 및 이의 합성방법 |
FI3506935T3 (fi) | 2016-09-02 | 2024-04-17 | Sanofi Pasteur Inc | Neisseria meningitidis -rokote |
SG11201906519RA (en) | 2017-01-31 | 2019-08-27 | Pfizer | Neisseria meningitidis compositions and methods thereof |
WO2018173068A1 (en) * | 2017-03-21 | 2018-09-27 | Msd Wellcome Trust Hilleman Laboratories Pvt. Ltd. | A novel synthetic neisseria meningitidis serogroup a oligomer and process for synthesizing thereof |
WO2021045227A1 (ja) | 2019-09-05 | 2021-03-11 | ダイキン工業株式会社 | 組成物およびその製造方法 |
GB202013262D0 (en) | 2020-08-25 | 2020-10-07 | Glaxosmithkline Biologicals Sa | Vaccine Composition |
Family Cites Families (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB408978A (en) | 1932-10-22 | 1934-04-19 | Zeiss Carl | Improvements in instruments for measuring parallel coordinates |
US4057685A (en) | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
US4673574A (en) | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
US4459286A (en) | 1983-01-31 | 1984-07-10 | Merck & Co., Inc. | Coupled H. influenzae type B vaccine |
US4663160A (en) | 1983-03-14 | 1987-05-05 | Miles Laboratories, Inc. | Vaccines for gram-negative bacteria |
US4761283A (en) | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
US6090406A (en) | 1984-04-12 | 2000-07-18 | The Liposome Company, Inc. | Potentiation of immune responses with liposomal adjuvants |
US5916588A (en) | 1984-04-12 | 1999-06-29 | The Liposome Company, Inc. | Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use |
US4695624A (en) | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
US4882317A (en) | 1984-05-10 | 1989-11-21 | Merck & Co., Inc. | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency |
US4808700A (en) | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
IT1187753B (it) | 1985-07-05 | 1987-12-23 | Sclavo Spa | Coniugati glicoproteici ad attivita' immunogenica trivalente |
US4879213A (en) * | 1986-12-05 | 1989-11-07 | Scripps Clinic And Research Foundation | Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
NL8802046A (nl) | 1988-08-18 | 1990-03-16 | Gen Electric | Polymeermengsel met polyester en alkaansulfonaat, daaruit gevormde voorwerpen. |
JPH04500203A (ja) | 1988-08-25 | 1992-01-16 | ザ リポソーム カンパニー,インコーポレイテッド | インフルエンザワクチンおよび新規なアジュバント |
DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
EP0378881B1 (de) | 1989-01-17 | 1993-06-09 | ENIRICERCHE S.p.A. | Synthetische Peptide und deren Verwendung als allgemeine Träger für die Herstellung von immunogenischen Konjugaten, die für die Entwicklung von synthetischen Impfstoffen geeignet sind |
HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
AU651949B2 (en) | 1989-07-14 | 1994-08-11 | American Cyanamid Company | Cytokine and hormone carriers for conjugate vaccines |
IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
DE69113564T2 (de) | 1990-08-13 | 1996-05-30 | American Cyanamid Co | Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff. |
ATE253114T1 (de) | 1990-08-23 | 2003-11-15 | Univ North Carolina | Transferrin bindende proteine aus neisseria- gonorrhoeae und neisseria-meningitidis |
US5912336A (en) | 1990-08-23 | 1999-06-15 | University Of North Carolina At Chapel Hill | Isolated nucleic acid molecules encoding transferrin binding proteins from Neisseria gonorrhoeae and Neisseria meningitidis |
US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
FR2682041B1 (fr) | 1991-10-03 | 1994-01-14 | Pasteur Merieux Serums Vaccins | Vaccin contre les infections a neisseria meningitidis. |
IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
CA2136429C (en) | 1992-05-23 | 2001-12-11 | Jean Petre | Combined vaccines comprising hepatitis b surface antigen and other antigens |
FR2692592B1 (fr) | 1992-06-19 | 1995-03-31 | Pasteur Merieux Serums Vacc | Fragments d'ADN codant pour les sous-unités du récepteur de la transferrine de Neisseria meningitidis et procédés les exprimant. |
DE69327599T2 (de) | 1992-06-25 | 2000-08-10 | Smithkline Beecham Biolog | Adjuvantien enthaltende Impfstoffzusammensetzung |
IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
US5425946A (en) | 1992-08-31 | 1995-06-20 | North American Vaccine, Inc. | Vaccines against group C Neisseria meningitidis |
AU4841693A (en) | 1992-08-31 | 1994-03-29 | North American Vaccine, Inc. | Vaccines against group c neisseria meningitidis |
ATE204762T1 (de) | 1993-03-23 | 2001-09-15 | Smithkline Beecham Biolog | 3-0-deazylierte monophosphoryl lipid a enthaltende impfstoff-zusammensetzungen |
AU678613B2 (en) | 1993-09-22 | 1997-06-05 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Method of activating soluble carbohydrate using novel cyanylating reagents for the production of immunogenic constructs |
GB9326174D0 (en) | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
GB9422096D0 (en) | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
FR2734484B1 (fr) | 1995-05-24 | 1997-06-27 | Pasteur Merieux Serums Vacc | Composition vaccinale liquide et procede de fabrication |
DK1090642T3 (da) | 1995-06-07 | 2008-09-22 | Glaxosmithkline Biolog Sa | Vacciner omfattende et polysaccharidantigen-bæreprotein-konjugat og frit bæreprotein |
EP0833662B2 (de) | 1995-06-23 | 2011-01-26 | SmithKline Beecham Biologicals S.A. | Eine Impfstoffzusammensetzung, bestehend aus einem Haemophilus influenzae B Polysaccharid Antigen-Konjugat adsorbiert an Aluminiumphosphat |
GB9513261D0 (en) | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
JP5087758B2 (ja) | 1997-03-10 | 2012-12-05 | オタワ ホスピタル リサーチ インスティチュート | アジュバントとして非メチル化CpGジヌクレオチドを含む核酸の使用 |
US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
WO1999011241A1 (en) | 1997-09-05 | 1999-03-11 | Smithkline Beecham Biologicals S.A. | Oil in water emulsions containing saponins |
AU9363798A (en) | 1997-11-06 | 1999-05-31 | Chiron S.P.A. | Neisserial antigens |
GB9725084D0 (en) | 1997-11-28 | 1998-01-28 | Medeva Europ Ltd | Vaccine compositions |
GB9726398D0 (en) | 1997-12-12 | 1998-02-11 | Isis Innovation | Polypeptide and coding sequences |
EP2210945B1 (de) | 1998-01-14 | 2013-06-26 | Novartis Vaccines and Diagnostics S.r.l. | Antigene aus Neisseria meningitidis |
CN1200730C (zh) | 1998-02-12 | 2005-05-11 | 惠氏控股有限公司 | 用白细胞介素-12配制的肺炎球菌和脑膜炎球菌疫苗 |
US7018637B2 (en) | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
US6303114B1 (en) | 1998-03-05 | 2001-10-16 | The Medical College Of Ohio | IL-12 enhancement of immune responses to T-independent antigens |
TR200002930T2 (tr) | 1998-04-09 | 2000-12-21 | Smithkline Beecham Biologicals S.A. | Kolaylaştırıcı kompozisyonlar |
AU761780B2 (en) | 1998-05-01 | 2003-06-12 | Glaxosmithkline Biologicals Sa | Neisseria meningitidis antigens and compositions |
GB9810276D0 (en) | 1998-05-13 | 1998-07-15 | Smithkline Beecham Biolog | Novel compounds |
DK1079857T3 (da) * | 1998-05-29 | 2007-01-29 | Novartis Vaccines & Diagnostic | Meningitidis B/C-kombinationsvacciner |
US6562798B1 (en) | 1998-06-05 | 2003-05-13 | Dynavax Technologies Corp. | Immunostimulatory oligonucleotides with modified bases and methods of use thereof |
GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
DE69941574D1 (de) | 1998-08-19 | 2009-12-03 | Baxter Healthcare Sa | Immunogenes beta-propionamido-gebundenes polysaccharid-protein konjugat geeignet als impfstoff und hergestellt bei verwendung von n-acryloyliertem polysaccharid |
AU1202200A (en) | 1998-10-09 | 2000-05-01 | Chiron Corporation | Neisseria genomic sequences and methods of their use |
US6146902A (en) | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
AR022963A1 (es) * | 1999-03-19 | 2002-09-04 | Smithkline Beecham Biolog | Vacuna |
FR2791895B1 (fr) | 1999-03-23 | 2001-06-15 | Pasteur Merieux Serums Vacc | Utilisation de trehalose pour stabiliser un vaccin liquide |
JP2002541808A (ja) | 1999-04-09 | 2002-12-10 | テクラブ, インコーポレイテッド | ポリサッカリド結合体ワクチンのための組換えトキシンaタンパク質キャリア |
US7368261B1 (en) | 1999-04-30 | 2008-05-06 | Novartis Vaccines And Diagnostics Srl | Conserved Neisserial antigens |
CN1399539A (zh) | 1999-09-24 | 2003-02-26 | 史密丝克莱恩比彻姆生物有限公司 | 含有聚氧乙烯烷基醚或聚氧乙烯烷基酯以及至少一种非离子表面活性剂的佐剂 |
