JP2007504284A5 - - Google Patents
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- Publication number
- JP2007504284A5 JP2007504284A5 JP2006533807A JP2006533807A JP2007504284A5 JP 2007504284 A5 JP2007504284 A5 JP 2007504284A5 JP 2006533807 A JP2006533807 A JP 2006533807A JP 2006533807 A JP2006533807 A JP 2006533807A JP 2007504284 A5 JP2007504284 A5 JP 2007504284A5
- Authority
- JP
- Japan
- Prior art keywords
- halo
- compound according
- compound
- alkyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000005843 halogen group Chemical group 0.000 claims 92
- 150000001875 compounds Chemical class 0.000 claims 45
- 125000001475 halogen functional group Chemical group 0.000 claims 37
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 18
- -1 -OH Chemical group 0.000 claims 12
- 125000006370 trihalo methyl group Chemical group 0.000 claims 12
- 125000004076 pyridyl group Chemical group 0.000 claims 10
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- 125000005842 heteroatoms Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
- 125000006375 C2-C10 alkynyl group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 150000001602 bicycloalkyls Chemical group 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000002551 Irritable Bowel Syndrome Diseases 0.000 claims 1
- 206010068760 Ulcers Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47774403P | 2003-06-12 | 2003-06-12 | |
| US60/477,744 | 2003-06-12 | ||
| PCT/US2004/019189 WO2005004866A1 (en) | 2003-06-12 | 2004-06-14 | Therapeutic agents useful for treating pain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011159464A Division JP2012021000A (ja) | 2003-06-12 | 2011-07-21 | 疼痛を治療するのに有用な治療薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007504284A JP2007504284A (ja) | 2007-03-01 |
| JP2007504284A5 true JP2007504284A5 (US07094801-20060822-C00072.png) | 2011-09-08 |
| JP5269315B2 JP5269315B2 (ja) | 2013-08-21 |
Family
ID=34061917
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533807A Expired - Fee Related JP5269315B2 (ja) | 2003-06-12 | 2004-06-14 | 疼痛を治療するのに有用な治療薬 |
| JP2011159464A Withdrawn JP2012021000A (ja) | 2003-06-12 | 2011-07-21 | 疼痛を治療するのに有用な治療薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011159464A Withdrawn JP2012021000A (ja) | 2003-06-12 | 2011-07-21 | 疼痛を治療するのに有用な治療薬 |
Country Status (28)
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4077320B2 (ja) | 2001-01-29 | 2008-04-16 | 塩野義製薬株式会社 | ５−メチル−１−フェニル−２−（１ｈ）−ピリドンを有効成分として含有する医薬製剤 |
| ATE556067T1 (de) | 2003-05-20 | 2012-05-15 | Ajinomoto Kk | Modulatoren des vanilloid rezeptors |
| TWI287010B (en) * | 2003-06-12 | 2007-09-21 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
| US20050009841A1 (en) * | 2003-07-11 | 2005-01-13 | Zheng Guo Zhu | Novel amides useful for treating pain |
| DE602004017316D1 (de) * | 2003-07-24 | 2008-12-04 | Euro Celtique Sa | Heteroaryl-tetrahydropyridylverbindungen, die sich für die behandlung bzw. die prävention von schmerzen eignen |
| ES2326979T3 (es) * | 2003-07-24 | 2009-10-22 | Euro-Celtique S.A. | Compuestos de piperidina y composiciones farmaceuticas que contienen a los mismos. |
| TW200738232A (en) * | 2006-01-31 | 2007-10-16 | Alcon Mfg Ltd | Use of vanilloid receptor-1 antagonists for the prevention and treatment of glaucoma |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| KR100801278B1 (ko) * | 2006-08-29 | 2008-02-04 | 삼성전기주식회사 | 하이브리드형 광도파로 센서 |
| US7645767B2 (en) * | 2006-08-31 | 2010-01-12 | Trinity Laboratories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
| WO2008057300A2 (en) * | 2006-10-27 | 2008-05-15 | Redpoint Bio Corporation | Trpvi antagonists and uses thereof |
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| MY148657A (en) | 2007-04-27 | 2013-05-15 | Purdue Pharma Lp | Trpv1 antagonists and uses thereof |
| ES2398606T3 (es) | 2007-05-03 | 2013-03-20 | Pfizer Limited | Derivados de 2-piridin-carboxamida como moduladores de los canales de sodio |
| EP2185538A2 (en) * | 2007-08-09 | 2010-05-19 | Abbott Laboratories | Tetrahydropyridine carboxamide derivatives as trpvl antagonists |
| US8084616B2 (en) | 2007-10-24 | 2011-12-27 | Abbott Laboratories | TRPV1 antagonists |
| RU2496494C2 (ru) | 2008-06-30 | 2013-10-27 | Новартис Аг | КОМБИНАЦИИ, СОДЕРЖАЩИЕ МОДУЛЯТОРЫ mGluR, ДЛЯ ЛЕЧЕНИЯ БОЛЕЗНИ ПАРКИНСОНА |
| EP2585446A4 (en) | 2010-06-22 | 2013-12-25 | Shionogi & Co | COMPOUNDS WITH ANTAGONISTIC EFFECT AGAINST TRPV1 AND THEIR USE |
| WO2012158844A1 (en) | 2011-05-17 | 2012-11-22 | Shionogi & Co., Ltd. | Heterocyclic compounds |
| MY185061A (en) | 2011-06-22 | 2021-04-30 | Shionogi & Co | Trpv1 antagonists including dihydroxy substituent and uses thereof |
| WO2013146970A1 (ja) * | 2012-03-29 | 2013-10-03 | 第一三共株式会社 | 新規キノリン誘導体 |
| US9938265B2 (en) * | 2015-11-30 | 2018-04-10 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| CN109561680B (zh) * | 2016-06-23 | 2021-07-13 | 圣朱德儿童研究医院 | 泛酸激酶的小分子调节剂 |
| GB201709459D0 (en) * | 2017-06-14 | 2017-07-26 | Intrabio Ltd | Treatment for migraine |
| JP6964506B2 (ja) * | 2017-12-19 | 2021-11-10 | ライオン株式会社 | 錠剤及び錠剤の製造方法 |
| CA3086671A1 (en) | 2017-12-27 | 2019-07-04 | St. Jude Children's Research Hospital, Inc. | Small molecule modulators of pantothenate kinases |
| CA3086711A1 (en) | 2017-12-27 | 2019-07-04 | St. Jude Children's Research Hospital, Inc. | Methods of treating disorders associated with castor |
| RU2744162C1 (ru) * | 2020-03-18 | 2021-03-03 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ПГФА Минздрава России) | Анальгетическое средство на основе 5-(2-аминопропил)-6-оксо-3,4-дифенилпирроло[3,4-c]пиразола |
| CN113061593B (zh) * | 2021-04-02 | 2023-11-10 | 洛阳华荣生物技术有限公司 | 一种l-苹果酸脱氢酶突变体及其应用 |
| DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
| CN114957214A (zh) * | 2022-06-22 | 2022-08-30 | 九江善水科技股份有限公司 | 一种氯虫苯甲酰胺中间体的制备方法 |
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| US7129235B2 (en) * | 2003-07-11 | 2006-10-31 | Abbott Laboratories | Amides useful for treating pain |
| US20050009841A1 (en) * | 2003-07-11 | 2005-01-13 | Zheng Guo Zhu | Novel amides useful for treating pain |
| ES2326979T3 (es) * | 2003-07-24 | 2009-10-22 | Euro-Celtique S.A. | Compuestos de piperidina y composiciones farmaceuticas que contienen a los mismos. |
| DE602004017316D1 (de) * | 2003-07-24 | 2008-12-04 | Euro Celtique Sa | Heteroaryl-tetrahydropyridylverbindungen, die sich für die behandlung bzw. die prävention von schmerzen eignen |
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-
2004
- 2004-06-11 TW TW093116961A patent/TWI287010B/zh not_active IP Right Cessation
- 2004-06-11 AR ARP040102043A patent/AR044688A1/es unknown
- 2004-06-11 MY MYPI20042274A patent/MY142655A/en unknown
- 2004-06-14 KR KR1020057023740A patent/KR100896497B1/ko not_active IP Right Cessation
- 2004-06-14 DK DK07113391T patent/DK1862458T3/da active
- 2004-06-14 JP JP2006533807A patent/JP5269315B2/ja not_active Expired - Fee Related
- 2004-06-14 ES ES07113391T patent/ES2317623T3/es active Active
- 2004-06-14 SI SI200431012T patent/SI1862458T1/sl unknown
- 2004-06-14 DE DE602004008069T patent/DE602004008069D1/de active Active
- 2004-06-14 WO PCT/US2004/019189 patent/WO2005004866A1/en not_active Application Discontinuation
- 2004-06-14 BR BRPI0411241-5A patent/BRPI0411241A/pt not_active IP Right Cessation
- 2004-06-14 CA CA2528920A patent/CA2528920C/en not_active Expired - Fee Related
- 2004-06-14 EP EP08168291A patent/EP2060260A1/en not_active Withdrawn
- 2004-06-14 CN CN200480023060XA patent/CN1835751B/zh not_active Expired - Fee Related
- 2004-06-14 KR KR1020087029450A patent/KR20090008439A/ko not_active Application Discontinuation
- 2004-06-14 EA EA200501820A patent/EA009593B1/ru not_active IP Right Cessation
- 2004-06-14 AU AU2004255169A patent/AU2004255169B2/en not_active Ceased
- 2004-06-14 AT AT04776652T patent/ATE369133T1/de active
- 2004-06-14 PL PL07113391T patent/PL1862458T3/pl unknown
- 2004-06-14 MX MXPA05013587A patent/MXPA05013587A/es active IP Right Grant
- 2004-06-14 PT PT07113391T patent/PT1862458E/pt unknown
- 2004-06-14 US US10/867,546 patent/US7683063B2/en active Active
- 2004-06-14 EP EP07113391A patent/EP1862458B1/en active Active
- 2004-06-14 EP EP04776652A patent/EP1631285B1/en not_active Withdrawn - After Issue
- 2004-06-14 AT AT07113391T patent/ATE413385T1/de active
- 2004-06-14 DE DE602004017658T patent/DE602004017658D1/de active Active
- 2004-06-14 GE GEAP20049166A patent/GEP20084488B/en unknown
- 2004-06-14 CN CN201010168011A patent/CN101863877A/zh active Pending
-
2005
- 2005-10-28 ZA ZA200508744A patent/ZA200508744B/xx unknown
- 2005-11-23 IS IS8142A patent/IS8142A/is unknown
- 2005-12-06 IL IL172418A patent/IL172418A/en not_active IP Right Cessation
-
2006
- 2006-01-09 MA MA28715A patent/MA27908A1/fr unknown
- 2006-01-12 NO NO20060192A patent/NO20060192L/no not_active Application Discontinuation
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2009
- 2009-01-30 CY CY20091100110T patent/CY1108738T1/el unknown
-
2010
- 2010-02-16 US US12/706,571 patent/US8227467B2/en active Active
-
2011
- 2011-07-21 JP JP2011159464A patent/JP2012021000A/ja not_active Withdrawn
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2012
- 2012-06-18 US US13/525,950 patent/US8680118B2/en active Active