EP1221971A2 (de) | 1999-09-24 | 2002-07-17 | SmithKline Beecham Biologics SA | Verwendung der kombination von polyoxyethylen sorbitan ester und octoxynol als adjuvans und seine verwendung in impfstoffen |
GB9925559D0 (en) | 1999-10-28 | 1999-12-29 | Smithkline Beecham Biolog | Novel method |
GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
AU3108001A (en) | 2000-01-20 | 2001-12-24 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for inducing a th2 immune response |
NZ521396A (en) | 2000-02-28 | 2004-06-25 | Chiron S | Fusion proteins comprising two or more Neisseria polypeptides |
GB0007432D0 (en) | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
EA006313B1 (ru) * | 2000-06-29 | 2005-10-27 | Глаксосмитклайн Байолоджикалс С.А. | Поливалентные иммуногенные композиции и способы их применения |
GB0108364D0 (en) | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
DE60132471T2 (de) | 2000-09-26 | 2009-01-15 | Idera Pharmaceuticals, Inc., Cambridge | Modulation der immunostimulatorischen aktivität von immunostimulierenden oligonukleotidanaloga durch positionelle chemische veränderungen |
SI21352A (sl) * | 2001-01-23 | 2004-06-30 | Aventis Pasteur | Multivalentno meningokokno cepivo iz konjugata polisaharida-proteina |
US20030035806A1 (en) | 2001-05-11 | 2003-02-20 | D'ambra Anello J. | Novel meningitis conjugate vaccine |
GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
CN100350972C (zh) | 2001-07-26 | 2007-11-28 | 启龙股份公司 | 含有铝佐剂和组氨酸的疫苗 |
EP1412381B1 (de) * | 2001-07-27 | 2010-06-02 | Novartis Vaccines and Diagnostics S.r.l. | Antikörper gegen das meningokokken adhäsin app |
GB0121591D0 (en) * | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
CA2492823A1 (en) | 2001-09-14 | 2003-03-27 | Martin F. Bachmann | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
ES2335979T3 (es) | 2001-09-14 | 2010-04-07 | Cytos Biotechnology Ag | Empaquetamiento de cpg inmunoestimuladores en particulas similares a virus: metodo de preparacion y su uso. |
US7838015B2 (en) * | 2001-10-03 | 2010-11-23 | Novartis Vaccines And Diagnostics, Inc. | Adjuvanted meningococcus compositions |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
WO2003035836A2 (en) | 2001-10-24 | 2003-05-01 | Hybridon Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends |
GB0129007D0 (en) * | 2001-12-04 | 2002-01-23 | Chiron Spa | Adjuvanted antigenic meningococcal compositions |
ES2616180T3 (es) | 2002-03-26 | 2017-06-09 | Glaxosmithkline Biologicals Sa | Sacáridos modificados con estabilidad mejorada en agua para su uso como medicamento |
DE60328481D1 (de) | 2002-05-14 | 2009-09-03 | Novartis Vaccines & Diagnostic | Schleimhautapplizierter impfstoff, der das adjuvanz chitosan und menigokokkenantigene enthält |
GB0302218D0 (en) * | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
PT1524993E (pt) | 2002-08-02 | 2013-06-12 | Glaxosmithkline Biolog Sa | Composições de vacina de neisseria compreendendo uma combinação de antigénios |
EP2353608B1 (de) | 2002-10-11 | 2019-12-18 | Novartis Vaccines and Diagnostics S.r.l. | Polypeptidimpstoffe zum breiten schutz gegen hypervirulente meningokokken-linien |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
ES2411080T3 (es) * | 2003-01-30 | 2013-07-04 | Novartis Ag | Vacunas inyectables contra múltiples serogrupos de meningococos |
US20060251675A1 (en) | 2003-03-17 | 2006-11-09 | Michael Hagen | Mutant cholera holotoxin as an adjuvant and an antigen carrier protein |
GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
PT1670506E (pt) * | 2003-10-02 | 2013-01-28 | Novartis Ag | Vacinas líquidas para serogrupos meningocócicos múltiplos |
-
2004
- 2004-10-04 PT PT47917034T patent/PT1670506E/pt unknown
- 2004-10-04 JP JP2006530762A patent/JP4738339B2/ja active Active
- 2004-10-04 PL PL04791703T patent/PL1670506T3/pl unknown
- 2004-10-04 CA CA2540896A patent/CA2540896C/en active Active
- 2004-10-04 BR BRPI0415025-2A patent/BRPI0415025A/pt not_active Application Discontinuation
- 2004-10-04 DK DK08075538.2T patent/DK1961426T3/da active
- 2004-10-04 WO PCT/IB2004/003373 patent/WO2005032583A2/en active Application Filing
- 2004-10-04 RU RU2006114677/13A patent/RU2378010C2/ru active
- 2004-10-04 CN CN2013102049520A patent/CN103405761A/zh active Pending
- 2004-10-04 PT PT08075538T patent/PT1961426E/pt unknown
- 2004-10-04 BR BR122017002991-6A patent/BR122017002991B1/pt active IP Right Grant
- 2004-10-04 EP EP04791703A patent/EP1670506B1/de active Active
- 2004-10-04 SI SI200431702T patent/SI1961426T1/sl unknown
- 2004-10-04 EP EP08075538A patent/EP1961426B1/de not_active Revoked
- 2004-10-04 US US10/574,424 patent/US8765135B2/en active Active
- 2004-10-04 NZ NZ546430A patent/NZ546430A/en not_active IP Right Cessation
- 2004-10-04 DK DK04791703.4T patent/DK1670506T3/da active
- 2004-10-04 SI SI200431991T patent/SI1670506T1/sl unknown
- 2004-10-04 EP EP10180408A patent/EP2277538A1/de not_active Withdrawn
- 2004-10-04 CN CN2013102056030A patent/CN103357002A/zh active Pending
- 2004-10-04 PL PL08075538T patent/PL1961426T3/pl unknown
- 2004-10-04 AU AU2004277758A patent/AU2004277758A1/en not_active Abandoned
- 2004-10-04 CA CA2885040A patent/CA2885040C/en active Active
- 2004-10-04 DE DE602004032481T patent/DE602004032481D1/de active Active
- 2004-10-04 AT AT08075538T patent/ATE506963T1/de active
- 2004-10-04 ES ES04791703T patent/ES2397923T3/es active Active
-
2006
- 2006-09-08 HK HK06110004.7A patent/HK1087946A1/xx not_active IP Right Cessation
-
2008
- 2008-09-12 HK HK08110172.1A patent/HK1114784A1/xx not_active IP Right Cessation
-
2009
- 2009-01-16 AU AU2009200203A patent/AU2009200203A1/en not_active Abandoned
- 2009-09-10 RU RU2009134033/15A patent/RU2595845C2/ru active
-
2011
- 2011-01-11 JP JP2011003484A patent/JP5618842B2/ja active Active
- 2011-07-22 CY CY20111100726T patent/CY1113522T1/el unknown
-
2013
- 2013-02-08 CY CY20131100121T patent/CY1113888T1/el unknown
-
2014
- 2014-06-30 US US14/319,331 patent/US9180204B2/en active Active
- 2014-07-22 JP JP2014148501A patent/JP2014196362A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE506963T1 (de) | Kombinationsimpfstoffe gegen meningitis | |
CY2012030I1 (el) | Πολυδυναμο εμβολιο προϊοντος συζευξης μηνιγγοκοκκικου πολυσακχαριδιου-πρωτεϊνης | |
DK1592457T3 (da) | Folat-vinblastin-konjugat som lægemiddel | |
NO2017005I1 (no) | Human pappilomavirus vaksine [type 6, 11, 16, 18, 31, 33, 45, 52, 58] | |
CY2011001I1 (el) | Εμβολια συνδυασμου για neisseria meningitidis | |
FR2863312B1 (fr) | Turboreacteur a double corps avec moyen d'entrainement des machines accessoires | |
IL184154A0 (en) | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine | |
JP2007169302A5 (de) | ||
ATE432082T1 (de) | Impfstoff gegen periodontale krankheit | |
DK1797893T3 (da) | Antistoffer mod phosphorylcholinkonjugater | |
DE60336350D1 (de) | Handstück für eine medizinische vorrichtung, sowieück | |
IL181951A0 (en) | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine | |
IL181551A0 (en) | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine | |
FR2850163B1 (fr) | Instrument a aiguille avec aiguille double | |
FR2889940B1 (fr) | Fard a paupieres comprenant des nacres | |
ITBO20040519A1 (it) | Unita' di goffratura | |
ITBO20040033A1 (it) | Unita' applicatrice di bocchini a sigari | |
ITBO20030165A1 (it) | Riunito dentale. | |
ITPR20040020A1 (it) | Attrezzo da palestra per traslare l'appoggio rovesciato. | |
NO20026049D0 (no) | Protein-basert vaksine mot meningokokk serogruppe W-135 sykdom | |
ITBO20030116A1 (it) | Dispositivo guida barra universale a smorzamento idraulico | |
ITMC20030025A1 (it) | Soletta sottopiede massaggiante a tenuta d'aria. | |
ITRM20050220A1 (it) | Cappello per divertimento azionato a motore. | |
FR2861633B1 (fr) | Machine a bois a unite de selection | |
ITRM20050567A1 (it) | Dispositivo a sfera guidata denominato "skiball". |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
R082 | Change of representative |
Ref document number: 1961426 Country of ref document: EP Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN, DE |